Publications by authors named "David C Whitcomb"

263Publications

Assessment of Weight Loss and Gastrointestinal Symptoms Suggestive of Exocrine Pancreatic Dysfunction After Acute Pancreatitis.

Authors:
Anna Evans Phillips Kohtaro Ooka Ioannis Pothoulakis Pedram Paragomi Nicole Komara Ali Lahooti Diala Harb Melanie Mays Filippos Koutroumpakis Kimberly Stello Phil J Greer David C Whitcomb Georgios I Papachristou

Clin Transl Gastroenterol 2020 Dec 15;11(12):e00283. Epub 2020 Dec 15.

Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University, Wexler Medical Center, Columbus, Ohio, USA.

View Article and Find Full Text PDF
December 2020

TOFACITINIB INHIBITS INFLAMMATORY CYTOKINES FROM ULCERATIVE COLITIS AND HEALTHY MUCOSAL EXPLANTS AND IS ASSOCIATED WITH P-STAT1/3 REDUCTION IN T-CELLS.

Authors:
Rhonda M Brand Beverly A Moore Ashley Zyhowski Aaron Siegel Shikhar Uttam E Jeffrey Metter Jarret Engstrom Randall E Brand Nabanita Biswas David C Whitcomb David G Binion Marc Schwartz Ian McGowan

Am J Physiol Gastrointest Liver Physiol 2020 Dec 23. Epub 2020 Dec 23.

Medicine, University of Pittsburgh, United States.

View Article and Find Full Text PDF
December 2020

Divergent trends in lifetime drinking and smoking between Black and White Americans diagnosed with chronic pancreatitis.

Authors:
Christie Y Jeon Robert Feldman Felicity J Pendergast Samer AlKaade Randall E Brand Nalini Guda Bimaljit S Sandhu Vikesh K Singh C Mel Wilcox Adam Slivka David C Whitcomb Dhiraj Yadav

Pancreatology 2020 Dec 12;20(8):1667-1672. Epub 2020 Oct 12.

Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

View Article and Find Full Text PDF
December 2020

Introduction and Validation of a Novel Acute Pancreatitis Digital Tool: Interrogating Large Pooled Data From 2 Prospectively Ascertained Cohorts.

Authors:
Pedram Paragomi Daniel M Spagnolo Cameron R Breze Amir Gougol Rupjyoti Talukdar Rakesh Kochhar Mahesh Kumar Goenka Aiste Gulla Jose A Gonzalez Vikesh K Singh Miguel Ferreira Tyler Stevens Sorin T Barbu Haq Nawaz Silvia C Gutierrez Narcis O Zarnescu Livia Archibugi Jeffrey J Easler Konstantinos Triantafyllou Mario Pelaez-Luna Shyam Thakkar Carlos Ocampo Enrique de-Madaria Gregory A Cote Bechien U Wu Ioannis Pothoulakis Mark Haupt David C Whitcomb Georgios I Papachristou

Pancreas 2020 Nov/Dec;49(10):1276-1282

Department of Internal Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Ohio State University, Wexner Medical Center, Columbus, OH.

View Article and Find Full Text PDF
October 2020

The histopathology of SPINK1-associated chronic pancreatitis.

Authors:
Terrell E Jones Melena D Bellin Dhiraj Yadav Martin L Freeman Sarah J Schwarzenberg Adam Slivka Jennifer S Chennat Gregory J Beilman Srinath Chinnakotla Timothy L Pruett Varvara Kirchner Abhinav Humar Martin Wijkstrom Amer H Zureikat Marina N Nikiforova Abigail I Wald David C Whitcomb Aatur D Singhi

Pancreatology 2020 Dec 16;20(8):1648-1655. Epub 2020 Oct 16.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address:

View Article and Find Full Text PDF
December 2020

Low serum trypsinogen levels in chronic pancreatitis: Correlation with parenchymal loss, exocrine pancreatic insufficiency, and diabetes but not CT-based cambridge severity scores for fibrosis.

Authors:
Wei Zhan Venkata Akshintala Phil J Greer Julia B Greer Samer Alkaade Michelle A Anderson Thiruvengadam Muniraj Georgios I Papachristou Bimaljit S Sandhu Adam Slivka C Mel Wilcox Melena D Bellin Vikesh K Singh Dhiraj Yadav Randall E Brand David C Whitcomb

Pancreatology 2020 Oct 5;20(7):1368-1378. Epub 2020 Sep 5.

Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Cell Biology and Molecular Physiology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

View Article and Find Full Text PDF
October 2020

Severe acute pancreatitis: capillary permeability model linking systemic inflammation to multiorgan failure.

Authors:
Nicole L Komara Pedram Paragomi Phil J Greer Anette S Wilson Cameron Breze Georgios I Papachristou David C Whitcomb

Am J Physiol Gastrointest Liver Physiol 2020 11 2;319(5):G573-G583. Epub 2020 Sep 2.

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

View Article and Find Full Text PDF
November 2020

Bone health assessment in clinical practice is infrequenty performed in patients with chronic pancreatitis.

Authors:
Allison Kanakis Kishore Vipperla Georgios I Papachristou Randall E Brand Adam Slivka David C Whitcomb Dhiraj Yadav

Pancreatology 2020 Sep 25;20(6):1109-1114. Epub 2020 Jul 25.

Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address:

View Article and Find Full Text PDF
September 2020

International consensus guidelines on interventional endoscopy in chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club.

Authors:
Masayuki Kitano Thomas M Gress Pramod K Garg Takao Itoi Atsushi Irisawa Hiroyuki Isayama Atsushi Kanno Kei Takase Michael Levy Ichiro Yasuda Phillipe Lévy Shuiji Isaji Carlos Fernandez-Del Castillo Asbjørn M Drewes Andrea R G Sheel John P Neoptolemos Tooru Shimosegawa Marja Boermeester C Mel Wilcox David C Whitcomb

Pancreatology 2020 Sep 10;20(6):1045-1055. Epub 2020 Jul 10.

Departments of Medicine, Cell Biology & Molecular Physiology and Human Genetics, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh and UPMC, Pittsburgh, PA, USA. Electronic address:

View Article and Find Full Text PDF
September 2020

Clinical Characteristics of Inflammatory Bowel Disease Patients Requiring Long-Term Parenteral Support in the Present Era of Highly Effective Biologic Therapy.

Authors:
Michael Kurin Alyce Anderson Claudia Ramos Rivers Filippos Koutroumpakis Patricia Centa Juliette Bender-Heine Gina Kozak Elisabeth Kramer Stephen J O'Keefe David C Whitcomb David J Levinthal Ioannis E Koutroubakis Michael A Dunn Jana G Hashash David G Binion

JPEN J Parenter Enteral Nutr 2020 Aug 9. Epub 2020 Aug 9.

Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

View Article and Find Full Text PDF
August 2020

Gene Expression Profiling of the Pancreas in Patients Undergoing Total Pancreatectomy With Islet Autotransplant Suggests Unique Features of Alcoholic, Idiopathic, and Hereditary Pancreatitis.

Authors:
Brandon M Blobner Melena D Bellin Gregory J Beilman Celeste A Shelton Hyung Jung Park David C Whitcomb

Pancreas 2020 09;49(8):1037-1043

From the Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA.

View Article and Find Full Text PDF
September 2020

Precision medicine for pancreatic diseases.

Authors:
Celeste A Shelton David C Whitcomb

Curr Opin Gastroenterol 2020 09;36(5):428-436

Departments of Medicine, Cell Biology and Molecular Physiology, and Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

View Article and Find Full Text PDF
September 2020

Constant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort.

Authors:
Ellyn Dunbar Phil J Greer Nadine Melhem Samer Alkaade Stephen T Amann Randall Brand Gregory A Coté Christopher E Forsmark Timothy B Gardner Andres Gelrud Nalini M Guda Jessica LaRusch Michele D Lewis Jorge D Machicado Thiruvengadam Muniraj Georgios I Papachristou Joseph Romagnuolo Bimaljit S Sandhu Stuart Sherman Charles M Wilcox Vikesh K Singh Dhiraj Yadav David C Whitcomb

J Gastroenterol 2020 Oct 17;55(10):1000-1009. Epub 2020 Jul 17.

Department of Medicine, University of Pittsburgh, Room 401.4, 3708 Fifth Ave, Pittsburgh, PA, 15213, USA.

View Article and Find Full Text PDF
October 2020

Complex Genetics in Pancreatitis: Insights Gained From a New Candidate Locus Panel.

Authors:
Mitchell A Ellison Daniel M Spagnolo Celeste Shelton Ekatarina Orlova Jessica LaRusch David C Whitcomb Mark Haupt

Pancreas 2020 08;49(7):983-998

From the Ariel Precision Medicine.

View Article and Find Full Text PDF
August 2020

International consensus guidelines on the role of diagnostic endoscopic ultrasound in the management of chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club.

Authors:
C Mel Wilcox Thomas Gress Marja Boermeester Atsushi Masamune Philippe Lévy Takao Itoi Shyam Varadarajulu Atsushi Irisawa Michael Levy Masayuki Kitano Pramod Garg Shuiji Isaji Tooru Shimosegawa Andrea R G Sheel David C Whitcomb John P Neoptolemos

Pancreatology 2020 Jul 18;20(5):822-827. Epub 2020 Jun 18.

Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany. Electronic address:

View Article and Find Full Text PDF
July 2020

Guidelines on the histopathology of chronic pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and the European Pancreatic Club.

Authors:
Irene Esposito Ralph H Hruban Caroline Verbeke Benoit Terris Giuseppe Zamboni Aldo Scarpa Toshio Morohoshi Koichi Suda Claudio Luchini David S Klimstra Volkan Adsay Lena Haeberle Ashok Saluja Carlos Fernandez-Del Castillo Andrea Sheel John P Neoptolemos Shuiji Isaji Tooru Shimosegawa David C Whitcomb Fiona Campbell

Pancreatology 2020 Jun 29;20(4):586-593. Epub 2020 Apr 29.

Department of Pathology, Royal Liverpool University Hospital, Liverpool, UK. Electronic address:

View Article and Find Full Text PDF
June 2020

International Consensus Guidelines for Risk Factors in Chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club.

Authors:
Péter Hegyi Andrea Párniczky Markus M Lerch Andrea R G Sheel Vinciane Rebours Chris E Forsmark Marco Del Chiaro Jonas Rosendahl Enrique de-Madaria Ákos Szücs Kyoichi Takaori Dhiraj Yadav Cristian Gheorghe Zoltán Rakonczay Xavier Molero Kazuo Inui Atsushi Masamune Carlos Fernandez-Del Castillo Tooru Shimosegawa John P Neoptolemos David C Whitcomb Miklós Sahin-Tóth

Pancreatology 2020 Jun 8;20(4):579-585. Epub 2020 Apr 8.

Department of Surgery, University of California Los Angeles, Los Angeles, CA, USA.

View Article and Find Full Text PDF
June 2020

Activin A Modulates Inflammation in Acute Pancreatitis and Strongly Predicts Severe Disease Independent of Body Mass Index.

Authors:
Alexandra L Thomas Karla Castellanos Georgina Mancinelli Yinglin Xia Jessica Bauer Cemal Yazici Giamila Fantuzzi Rosa F Hwang Nancy L Krett Georgios I Papachristou David C Whitcomb Barbara Jung

Clin Transl Gastroenterol 2020 05;11(5):e00152

Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.

View Article and Find Full Text PDF
May 2020

The role of total pancreatectomy with islet autotransplantation in the treatment of chronic pancreatitis: A report from the International Consensus Guidelines in chronic pancreatitis.

Authors:
Maisam Abu-El-Haija Takayuki Anazawa Gregory J Beilman Marc G Besselink Marco Del Chiaro Ihsan Ekin Demir Ashley R Dennison Vikas Dudeja Martin L Freeman Helmut Friess Thilo Hackert Jorg Kleeff Johanna Laukkarinen Marlon F Levy Jaimie D Nathan Jens Werner John A Windsor John P Neoptolemos Andrea R G Sheel Tooru Shimosegawa David C Whitcomb Melena D Bellin

Pancreatology 2020 Jun 14;20(4):762-771. Epub 2020 Apr 14.

Department of Surgery, University of Minnesota Medical Center, Minneapolis, MN, USA; Department of Pediatrics, University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA. Electronic address:

View Article and Find Full Text PDF
June 2020