David E Arnot

David E Arnot

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David E Arnot

David E Arnot

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Tying up Loose Ends in the Malaria Antigenic Variation Story.

Authors:
David E Arnot

Trends Parasitol 2019 Aug 29;35(8):588-590. Epub 2019 Jun 29.

Zhejiang University-University of Edinburgh (ZJE) Institute and Second Affiliated Hospital, Zhejiang University School of Medicine, China. Electronic address:

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http://dx.doi.org/10.1016/j.pt.2019.06.006DOI Listing
August 2019

A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds.

Nat Commun 2019 05 14;10(1):2060. Epub 2019 May 14.

Department of Orthopaedic Surgery, Second Affiliated Hospital and Zhejiang University-University of Edinburgh Institute and School of Basic Medicine, Zhejiang University School of Medicine, Hangzhou, 310003, China.

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http://dx.doi.org/10.1038/s41467-019-10004-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517429PMC
May 2019

Antigenic Variation and the Genetics and Epigenetics of the PfEMP1 Erythrocyte Surface Antigens in Plasmodium falciparum Malaria.

Adv Appl Microbiol 2011 ;74:77-96

Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, CSS Oester Farimagsgade 5, Copenhagen K, Denmark; Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), CSS Oester Farimagsgade 5, Copenhagen K, Denmark; Institute of Immunology and Infection Research, School of Biology, University of Edinburgh, Edinburgh, Scotland, United Kingdom.

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http://dx.doi.org/10.1016/B978-0-12-387022-3.00007-0DOI Listing
April 2016

How malaria parasites avoid running out of ammo.

Authors:
David E Arnot

PLoS Genet 2014 Dec 18;10(12):e1004878. Epub 2014 Dec 18.

University of Edinburgh, School of Biological Sciences, Institute for Immunology and Infection Research, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1004878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270491PMC
December 2014

DNA secondary structures are associated with recombination in major Plasmodium falciparum variable surface antigen gene families.

Nucleic Acids Res 2014 Feb 18;42(4):2270-81. Epub 2013 Nov 18.

Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Farimagsgade 5, Building 22 & 23, PO Box 2099, 1014 Copenhagen K, Denmark, Centre for Medical Parasitology, Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen K, Denmark, Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, 2800 Lyngby, Denmark, Department of Biology, University of Copenhagen, Ole Maaloees Vej 5, DK-2200 Copenhagen N, Denmark, Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark, Institute of Infection and Immunology Research, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland, UK and Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1093/nar/gkt1174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936766PMC
February 2014

Expression of a type B RIFIN in Plasmodium falciparum merozoites and gametes.

Malar J 2012 Dec 21;11:429. Epub 2012 Dec 21.

Centre for Medical Parasitology, Department of International Health, Immunology, and Microbiology, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1186/1475-2875-11-429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544569PMC
December 2012

Analysis of single-cell gene transcription by RNA fluorescent in situ hybridization (FISH).

J Vis Exp 2012 Oct 7(68). Epub 2012 Oct 7.

Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, University of Copenhagen, Copenhagen.

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http://dx.doi.org/10.3791/4073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912591PMC
October 2012

Comparative decline in funding of European Commission malaria vaccine projects: what next for the European scientists working in this field?

Malar J 2011 Sep 1;10:255. Epub 2011 Sep 1.

European Vaccine Initiative, UniversitätsKlinikum Heidelberg, Im Neuenheimer Feld 326, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1186/1475-2875-10-255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196926PMC
September 2011

Positive selection of Plasmodium falciparum parasites with multiple var2csa-type PfEMP1 genes during the course of infection in pregnant women.

J Infect Dis 2011 Jun;203(11):1679-85

Centre for Medical Parasitology, Department of International Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1093/infdis/jir168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096795PMC
June 2011

The chondroitin sulfate A-binding site of the VAR2CSA protein involves multiple N-terminal domains.

J Biol Chem 2011 May 11;286(18):15908-17. Epub 2011 Mar 11.

Department of International Health, Immunology, University of Copenhagen and the Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen K, Denmark.

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http://dx.doi.org/10.1074/jbc.M110.191510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3091200PMC
May 2011

The progression of the intra-erythrocytic cell cycle of Plasmodium falciparum and the role of the centriolar plaques in asynchronous mitotic division during schizogony.

Int J Parasitol 2011 Jan 17;41(1):71-80. Epub 2010 Sep 17.

Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, 1014 København K, Denmark.

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http://dx.doi.org/10.1016/j.ijpara.2010.07.012DOI Listing
January 2011

Surface co-expression of two different PfEMP1 antigens on single plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1.

PLoS Pathog 2010 Sep 2;6(9):e1001083. Epub 2010 Sep 2.

Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.

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http://dx.doi.org/10.1371/journal.ppat.1001083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932717PMC
September 2010

The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs.

Malar J 2010 Apr 19;9:100. Epub 2010 Apr 19.

Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), CSS Øster Farimagsgade 5, Building 22 & 23, Postbox 2099, 1014 Copenhagen K, Denmark.

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http://dx.doi.org/10.1186/1475-2875-9-100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868858PMC
April 2010

The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer.

Parasitol Int 2009 Dec 16;58(4):478-80. Epub 2009 Jul 16.

Department of International Health, Immunology, and Microbiology, University of Copenhagen, Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.parint.2009.07.004DOI Listing
December 2009

Multiple var2csa-type PfEMP1 genes located at different chromosomal loci occur in many Plasmodium falciparum isolates.

PLoS One 2009 Aug 19;4(8):e6667. Epub 2009 Aug 19.

Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen & Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006667PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723927PMC
August 2009

Dual fluorescence labeling of surface-exposed and internal proteins in erythrocytes infected with the malaria parasite Plasmodium falciparum.

Nat Protoc 2008 ;3(12):1990-6

Department of International Health, Immunology and Microbiology, Centre for Medical Parasitology, University of Copenhagen, Copenhagen University Hospital (Rigshospitalet), CSS Øster Farimagsgade 5, Building 22, PO Box 2099, 1014 Copenhagen K, Denmark.

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http://dx.doi.org/10.1038/nprot.2008.196DOI Listing
April 2009

Comparative testing of six antigen-based malaria vaccine candidates directed toward merozoite-stage Plasmodium falciparum.

Clin Vaccine Immunol 2008 Sep 11;15(9):1345-55. Epub 2008 Jun 11.

Centre for Medical Parasitology, Institute for International Health, Immunology and Microbiology, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1128/CVI.00172-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546674PMC
September 2008

A method for visualizing surface-exposed and internal PfEMP1 adhesion antigens in Plasmodium falciparum infected erythrocytes.

Malar J 2008 Jun 5;7:101. Epub 2008 Jun 5.

Centre for Medical Parasitology, Department of International Health, Immunology & Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen K, Denmark.

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http://dx.doi.org/10.1186/1475-2875-7-101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453135PMC
June 2008

Changes in var gene mRNA levels during erythrocytic development in two phenotypically distinct Plasmodium falciparum parasites.

Malar J 2007 Jun 12;6:78. Epub 2007 Jun 12.

Centre for Medical Parasitology at Department of International Health, Immunology and Microbiology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.

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http://dx.doi.org/10.1186/1475-2875-6-78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904452PMC
June 2007

Rapid and specific biotin labelling of the erythrocyte surface antigens of both cultured and ex-vivo Plasmodium parasites.

Malar J 2007 May 22;6:66. Epub 2007 May 22.

Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, King's Buildings, Edinburgh, Scotland, UK.

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http://dx.doi.org/10.1186/1475-2875-6-66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891309PMC
May 2007

Further definition of PfEMP-1 DBL-1alpha domains mediating rosetting adhesion of Plasmodium falciparum.

Mol Biochem Parasitol 2005 Nov;144(1):109-13

Institute of Immunology and Infection Research, Division of Biological Sciences, Ashworth Laboratory, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JT, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2005.06.009DOI Listing
November 2005

Antibodies from malaria-exposed pregnant women recognize trypsin resistant epitopes on the surface of Plasmodium falciparum-infected erythrocytes selected for adhesion to chondroitin sulphate A.

Malar J 2004 Sep 6;3:31. Epub 2004 Sep 6.

Institute of Cell, Animal and Population Biology, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh, EH9 3JT, Scotland, UK.

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http://dx.doi.org/10.1186/1475-2875-3-31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC517943PMC
September 2004

High throughput immuno-screening of cDNA expression libraries produced by in vitro recombination; exploring the Plasmodium falciparum proteome.

Mol Biochem Parasitol 2004 Feb;133(2):267-74

Institute of Cell, Animal and Population Biology, Ashworth Laboratories, Kings' Buildings, University of Edinburgh, West Mains Road, Edinburgh, Scotland, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2003.10.013DOI Listing
February 2004

Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions.

Malar J 2003 Sep 10;2:27. Epub 2003 Sep 10.

Centre for Medical Parasitology at Institute for Medical Microbiology and Immunology, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1186/1475-2875-2-27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC222925PMC
September 2003

Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria.

Mol Microbiol 2003 Jul;49(1):179-91

Centre for Medical Parasitology at the Institute for Medical Microbiology and Immunology, University of Copenhagen, Panum Institute 24-2, and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Denmark.

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http://dx.doi.org/10.1046/j.1365-2958.2003.03570.xDOI Listing
July 2003

In vivo switching between variant surface antigens in human Plasmodium falciparum infection.

J Infect Dis 2002 Sep 5;186(5):719-22. Epub 2002 Aug 5.

Centre for Medical Parasitology, Copenhagen University Hospital, Rigshospitalet, and Institute for Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1086/342390DOI Listing
September 2002

A sub-family of common and highly conserved Plasmodium falciparum var genes.

Mol Biochem Parasitol 2002 Jun;122(1):111-5

Centre for Medical Parasitology at Institute for Medical Microbiology and Immunology, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/s0166-6851(02)00080-4DOI Listing
June 2002

The influence of the genetic complexity of Plasmodium falciparum infections on the epidemiology of malaria.

Authors:
David E Arnot

Trans R Soc Trop Med Hyg 2002 Apr;96 Suppl 1:S131-6

Institute of Cell, Animal and Population Biology, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK.

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http://dx.doi.org/10.1016/s0035-9203(02)90064-7DOI Listing
April 2002