David Clapham

David Clapham

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David Clapham

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Isomeric Tuning Yields Bright and Targetable Red Ca Indicators.

J Am Chem Soc 2019 Sep 23;141(35):13734-13738. Epub 2019 Aug 23.

Janelia Research Campus , Howard Hughes Medical Institute , Ashburn , Virginia 20147 , United States.

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http://dx.doi.org/10.1021/jacs.9b06092DOI Listing
September 2019

Making Medicines Baby Size: The Challenges in Bridging the Formulation Gap in Neonatal Medicine.

Int J Mol Sci 2019 May 31;20(11). Epub 2019 May 31.

University College London School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK.

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http://dx.doi.org/10.3390/ijms20112688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600135PMC
May 2019

Automation and Scale Up of Somatic Embryogenesis for Commercial Plant Production, With Emphasis on Conifers.

Front Plant Sci 2019 18;10:109. Epub 2019 Feb 18.

Department of Plant Biology, Uppsala BioCenter, Swedish University of Agricultural Sciences, Uppsala, Sweden.

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http://dx.doi.org/10.3389/fpls.2019.00109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388443PMC
February 2019

Structure of the mouse TRPC4 ion channel.

Nat Commun 2018 08 6;9(1):3102. Epub 2018 Aug 6.

School of Basic Medical Sciences, Nanchang University, 330031, Nanchang, Jiangxi, China.

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http://dx.doi.org/10.1038/s41467-018-05247-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079076PMC
August 2018

Structure of the mammalian TRPM7, a magnesium channel required during embryonic development.

Proc Natl Acad Sci U S A 2018 08 14;115(35):E8201-E8210. Epub 2018 Aug 14.

Department of Cardiology, Boston Children's Hospital, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1810719115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126765PMC
August 2018

Cryo-EM structure of the polycystin 2-l1 ion channel.

Elife 2018 07 13;7. Epub 2018 Jul 13.

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.

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http://dx.doi.org/10.7554/eLife.36931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056229PMC
July 2018

Influences: Short circuits.

Authors:
David E Clapham

J Gen Physiol 2018 04 20;150(4):513-515. Epub 2018 Mar 20.

Howard Hughes Medical Institute, Chevy Chase, MD

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http://dx.doi.org/10.1085/jgp.201812034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881450PMC
April 2018

Structure of full-length human TRPM4.

Proc Natl Acad Sci U S A 2018 03 20;115(10):2377-2382. Epub 2018 Feb 20.

Howard Hughes Medical Institute, Ashburn, VA 20147;

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http://dx.doi.org/10.1073/pnas.1722038115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877947PMC
March 2018

Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium.

Elife 2018 02 14;7. Epub 2018 Feb 14.

Department of Cardiology, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, United States.

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http://dx.doi.org/10.7554/eLife.33183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5812715PMC
February 2018

Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression.

Proc Natl Acad Sci U S A 2017 08 7;114(34):E7092-E7100. Epub 2017 Aug 7.

Howard Hughes Medical Institute, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1708427114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576826PMC
August 2017

TRPM7 senses oxidative stress to release Zn from unique intracellular vesicles.

Proc Natl Acad Sci U S A 2017 07 10;114(30):E6079-E6088. Epub 2017 Jul 10.

Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1707380114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544332PMC
July 2017

Bitter tastant responses in the amoeba Dictyostelium correlate with rat and human taste assays.

ALTEX 2016 22;33(3):225-36. Epub 2015 Dec 22.

Centre of Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, UK.

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http://www.altex.ch/resources/Cocorocchio_of_151222.pdf
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http://www.altex.ch/Online-first.95.html
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http://dx.doi.org/10.14573/altex.1509011DOI Listing
January 2017

Progress in ciliary ion channel physiology.

J Gen Physiol 2017 Jan 20;149(1):37-47. Epub 2016 Dec 20.

Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115

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http://dx.doi.org/10.1085/jgp.201611696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217089PMC
January 2017

The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs.

Cell 2016 Oct;167(3):763-773.e11

Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112-5650, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.09.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055481PMC
October 2016

Effect of formulation variables on oral grittiness and preferences of multiparticulate formulations in adult volunteers.

Eur J Pharm Sci 2016 Sep 9;92:156-62. Epub 2016 Jul 9.

Department of Pharmaceutics, School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.

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http://dx.doi.org/10.1016/j.ejps.2016.07.006DOI Listing
September 2016

Atypical calcium regulation of the PKD2-L1 polycystin ion channel.

Elife 2016 06 27;5. Epub 2016 Jun 27.

Department of Cardiology, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, United States.

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http://dx.doi.org/10.7554/eLife.13413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922860PMC
June 2016

Naturally Produced Defensive Alkenal Compounds Activate TRPA1.

Chem Senses 2016 05 3;41(4):281-92. Epub 2016 Feb 3.

Howard Hughes Medical Institute (HHMI), Boston, MA, USA, Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA,

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http://dx.doi.org/10.1093/chemse/bjv071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863776PMC
May 2016

Molecular basis of ion permeability in a voltage-gated sodium channel.

EMBO J 2016 Apr 12;35(8):820-30. Epub 2016 Feb 12.

Institute of Structural and Molecular Biology, Birkbeck College University of London, London, UK

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http://dx.doi.org/10.15252/embj.201593285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972137PMC
April 2016

Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition.

Proc Natl Acad Sci U S A 2016 Mar 14;113(13):E1872-80. Epub 2016 Mar 14.

Howard Hughes Medical Institute, Department of Cardiology, Boston Children's Hospital, Boston, MA 02115; Department of Neurobiology, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1602264113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822583PMC
March 2016

The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex.

ACS Chem Biol 2016 Feb 16;11(2):452-9. Epub 2015 Dec 16.

Department of Medicinal Chemistry and Institute for Therapeutics Discovery and Development, College of Pharmacy, University of Minnesota , Minneapolis, Minnesota 55414, United States.

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http://dx.doi.org/10.1021/acschembio.5b00748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761407PMC
February 2016

Ion channels and calcium signaling in motile cilia.

Elife 2015 Dec 9;4. Epub 2015 Dec 9.

Department of Cardiology, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, United States.

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http://dx.doi.org/10.7554/eLife.11066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714969PMC
December 2015

Structural biology: Pain-sensing TRPA1 channel resolved.

Authors:
David E Clapham

Nature 2015 Apr 8;520(7548):439-41. Epub 2015 Apr 8.

Howard Hughes Medical Institute, Department of Cardiology, Boston Children's Hospital, and the Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature14383DOI Listing
April 2015

Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view.

Cell Calcium 2015 Mar 2;57(3):166-73. Epub 2014 Dec 2.

Howard Hughes Medical Institute, Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ceca.2014.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355082PMC
March 2015

Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus.

Elife 2014 Nov 11;3. Epub 2014 Nov 11.

Department of Cardiology, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, United States.

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https://elifesciences.org/articles/04387
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http://dx.doi.org/10.7554/eLife.04387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225499PMC
November 2014

Early evolution of the eukaryotic Ca2+ signaling machinery: conservation of the CatSper channel complex.

Mol Biol Evol 2014 Oct 24;31(10):2735-40. Epub 2014 Jul 24.

Howard Hughes Medical Institute, Department of Cardiology, Boston Children's Hospital, Boston, MA Department of Neurobiology, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.1093/molbev/msu218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169769PMC
October 2014

Outstanding questions regarding the permeation, selectivity, and regulation of the mitochondrial calcium uniporter.

Biochem Biophys Res Commun 2014 Jul 30;449(4):367-9. Epub 2014 Apr 30.

Department of Cardiology, Howard Hughes Medical Institute, Boston Children's Hospital, Boston, United States; Department of Neurobiology, Harvard Medical School, Boston, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X140080
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http://dx.doi.org/10.1016/j.bbrc.2014.04.141DOI Listing
July 2014

Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.

Proc Natl Acad Sci U S A 2014 Jun 21;111(23):8428-33. Epub 2014 May 21.

Institute of Structural and Molecular Biology, School of Biological Sciences, Birkbeck College, University of London, London WC1E 7HX, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1406855111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060673PMC
June 2014

Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain.

JAMA Neurol 2014 May;71(5):640-5

F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts7Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaneurol.2014.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465580PMC
May 2014

Structurally distinct Ca(2+) signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility.

Cell 2014 May;157(4):808-22

Howard Hughes Medical Institute, Department of Cardiology, Boston Children's Hospital, 320 Longwood Avenue, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.02.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032590PMC
May 2014

The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase.

Cell 2014 May;157(5):1061-72

Howard Hughes Medical Institute, Department of Cardiology, Boston Children's Hospital, Enders Building 1309, 320 Longwood Avenue, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.03.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156102PMC
May 2014

Role of the C-terminal domain in the structure and function of tetrameric sodium channels.

Nat Commun 2013 ;4:2465

1] School of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, UK [2].

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http://dx.doi.org/10.1038/ncomms3465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791462PMC
April 2014

No time for spruce: rapid dampening of circadian rhythms in Picea abies (L. Karst).

Plant Cell Physiol 2014 Mar 19;55(3):535-50. Epub 2013 Dec 19.

Department of Plant Biology and Forest Genetics, Uppsala Biocenter, Swedish University for Agricultural Sciences, Uppsala, PO Box 7080, SE-750 07 Uppsala, Sweden.

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http://dx.doi.org/10.1093/pcp/pct199DOI Listing
March 2014

Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels.

J Neurosci 2014 Mar;34(10):3653-67

Howard Hughes Medical Institute, Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts 02115, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, and Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia.

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http://dx.doi.org/10.1523/JNEUROSCI.2274-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942581PMC
March 2014

Caspase-11 controls interleukin-1β release through degradation of TRPC1.

Cell Rep 2014 Mar 13;6(6):1122-1128. Epub 2014 Mar 13.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239700PMC
March 2014

Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1.

J Gen Physiol 2014 Jan 16;143(1):67-73. Epub 2013 Dec 16.

Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02454.

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http://dx.doi.org/10.1085/jgp.201311096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874562PMC
January 2014

EMRE is an essential component of the mitochondrial calcium uniporter complex.

Science 2013 Dec 14;342(6164):1379-82. Epub 2013 Nov 14.

Department of Molecular Biology, Massachusetts General Hospital, Department of Systems Biology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1126/science.1242993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091629PMC
December 2013

TRPV3 channels mediate strontium-induced mouse-egg activation.

Cell Rep 2013 Dec 5;5(5):1375-86. Epub 2013 Dec 5.

Howard Hughes Medical Institute, Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918412PMC
December 2013

Primary cilia are specialized calcium signalling organelles.

Nature 2013 Dec;504(7479):311-4

1] Howard Hughes Medical Institute, Department of Cardiology, Boston Children's Hospital, 320 Longwood Avenue, Boston, Massachusetts 02115, USA [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature12833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112737PMC
December 2013

Direct recording and molecular identification of the calcium channel of primary cilia.

Nature 2013 Dec;504(7479):315-8

1] Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital Boston, 320 Longwood Avenue, Boston, Massachusetts 02115, USA [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/nature12832
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http://dx.doi.org/10.1038/nature12832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073646PMC
December 2013

The mother of all endocytosis.

Authors:
David E Clapham

Elife 2013 Nov 26;2:e01738. Epub 2013 Nov 26.

David E Clapham is in the Howard Hughes Medical Institute, Department of Cardiology, Boston Children's Hospital, Boston, United States and the Department of Neurobiology, Harvard Medical School, Boston, United States

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http://dx.doi.org/10.7554/eLife.01738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839537PMC
November 2013

FLOWERING LOCUS T/TERMINAL FLOWER1-like genes affect growth rhythm and bud set in Norway spruce.

Plant Physiol 2013 Oct 19;163(2):792-803. Epub 2013 Aug 19.

Department of Plant Ecology and Evolution, Evolutionary Biology Center, Uppsala University, SE-752 36 Uppsala, Sweden.

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http://dx.doi.org/10.1104/pp.113.224139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793058PMC
October 2013

Sperm BerserKers.

Authors:
David E Clapham

Elife 2013 Oct 8;2:e01469. Epub 2013 Oct 8.

is at the Howard Hughes Medical Institute, Department of Cardiology , Boston Children's Hospital , Boston , United States , and the Department of Neurobiology , Harvard Medical School , Boston , United States

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http://dx.doi.org/10.7554/eLife.01469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791457PMC
October 2013

Sperm patch-clamp.

Methods Enzymol 2013 ;525:59-83

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.

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http://dx.doi.org/10.1016/B978-0-12-397944-5.00004-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909741PMC
September 2013

The G-protein-gated K+ channel, IKACh, is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation.

J Gen Physiol 2013 Aug 15;142(2):113-26. Epub 2013 Jul 15.

Centre National de la Recherche Scientifique UMR 5203, Institut de Génomique Fonctionnelle, Département de Physiologie, Laboratoire d'Excellence Canaux Ioniques d'Intérêt Thérapeutique, 34094 Montpellier, France.

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http://dx.doi.org/10.1085/jgp.201310996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727310PMC
August 2013

Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity.

Proc Natl Acad Sci U S A 2013 Aug 22;110(32):E3037-46. Epub 2013 Jul 22.

Howard Hughes Medical Institute, Department of Cardiology, Boston Children's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1311865110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740880PMC
August 2013

Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization.

Circulation 2013 Jul 3;128(2):101-14. Epub 2013 Jun 3.

Howard Hughes Medical Institute, Department of Cardiology, Manton Center for Orphan Disease, Children's Hospital Boston, 320 Longwood Ave, Enders 1309, Boston, MA 02115, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.000768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800036PMC
July 2013

Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.

Proc Natl Acad Sci U S A 2013 Jun 28;110(24):E2249-54. Epub 2013 May 28.

Department of Cardiology, Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children's Hospital Boston, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1308558110
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http://dx.doi.org/10.1073/pnas.1308558110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683736PMC
June 2013

MCU encodes the pore conducting mitochondrial calcium currents.

Elife 2013 Jun 4;2:e00704. Epub 2013 Jun 4.

Cardiovascular Research Center , Massachusetts General Hospital , Boston , United States ; Department of Cardiology , Howard Hughes Medical Institute, Boston Children's Hospital , Boston , United States.

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http://dx.doi.org/10.7554/eLife.00704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673318PMC
June 2013

Anion-sensitive fluorophore identifies the Drosophila swell-activated chloride channel in a genome-wide RNA interference screen.

PLoS One 2012 4;7(10):e46865. Epub 2012 Oct 4.

Howard Hughes Medical Institute, Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046865PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464265PMC
May 2013

Assessment of bitter taste of pharmaceuticals with multisensor system employing 3 way PLS regression.

Anal Chim Acta 2013 Apr 15;770:45-52. Epub 2013 Feb 15.

CESAM and Chemistry Department, University of Aveiro, Aveiro, Portugal.

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http://dx.doi.org/10.1016/j.aca.2013.02.006DOI Listing
April 2013

Molecular dynamics of ion transport through the open conformation of a bacterial voltage-gated sodium channel.

Proc Natl Acad Sci U S A 2013 Apr 29;110(16):6364-9. Epub 2013 Mar 29.

Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1214667110
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http://dx.doi.org/10.1073/pnas.1214667110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631666PMC
April 2013

Analysis of the selectivity filter of the voltage-gated sodium channel Na(v)Rh.

Cell Res 2013 Mar 18;23(3):409-22. Epub 2012 Dec 18.

State Key Laboratory of Bio-membrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1038/cr.2012.173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587708PMC
March 2013

Rheotaxis guides mammalian sperm.

Curr Biol 2013 Mar 28;23(6):443-52. Epub 2013 Feb 28.

Howard Hughes Medical Institute, Department of Cardiology, Manton Center for Orphan Disease Research, Boston Children's Hospital, 320 Longwood Avenue, Enders 1309, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cub.2013.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607503PMC
March 2013

Early cone setting in Picea abies acrocona is associated with increased transcriptional activity of a MADS box transcription factor.

Plant Physiol 2013 Feb 7;161(2):813-23. Epub 2012 Dec 7.

Department of Plant Biology and Forest Genetics, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, SE-750 07 Uppsala, Sweden.

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http://dx.doi.org/10.1104/pp.112.207746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561021PMC
February 2013

mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state.

Cell 2013 Feb 7;152(4):778-790. Epub 2013 Feb 7.

Department of Biology, University of Pennsylvania, 415 S. University Ave., Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1016/j.cell.2013.01.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908667PMC
February 2013

Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL.

Nat Commun 2012 ;3:990

HHMI, Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.

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November 2012

Assessing taste without using humans: rat brief access aversion model and electronic tongue.

Int J Pharm 2012 Oct;435(2):137-9

GlaxoSmithKline Pharmaceuticals, Stevenage, UK.

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October 2012

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.

Cell 2012 Oct;151(2):372-83

Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 3089 Kraus Natural Science Building, 830 North University Avenue, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.cell.2012.08.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475186PMC
October 2012

The control of male fertility by spermatozoan ion channels.

Annu Rev Physiol 2012 13;74:453-75. Epub 2011 Oct 13.

Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914660PMC
June 2012

Calorimetric determination of rate constants and enthalpy changes for zero-order reactions.

J Phys Chem B 2012 Jun 29;116(22):6356-60. Epub 2012 May 29.

UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.

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June 2012

Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis.

Dev Cell 2012 Jun;22(6):1149-62

Department of Cardiology, Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children's Hospital Boston, and Department of Neurobiology, Harvard Medical School, Enders Building 1309, 320 Longwood Avenue, Boston, MA 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397829PMC
June 2012

Calpain cleaves and activates the TRPC5 channel to participate in semaphorin 3A-induced neuronal growth cone collapse.

Proc Natl Acad Sci U S A 2012 May 30;109(20):7888-92. Epub 2012 Apr 30.

Program in Neuroscience, Division of Medical Sciences, Harvard University, Boston, MA 02115, USA.

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May 2012

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel.

Nature 2012 May 20;486(7401):130-4. Epub 2012 May 20.

State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, Tsinghua University, Beijing 100084, China.

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May 2012

The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke.

Nat Neurosci 2012 Mar 4;15(4):565-73. Epub 2012 Mar 4.

Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital Boston and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.

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March 2012

Ancestral Ca2+ signaling machinery in early animal and fungal evolution.

Mol Biol Evol 2012 Jan 16;29(1):91-100. Epub 2011 Jun 16.

Molecular Pathogenesis Program, The Skirball Institute of Biomolecular Medicine, New York University Langone Medical Center, NY, USA.

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January 2012

The channel kinase, TRPM7, is required for early embryonic development.

Proc Natl Acad Sci U S A 2012 Jan 27;109(5):E225-33. Epub 2011 Dec 27.

Department of Cardiology, Manton Center for Orphan Disease, Children's Hospital Boston, Howard Hughes Medical Institute, Boston, MA 02115, USA.

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January 2012

A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels.

Proc Natl Acad Sci U S A 2011 Dec 22;108(49):19492-7. Epub 2011 Nov 22.

Department of Cardiology, Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children's Hospital Boston, and Harvard Medical School, Boston, MA 02115, USA.

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December 2011

Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system.

Proc Natl Acad Sci U S A 2011 Nov 24;108(44):18114-9. Epub 2011 Oct 24.

Department of Cardiology, Manton Center for Orphan Disease, and Harvard Medical School, Boston, MA 02115, USA.

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November 2011

POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.

Proc Natl Acad Sci U S A 2011 Nov 14;108(48):19234-9. Epub 2011 Nov 14.

Department of Cardiology, The Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children's Hospital Boston, Boston, MA 02115, USA.

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November 2011

ATP-activated P2X2 current in mouse spermatozoa.

Proc Natl Acad Sci U S A 2011 Aug 10;108(34):14342-7. Epub 2011 Aug 10.

Department of Cardiology, Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children's Hospital Boston, Boston, MA 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161588PMC
August 2011

TRPM7, the Mg(2+) inhibited channel and kinase.

Adv Exp Med Biol 2011 ;704:173-83

Department of Cardiology, Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children's Hospital Boston, 02115 Boston, MA, USA.

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July 2011

A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.

Nat Commun 2011 Jan;2:153

1] Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children's Hospital, Boston, Massachusetts 02115, USA.. [2] Department of Neurobiology, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA.

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January 2011

International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family.

Pharmacol Rev 2010 Sep;62(3):381-404

Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital Boston, 320 Longwood Avenue, Boston, MA 02115, USA.

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September 2010

If you have health you have hope, if you have hope you have everything.

Authors:
David Clapham

Perspect Public Health 2010 Sep;130(5):207-8

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September 2010

Specific aspects of gastro-intestinal transit in children for drug delivery design.

Int J Pharm 2010 Aug 15;395(1-2):37-43. Epub 2010 May 15.

Department of Pharmaceutics, The School of Pharmacy, University of London, United Kingdom.

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August 2010

An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1.

Nat Struct Mol Biol 2010 Jul 13;17(7):869-875. Epub 2010 Jun 13.

Howard Hughes Medical Institute, Department of Cardiology and Manton Center for Orphan Disease, Children's Hospital Boston, Boston, Massachusetts, USA.

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July 2010

Targeted cytosolic delivery of cell-impermeable compounds by nanoparticle-mediated, light-triggered endosome disruption.

Nano Lett 2010 Jun;10(6):2211-9

Department of Cardiology, Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children's Hospital Boston, Boston, Massachusetts 02115, USA.

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June 2010

TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation.

Cell 2010 Apr;141(2):331-43

The Department of Molecular, Cellular, and Developmental Biology, the University of Michigan, 3089 Natural Science Building (Kraus), 830 North University, Ann Arbor, MI 48109, USA.

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April 2010

Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter.

Science 2009 Oct;326(5949):144-7

Department of Cardiology, Howard Hughes Medical Institute, Children's Hospital Boston, Manton Center for Orphan Disease, and Department of Neurobiology, Harvard Medical School, Enders Building 1309, 320 Longwood Avenue, Boston, MA 02115, USA.

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October 2009

Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development.

Proc Natl Acad Sci U S A 2009 Sep 26;106(37):15750-5. Epub 2009 Aug 26.

Department of Cardiology, Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children's Hospital Boston, and Harvard Medical School, 1309 Enders, 320 Longwood Avenue, Boston, MA 02115, USA.

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September 2009

Sparklebunnies are go!

Authors:
David Clapham

Perspect Public Health 2009 Jul;129(4):160-1

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July 2009

Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst.

Proc Natl Acad Sci U S A 2009 May 16;106(18):7642-7. Epub 2009 Apr 16.

Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, and Department of Cardiovascular Research, Manton Center for Orphan Disease, Children's Hospital, 320 Longwood Avenue, Boston, MA 02115, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669790PMC
May 2009

Intracellular calcium strongly potentiates agonist-activated TRPC5 channels.

J Gen Physiol 2009 May;133(5):525-46

Howard Hughes Medical Institute, Department of Cardiology and Manton Center for Orphan Disease, Children's Hospital Boston, and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

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May 2009

TRPM1 forms ion channels associated with melanin content in melanocytes.

Sci Signal 2009 May 12;2(70):ra21. Epub 2009 May 12.

Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scisignal.2000146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086358PMC
May 2009

Phenotyping sensory nerve endings in vitro in the mouse.

Nat Protoc 2009 ;4(2):174-96

Department of Physiology and Pathophysiology, Friedrich-Alexander University of Erlangen-Nuremberg, Universitätsstrasse 17, 91054 Erlangen, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082318PMC
April 2009

A STIMulus Package puts orai calcium channels to work.

Authors:
David E Clapham

Cell 2009 Mar;136(5):814-6

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March 2009