David E James

David E James

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Dynamic C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin.

iScience 2020 Feb 21;23(2):100855. Epub 2020 Jan 21.

Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan; CREST, Japan Science and Technology Agency, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2020.100855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005519PMC
February 2020

Growth Factor-Dependent and -Independent Activation of mTORC2.

Trends Endocrinol Metab 2020 Jan 4;31(1):13-24. Epub 2019 Nov 4.

Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2019.09.005DOI Listing
January 2020

Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes.

J Biol Chem 2020 Jan 19;295(1):99-110. Epub 2019 Nov 19.

School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia

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http://dx.doi.org/10.1074/jbc.RA119.011695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952605PMC
January 2020

Effects of lake water level fluctuation due to drought and extreme winter precipitation on mixing and water quality of an alpine lake, Case Study: Lake Arrowhead, California.

Sci Total Environ 2020 Jan 18;714:136762. Epub 2020 Jan 18.

Water Quality Solutions Inc., McGaheysville, VA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.scitotenv.2020.136762DOI Listing
January 2020

Estimation of water quality profiles in deep lakes based on easily measurable constituents at the water surface using artificial neural networks coupled with stationary wavelet transform.

Sci Total Environ 2019 Dec 1;694:133690. Epub 2019 Aug 1.

Environmental Laboratory, US Army Engineer Research and Development Center, Vicksburg, MS, USA. Electronic address:

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http://dx.doi.org/10.1016/j.scitotenv.2019.133690DOI Listing
December 2019

Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes.

J Biol Chem 2019 Nov 22;294(45):16729-16739. Epub 2019 Sep 22.

Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales 2006, Australia

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http://dx.doi.org/10.1074/jbc.RA119.010036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851323PMC
November 2019

Phosphoproteomics of Acute Cell Stressors Targeting Exercise Signaling Networks Reveal Drug Interactions Regulating Protein Secretion.

Cell Rep 2019 Nov;29(6):1524-1538.e6

Charles Perkins Centre, School of Life and Environmental Sciences, The University of Sydney, Camperdown, NSW, Australia; Charles Perkins Centre, Sydney Medical School, The University of Sydney, Camperdown, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.10.001DOI Listing
November 2019

Muscle and adipose tissue insulin resistance: malady without mechanism?

J Lipid Res 2019 Oct 27;60(10):1720-1732. Epub 2018 Jul 27.

School of Life and Environmental Sciences, Central Clinical School, University of Sydney, Camperdown, New South Wales, Australia

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http://dx.doi.org/10.1194/jlr.R087510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795081PMC
October 2019

Small-protein Enrichment Assay Enables the Rapid, Unbiased Analysis of Over 100 Low Abundance Factors from Human Plasma.

Mol Cell Proteomics 2019 09 15;18(9):1899-1915. Epub 2019 Jul 15.

‡Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, Australia

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http://dx.doi.org/10.1074/mcp.TIR119.001562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731089PMC
September 2019

A modified gas-trapping method for high-throughput metabolic experiments in .

Biotechniques 2019 09 6;67(3):123-125. Epub 2019 Aug 6.

Charles Perkins Centre, The University of Sydney, Camperdown, NSW 2006, Australia.

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https://www.future-science.com/doi/10.2144/btn-2019-0062
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http://dx.doi.org/10.2144/btn-2019-0062DOI Listing
September 2019

Reduced insulin action in muscle of high fat diet rats over the diurnal cycle is not associated with defective insulin signaling.

Mol Metab 2019 07 12;25:107-118. Epub 2019 Apr 12.

Diabetes and Metabolism Division, The Garvan Institute of Medical Research, Sydney, NSW, Australia; The University of Sydney, School of Medical Science, Charles Perkins Centre D17, Sydney, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600078PMC
July 2019

ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation.

Mol Metab 2019 07 6;25:83-94. Epub 2019 May 6.

Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, 2006, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, 2006, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778193032
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http://dx.doi.org/10.1016/j.molmet.2019.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601125PMC
July 2019

Thirty sweet years of GLUT4.

J Biol Chem 2019 07 7;294(30):11369-11381. Epub 2019 Jun 7.

Charles Perkins Centre, School of Life and Environmental Sciences, Sydney Medical School, University of Sydney, Camperdown, New South Wales 2050, Australia

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http://dx.doi.org/10.1074/jbc.REV119.008351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663870PMC
July 2019

Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway.

Cell Stem Cell 2019 06 28;24(6):895-907.e6. Epub 2019 Mar 28.

School of Biomedical Sciences, The University of Queensland, St Lucia 4072, QLD, Australia; Centre for Cardiac and Vascular Biology, The University of Queensland, St Lucia 4072, QLD, Australia; QIMR Berghofer Medical Research Institute, Brisbane 4006, QLD, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909193010
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http://dx.doi.org/10.1016/j.stem.2019.03.009DOI Listing
June 2019

Proteomic Analysis of Human Plasma during Intermittent Fasting.

J Proteome Res 2019 05 1;18(5):2228-2240. Epub 2019 Apr 1.

Charles Perkins Centre, School of Life and Environmental Sciences , University of Sydney , Sydney , NSW 2006 , Australia.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.9b00090
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http://dx.doi.org/10.1021/acs.jproteome.9b00090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503536PMC
May 2019

Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency.

Cell Syst 2019 May 8;8(5):427-445.e10. Epub 2019 May 8.

Epigenetics & Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24054712193011
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http://dx.doi.org/10.1016/j.cels.2019.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544180PMC
May 2019

Development of a human skeletal micro muscle platform with pacing capabilities.

Biomaterials 2019 04 28;198:217-227. Epub 2018 Nov 28.

School of Biomedical Sciences, The University of Queensland, St Lucia, 4072, Queensland, Australia; Centre for Cardiac and Vascular Biology, The University of Queensland, St Lucia, 4072, Queensland, Australia; QIMR Berghofer Medical Research Institute, Brisbane, 4006, Queensland, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2018.11.030DOI Listing
April 2019

RagC phosphorylation autoregulates mTOR complex 1.

EMBO J 2019 02 14;38(3). Epub 2018 Dec 14.

School of Life and Environmental Sciences, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia

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http://dx.doi.org/10.15252/embj.201899548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356064PMC
February 2019

Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance.

Cell Metab 2019 01 11;29(1):183-191.e7. Epub 2018 Oct 11.

Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; St Vincent's Clinical School, University of New South Wales, Sydney, NSW 2010, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183057
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http://dx.doi.org/10.1016/j.cmet.2018.09.013DOI Listing
January 2019

Illuminating the dark phosphoproteome.

Sci Signal 2019 01 22;12(565). Epub 2019 Jan 22.

School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia.

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http://stke.sciencemag.org/lookup/doi/10.1126/scisignal.aau8
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http://dx.doi.org/10.1126/scisignal.aau8645DOI Listing
January 2019

Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle.

Mol Metab 2018 10 25;16:24-34. Epub 2018 Jul 25.

Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, DK-2100, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158101PMC
October 2018

High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform.

Nat Protoc 2018 09;13(9):1897-1916

Max Planck Institute of Biochemistry, Martinsried, Germany.

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http://www.nature.com/articles/s41596-018-0014-9
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http://dx.doi.org/10.1038/s41596-018-0014-9DOI Listing
September 2018

Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake.

Am J Physiol Endocrinol Metab 2018 08 6;315(2):E258-E266. Epub 2018 Feb 6.

Diabetes and Metabolism Division, Garvan Institute , Sydney, New South Wales , Australia.

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http://dx.doi.org/10.1152/ajpendo.00386.2017DOI Listing
August 2018

Glucose Transport: Methods for Interrogating GLUT4 Trafficking in Adipocytes.

Methods Mol Biol 2018 ;1713:193-215

School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, 2006, Australia.

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http://dx.doi.org/10.1007/978-1-4939-7507-5_15DOI Listing
July 2018

Membrane Topology of Trafficking Regulator of GLUT4 1 (TRARG1).

Biochemistry 2018 07 7;57(26):3606-3615. Epub 2018 Jun 7.

Charles Perkins Centre, School of Life and Environmental Sciences , The University of Sydney , Sydney , New South Wales 2006 , Australia.

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http://dx.doi.org/10.1021/acs.biochem.8b00361DOI Listing
July 2018

Tankyrase modulates insulin sensitivity in skeletal muscle cells by regulating the stability of GLUT4 vesicle proteins.

J Biol Chem 2018 06 18;293(22):8578-8587. Epub 2018 Apr 18.

From the Charles Perkins Centre, School of Life and Environmental Sciences and

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http://dx.doi.org/10.1074/jbc.RA117.001058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986224PMC
June 2018

Investigation of kinetics and absorption isotherm models for hydroponic phytoremediation of waters contaminated with sulfate.

J Environ Manage 2018 Feb 12;207:276-291. Epub 2017 Dec 12.

Department of Civil and Environmental Engineering and Construction, University of Nevada, Las Vegas, Las Vegas, NV, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jenvman.2017.11.039DOI Listing
February 2018

Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise.

Cell Metab 2018 01;27(1):237-251.e4

Cellular and Molecular Metabolism, Garvan Institute of Medical Research, Sydney, NSW, Australia; St Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.12.001DOI Listing
January 2018

A gas trapping method for high-throughput metabolic experiments.

Biotechniques 2018 01 1;64(1):27-29. Epub 2018 Jan 1.

School of Life and Environmental Sciences, Charles Perkins Centre, The University of Sydney.

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http://dx.doi.org/10.2144/000114629DOI Listing
January 2018

Multiplexed Temporal Quantification of the Exercise-regulated Plasma Peptidome.

Mol Cell Proteomics 2017 Dec 5;16(12):2055-2068. Epub 2017 Oct 5.

From the ‡Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia;

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http://dx.doi.org/10.1074/mcp.RA117.000020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724171PMC
December 2017

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism.

Cell Rep 2017 Dec;21(12):3536-3547

School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia; Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia; Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.11.085DOI Listing
December 2017

The Geometric Framework for Nutrition as a tool in precision medicine.

Nutr Healthy Aging 2017 Dec 7;4(3):217-226. Epub 2017 Dec 7.

Charles Perkins Centre, The University of Sydney, NSW, Australia.

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http://dx.doi.org/10.3233/NHA-170027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734128PMC
December 2017

Bicarbonate alters cellular responses in respiration assays.

Biochem Biophys Res Commun 2017 08 27;489(4):399-403. Epub 2017 May 27.

School of Life and Environmental Sciences and Charles Perkins Centre, The University of Sydney, Sydney, 2050, Australia; Sydney Medical School, The University of Sydney, Sydney 2050, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.05.151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568524PMC
August 2017

An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction.

J Cell Sci 2017 Aug 29;130(16):2757-2766. Epub 2017 Jun 29.

Charles Perkins Centre, School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia

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http://dx.doi.org/10.1242/jcs.205369DOI Listing
August 2017

Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice.

J Physiol 2017 07 11;595(14):4845-4855. Epub 2017 Jun 11.

Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1113/JP274203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509878PMC
July 2017

The amino acid transporter, SLC1A3, is plasma membrane-localised in adipocytes and its activity is insensitive to insulin.

FEBS Lett 2017 01 13;591(2):322-330. Epub 2017 Jan 13.

School of Life and Environmental Sciences and Charles Perkins Centre, The University of Sydney, NSW, Australia.

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http://dx.doi.org/10.1002/1873-3468.12549DOI Listing
January 2017

A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets.

Sci Adv 2016 Dec 16;2(12):e1601470. Epub 2016 Dec 16.

Department of Biochemistry and Molecular Biology and the Center for Digestive Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1126/sciadv.1601470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161429PMC
December 2016

mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.

Cell Rep 2016 09;17(1):29-36

Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia; School of Medicine, University of Sydney, Sydney, NSW 2006, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.08.086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485955PMC
September 2016

mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3.

Mol Metab 2016 Aug 22;5(8):646-655. Epub 2016 Jun 22.

Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2016.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021677PMC
August 2016

KinasePA: Phosphoproteomics data annotation using hypothesis driven kinase perturbation analysis.

Proteomics 2016 07 27;16(13):1868-71. Epub 2016 May 27.

School of Mathematics and Statistics, University of Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1002/pmic.201600068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027648PMC
July 2016

Acetyl CoA Carboxylase 2 Is Dispensable for CD8+ T Cell Responses.

PLoS One 2015 14;10(9):e0137776. Epub 2015 Sep 14.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137776PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569334PMC
May 2016

PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells.

J Cell Sci 2016 Apr 12;129(7):1340-54. Epub 2016 Feb 12.

The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia St. Vincent's Clinical School, Faculty of Medicine, UNSW, Darlinghurst 2010, New South Wales, Australia

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http://dx.doi.org/10.1242/jcs.179754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852720PMC
April 2016

Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans.

Obesity (Silver Spring) 2016 Apr 24;24(4):908-16. Epub 2016 Feb 24.

Diabetes and Metabolism Division, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1002/oby.21448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585800PMC
April 2016

Integrated expression analysis of muscle hypertrophy identifies as a negative regulator of muscle mass.

JCI Insight 2016 Apr;1(5)

Baker IDI Heart and Diabetes Institute, Melbourne, Australia; Department of Physiology, The University of Melbourne, Melbourne, Australia; Department of Neurology, The University of Washington, Seattle, Washington, USA; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.

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http://dx.doi.org/10.1172/jci.insight.85477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863241PMC
April 2016

Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice.

J Endocrinol 2016 Mar 14;228(3):127-34. Epub 2015 Dec 14.

Diabetes and Metabolism DivisionGarvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, AustraliaSt Vincent's Clinical SchoolUniversity of New South Wales Australia, Sydney, New South Wales, AustraliaSchool of Medical SciencesUniversity of New South Wales Australia, Sydney, New South Wales, AustraliaSchool of Biotechnology and Biomolecular SciencesUniversity of New South Wales Australia, Sydney, New South Wales, AustraliaSchool of Molecular Bioscience and Sydney Medical SchoolCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia Diabetes and Metabolism DivisionGarvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, AustraliaSt Vincent's Clinical SchoolUniversity of New South Wales Australia, Sydney, New South Wales, AustraliaSchool of Medical SciencesUniversity of New South Wales Australia, Sydney, New South Wales, AustraliaSchool of Biotechnology and Biomolecular SciencesUniversity of New South Wales Australia, Sydney, New South Wales, AustraliaSchool of Molecular Bioscience and Sydney Medical SchoolCharles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia

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http://dx.doi.org/10.1530/JOE-15-0444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906541PMC
March 2016

Positive-unlabeled ensemble learning for kinase substrate prediction from dynamic phosphoproteomics data.

Bioinformatics 2016 Jan 22;32(2):252-9. Epub 2015 Sep 22.

Systems Biology Section, Epigenetics & Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, RTP, NC 27709, USA.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btv550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739180PMC
January 2016

Terminal Galactosylation and Sialylation Switching on Membrane Glycoproteins upon TNF-Alpha-Induced Insulin Resistance in Adipocytes.

Mol Cell Proteomics 2016 Jan 4;15(1):141-53. Epub 2015 Nov 4.

From the ‡Charles Perkins Centre, School of Molecular Bioscience and §School of MedicineUniversity of Sydney, Sydney, Australia;

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http://dx.doi.org/10.1074/mcp.M115.054221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762517PMC
January 2016

Carcinogenic Chromium(VI) Compounds Formed by Intracellular Oxidation of Chromium(III) Dietary Supplements by Adipocytes.

Angew Chem Int Ed Engl 2016 Jan 22;55(5):1742-5. Epub 2015 Dec 22.

School of Chemistry, The University of Sydney, NSW, 2006, Australia.

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http://dx.doi.org/10.1002/anie.201509065DOI Listing
January 2016

Dataset from the global phosphoproteomic mapping of early mitotic exit in human cells.

Data Brief 2015 Dec 24;5:45-52. Epub 2015 Aug 24.

The Kinghorn Cancer Center, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia ; Department of Biochemistry and Molecular Biology, School of Biomedical Sciences Monash University, Clatyon, VIC 3800, Australia.

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http://dx.doi.org/10.1016/j.dib.2015.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564385PMC
December 2015

Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation.

Trends Endocrinol Metab 2015 Dec 20;26(12):676-687. Epub 2015 Oct 20.

Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried 82152, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10432760150019
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http://dx.doi.org/10.1016/j.tem.2015.09.013DOI Listing
December 2015

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates.

Cell Metab 2015 Nov 1;22(5):922-35. Epub 2015 Oct 1.

Charles Perkins Centre, School of Molecular Bioscience, The University of Sydney, Sydney, NSW 2006, Australia; School of Medicine, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635038PMC
November 2015

Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes.

J Biol Chem 2015 Sep 3;290(39):23528-42. Epub 2015 Aug 3.

From the Charles Perkins Centre, School of Molecular Bioscience, and The Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia, and School of Medicine, University of Sydney, Sydney, New South Wales 2006, Australia,

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http://dx.doi.org/10.1074/jbc.M115.657361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583025PMC
September 2015

Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs.

Mol Cell Proteomics 2015 Aug 8;14(8):2194-212. Epub 2015 Jun 8.

¶St. Vincent's Clinical School, Faculty of Medicine, UNSW, Darlinghurst, NSW, Australia; From the ‡The Kinghorn Cancer Center, Garvan Institute of Medical Research, Darlinghurst, NSW, 2010, Australia;

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http://www.mcponline.org/lookup/doi/10.1074/mcp.M114.046938
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http://dx.doi.org/10.1074/mcp.M114.046938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528247PMC
August 2015

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation.

Cell Rep 2015 Aug 30;12(6):937-43. Epub 2015 Jul 30.

Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia; The Charles Perkins Centre, The School of Molecular Bioscience, Sydney Medical School, The University of Sydney, Sydney, NSW 2006, Australia. Electronic address:

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August 2015

The RabGAP TBC1D1 plays a central role in exercise-regulated glucose metabolism in skeletal muscle.

Diabetes 2015 Jun 9;64(6):1914-22. Epub 2015 Jan 9.

Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia School of Molecular Bioscience, University of Sydney, Sydney, New South Wales, Australia Garvan Institute of Medical Research, Sydney, New South Wales, Australia School of Medicine, University of Sydney, Sydney, New South Wales, Australia

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db13
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http://dx.doi.org/10.2337/db13-1489DOI Listing
June 2015

Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry.

Sci Signal 2015 Jun 9;8(380):rs6. Epub 2015 Jun 9.

Charles Perkins Centre, School of Molecular Bioscience, University of Sydney, Sydney, New South Wales 2006, Australia. Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia. School of Medicine, University of Sydney, Sydney, New South Wales 2006, Australia.

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http://stke.sciencemag.org/lookup/doi/10.1126/scisignal.aaa3
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http://dx.doi.org/10.1126/scisignal.aaa3139DOI Listing
June 2015

Selective insulin resistance in adipocytes.

J Biol Chem 2015 May 26;290(18):11337-48. Epub 2015 Feb 26.

the Charles Perkins Centre, School of Molecular Biosciences and the School of Medicine, University of Sydney, New South Wales 2006, Australia, and

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http://dx.doi.org/10.1074/jbc.M114.623686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416839PMC
May 2015

SnapShot: Insulin/IGF1 Signaling.

Cell 2015 May;161(4):948-948.e1

Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia; CSIRO, North Ryde NSW 1670, Australia.

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http://dx.doi.org/10.1016/j.cell.2015.04.041DOI Listing
May 2015

Control of adipocyte differentiation in different fat depots; implications for pathophysiology or therapy.

Front Endocrinol (Lausanne) 2015 30;6. Epub 2015 Jan 30.

Charles Perkins Centre, School of Molecular Bioscience, School of Medicine, The University of Sydney , Sydney, NSW , Australia.

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http://dx.doi.org/10.3389/fendo.2015.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311677PMC
February 2015

DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake.

Diabetologia 2014 Oct 9;57(10):2173-82. Epub 2014 Jul 9.

Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

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http://dx.doi.org/10.1007/s00125-014-3312-yDOI Listing
October 2014

ISL1 regulates peroxisome proliferator-activated receptor γ activation and early adipogenesis via bone morphogenetic protein 4-dependent and -independent mechanisms.

Mol Cell Biol 2014 Oct 21;34(19):3607-17. Epub 2014 Jul 21.

Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia Charles Perkins Centre Research and Education Hub, The University of Sydney, Sydney, New South Wales, Australia

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http://dx.doi.org/10.1128/MCB.00583-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187726PMC
October 2014

Structural basis for phosphorylation and lysine acetylation cross-talk in a kinase motif associated with myocardial ischemia and cardioprotection.

J Biol Chem 2014 Sep 9;289(37):25890-906. Epub 2014 Jul 9.

From the Discipline of Pathology, School of Medical Sciences, University of Sydney, Sydney 2006, Australia, the School of Molecular Bioscience and the Charles Perkins Centre, University of Sydney, Sydney 2006, Australia, and

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162189PMC
September 2014

Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo.

Mol Metab 2014 Sep 27;3(6):630-41. Epub 2014 Jun 27.

Molecular Physiology Group, Department of Nutrition, Exercise and Sports, August Krogh Centre, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.molmet.2014.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142396PMC
September 2014

Systemic VEGF-A neutralization ameliorates diet-induced metabolic dysfunction.

Diabetes 2014 Aug 2;63(8):2656-67. Epub 2014 Apr 2.

Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, AustraliaCharles Perkins Centre, School of Molecular Bioscience, The University of Sydney, Sydney, Australia

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http://dx.doi.org/10.2337/db13-1665DOI Listing
August 2014

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.

Mol Metab 2014 Jul 12;3(4):419-31. Epub 2014 Mar 12.

Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA ; Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.

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http://dx.doi.org/10.1016/j.molmet.2014.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060285PMC
July 2014

Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity.

Mol Metab 2014 Jul 14;3(4):465-73. Epub 2014 Mar 14.

Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia ; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, New South Wales 2010, Australia ; Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, United Kingdom.

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http://dx.doi.org/10.1016/j.molmet.2014.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060222PMC
July 2014

Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity.

J Immunol 2014 Apr 24;192(7):3190-9. Epub 2014 Feb 24.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

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http://www.jimmunol.org/content/early/2014/02/21/jimmunol.13
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1302985
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965631PMC
April 2014

Direction pathway analysis of large-scale proteomics data reveals novel features of the insulin action pathway.

Bioinformatics 2014 Mar 27;30(6):808-14. Epub 2013 Oct 27.

Systems Biology Group, Biostatistics Branch, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA, School of Mathematics and Statistics, University of Sydney, Diabetes and Obesity Program, Garvan Institute of Medical Research, NSW 2006, Australia and Metabolism in Human Disease Unit, Institute of Molecular and Cellular Biology, A*Star, 61 Biopolis Drive, Proteos 138673, Singapore.

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http://dx.doi.org/10.1093/bioinformatics/btt616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957074PMC
March 2014

Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins.

Proc Natl Acad Sci U S A 2013 Aug 5;110(35):E3271-80. Epub 2013 Aug 5.

Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761595PMC
August 2013