David Darr

David Darr

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David Darr

David Darr

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The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor.

Dis Model Mech 2019 07 5;12(7). Epub 2019 Jul 5.

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA

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http://dx.doi.org/10.1242/dmm.037192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679375PMC
July 2019

A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer.

Breast Cancer Res Treat 2019 Feb 27;174(1):143-155. Epub 2018 Nov 27.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 450 West Drive, CB#7264, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s10549-018-5061-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418066PMC
February 2019

Competitive Kinase Enrichment Proteomics Reveals that Abemaciclib Inhibits GSK3β and Activates WNT Signaling.

Mol Cancer Res 2018 02 13;16(2):333-344. Epub 2017 Nov 13.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/1541-7786.MCR-17-0468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805620PMC
February 2018

New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging.

Cancer Res 2018 01 27;78(2):542-557. Epub 2017 Nov 27.

UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-1653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132242PMC
January 2018

Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.

Cancer Lett 2017 12 28;411:136-149. Epub 2017 Sep 28.

Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, 27707, USA; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA; Duke Cancer Institute, Duke University, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.09.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720365PMC
December 2017

A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity.

Biomaterials 2016 09 4;101:296-309. Epub 2016 Jun 4.

Center for Nanotechnology in Drug Delivery and Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC, 27599, USA; Laboratory of Chemical Design of Bionanomaterials, Faculty of Chemistry, M.V. Lomonosov Moscow State University, Moscow, 119992, Russia. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S014296121630256
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http://dx.doi.org/10.1016/j.biomaterials.2016.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035646PMC
September 2016

Weight loss reduces basal-like breast cancer through kinome reprogramming.

Cancer Cell Int 2016 1;16:26. Epub 2016 Apr 1.

CB 7461, Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 2203 McGavran Greenberg Hall, Chapel Hill, NC 27599-7461 USA ; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC USA.

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http://dx.doi.org/10.1186/s12935-016-0300-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818517PMC
April 2016

Overview of Genetically Engineered Mouse Models of Distinct Breast Cancer Subtypes.

Curr Protoc Pharmacol 2016 Mar 18;72:14.38.1-14.38.11. Epub 2016 Mar 18.

Deptartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, N.C.

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http://dx.doi.org/10.1002/0471141755.ph1438s72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826719PMC
March 2016

Obesity-mediated regulation of HGF/c-Met is associated with reduced basal-like breast cancer latency in parous mice.

PLoS One 2014 29;9(10):e111394. Epub 2014 Oct 29.

UNC Nutrition Obesity Research Center, Gillings School of Global Public Health and School of Medicine, UNC Chapel Hill, Chapel Hill, North Carolina, United States of America; Lineberger Comprehensive Cancer Center, Gillings School of Global Public Health and School of Medicine, UNC Chapel Hill, Chapel Hill, North Carolina, United States of America; Department of Medicine, Gillings School of Global Public Health and School of Medicine, UNC Chapel Hill, Chapel Hill, North Carolina, United States of America; Department of Nutrition, Gillings School of Global Public Health and School of Medicine, UNC Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111394PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213021PMC
July 2015

Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: preparation, in vitro and in vivo evaluation.

J Control Release 2015 Jun 26;208:67-75. Epub 2015 Feb 26.

Functional Polymer Materials, Chair for Chemical Technology of Materials Synthesis, Universität Würzburg, 97070 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.jconrel.2015.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479148PMC
June 2015

Local iontophoretic administration of cytotoxic therapies to solid tumors.

Sci Transl Med 2015 Feb;7(273):273ra14

Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA.

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http://desimone-group.chem.unc.edu/wp-content/uploads/2015/0
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http://stm.sciencemag.org/cgi/doi/10.1126/scitranslmed.30099
Publisher Site
http://dx.doi.org/10.1126/scitranslmed.3009951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545246PMC
February 2015

Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling.

Nat Commun 2015 Jan 27;6:6118. Epub 2015 Jan 27.

1] Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA [2] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1038/ncomms7118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308813PMC
January 2015

Effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models.

Clin Cancer Res 2014 Dec 17;20(23):6083-95. Epub 2014 Sep 17.

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, North Carolina. Lineberger Comprehensive Cancer Center, UNC at Chapel Hill, Chapel Hill, North Carolina. Carolina Center of Cancer Nanotechnology Excellence, UNC at Chapel Hill, Chapel Hill, North Carolina. Center for Pharmacogenomics and Individualized Therapy, UNC at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565518PMC
December 2014

Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma.

Cancer Discov 2014 Dec 24;4(12):1418-29. Epub 2014 Sep 24.

Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, North Carolina. The Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/2159-8290.CD-14-0729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258185PMC
December 2014

Weight Loss Reversed Obesity-Induced HGF/c-Met Pathway and Basal-Like Breast Cancer Progression.

Front Oncol 2014 8;4:175. Epub 2014 Jul 8.

Department of Nutrition, Gillings School of Global Public Health and School of Medicine, The University of North Carolina at Chapel Hill , Chapel Hill, NC , USA ; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill , Chapel Hill, NC , USA ; UNC Nutrition Obesity Research Center, The University of North Carolina at Chapel Hill , Chapel Hill, NC , USA ; Department of Medicine, The University of North Carolina at Chapel Hill , Chapel Hill, NC , USA.

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http://dx.doi.org/10.3389/fonc.2014.00175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085881PMC
July 2014

Role of HGF in obesity-associated tumorigenesis: C3(1)-TAg mice as a model for human basal-like breast cancer.

Breast Cancer Res Treat 2013 Dec 12;142(3):489-503. Epub 2013 Nov 12.

Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, CB 7461, 2203 McGavran Greenberg Hall, Chapel Hill, NC, 27599-7461, USA,

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http://dx.doi.org/10.1007/s10549-013-2741-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904507PMC
December 2013

Predicting drug responsiveness in human cancers using genetically engineered mice.

Clin Cancer Res 2013 Sep 18;19(17):4889-99. Epub 2013 Jun 18.

Lineberger Comprehensive Cancer Center, Department of Genetics, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778918PMC
September 2013

Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy.

J Natl Cancer Inst 2012 Mar 1;104(6):476-87. Epub 2012 Feb 1.

Department of Genetics, The University of North Carolina School of Medicine, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1093/jnci/djs002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309128PMC
March 2012