Publications by authors named "David E Fisher"

99Publications

Author Correction: From genes to drugs: targeted strategies for melanoma.

Nat Rev Cancer 2020 Oct 12. Epub 2020 Oct 12.

Massachusetts General Hospital Cancer Center, 55 Fruit Street, Boston, Massachusetts, 02114, USA.

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http://dx.doi.org/10.1038/s41568-020-00311-3DOI Listing
October 2020

Up-Regulation of Activating Transcription Factor 3 in Human Fibroblasts Inhibits Melanoma Cell Growth and Migration Through a Paracrine Pathway.

Front Oncol 2020 21;10:624. Epub 2020 Apr 21.

Department of Tissue Engineering and Regeneration, School and Hospital of Stomatology, Shandong University, Jinan, China.

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http://dx.doi.org/10.3389/fonc.2020.00624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187895PMC
April 2020

Treatment of Advanced Melanoma in 2020 and Beyond.

J Invest Dermatol 2020 Apr 5. Epub 2020 Apr 5.

Cutaneous Biology Research Center, Department of Dermatology and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2020.03.943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7541692PMC
April 2020

Topical treatment strategies to manipulate human skin pigmentation.

Adv Drug Deliv Rev 2020 Jan 21;153:65-71. Epub 2020 Feb 21.

Cutaneous Biology Research Center, Massachusetts General Hospital Department of Dermatology, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2020.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442613PMC
January 2020

Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells.

Nature 2020 01 22;577(7792):676-681. Epub 2020 Jan 22.

Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Stem Cell Institute, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41586-020-1935-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184936PMC
January 2020

FOXD3 Regulates VISTA Expression in Melanoma.

Cell Rep 2020 01;30(2):510-524.e6

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.12.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995351PMC
January 2020

Rational Combination Therapy for Melanoma with Dinaciclib by Targeting BAK-Dependent Cell Death.

Mol Cancer Ther 2020 02 19;19(2):627-636. Epub 2019 Nov 19.

Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, Toyama, Japan.

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http://dx.doi.org/10.1158/1535-7163.MCT-19-0451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007861PMC
February 2020

Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies.

Nat Commun 2019 11 14;10(1):5157. Epub 2019 Nov 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, Boston, 02115, MA, USA.

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http://dx.doi.org/10.1038/s41467-019-12477-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856172PMC
November 2019

A ROCK inhibitor promotes keratinocyte survival and paracrine secretion, enhancing establishment of primary human melanocytes and melanocyte-keratinocyte co-cultures.

Pigment Cell Melanoma Res 2020 01 22;33(1):16-29. Epub 2019 Aug 22.

Department of Tissue Engineering and Regeneration, School and Hospital of Stomatology, Shandong University & Shandong Provincial Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China.

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http://dx.doi.org/10.1111/pcmr.12816DOI Listing
January 2020

Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy.

Immunity 2019 06 13;50(6):1498-1512.e5. Epub 2019 May 13.

Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527362PMC
June 2019

Cell-state dynamics and therapeutic resistance in melanoma from the perspective of MITF and IFNγ pathways.

Nat Rev Clin Oncol 2019 09;16(9):549-562

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41571-019-0204-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185899PMC
September 2019

Microphthalmia-associated transcription factor phosphorylation: Cross talk between GSK3 and MAPK signaling.

Pigment Cell Melanoma Res 2019 05 24;32(3):345-347. Epub 2019 Jan 24.

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http://dx.doi.org/10.1111/pcmr.12765DOI Listing
May 2019

Local genomic features predict the distinct and overlapping binding patterns of the bHLH-Zip family oncoproteins MITF and MYC-MAX.

Pigment Cell Melanoma Res 2019 07 21;32(4):500-509. Epub 2018 Dec 21.

Department of Physics, University of Illinois at Urbana-Champaign, Urbana, Illinois.

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http://dx.doi.org/10.1111/pcmr.12762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555698PMC
July 2019

The lncRNA RMEL3 protects immortalized cells from serum withdrawal-induced growth arrest and promotes melanoma cell proliferation and tumor growth.

Pigment Cell Melanoma Res 2019 03 16;32(2):303-314. Epub 2018 Dec 16.

Department of Cell and Molecular Biology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

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http://dx.doi.org/10.1111/pcmr.12751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613776PMC
March 2019

miRNA-211 stops the clock.

Noncoding RNA Investig 2018 May 6;2. Epub 2018 May 6.

Department of Dermatology, Cutaneous Biology Research Center, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.21037/ncri.2018.04.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124680PMC
May 2018

ROCK inhibitor enhances the growth and migration of BRAF-mutant skin melanoma cells.

Cancer Sci 2018 Nov 23;109(11):3428-3437. Epub 2018 Sep 23.

Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of Stomatology, Shandong University, Jinan, China.

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http://dx.doi.org/10.1111/cas.13786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215891PMC
November 2018

Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential.

Trends Endocrinol Metab 2018 10 24;29(10):723-735. Epub 2018 Aug 24.

Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.tem.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151151PMC
October 2018

MITF and UV responses in skin: From pigmentation to addiction.

Pigment Cell Melanoma Res 2019 03 3;32(2):224-236. Epub 2018 Aug 3.

Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/pcmr.12726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336527PMC
March 2019

Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion.

Dev Biol 2019 05 5;449(2):107-114. Epub 2018 Jun 5.

Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute, Boston, MA 02115, USA; Harvard Stem Cell Institute, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2018.05.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281797PMC
May 2019

Targeting the (Un)differentiated State of Cancer.

Cancer Cell 2018 05;33(5):793-795

Cutaneous Biology Research Center, Department of Dermatology and Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.04.007DOI Listing
May 2018

Nonmalignant late cutaneous changes after allogeneic hematopoietic stem cell transplant in children.

J Am Acad Dermatol 2018 Aug 26;79(2):230-237. Epub 2018 Mar 26.

Harvard Medical School, Boston, Massachusetts; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jaad.2018.03.029DOI Listing
August 2018

Pathways in melanoma development.

G Ital Dermatol Venereol 2018 Feb;153(1):68-76

Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA -

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http://dx.doi.org/10.23736/S0392-0488.17.05795-9DOI Listing
February 2018

Negative Regulation of Skin Pigmentation in Three-Dimensional Reconstructs by Adipose-Derived Mesenchymal Cells.

J Invest Dermatol 2017 12;137(12):2464-2466

Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Harvard Medical School, Charlestown, Massachusetts 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.08.001DOI Listing
December 2017

Erratum for Salma et al., "Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor γ2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice".

Mol Cell Biol 2017 11 13;37(21). Epub 2017 Oct 13.

Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1128/MCB.00466-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640810PMC
November 2017

Topical ROR Inverse Agonists Suppress Inflammation in Mouse Models of Atopic Dermatitis and Acute Irritant Dermatitis.

J Invest Dermatol 2017 12 31;137(12):2523-2531. Epub 2017 Jul 31.

Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.07.819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990371PMC
December 2017

A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin.

Cell Rep 2017 06;19(11):2177-2184

Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549921PMC
June 2017

Immune and molecular correlates in melanoma treated with immune checkpoint blockade.

Cancer 2017 06;123(S11):2143-2153

Department of Dermatology and Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.30444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445935PMC
June 2017

Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor γ2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice.

Mol Cell Biol 2017 08 14;37(15). Epub 2017 Jul 14.

Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA

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http://dx.doi.org/10.1128/MCB.00608-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514458PMC
August 2017

The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology.

Lab Invest 2017 06 6;97(6):649-656. Epub 2017 Mar 6.

Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/labinvest.2017.9DOI Listing
June 2017

The melanoma-linked "redhead" MC1R influences dopaminergic neuron survival.

Ann Neurol 2017 Mar 23;81(3):395-406. Epub 2017 Jan 23.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA.

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http://dx.doi.org/10.1002/ana.24852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085083PMC
March 2017

Immunotherapy in the Precision Medicine Era: Melanoma and Beyond.

PLoS Med 2016 Dec 13;13(12):e1002196. Epub 2016 Dec 13.

Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1002196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154509PMC
December 2016

Signaling and Immune Regulation in Melanoma Development and Responses to Therapy.

Annu Rev Pathol 2017 Jan 5;12:75-102. Epub 2016 Dec 5.

Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts 02114.

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http://dx.doi.org/10.1146/annurev-pathol-052016-100208DOI Listing
January 2017

MYO5A Gene Is a Target of MITF in Melanocytes.

J Invest Dermatol 2017 04 6;137(4):985-989. Epub 2016 Dec 6.

Department of Cell and Molecular Biology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X163277
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http://dx.doi.org/10.1016/j.jid.2016.11.026DOI Listing
April 2017

In vivo coherent Raman imaging of the melanomagenesis-associated pigment pheomelanin.

Sci Rep 2016 11 28;6:37986. Epub 2016 Nov 28.

Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/srep37986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125099PMC
November 2016

Bioinformatic Analysis of Gene Expression for Melanoma Treatment.

J Invest Dermatol 2016 12;136(12):2342-2344

Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217826PMC
December 2016

A phase I trial of panobinostat (LBH589) in patients with metastatic melanoma.

Cancer Med 2016 11 17;5(11):3041-3050. Epub 2016 Oct 17.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cam4.862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119958PMC
November 2016

Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma.

Nat Med 2016 09 8;22(9):1056-61. Epub 2016 Aug 8.

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.4155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014622PMC
September 2016

Metastatic melanoma and immunotherapy.

Clin Immunol 2016 Nov 16;172:105-110. Epub 2016 Jul 16.

Department of Dermatology and MGH Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.clim.2016.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569887PMC
November 2016

Inhibition of Cell Proliferation in an NRAS Mutant Melanoma Cell Line by Combining Sorafenib and α-Mangostin.

PLoS One 2016 6;11(5):e0155217. Epub 2016 May 6.

Cutaneous Biology Research Center, Massachusetts General Hospital, 149 Building 13th ST, Charlestown, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155217PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859503PMC
July 2017

Red Hair, Light Skin, and UV-Independent Risk for Melanoma Development in Humans.

JAMA Dermatol 2016 07;152(7):751-3

Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.

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http://dx.doi.org/10.1001/jamadermatol.2016.0524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241673PMC
July 2016

Precision medicine for cancer with next-generation functional diagnostics.

Nat Rev Cancer 2015 Dec 5;15(12):747-56. Epub 2015 Nov 5.

Massachusetts General Hospital Cancer Center, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nrc4015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970460PMC
December 2015

Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment.

PLoS One 2015 13;10(10):e0140310. Epub 2015 Oct 13.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, United States of America; Dermatology and Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140310PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604168PMC
June 2016

Label-free DNA imaging in vivo with stimulated Raman scattering microscopy.

Proc Natl Acad Sci U S A 2015 Sep 31;112(37):11624-9. Epub 2015 Aug 31.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138;

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http://dx.doi.org/10.1073/pnas.1515121112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577158PMC
September 2015

Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.

Science 2015 Jul;349(6247):1261669

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA. Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1126/science.1261669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215039PMC
July 2015

Authors' Reply.

Am J Pathol 2015 Jul;185(7):2070

Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts; Department of Pediatric Hematology/Oncology, Melanoma Program in Medical Oncology, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ajpath.2015.05.002DOI Listing
July 2015

FHL2 switches MITF from activator to repressor of Erbin expression during cardiac hypertrophy.

Int J Cardiol 2015 Sep 20;195:85-94. Epub 2015 May 20.

Department of Nuclear Medicine, Hadassah-Hebrew University Medical Center, P.O. Box 12000, Jerusalem 91120, Israel.

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http://dx.doi.org/10.1016/j.ijcard.2015.05.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478144PMC
September 2015

ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM.

Mol Cancer Res 2015 Aug 20;13(8):1206-17. Epub 2015 May 20.

Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543565PMC
August 2015

Biologic Activity of Autologous, Granulocyte-Macrophage Colony-Stimulating Factor Secreting Alveolar Soft-Part Sarcoma and Clear Cell Sarcoma Vaccines.

Clin Cancer Res 2015 Jul 24;21(14):3178-86. Epub 2015 Mar 24.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Cancer Vaccine Center, Center for Immuno-oncology, and Melanoma Disease Center, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506240PMC
July 2015

Transcription Factor Tfe3 Directly Regulates Pgc-1alpha in Muscle.

J Cell Physiol 2015 Oct;230(10):2330-6

Department of Dermatology, Cutaneous Biology Research Center (CBRC), Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.

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http://doi.wiley.com/10.1002/jcp.24978
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http://dx.doi.org/10.1002/jcp.24978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617629PMC
October 2015

Genome-Wide DNA Methylation Analysis in Melanoma Reveals the Importance of CpG Methylation in MITF Regulation.

J Invest Dermatol 2015 Jul 23;135(7):1820-1828. Epub 2015 Feb 23.

Department of Clinical Sciences, Division of Oncology and Pathology, Lund University, Lund, Sweden; CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1038/jid.2015.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720161PMC
July 2015

Metabolic vulnerability in melanoma: a ME2 (me too) story.

J Invest Dermatol 2015 Mar;135(3):657-659

Department of Dermatology, Cutaneous Biology Research Center, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689190PMC
March 2015

Melanoma.

Nat Rev Dis Primers 2015 04 23;1:15003. Epub 2015 Apr 23.

Department of Dermatology, University Hospital Schleswig-Holstein (UKSH), Kiel, Germany.

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http://dx.doi.org/10.1038/nrdp.2015.3DOI Listing
April 2015

A novel role for microphthalmia-associated transcription factor-regulated pigment epithelium-derived factor during melanoma progression.

Am J Pathol 2015 Jan 6;185(1):252-65. Epub 2014 Nov 6.

Cutaneous Biology Research Center and Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts; Department of Pediatric Hematology/Oncology, Melanoma Program in Medical Oncology, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ajpath.2014.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278358PMC
January 2015

The melanoma revolution: from UV carcinogenesis to a new era in therapeutics.

Science 2014 Nov;346(6212):945-9

Cutaneous Biology Research Center, Department of Dermatology and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1126/science.1253735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701046PMC
November 2014

Tanning as a substance abuse.

Commun Integr Biol 2014 Oct 31;7(5). Epub 2014 Oct 31.

Cutaneous Biology Research Center; Department of Dermatology and MGH Cancer Center; Massachusetts General Hospital; Harvard Medical School ; Boston, MA USA.

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http://dx.doi.org/10.4161/cib.29890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594601PMC
October 2014

The roles of microphthalmia-associated transcription factor and pigmentation in melanoma.

Arch Biochem Biophys 2014 Dec 9;563:28-34. Epub 2014 Aug 9.

Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA; Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.abb.2014.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336945PMC
December 2014

Melanocyte stem cells as potential therapeutics in skin disorders.

Expert Opin Biol Ther 2014 Nov 8;14(11):1569-79. Epub 2014 Aug 8.

Massachusetts General Hospital, Harvard Medical School, Department of Dermatology and Cutaneous Biology Research Center , Boston, MA 02129 , USA +1 617 643 5428 ; +1 617 643 6588 ;

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http://dx.doi.org/10.1517/14712598.2014.935331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616011PMC
November 2014

UV and melanoma: the TP53 link.

Cell Res 2014 Oct 18;24(10):1157-8. Epub 2014 Jul 18.

Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1038/cr.2014.95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185355PMC
October 2014

Skin β-endorphin mediates addiction to UV light.

Cell 2014 Jun;157(7):1527-34

Cutaneous Biology Research Center, Department of Dermatology and MGH Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117380PMC
June 2014

Understanding the biology of melanoma and therapeutic implications.

Hematol Oncol Clin North Am 2014 Jun;28(3):437-53

Department of Dermatology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Bartlett 6, 55 Fruit Street, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.hoc.2014.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116747PMC
June 2014

UV signaling pathways within the skin.

J Invest Dermatol 2014 Aug 12;134(8):2080-2085. Epub 2014 Mar 12.

Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102648PMC
August 2014

Isolation and molecular characterization of circulating melanoma cells.

Cell Rep 2014 May 18;7(3):645-53. Epub 2014 Apr 18.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA; Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Howard Hughes Medical Institute, Bethesda, MD 20815, USA. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(14)00217-4.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471400217
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http://dx.doi.org/10.1016/j.celrep.2014.03.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079008PMC
May 2014

Molecular pathways: BRAF induces bioenergetic adaptation by attenuating oxidative phosphorylation.

Clin Cancer Res 2014 May 7;20(9):2257-63. Epub 2014 Mar 7.

Authors' Affiliations: Massachusetts General Hospital, Department of Dermatology, Cutaneous Biology Research Center, Harvard Medical School, Charlestown; Center for Melanoma, Massachusetts General Hospital Cancer Center; and Brigham and Women's Hospital, Department of Dermatology, Harvard Skin Diseases Research Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008642PMC
May 2014

High-throughput, high-content screening for novel pigmentation regulators using a keratinocyte/melanocyte co-culture system.

Exp Dermatol 2014 Feb;23(2):125-9

Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

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http://doi.wiley.com/10.1111/exd.12322
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http://dx.doi.org/10.1111/exd.12322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977999PMC
February 2014

The impact of MITF on melanoma development: news from bench and bedside.

J Invest Dermatol 2014 Jan;134(1):16-17

Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2013.390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899893PMC
January 2014

Current status of diagnostic and prognostic markers in melanoma.

Methods Mol Biol 2014 ;1102:177-97

Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-62703-727-3_11DOI Listing
June 2014

BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes.

Oncoimmunology 2013 Oct 15;2(10):e26615. Epub 2013 Oct 15.

Department of Surgical Oncology; University of Texas MD Anderson Cancer Center; Houston, TX USA ; Department of Genomic Medicine; University of Texas MD Anderson Cancer Center; Houston, TX USA.

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http://www.tandfonline.com/doi/abs/10.4161/onci.26615
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http://dx.doi.org/10.4161/onci.26615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827093PMC
October 2013

Improving apoptotic responses to targeted therapy.

Oncotarget 2013 Sep;4(9):1331

Department of Dermatology, Massachusetts General Hospital.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824529PMC
http://dx.doi.org/10.18632/oncotarget.1261DOI Listing
September 2013

Disproportionate burden of melanoma mortality in young U.S. men: the possible role of biology and behavior.

JAMA Dermatol 2013 Aug;149(8):903-4

Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1001/jamadermatol.2013.4437DOI Listing
August 2013

Imatinib for melanomas harboring mutationally activated or amplified KIT arising on mucosal, acral, and chronically sun-damaged skin.

J Clin Oncol 2013 Sep 17;31(26):3182-90. Epub 2013 Jun 17.

F. Stephen Hodi, Anita Giobbie-Hurder, Philip Friedlander, Jason J. Luke, Katherine A. Zukotynski, Jeffrey T. Yap, Annick D. Van den Abbeele, and George D. Demetri, Dana-Farber Cancer Institute; Jonathan A. Fletcher, Meijun Zhu, and Adrian Marino-Enriquez, Brigham and Women's Hospital; Donald Lawrence, Keith T. Flaherty, and David E. Fisher, Massachusetts General Hospital, Boston, MA; Christopher L. Corless, Michael C. Heinrich, and Carol Beadling, Portland Veterans Administration Medical Center and Oregon Health & Science University, Portland, OR; Philip Friedlander, Mount Sinai Medical Center, New York, NY; Rene Gonzalez, University of Colorado Cancer Center, Aurora, CO; Jeffrey S. Weber, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Thomas F. Gajewski, University of Chicago, Chicago, IL; Steven J. O'Day, Beverly Hills Cancer Center, Beverly Hills, CA; Kevin B. Kim, The University of Texas MD Anderson Cancer Center, Houston, TX; Frances A. Collichio, The University of North Carolina at Chapel Hill, Chapel Hill, NC; and Marc S. Ernstoff, Geisel School of Medicine and Norris Cotton Cancer Center, Hanover, NH.

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http://dx.doi.org/10.1200/JCO.2012.47.7836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878082PMC
September 2013

Myosin-Va contributes to manifestation of malignant-related properties in melanoma cells.

J Invest Dermatol 2013 Dec 7;133(12):2809-2812. Epub 2013 May 7.

Department of Cellular and Molecular Biology and Pathogenic Bioagents, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Electronic address:

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http://dx.doi.org/10.1038/jid.2013.218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806899PMC
December 2013

How does pheomelanin synthesis contribute to melanomagenesis?: Two distinct mechanisms could explain the carcinogenicity of pheomelanin synthesis.

Bioessays 2013 Aug 7;35(8):672-6. Epub 2013 May 7.

Cutaneous Biology Research Center, Massachusetts General Hospital, Charlestown, MA, USA.

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http://dx.doi.org/10.1002/bies.201300020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033715PMC
August 2013

Targeting melanoma by small molecules: challenges ahead.

Pigment Cell Melanoma Res 2013 Jul 28;26(4):464-9. Epub 2013 May 28.

Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/pcmr.12109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971475PMC
July 2013

Teens and indoor tanning: a cancer prevention opportunity for pediatricians.

Pediatrics 2013 Apr 18;131(4):772-85. Epub 2013 Mar 18.

Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, New York, USA.

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http://dx.doi.org/10.1542/peds.2012-2404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535027PMC
April 2013

BRAF and MC1R in melanoma: different in head and neck tumors?

J Invest Dermatol 2013 Apr;133(4):878-80

Department of Dermatology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/jid.2012.475DOI Listing
April 2013