David C Wedge

David C Wedge

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David C Wedge

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Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2019 02;566(7742):E1

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

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http://www.nature.com/articles/s41586-019-0883-2
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http://dx.doi.org/10.1038/s41586-019-0883-2DOI Listing
February 2019

Classification and Personalized Prognosis in Myeloproliferative Neoplasms.

N Engl J Med 2018 10;379(15):1416-1430

From the Wellcome-MRC Cambridge Stem Cell Institute and Cambridge Institute for Medical Research (J.G., C.E.M., F.L.N., A.R.G., P.J.C.), the Department of Haematology, University of Cambridge (J.G., E.J.B., C.M., J.C., C.E.M., F.L.N., A.R.G.), and the Department of Haematology, Cambridge University Hospitals NHS Foundation Trust (J.G., E.J.B., A.L.G., C.M., J.C., A.R.G.), Cambridge, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus (J.N., D.C.W., N.A., E.P., G.G., L.O., S.O., J.W.T., A.P.B., N.W., P.J.C.), and the European Molecular Biology Laboratory, European Bioinformatics Institute (R.C., M.G.), Hinxton, Big Data Institute, University of Oxford, Oxford (D.C.W.), the Department of Haematology, Queen's University Belfast, Belfast (M.F.M.), and the Department of Haematology, Guy's and St. Thomas' NHS Foundation Trust, London (C.N.H.) - all in the United Kingdom; the Center for Molecular Oncology and the Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York (E.P., G.G.); the Department of Hematology, Zealand University Hospital, Roskilde, and the University of Copenhagen, Copenhagen (C.L.A., H.C.H.); and the Department of Experimental and Clinical Medicine, Center of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, University of Florence, Florence, Italy (P.G., A.M.V.).

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http://www.nejm.org/doi/10.1056/NEJMoa1716614
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http://dx.doi.org/10.1056/NEJMoa1716614DOI Listing
October 2018

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Nat Genet 2018 05 16;50(5):682-692. Epub 2018 Apr 16.

The Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/s41588-018-0086-z
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http://dx.doi.org/10.1038/s41588-018-0086-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372064PMC
May 2018

Principles of Reconstructing the Subclonal Architecture of Cancers.

Cold Spring Harb Perspect Med 2017 Aug 1;7(8). Epub 2017 Aug 1.

The Francis Crick Institute, London NW1 1AT, United Kingdom.

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http://dx.doi.org/10.1101/cshperspect.a026625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538405PMC
August 2017

How Subclonal Modeling Is Changing the Metastatic Paradigm.

Clin Cancer Res 2017 Feb 18;23(3):630-635. Epub 2016 Nov 18.

Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Parkville, Australia.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0234DOI Listing
February 2017

ascatNgs: Identifying Somatically Acquired Copy-Number Alterations from Whole-Genome Sequencing Data.

Curr Protoc Bioinformatics 2016 12 8;56:15.9.1-15.9.17. Epub 2016 Dec 8.

Cancer Genome Project, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/cpbi.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097604PMC
December 2016

The Genomic Landscape of Pancreatic and Periampullary Adenocarcinoma.

Cancer Res 2016 09 3;76(17):5092-102. Epub 2016 Aug 3.

Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. Department for Environmental Health and Science, University College of Southeast Norway, Bø, Norway.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0658DOI Listing
September 2016

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2016 06 2;534(7605):47-54. Epub 2016 May 2.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature17676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910866PMC
June 2016

Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer.

Elife 2016 05 17;5. Epub 2016 May 17.

Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.7554/eLife.14552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869914PMC
May 2016

Clock-like mutational processes in human somatic cells.

Nat Genet 2015 Dec 9;47(12):1402-7. Epub 2015 Nov 9.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.3441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783858PMC
December 2015

DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype.

Haematologica 2015 Nov 6;100(11):e438-42. Epub 2015 Aug 6.

Department of Haematology, Cambridge Institute for Medical Research and Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Haematology, Addenbrooke's Hospital, Cambridge, UK

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http://dx.doi.org/10.3324/haematol.2015.129510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825297PMC
November 2015

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

Nat Genet 2015 Apr 2;47(4):367-372. Epub 2015 Mar 2.

Urological Research Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge, UK.

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https://ueaeprints.uea.ac.uk/52532/2/39739_3_merged_14193243
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http://www.nature.com/doifinder/10.1038/ng.3221
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http://dx.doi.org/10.1038/ng.3221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380509PMC
April 2015

Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast-rich mimics.

J Pathol Clin Res 2015 Apr 16;1(2):113-23. Epub 2015 Mar 16.

UCL Cancer Institute, University College LondonHuntley StreetLondonUK; Sarah Cannon-University College London Advanced Diagnostics Molecular Profiling Research LaboratoriesUCL Cancer Institute, UCLLondonUK; Department of HistopathologyRoyal National Orthopaedic Hospital NHS TrustMiddlesexUK.

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http://dx.doi.org/10.1002/cjp2.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858131PMC
April 2015

Effect of mutation order on myeloproliferative neoplasms.

N Engl J Med 2015 Feb;372(7):601-612

Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Stem Cell Institute (C.A.O., D.G.K., J.N., Y.S., J.G., E.J.B., C.E.M., A.L.G., D.D., A.R.G.) and Department of Hematology (C.A.O., D.G.K., J.N., Y.S., J.G., E.J.B., C.E.M., A.L.G., D.D., G.S.V., P.J.C., A.R.G.), University of Cambridge, Department of Haematology, Addenbrooke's Hospital (C.A.O., J.N., J.G., E.J.B., A.L.G., G.S.V., P.J.C., A.R.G.), Wellcome Trust Sanger Institute (D.C.W., E.P., G.S.V., P.J.C.), and Cancer Research U.K. Cambridge Institute, Li Ka Shing Centre (S.M.), Cambridge, and Guy's and St. Thomas' National Health Service Foundation Trust, Guy's Hospital, London (C.N.H.) - all in the United Kingdom; Dipartimento di Medicina Sperimentale e Clinica, University of Florence, Florence, Italy (P.G., A.V.); Departments of Pathology (B.B.) and Hematology (C.B.), Hospital del Mar, Barcelona; and the Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany (K.D.).

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http://dx.doi.org/10.1056/NEJMoa1412098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660033PMC
February 2015

Differential and limited expression of mutant alleles in multiple myeloma.

Blood 2014 Nov 18;124(20):3110-7. Epub 2014 Sep 18.

Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Department of Hematology/Oncology, Boston Veterans Administration Healthcare System, West Roxbury, MA;

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http://dx.doi.org/10.1182/blood-2014-04-569327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231420PMC
November 2014

A comparison of different chemometrics approaches for the robust classification of electronic nose data.

Anal Bioanal Chem 2014 Nov 7;406(29):7581-90. Epub 2014 Oct 7.

School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.

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http://link.springer.com/10.1007/s00216-014-8216-7
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http://dx.doi.org/10.1007/s00216-014-8216-7DOI Listing
November 2014

Fast randomization of large genomic datasets while preserving alteration counts.

Bioinformatics 2014 Sep;30(17):i617-23

Fondazione Bruno Kessler, I-38100 Povo (Trento), Italy, European Molecular Biology Laboratory, European Bioinformatics Institute, Cambridge CB10 1SD, UK, Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK and Universitat Pompeu Fabra, Barcelona 08003, Spain.

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http://dx.doi.org/10.1093/bioinformatics/btu474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147926PMC
September 2014

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

Science 2014 Aug;345(6196):1251343

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1126/science.1251343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380235PMC
August 2014

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo.

Cancer Cell 2014 Jun 15;25(6):794-808. Epub 2014 May 15.

Haematopoietic Stem Cell Biology Laboratory, MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK; Departments of Cell and Molecular Biology, Medicine Huddinge, and Laboratory Medicine, Huddinge, Karolinska Institutet and Center for Hematology and Regenerative Medicine, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.03.036DOI Listing
June 2014

Signatures of mutational processes in human cancer.

Nature 2013 Aug 14;500(7463):415-21. Epub 2013 Aug 14.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature12477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776390PMC
August 2013

Deciphering signatures of mutational processes operative in human cancer.

Cell Rep 2013 Jan 10;3(1):246-59. Epub 2013 Jan 10.

Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.

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http://dx.doi.org/10.1016/j.celrep.2012.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588146PMC
January 2013

Liquid chromatography-mass spectrometry calibration transfer and metabolomics data fusion.

Anal Chem 2012 Nov 29;84(22):9848-57. Epub 2012 Oct 29.

School of Chemistry, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, United Kingdom.

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http://pubs.acs.org/doi/10.1021/ac302227c
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http://dx.doi.org/10.1021/ac302227cDOI Listing
November 2012

CONSeQuence: prediction of reference peptides for absolute quantitative proteomics using consensus machine learning approaches.

Mol Cell Proteomics 2011 Nov 3;10(11):M110.003384. Epub 2011 Aug 3.

Michael Barber Centre for Mass Spectrometry, The University of Manchester, Manchester, M1 7DN, UK.

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http://dx.doi.org/10.1074/mcp.M110.003384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226394PMC
November 2011

FDRAnalysis: a tool for the integrated analysis of tandem mass spectrometry identification results from multiple search engines.

J Proteome Res 2011 Apr 21;10(4):2088-94. Epub 2011 Feb 21.

Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom.

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http://dx.doi.org/10.1021/pr101157sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707089PMC
April 2011

Predictive models for population performance on real biological fitness landscapes.

Bioinformatics 2010 Sep 17;26(17):2145-52. Epub 2010 Jul 17.

Faculty of Life Sciences, The University of Manchester, Michael Smith Building, UK.

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http://dx.doi.org/10.1093/bioinformatics/btq353DOI Listing
September 2010

Analysis of a complete DNA-protein affinity landscape.

J R Soc Interface 2010 Mar 22;7(44):397-408. Epub 2009 Jul 22.

Manchester Interdisciplinary Biocentre, University of Manchester , 131 Princess Street, Manchester M1 7DN, UK.

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http://rsif.royalsocietypublishing.org/cgi/doi/10.1098/rsif.
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http://dx.doi.org/10.1098/rsif.2009.0193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842790PMC
March 2010

Aptamer evolution for array-based diagnostics.

Anal Biochem 2009 Jul 15;390(2):203-5. Epub 2009 Apr 15.

Manchester Interdisciplinary Biocenter, University of Manchester, Manchester M1 7DN, UK.

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http://dx.doi.org/10.1016/j.ab.2009.04.013DOI Listing
July 2009

In silico modelling of directed evolution: Implications for experimental design and stepwise evolution.

J Theor Biol 2009 Mar 17;257(1):131-41. Epub 2008 Nov 17.

Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester, M1 7ND, UK.

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http://dx.doi.org/10.1016/j.jtbi.2008.11.005DOI Listing
March 2009

Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape.

Nucleic Acids Res 2009 Jan 23;37(1):e6. Epub 2008 Nov 23.

Manchester Interdisciplinary Biocentre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1093/nar/gkn899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615635PMC
January 2009