David Cortez

David Cortez

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David Cortez

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Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators.

Cell Rep 2019 Sep;28(13):3497-3509.e4

Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.051DOI Listing
September 2019

Protection of abasic sites during DNA replication by a stable thiazolidine protein-DNA cross-link.

Nat Struct Mol Biol 2019 Jul 24;26(7):613-618. Epub 2019 Jun 24.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.1038/s41594-019-0255-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628887PMC
July 2019

Replication-Coupled DNA Repair.

Authors:
David Cortez

Mol Cell 2019 06;74(5):866-876

Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557297PMC
June 2019

Common motifs in ETAA1 and TOPBP1 required for ATR kinase activation.

J Biol Chem 2019 May 2;294(21):8395-8402. Epub 2019 Apr 2.

From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

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http://dx.doi.org/10.1074/jbc.RA119.008154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544864PMC
May 2019

Quantitative phosphoproteomics reveals mitotic function of the ATR activator ETAA1.

J Cell Biol 2019 Apr 12;218(4):1235-1249. Epub 2019 Feb 12.

Department of Biochemistry, Vanderbilt University School of Medicine, Vanderbilt University, Nashville, TN

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http://dx.doi.org/10.1083/jcb.201810058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446857PMC
April 2019

HMCES Maintains Genome Integrity by Shielding Abasic Sites in Single-Strand DNA.

Cell 2019 01 13;176(1-2):144-153.e13. Epub 2018 Dec 13.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.10.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329640PMC
January 2019

An intrinsic S/G checkpoint enforced by ATR.

Science 2018 08;361(6404):806-810

Department of Chemical and Systems Biology, Stanford University School of Medicine, 318 Campus Drive, Stanford, CA 94305-5441, USA.

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http://dx.doi.org/10.1126/science.aap9346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365305PMC
August 2018

RADX Modulates RAD51 Activity to Control Replication Fork Protection.

Cell Rep 2018 07;24(3):538-545

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086571PMC
July 2018

RPA and RAD51: fork reversal, fork protection, and genome stability.

Nat Struct Mol Biol 2018 06 28;25(6):446-453. Epub 2018 May 28.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1038/s41594-018-0075-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006513PMC
June 2018

Proteomic Analyses of the Eukaryotic Replication Machinery.

Authors:
David Cortez

Methods Enzymol 2017 6;591:33-53. Epub 2017 Apr 6.

Vanderbilt University School of Medicine, Nashville, TN, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mie.2017.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962280PMC
April 2018

Functions of SMARCAL1, ZRANB3, and HLTF in maintaining genome stability.

Crit Rev Biochem Mol Biol 2017 12 28;52(6):696-714. Epub 2017 Sep 28.

a Department of Biochemistry , Vanderbilt University School of Medicine , Nashville , TN , USA.

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http://dx.doi.org/10.1080/10409238.2017.1380597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962345PMC
December 2017

The essential kinase ATR: ensuring faithful duplication of a challenging genome.

Nat Rev Mol Cell Biol 2017 10 16;18(10):622-636. Epub 2017 Aug 16.

Department of Chemical and Systems Biology, Stanford University School of Medicine, 318 Campus Drive, Stanford, California 94305-5441, USA.

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http://dx.doi.org/10.1038/nrm.2017.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796526PMC
October 2017

RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks.

Mol Cell 2017 Aug 20;67(3):374-386.e5. Epub 2017 Jul 20.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548441PMC
August 2017

ETAA1 acts at stalled replication forks to maintain genome integrity.

Nat Cell Biol 2016 Nov 10;18(11):1185-1195. Epub 2016 Oct 10.

Department of Biochemistry, Vanderbilt University School of Medicine, 613 Light Hall, 2215 Garland Avenue, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1038/ncb3415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245861PMC
November 2016

Fork reversal, too much of a good thing.

Cell Cycle 2014 18;13(7):1049-50. Epub 2014 Feb 18.

Department of Biochemistry; Vanderbilt University School of Medicine; Nashville, TN USA.

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http://dx.doi.org/10.4161/cc.28212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013150PMC
May 2016

SMARCAL1 and telomeres: Replicating the troublesome ends.

Nucleus 2016 May 29;7(3):270-4. Epub 2016 Jun 29.

a Department of Biochemistry , Vanderbilt University School of Medicine , Nashville , TN , USA.

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http://dx.doi.org/10.1080/19491034.2016.1179413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991236PMC
May 2016

Identification of a Substrate Recognition Domain in the Replication Stress Response Protein Zinc Finger Ran-binding Domain-containing Protein 3 (ZRANB3).

J Biol Chem 2016 Apr 16;291(15):8251-7. Epub 2016 Feb 16.

From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 and

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http://dx.doi.org/10.1074/jbc.M115.709733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414104PMC
April 2016

SMARCAL1 maintains telomere integrity during DNA replication.

Proc Natl Acad Sci U S A 2015 Dec 17;112(48):14864-9. Epub 2015 Nov 17.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37027;

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http://www.pnas.org/content/112/48/14864.full.pdf
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http://www.pnas.org/lookup/doi/10.1073/pnas.1510750112
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http://dx.doi.org/10.1073/pnas.1510750112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672769PMC
December 2015

A whole genome RNAi screen identifies replication stress response genes.

DNA Repair (Amst) 2015 Nov 26;35:55-62. Epub 2015 Sep 26.

Department of Biochemistry, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15687864153000
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http://dx.doi.org/10.1016/j.dnarep.2015.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651756PMC
November 2015

Stephen Elledge and the DNA damage response.

DNA Repair (Amst) 2015 Nov;35:156-7

Department of Pharmacology and Toxicology, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, United States; Dartmouth-Hitchcock Norris Cotton Cancer Center, Lebanon, NH 03756, United States.

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http://dx.doi.org/10.1016/j.dnarep.2015.11.001DOI Listing
November 2015

Mutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinase.

PLoS One 2014 5;9(6):e99397. Epub 2014 Jun 5.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099397PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047089PMC
October 2015

A novel splice site mutation in SMARCAL1 results in aberrant exon definition in a child with Schimke immunoosseous dysplasia.

Am J Med Genet A 2015 Oct 5;167A(10):2260-4. Epub 2015 May 5.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee.

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http://dx.doi.org/10.1002/ajmg.a.37146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743909PMC
October 2015

Enhancer of Rudimentary Homolog Affects the Replication Stress Response through Regulation of RNA Processing.

Mol Cell Biol 2015 Sep 22;35(17):2979-90. Epub 2015 Jun 22.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

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http://dx.doi.org/10.1128/MCB.01276-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525316PMC
September 2015

The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability.

Mol Cell 2015 Sep 10;59(6):998-1010. Epub 2015 Sep 10.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.07.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575883PMC
September 2015

Preventing replication fork collapse to maintain genome integrity.

Authors:
David Cortez

DNA Repair (Amst) 2015 Aug 1;32:149-157. Epub 2015 May 1.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37027, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2015.04.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522347PMC
August 2015

Purification of proteins on newly synthesized DNA using iPOND.

Methods Mol Biol 2015 ;1228:123-31

Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Ave., Nashville, TN, 37232, USA.

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http://dx.doi.org/10.1007/978-1-4939-1680-1_10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384176PMC
June 2015

High-affinity DNA-binding domains of replication protein A (RPA) direct SMARCAL1-dependent replication fork remodeling.

J Biol Chem 2015 Feb 31;290(7):4110-7. Epub 2014 Dec 31.

From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

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http://dx.doi.org/10.1074/jbc.M114.627083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326820PMC
February 2015

SV40 utilizes ATM kinase activity to prevent non-homologous end joining of broken viral DNA replication products.

PLoS Pathog 2014 Dec 4;10(12):e1004536. Epub 2014 Dec 4.

Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256475PMC
December 2014

ATR pathway inhibition is synthetically lethal in cancer cells with ERCC1 deficiency.

Cancer Res 2014 May 24;74(10):2835-45. Epub 2014 Mar 24.

Authors' Affiliation: Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043842PMC
May 2014

A structure-specific nucleic acid-binding domain conserved among DNA repair proteins.

Proc Natl Acad Sci U S A 2014 May 12;111(21):7618-23. Epub 2014 May 12.

Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232;Department of Biochemistry, Vanderbilt School of Medicine, Nashville, TN 37232

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http://www.pnas.org/cgi/doi/10.1073/pnas.1324143111
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http://dx.doi.org/10.1073/pnas.1324143111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040553PMC
May 2014

Phosphorylation of a C-terminal auto-inhibitory domain increases SMARCAL1 activity.

Nucleic Acids Res 2014 Jan 22;42(2):918-25. Epub 2013 Oct 22.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 USA, Division of Pediatric Hematology/Oncology, Vanderbilt University School of Medicine and Verna and Mars McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1093/nar/gkt929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902923PMC
January 2014

Identification and characterization of SMARCAL1 protein complexes.

PLoS One 2013 9;8(5):e63149. Epub 2013 May 9.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063149PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650004PMC
December 2013

Schimke Immunoosseous Dysplasia associated with undifferentiated carcinoma and a novel SMARCAL1 mutation in a child.

Pediatr Blood Cancer 2013 Sep 29;60(9):E88-90. Epub 2013 Apr 29.

Division of Pediatric Hematology/Oncology, Monroe Carell Jr. Children's Hospital, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6310, USA.

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http://dx.doi.org/10.1002/pbc.24542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713188PMC
September 2013

DNA damage response: three levels of DNA repair regulation.

Cold Spring Harb Perspect Biol 2013 Aug 1;5(8):a012724. Epub 2013 Aug 1.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37027, USA.

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http://dx.doi.org/10.1101/cshperspect.a012724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721278PMC
August 2013

Substrate-selective repair and restart of replication forks by DNA translocases.

Cell Rep 2013 Jun 6;3(6):1958-69. Epub 2013 Jun 6.

Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S22111247130021
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http://dx.doi.org/10.1016/j.celrep.2013.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700663PMC
June 2013

Monitoring the spatiotemporal dynamics of proteins at replication forks and in assembled chromatin using isolation of proteins on nascent DNA.

Nat Protoc 2012 Mar 1;7(3):594-605. Epub 2012 Mar 1.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1038/nprot.2012.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671908PMC
March 2012

SMARCAL1 and replication stress: an explanation for SIOD?

Nucleus 2010 May-Jun;1(3):245-8. Epub 2010 Feb 16.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA.

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http://dx.doi.org/10.4161/nucl.1.3.11739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027029PMC
January 2012

Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase.

J Biol Chem 2011 Oct 9;286(43):37320-7. Epub 2011 Sep 9.

Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1074/jbc.M111.276113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199479PMC
October 2011

Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase.

J Biol Chem 2011 Aug 24;286(33):28707-14. Epub 2011 Jun 24.

Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1074/jbc.M111.248914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190678PMC
August 2011

Defining genome maintenance pathways using functional genomic approaches.

Crit Rev Biochem Mol Biol 2011 Aug;46(4):327-41

Department of Biochemistry, Vanderbilt University School of Medicine, Light Hall, Nashville, TN 37232, USA.

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http://dx.doi.org/10.3109/10409238.2011.588938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144553PMC
August 2011

ATR signalling: more than meeting at the fork.

Biochem J 2011 Jun;436(3):527-36

Department of Biochemistry, Vanderbilt University School of Medicine, 613 Light Hall, 2215 Garland Avenue, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1042/BJ20102162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678388PMC
June 2011

Analysis of protein dynamics at active, stalled, and collapsed replication forks.

Genes Dev 2011 Jun;25(12):1320-7

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.2053211
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http://dx.doi.org/10.1101/gad.2053211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127432PMC
June 2011

A role for CDK9-cyclin K in maintaining genome integrity.

Cell Cycle 2011 Jan 1;10(1):28-32. Epub 2011 Jan 1.

Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048070PMC
http://dx.doi.org/10.4161/cc.10.1.14364DOI Listing
January 2011

ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled.

J Virol 2010 Dec 22;84(23):12152-64. Epub 2010 Sep 22.

Department of Molecular, Microbial and Structural Biology and Molecular Biology and Biochemistry Graduate Program, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.

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http://dx.doi.org/10.1128/JVI.01643-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976399PMC
December 2010

Cyclin-dependent kinase 9-cyclin K functions in the replication stress response.

EMBO Rep 2010 Nov 8;11(11):876-82. Epub 2010 Oct 8.

Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1038/embor.2010.153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966956PMC
November 2010

Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair.

J Biol Chem 2010 May 15;285(19):14565-71. Epub 2010 Mar 15.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1074/jbc.M110.104745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863164PMC
May 2010

Functional genomic screens identify CINP as a genome maintenance protein.

Proc Natl Acad Sci U S A 2009 Nov 4;106(46):19304-9. Epub 2009 Nov 4.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1073/pnas.0909345106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780779PMC
November 2009

The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks.

Genes Dev 2009 Oct 30;23(20):2405-14. Epub 2009 Sep 30.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1101/gad.1839909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2764496PMC
October 2009

Common mechanisms of PIKK regulation.

DNA Repair (Amst) 2009 Sep 21;8(9):1004-8. Epub 2009 May 21.

Department of Biochemistry, Vanderbilt University School of Medicine, 613 Light Hall, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.dnarep.2009.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725225PMC
September 2009

SOSS1/2: Sensors of single-stranded DNA at a break.

Mol Cell 2009 Aug;35(3):258-9

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.molcel.2009.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820400PMC
August 2009

The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.

Mol Cell Biol 2008 Dec 20;28(24):7345-53. Epub 2008 Oct 20.

Department of Biochemistry, Vanderbilt University School of Medicine, 613 Light Hall, 23rd at Pierce Avenue, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1128/MCB.01079-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593429PMC
December 2008

Dpb11 activates the Mec1-Ddc2 complex.

Proc Natl Acad Sci U S A 2008 Dec 21;105(48):18730-4. Epub 2008 Nov 21.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1073/pnas.0806621105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596233PMC
December 2008

Activation of ATR and related PIKKs.

Cell Cycle 2008 Sep 30;7(18):2809-12. Epub 2008 Sep 30.

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672405PMC
http://dx.doi.org/10.4161/cc.7.18.6689DOI Listing
September 2008

ATR: an essential regulator of genome integrity.

Nat Rev Mol Cell Biol 2008 Aug 2;9(8):616-27. Epub 2008 Jul 2.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Clark Center, 318 Campus Drive, W350B, Stanford, California 94305-5441, USA.

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http://dx.doi.org/10.1038/nrm2450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663384PMC
August 2008

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.

Genes Dev 2008 Jun;22(11):1478-89

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1101/gad.1666208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2418584PMC
June 2008

Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage.

Cancer Res 2007 Jul;67(14):6685-90

Department of Biochemistry and Mass Spectrometry Research Center, Vanderbilt University, 23rd Pierce Avenue, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728292PMC
July 2007

Function of a conserved checkpoint recruitment domain in ATRIP proteins.

Mol Cell Biol 2007 May 5;27(9):3367-77. Epub 2007 Mar 5.

Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1128/MCB.02238-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899971PMC
May 2007

Function of the ATR N-terminal domain revealed by an ATM/ATR chimera.

Exp Cell Res 2007 May 27;313(8):1667-74. Epub 2007 Feb 27.

Department of Biochemistry, Vanderbilt University, Pierce Avenue, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.yexcr.2007.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855264PMC
May 2007

DDB1 maintains genome integrity through regulation of Cdt1.

Mol Cell Biol 2006 Nov 28;26(21):7977-90. Epub 2006 Aug 28.

Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1128/MCB.00819-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636754PMC
November 2006

Rapid activation of ATR by ionizing radiation requires ATM and Mre11.

J Biol Chem 2006 Apr 23;281(14):9346-50. Epub 2006 Jan 23.

Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1074/jbc.M513265200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821075PMC
April 2006

ATRIP oligomerization is required for ATR-dependent checkpoint signaling.

J Biol Chem 2005 Sep 15;280(36):31390-6. Epub 2005 Jul 15.

Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1074/jbc.M504961200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360181PMC
September 2005

Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling.

Authors:
David Cortez

Genes Dev 2005 May;19(9):1007-12

Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1101/gad.1316905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360198PMC
May 2005

Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.

Proc Natl Acad Sci U S A 2004 Jul 21;101(27):10078-83. Epub 2004 Jun 21.

Department of Biochemistry, Vanderbilt University, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1073/pnas.0403410101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC454167PMC
July 2004

Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases.

Authors:
David Cortez

J Biol Chem 2003 Sep 7;278(39):37139-45. Epub 2003 Jul 7.

Department of Biochemistry, Vanderbilt University, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1074/jbc.M307088200DOI Listing
September 2003

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin.

Genes Dev 2002 Jan;16(2):198-208

Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.950302
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http://dx.doi.org/10.1101/gad.950302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC155323PMC
January 2002