David Dingli

David Dingli

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David Dingli

David Dingli

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Oral Selinexor-Dexamethasone for Triple-Class Refractory Multiple Myeloma.

N Engl J Med 2019 08;381(8):727-738

From the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai (A.C., S.P., S.J.), and New York University Langone Medical Center (D.K.) - both in New York; the Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia (D.T.V.); the School of Medicine, National and Kapodistrian University of Athens, Athens (M.G., M. Dimopoulos); the Winship Cancer Institute, Emory University, Atlanta (A.K.N., S.L.); Massachusetts General Hospital Cancer Center (A.J.Y.), Tufts Medical Center (R.L.C.), and the Dana-Farber Cancer Institute (P.G.R.), Boston, and Karyopharm Therapeutics, Newton (M.G.K., S.S., L.L., S. Tang, C.P., J.-R.S.-M., M.C., H.C., Y.L., J.S.) - all in Massachusetts; Johns Hopkins University, Baltimore (C.A.H.); the University of Nantes, Nantes (P.M.), Hôpital Necker (L.F.), Hôpital Saint-Antoine (M.M.), and La Pitié-Salpêtrière Hospital (S.C.), Paris, University Hospital, Lille (T.F.), Centre Hospitalier Lyon Sud, Pierre-Benite (L.K.), and Centre Hospitalo-Universitaire Vandoeuvre-lès-Nancy, Nancy (A.P.) - all in France; the Mayo Clinic, Rochester, MN (D.D.); the University of Michigan, Ann Arbor (C.C.); the Mayo Clinic of Arizona, Phoenix (A.K.S.); Hackensack University Medical Center, Hackensack, NJ (J.R.); Washington University School of Medicine, St. Louis (R.V.); Lineberger Comprehensive Cancer Center at University of North Carolina-Chapel Hill, Chapel Hill (S. Tuchman); the University of Heidelberg, Heidelberg (M.S.R.), University Medical Center Hamburg-Eppendorf, Hamburg (K.C.W.), the University of Tübingen, Tübingen (K.C.W.), University Hospital Würzburg, Würzburg (M.S.), the University of Freiburg, Freiburg (M.E.), and Gemeinschaftspraxis Hämatologie-Onkologie, Dresden (T.I.) - all in Germany; the University of Leuven, Leuven (M. Delforge), Institut Jules Bordet, Université Libre de Bruxelles, Brussels (N.M.), University Hospital Ghent, Ghent (P.V.), and Centre Hospitalier Universitaire Université Catholique de Louvain Namur, Yvoir (C.D.) - all in Belgium; Vanderbilt University Medical Center, Nashville (R.F.C.); Sylvester Cancer Center, University of Miami, Miami (J.E.H.); the University of Alabama at Birmingham, Birmingham (L.J.C.); Yale School of Medicine, New Haven, CT (T.L.P.); Baylor University Medical Center, Dallas (M.L.); the David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (G.S.); and University Hospital Krems, Karl Landsteiner University of Health Sciences, Krems an der Donau, Austria (K.P.).

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http://dx.doi.org/10.1056/NEJMoa1903455DOI Listing
August 2019

The invasion of de-differentiating cancer cells into hierarchical tissues.

PLoS Comput Biol 2019 Jul 1;15(7):e1007167. Epub 2019 Jul 1.

Department of Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Plön, Germany.

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http://dx.doi.org/10.1371/journal.pcbi.1007167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625723PMC
July 2019

Metformin inhibits IL-6 signaling by decreasing IL-6R expression on multiple myeloma cells.

Leukemia 2019 Apr 15. Epub 2019 Apr 15.

Division of Hematology, Mayo Clinic, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1038/s41375-019-0470-4DOI Listing
April 2019

How many samples are needed to infer truly clonal mutations from heterogenous tumours?

BMC Cancer 2019 Apr 29;19(1):403. Epub 2019 Apr 29.

Department of Evolutionary Theory, Max Planck Institute for Evolutionary Biology, August-Thienemann-Str. 2, Plön, 24306, Germany.

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5597-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489174PMC
April 2019

T-cell large granular lymphocytic leukemia and plasma cell disorders.

Haematologica 2019 Mar 20;104(3):e108-e110. Epub 2018 Sep 20.

Division of Hematology, Department of Internal Medicine

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http://dx.doi.org/10.3324/haematol.2018.204099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395327PMC
March 2019

Autologous Stem Cell Transplant for IgM-Associated Amyloid Light-Chain Amyloidosis.

Biol Blood Marrow Transplant 2019 03 7;25(3):e108-e111. Epub 2018 Dec 7.

Division of Hematology, Department of Internal Medicine, Mayo Clinic Rochester, Rochester, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2018.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445701PMC
March 2019

Imaging of Oncolytic Measles Virus Propagation with Single-Cell Resolution.

Mol Ther Oncolytics 2019 Mar 15;12:68-78. Epub 2018 Dec 15.

Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.omto.2018.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348983PMC
March 2019

Therapy for relapsed multiple myeloma.

Panminerva Med 2018 Dec 5;60(4):174-184. Epub 2018 Oct 5.

Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA -

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https://www.minervamedica.it/index2.php?show=R41Y9999N00A181
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http://dx.doi.org/10.23736/S0031-0808.18.03542-5DOI Listing
December 2018

A Patient With Hereditary ATTR and a Novel AGel p.Ala578Pro Amyloidosis.

Mayo Clin Proc 2018 11 7;93(11):1678-1682. Epub 2018 Aug 7.

Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00256196183049
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http://dx.doi.org/10.1016/j.mayocp.2018.06.016DOI Listing
November 2018

Oncolytic virotherapy - .

Oncotarget 2018 Nov 20;9(91):36254-36255. Epub 2018 Nov 20.

David Dingli: Department of Molecular Medicine, Mayo Clinic, Rochester, MN, USA; Division of Hematology and Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.18632/oncotarget.26364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284744PMC
November 2018

Estimation of Oncolytic Virus Populations within Tumors.

Cancer Res 2018 10 16;78(20):5992-6000. Epub 2018 Aug 16.

Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191353PMC
October 2018

HIV-1 Activation of Innate Immunity Depends Strongly on the Intracellular Level of TREX1 and Sensing of Incomplete Reverse Transcription Products.

J Virol 2018 08 31;92(16). Epub 2018 Jul 31.

Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, Colorado, USA

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http://dx.doi.org/10.1128/JVI.00001-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069178PMC
August 2018

Replicative cellular age distributions in compartmentalized tissues.

J R Soc Interface 2018 08;15(145)

Department of Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Plön, Germany.

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http://dx.doi.org/10.1098/rsif.2018.0272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127166PMC
August 2018

Evolutionary dynamics of paroxysmal nocturnal hemoglobinuria.

PLoS Comput Biol 2018 06 18;14(6):e1006133. Epub 2018 Jun 18.

Division of Hematology and Department of Molecular Medicine, Mayo Clinic, Rochester, MN, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1006133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023248PMC
June 2018

Selective Inhibition of Nuclear Export With Oral Selinexor for Treatment of Relapsed or Refractory Multiple Myeloma.

J Clin Oncol 2018 03 30;36(9):859-866. Epub 2018 Jan 30.

Dan T. Vogl, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; David Dingli, Mayo Clinic, Rochester, MN; Robert Frank Cornell, Vanderbilt University Medical Center, Nashville, TN; Carol Ann Huff, Johns Hopkins University, Baltimore, MD; Sundar Jagannath, Tisch Cancer Institute, Mount Sinai School of Medicine; David Kaminetzky, New York University Langone Medical Center; Ajai Chari, Icahn School of Medicine at Mount Sanai, New York, NY; Divaya Bhutani and Jeffrey Zonder, Karmanos Cancer Institute, Wayne State University, Detroit; Craig Cole, University of Michigan, Ann Arbor, MI; Rachid Baz, H. Lee Moffitt Cancer Center and Research Institute, Tampa; James E. Hoffman, Sylvester Cancer Center, University of Miami, Miami, FL; Ajay Nooka, Winship Cancer Institute, Emory University, Atlanta, GA; Joshua Richter and David Siegel, John Theurer Cancer Center at the Hackensack University Medical Center, Hackensack, NJ; Ravi Vij, Washington University School of Medicine, St Louis, MO; Andrzej Jakubowiak, University of Chicago Medical Center, Chicago, IL; Rafat Abonour, Indiana University Cancer Center, Indianapolis, IN; Gary Schiller, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA; Terri L. Parker, Yale School of Medicine, New Haven, CT; Luciano J. Costa, University of Alabama at Birmingham, Birmingham, AL; Andrew J. Yee, Massachusetts General Hospital Cancer Center, Boston; Michael Kauffman, Sharon Shacham, Jean-Richard Saint-Martin, Carla D. Picklesimer, and Cassandra Choe-Juliak, Karyopharm Therapeutics, Newton, MA; Rafael Fonseca, Scott Van Wier, Gregory Ahmann, Ilsel Lopez, and A. Keith Stewart, Mayo Clinic of Arizona, Phoenix, AZ.

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http://dx.doi.org/10.1200/JCO.2017.75.5207DOI Listing
March 2018

Detecting truly clonal alterations from multi-region profiling of tumours.

Sci Rep 2017 03 27;7:44991. Epub 2017 Mar 27.

Division of Hematology and Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

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http://www.nature.com/articles/srep44991
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http://dx.doi.org/10.1038/srep44991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5366809PMC
March 2017

Optimized Treatment Schedules for Chronic Myeloid Leukemia.

PLoS Comput Biol 2016 Oct 20;12(10):e1005129. Epub 2016 Oct 20.

Department of Industrial and Systems Engineering, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1371/journal.pcbi.1005129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072565PMC
October 2016