David C Chan

David C Chan

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Accuracy of Valuations of Surgical Procedures in the Medicare Fee Schedule.

N Engl J Med 2019 04;380(16):1546-1554

From the Center for Health Policy-Center for Primary Care and Outcomes Research, Stanford University School of Medicine (D.C.C., D.M.S.), and Stanford Law School (D.M.S.), Stanford, the Department of Medicine, Veterans Affairs Palo Alto Health Care System, Palo Alto (D.C.C.), and the Department of Economics, University of California Los Angeles, Los Angeles (J.H.) - all in California.

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http://www.nejm.org/doi/10.1056/NEJMsa1807379
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http://dx.doi.org/10.1056/NEJMsa1807379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543528PMC
April 2019

Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.

Cell Rep 2018 Jun;23(10):2989-3005

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.05.015DOI Listing
June 2018

OPA1 and cardiolipin team up for mitochondrial fusion.

Nat Cell Biol 2017 Jul 19;19(7):760-762. Epub 2017 Jun 19.

Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1038/ncb3565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757513PMC
July 2017

Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells.

Cell Metab 2017 Jul 22;26(1):39-48. Epub 2017 Jun 22.

Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, MC 114-96, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539982PMC
July 2017

The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility.

Nat Commun 2017 04 21;8:15074. Epub 2017 Apr 21.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1038/ncomms15074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413954PMC
April 2017

MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion.

Nature 2017 02 23;542(7641):372-376. Epub 2017 Jan 23.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.

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http://dx.doi.org/10.1038/nature21077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319402PMC
February 2017

Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1.

Elife 2016 11 17;5. Epub 2016 Nov 17.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.

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http://dx.doi.org/10.7554/eLife.17896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127638PMC
November 2016

Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells.

Cancer Res 2016 09 30;76(17):5006-18. Epub 2016 Jun 30.

Diabetes and Metabolism Research Institute, City of Hope, Duarte, California. Irell and Manella Graduate School of Biological Sciences, City of Hope, Duarte, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-2921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316485PMC
September 2016

A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy.

Am J Med Genet A 2016 08 4;170(8):2002-11. Epub 2016 May 4.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California.

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http://dx.doi.org/10.1002/ajmg.a.37721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100740PMC
August 2016

Metabolic regulation of mitochondrial dynamics.

J Cell Biol 2016 Feb 8;212(4):379-87. Epub 2016 Feb 8.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125

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http://dx.doi.org/10.1083/jcb.201511036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754720PMC
February 2016

Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress.

Science 2016 Jan;351(6270):275-281

Molecular and Cell Biology Laboratory and Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/science.aab4138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852862PMC
January 2016

The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1.

Mol Biol Cell 2015 Dec 7;26(24):4466-77. Epub 2015 Oct 7.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125

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http://dx.doi.org/10.1091/mbc.E15-08-0591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666140PMC
December 2015

Mitochondrial Dynamics is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization.

Cell Metab 2015 Dec 22;22(6):1033-44. Epub 2015 Oct 22.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.09.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670593PMC
December 2015

Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation.

Nat Commun 2014 ;5:3077

1] Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA [2] Howard Hughes Medical Institute, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1038/ncomms4077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936014PMC
November 2015

Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy.

J Cell Biol 2015 Nov;211(4):795-805

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125

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http://www.jcb.org/lookup/doi/10.1083/jcb.201507035
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http://dx.doi.org/10.1083/jcb.201507035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657172PMC
November 2015

MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases.

Mol Ther 2015 Oct 10;23(10):1592-9. Epub 2015 Jul 10.

Department of Neurology, University of Miami Miller School of Medicine Miami, Miami, Florida, USA.

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http://dx.doi.org/10.1038/mt.2015.126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817924PMC
October 2015

Analyzing mitochondrial dynamics in mouse organotypic slice cultures.

Methods Enzymol 2014 ;547:111-29

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA; Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-801415-8.00007-2DOI Listing
August 2015

Methods in Enzymology. Mitochondrial function. Preface.

Methods Enzymol 2014 ;547:xix-xx

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http://dx.doi.org/10.1016/B978-0-12-801415-8.09983-5DOI Listing
August 2015

The impact of Massachusetts health care reform on access, quality, and costs of care for the already-insured.

Health Serv Res 2015 Apr 15;50(2):599-613. Epub 2014 Sep 15.

Department of Health Policy and Management, Harvard School of Public Health, Brigham and Women's Hospital, Boston, MA; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA; VA Boston Healthcare System, Boston, MA.

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http://dx.doi.org/10.1111/1475-6773.12228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369224PMC
April 2015

Crystal structure and functional analysis of MiD49, a receptor for the mitochondrial fission protein Drp1.

Protein Sci 2015 Mar 14;24(3):386-94. Epub 2015 Jan 14.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, 91125.

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http://dx.doi.org/10.1002/pro.2629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353364PMC
March 2015

Mitochondrial DNA: impacting central and peripheral nervous systems.

Neuron 2014 Dec;84(6):1126-42

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271190PMC
December 2014

Mitochondrial dynamics and inheritance during cell division, development and disease.

Nat Rev Mol Cell Biol 2014 Oct 17;15(10):634-46. Epub 2014 Sep 17.

1] Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA. [2] Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1038/nrm3877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250044PMC
October 2014

Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2.

J Biol Chem 2014 Jul 22;289(28):19789-98. Epub 2014 May 22.

From the Division of Biology and Biological Engineering, the Howard Hughes Medical Institute, and

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http://dx.doi.org/10.1074/jbc.M114.569392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094088PMC
July 2014

Genome-wide analysis reveals coating of the mitochondrial genome by TFAM.

PLoS One 2013 26;8(8):e74513. Epub 2013 Aug 26.

Division of Biology, California Institute of Technology, Pasadena, California, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074513PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753274PMC
June 2014

Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation.

Cell Metab 2014 Apr;19(4):630-41

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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http://www.betacell-cellbio.eu/teaching/ITV_LITT/ROJO/Cell%2
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http://www.cell.com/cell-metabolism/pdf/S1550-4131(14)00115-
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http://linkinghub.elsevier.com/retrieve/pii/S155041311400115
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http://dx.doi.org/10.1016/j.cmet.2014.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018240PMC
April 2014

The mitochondrial fission receptor MiD51 requires ADP as a cofactor.

Structure 2014 Mar 6;22(3):367-77. Epub 2014 Feb 6.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2014.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066849PMC
March 2014

Fusion and fission: interlinked processes critical for mitochondrial health.

Authors:
David C Chan

Annu Rev Genet 2012 29;46:265-87. Epub 2012 Aug 29.

Division of Biology and the Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1146/annurev-genet-110410-132529DOI Listing
April 2013

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.

Mol Biol Cell 2013 Mar 2;24(5):659-67. Epub 2013 Jan 2.

Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1091/mbc.E12-10-0721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583668PMC
March 2013

Mouse lines with photo-activatable mitochondria to study mitochondrial dynamics.

Genesis 2012 Nov 11;50(11):833-43. Epub 2012 Aug 11.

Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1002/dvg.22050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508687PMC
November 2012

Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit.

Hum Mol Genet 2012 Nov 31;21(22):4817-26. Epub 2012 Jul 31.

Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1093/hmg/dds311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607482PMC
November 2012

Lysocardiolipin acyltransferase 1 (ALCAT1) controls mitochondrial DNA fidelity and biogenesis through modulation of MFN2 expression.

Proc Natl Acad Sci U S A 2012 May 16;109(18):6975-80. Epub 2012 Apr 16.

Shaanxi Center for Stem Cell Engineering and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.

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http://dx.doi.org/10.1073/pnas.1120043109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345005PMC
May 2012

Guidelines for the use and interpretation of assays for monitoring autophagy.

Authors:
Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli Lotta Agholme Maria Agnello Patrizia Agostinis Julio A Aguirre-Ghiso Hyung Jun Ahn Ouardia Ait-Mohamed Slimane Ait-Si-Ali Takahiko Akematsu Shizuo Akira Hesham M Al-Younes Munir A Al-Zeer Matthew L Albert Roger L Albin Javier Alegre-Abarrategui Maria Francesca Aleo Mehrdad Alirezaei Alexandru Almasan Maylin Almonte-Becerril Atsuo Amano Ravi Amaravadi Shoba Amarnath Amal O Amer Nathalie Andrieu-Abadie Vellareddy Anantharam David K Ann Shailendra Anoopkumar-Dukie Hiroshi Aoki Nadezda Apostolova Giuseppe Arancia John P Aris Katsuhiko Asanuma Nana Y O Asare Hisashi Ashida Valerie Askanas David S Askew Patrick Auberger Misuzu Baba Steven K Backues Eric H Baehrecke Ben A Bahr Xue-Yuan Bai Yannick Bailly Robert Baiocchi Giulia Baldini Walter Balduini Andrea Ballabio Bruce A Bamber Edward T W Bampton Gábor Bánhegyi Clinton R Bartholomew Diane C Bassham Robert C Bast Henri Batoko Boon-Huat Bay Isabelle Beau Daniel M Béchet Thomas J Begley Christian Behl Christian Behrends Soumeya Bekri Bryan Bellaire Linda J Bendall Luca Benetti Laura Berliocchi Henri Bernardi Francesca Bernassola Sébastien Besteiro Ingrid Bhatia-Kissova Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Lawrence H Boise Paolo Bonaldo David L Boone Beat C Bornhauser Karina R Bortoluci Ioannis Bossis Frédéric Bost Jean-Pierre Bourquin Patricia Boya Michaël Boyer-Guittaut Peter V Bozhkov Nathan R Brady Claudio Brancolini Andreas Brech Jay E Brenman Ana Brennand Emery H Bresnick Patrick Brest Dave Bridges Molly L Bristol Paul S Brookes Eric J Brown John H Brumell Nicola Brunetti-Pierri Ulf T Brunk Dennis E Bulman Scott J Bultman Geert Bultynck Lena F Burbulla Wilfried Bursch Jonathan P Butchar Wanda Buzgariu Sergio P Bydlowski Ken Cadwell Monika Cahová Dongsheng Cai Jiyang Cai Qian Cai Bruno Calabretta Javier Calvo-Garrido Nadine Camougrand Michelangelo Campanella Jenny Campos-Salinas Eleonora Candi Lizhi Cao Allan B Caplan Simon R Carding Sandra M Cardoso Jennifer S Carew Cathleen R Carlin Virginie Carmignac Leticia A M Carneiro Serena Carra Rosario A Caruso Giorgio Casari Caty Casas Roberta Castino Eduardo Cebollero Francesco Cecconi Jean Celli Hassan Chaachouay Han-Jung Chae Chee-Yin Chai David C Chan Edmond Y Chan Raymond Chuen-Chung Chang Chi-Ming Che Ching-Chow Chen Guang-Chao Chen Guo-Qiang Chen Min Chen Quan Chen Steve S-L Chen WenLi Chen Xi Chen Xiangmei Chen Xiequn Chen Ye-Guang Chen Yingyu Chen Yongqiang Chen Yu-Jen Chen Zhixiang Chen Alan Cheng Christopher H K Cheng Yan Cheng Heesun Cheong Jae-Ho Cheong Sara Cherry Russ Chess-Williams Zelda H Cheung Eric Chevet Hui-Ling Chiang Roberto Chiarelli Tomoki Chiba Lih-Shen Chin Shih-Hwa Chiou Francis V Chisari Chi Hin Cho Dong-Hyung Cho Augustine M K Choi DooSeok Choi Kyeong Sook Choi Mary E Choi Salem Chouaib Divaker Choubey Vinay Choubey Charleen T Chu Tsung-Hsien Chuang Sheau-Huei Chueh Taehoon Chun Yong-Joon Chwae Mee-Len Chye Roberto Ciarcia Maria R Ciriolo Michael J Clague Robert S B Clark Peter G H Clarke Robert Clarke Patrice Codogno Hilary A Coller María I Colombo Sergio Comincini Maria Condello Fabrizio Condorelli Mark R Cookson Graham H Coombs Isabelle Coppens Ramon Corbalan Pascale Cossart Paola Costelli Safia Costes Ana Coto-Montes Eduardo Couve Fraser P Coxon James M Cregg José L Crespo Marianne J Cronjé Ana Maria Cuervo Joseph J Cullen Mark J Czaja Marcello D'Amelio Arlette Darfeuille-Michaud Lester M Davids Faith E Davies Massimo De Felici John F de Groot Cornelis A M de Haan Luisa De Martino Angelo De Milito Vincenzo De Tata Jayanta Debnath Alexei Degterev Benjamin Dehay Lea M D Delbridge Francesca Demarchi Yi Zhen Deng Jörn Dengjel Paul Dent Donna Denton Vojo Deretic Shyamal D Desai Rodney J Devenish Mario Di Gioacchino Gilbert Di Paolo Chiara Di Pietro Guillermo Díaz-Araya Inés Díaz-Laviada Maria T Diaz-Meco Javier Diaz-Nido Ivan Dikic Savithramma P Dinesh-Kumar Wen-Xing Ding Clark W Distelhorst Abhinav Diwan Mojgan Djavaheri-Mergny Svetlana Dokudovskaya Zheng Dong Frank C Dorsey Victor Dosenko James J Dowling Stephen Doxsey Marlène Dreux Mark E Drew Qiuhong Duan Michel A Duchosal Karen Duff Isabelle Dugail Madeleine Durbeej Michael Duszenko Charles L Edelstein Aimee L Edinger Gustavo Egea Ludwig Eichinger N Tony Eissa Suhendan Ekmekcioglu Wafik S El-Deiry Zvulun Elazar Mohamed Elgendy Lisa M Ellerby Kai Er Eng Anna-Mart Engelbrecht Simone Engelender Jekaterina Erenpreisa Ricardo Escalante Audrey Esclatine Eeva-Liisa Eskelinen Lucile Espert Virginia Espina Huizhou Fan Jia Fan Qi-Wen Fan Zhen Fan Shengyun Fang Yongqi Fang Manolis Fanto Alessandro Fanzani Thomas Farkas Jean-Claude Farré Mathias Faure Marcus Fechheimer Carl G Feng Jian Feng Qili Feng Youji Feng László Fésüs Ralph Feuer Maria E Figueiredo-Pereira Gian Maria Fimia Diane C Fingar Steven Finkbeiner Toren Finkel Kim D Finley Filomena Fiorito Edward A Fisher Paul B Fisher Marc Flajolet Maria L Florez-McClure Salvatore Florio Edward A Fon Francesco Fornai Franco Fortunato Rati Fotedar Daniel H Fowler Howard S Fox Rodrigo Franco Lisa B Frankel Marc Fransen José M Fuentes Juan Fueyo Jun Fujii Kozo Fujisaki Eriko Fujita Mitsunori Fukuda Ruth H Furukawa Matthias Gaestel Philippe Gailly Malgorzata Gajewska Brigitte Galliot Vincent Galy Subramaniam Ganesh Barry Ganetzky Ian G Ganley Fen-Biao Gao George F Gao Jinming Gao Lorena Garcia Guillermo Garcia-Manero Mikel Garcia-Marcos Marjan Garmyn Andrei L Gartel Evelina Gatti Mathias Gautel Thomas R Gawriluk Matthew E Gegg Jiefei Geng Marc Germain Jason E Gestwicki David A Gewirtz Saeid Ghavami Pradipta Ghosh Anna M Giammarioli Alexandra N Giatromanolaki Spencer B Gibson Robert W Gilkerson Michael L Ginger Henry N Ginsberg Jakub Golab Michael S Goligorsky Pierre Golstein Candelaria Gomez-Manzano Ebru Goncu Céline Gongora Claudio D Gonzalez Ramon Gonzalez Cristina González-Estévez Rosa Ana González-Polo Elena Gonzalez-Rey Nikolai V Gorbunov Sharon Gorski Sandro Goruppi Roberta A Gottlieb Devrim Gozuacik Giovanna Elvira Granato Gary D Grant Kim N Green Aleš Gregorc Frédéric Gros Charles Grose Thomas W Grunt Philippe Gual Jun-Lin Guan Kun-Liang Guan Sylvie M Guichard Anna S Gukovskaya Ilya Gukovsky Jan Gunst Asa B Gustafsson Andrew J Halayko Amber N Hale Sandra K Halonen Maho Hamasaki Feng Han Ting Han Michael K Hancock Malene Hansen Hisashi Harada Masaru Harada Stefan E Hardt J Wade Harper Adrian L Harris James Harris Steven D Harris Makoto Hashimoto Jeffrey A Haspel Shin-ichiro Hayashi Lori A Hazelhurst Congcong He You-Wen He Marie-Joseé Hébert Kim A Heidenreich Miep H Helfrich Gudmundur V Helgason Elizabeth P Henske Brian Herman Paul K Herman Claudio Hetz Sabine Hilfiker Joseph A Hill Lynne J Hocking Paul Hofman Thomas G Hofmann Jörg Höhfeld Tessa L Holyoake Ming-Huang Hong David A Hood Gökhan S Hotamisligil Ewout J Houwerzijl Maria Høyer-Hansen Bingren Hu Chien-An A Hu Hong-Ming Hu Ya Hua Canhua Huang Ju Huang Shengbing Huang Wei-Pang Huang Tobias B Huber Won-Ki Huh Tai-Ho Hung Ted R Hupp Gang Min Hur James B Hurley Sabah N A Hussain Patrick J Hussey Jung Jin Hwang Seungmin Hwang Atsuhiro Ichihara Shirin Ilkhanizadeh Ken Inoki Takeshi Into Valentina Iovane Juan L Iovanna Nancy Y Ip Yoshitaka Isaka Hiroyuki Ishida Ciro Isidoro Ken-ichi Isobe Akiko Iwasaki Marta Izquierdo Yotaro Izumi Panu M Jaakkola Marja Jäättelä George R Jackson William T Jackson Bassam Janji Marina Jendrach Ju-Hong Jeon Eui-Bae Jeung Hong Jiang Hongchi Jiang Jean X Jiang Ming Jiang Qing Jiang Xuejun Jiang Xuejun Jiang Alberto Jiménez Meiyan Jin Shengkan Jin Cheol O Joe Terje Johansen Daniel E Johnson Gail V W Johnson Nicola L Jones Bertrand Joseph Suresh K Joseph Annie M Joubert Gábor Juhász Lucienne Juillerat-Jeanneret Chang Hwa Jung Yong-Keun Jung Kai Kaarniranta Allen Kaasik Tomohiro Kabuta Motoni Kadowaki Katarina Kagedal Yoshiaki Kamada Vitaliy O Kaminskyy Harm H Kampinga Hiromitsu Kanamori Chanhee Kang Khong Bee Kang Kwang Il Kang Rui Kang Yoon-A Kang Tomotake Kanki Thirumala-Devi Kanneganti Haruo Kanno Anumantha G Kanthasamy Arthi Kanthasamy Vassiliki Karantza Gur P Kaushal Susmita Kaushik Yoshinori Kawazoe Po-Yuan Ke John H Kehrl Ameeta Kelekar Claus Kerkhoff David H Kessel Hany Khalil Jan A K W Kiel Amy A Kiger Akio Kihara Deok Ryong Kim Do-Hyung Kim Dong-Hou Kim Eun-Kyoung Kim Hyung-Ryong Kim Jae-Sung Kim Jeong Hun Kim Jin Cheon Kim John K Kim Peter K Kim Seong Who Kim Yong-Sun Kim Yonghyun Kim Adi Kimchi Alec C Kimmelman Jason S King Timothy J Kinsella Vladimir Kirkin Lorrie A Kirshenbaum Katsuhiko Kitamoto Kaio Kitazato Ludger Klein Walter T Klimecki Jochen Klucken Erwin Knecht Ben C B Ko Jan C Koch Hiroshi Koga Jae-Young Koh Young Ho Koh Masato Koike Masaaki Komatsu Eiki Kominami Hee Jeong Kong Wei-Jia Kong Viktor I Korolchuk Yaichiro Kotake Michael I Koukourakis Juan B Kouri Flores Attila L Kovács Claudine Kraft Dimitri Krainc Helmut Krämer Carole Kretz-Remy Anna M Krichevsky Guido Kroemer Rejko Krüger Oleg Krut Nicholas T Ktistakis Chia-Yi Kuan Roza Kucharczyk Ashok Kumar Raj Kumar Sharad Kumar Mondira Kundu Hsing-Jien Kung Tino Kurz Ho Jeong Kwon Albert R La Spada Frank Lafont Trond Lamark Jacques Landry Jon D Lane Pierre Lapaquette Jocelyn F Laporte Lajos László Sergio Lavandero Josée N Lavoie Robert Layfield Pedro A Lazo Weidong Le Laurent Le Cam Daniel J Ledbetter Alvin J X Lee Byung-Wan Lee Gyun Min Lee Jongdae Lee Ju-Hyun Lee Michael Lee Myung-Shik Lee Sug Hyung Lee Christiaan Leeuwenburgh Patrick Legembre Renaud Legouis Michael Lehmann Huan-Yao Lei Qun-Ying Lei David A Leib José Leiro John J Lemasters Antoinette Lemoine Maciej S Lesniak Dina Lev Victor V Levenson Beth Levine Efrat Levy Faqiang Li Jun-Lin Li Lian Li Sheng Li Weijie Li Xue-Jun Li Yan-bo Li Yi-Ping Li Chengyu Liang Qiangrong Liang Yung-Feng Liao Pawel P Liberski Andrew Lieberman Hyunjung J Lim Kah-Leong Lim Kyu Lim Chiou-Feng Lin Fu-Cheng Lin Jian Lin Jiandie D Lin Kui Lin Wan-Wan Lin Weei-Chin Lin Yi-Ling Lin Rafael Linden Paul Lingor Jennifer Lippincott-Schwartz Michael P Lisanti Paloma B Liton Bo Liu Chun-Feng Liu Kaiyu Liu Leyuan Liu Qiong A Liu Wei Liu Young-Chau Liu Yule Liu Richard A Lockshin Chun-Nam Lok Sagar Lonial Benjamin Loos Gabriel Lopez-Berestein Carlos López-Otín Laura Lossi Michael T Lotze Peter Lőw Binfeng Lu Bingwei Lu Bo Lu Zhen Lu Frédéric Luciano Nicholas W Lukacs Anders H Lund Melinda A Lynch-Day Yong Ma Fernando Macian Jeff P MacKeigan Kay F Macleod Frank Madeo Luigi Maiuri Maria Chiara Maiuri Davide Malagoli May Christine V Malicdan Walter Malorni Na Man Eva-Maria Mandelkow Stéphen Manon Irena Manov Kai Mao Xiang Mao Zixu Mao Philippe Marambaud Daniela Marazziti Yves L Marcel Katie Marchbank Piero Marchetti Stefan J Marciniak Mateus Marcondes Mohsen Mardi Gabriella Marfe Guillermo Mariño Maria Markaki Mark R Marten Seamus J Martin Camille Martinand-Mari Wim Martinet Marta Martinez-Vicente Matilde Masini Paola Matarrese Saburo Matsuo Raffaele Matteoni Andreas Mayer Nathalie M Mazure David J McConkey Melanie J McConnell Catherine McDermott Christine McDonald Gerald M McInerney Sharon L McKenna BethAnn McLaughlin Pamela J McLean Christopher R McMaster G Angus McQuibban Alfred J Meijer Miriam H Meisler Alicia Meléndez Thomas J Melia Gerry Melino Maria A Mena Javier A Menendez Rubem F S Menna-Barreto Manoj B Menon Fiona M Menzies Carol A Mercer Adalberto Merighi Diane E Merry Stefania Meschini Christian G Meyer Thomas F Meyer Chao-Yu Miao Jun-Ying Miao Paul A M Michels Carine Michiels Dalibor Mijaljica Ana Milojkovic Saverio Minucci Clelia Miracco Cindy K Miranti Ioannis Mitroulis Keisuke Miyazawa Noboru Mizushima Baharia Mograbi Simin Mohseni Xavier Molero Bertrand Mollereau Faustino Mollinedo Takashi Momoi Iryna Monastyrska Martha M Monick Mervyn J Monteiro Michael N Moore Rodrigo Mora Kevin Moreau Paula I Moreira Yuji Moriyasu Jorge Moscat Serge Mostowy Jeremy C Mottram Tomasz Motyl Charbel E-H Moussa Sylke Müller Sylviane Muller Karl Münger Christian Münz Leon O Murphy Maureen E Murphy Antonio Musarò Indira Mysorekar Eiichiro Nagata Kazuhiro Nagata Aimable Nahimana Usha Nair Toshiyuki Nakagawa Kiichi Nakahira Hiroyasu Nakano Hitoshi Nakatogawa Meera Nanjundan Naweed I Naqvi Derek P Narendra Masashi Narita Miguel Navarro Steffan T Nawrocki Taras Y Nazarko Andriy Nemchenko Mihai G Netea Thomas P Neufeld Paul A Ney Ioannis P Nezis Huu Phuc Nguyen Daotai Nie Ichizo Nishino Corey Nislow Ralph A Nixon Takeshi Noda Angelika A Noegel Anna Nogalska Satoru Noguchi Lucia Notterpek Ivana Novak Tomoyoshi Nozaki Nobuyuki Nukina Thorsten Nürnberger Beat Nyfeler Keisuke Obara Terry D Oberley Salvatore Oddo Michinaga Ogawa Toya Ohashi Koji Okamoto Nancy L Oleinick F Javier Oliver Laura J Olsen Stefan Olsson Onya Opota Timothy F Osborne Gary K Ostrander Kinya Otsu Jing-hsiung James Ou Mireille Ouimet Michael Overholtzer Bulent Ozpolat Paolo Paganetti Ugo Pagnini Nicolas Pallet Glen E Palmer Camilla Palumbo Tianhong Pan 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Yoshikawa Tamotsu Yoshimori Kohki Yoshimoto Ho Jin You Richard J Youle Anas Younes Li Yu Long Yu Seong-Woon Yu Wai Haung Yu Zhi-Min Yuan Zhenyu Yue Cheol-Heui Yun Michisuke Yuzaki Olga Zabirnyk Elaine Silva-Zacarin David Zacks Eldad Zacksenhaus Nadia Zaffaroni Zahra Zakeri Herbert J Zeh Scott O Zeitlin Hong Zhang Hui-Ling Zhang Jianhua Zhang Jing-Pu Zhang Lin Zhang Long Zhang Ming-Yong Zhang Xu Dong Zhang Mantong Zhao Yi-Fang Zhao Ying Zhao Zhizhuang J Zhao Xiaoxiang Zheng Boris Zhivotovsky Qing Zhong Cong-Zhao Zhou Changlian Zhu Wei-Guo Zhu Xiao-Feng Zhu Xiongwei Zhu Yuangang Zhu Teresa Zoladek Wei-Xing Zong Antonio Zorzano Jürgen Zschocke Brian Zuckerbraun

Autophagy 2012 Apr;8(4):445-544

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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April 2012

Crystal structure of mitochondrial fission complex reveals scaffolding function for mitochondrial division 1 (Mdv1) coiled coil.

J Biol Chem 2012 Mar 1;287(13):9855-61. Epub 2012 Feb 1.

Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.

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March 2012

Eliminating mitochondrial DNA from sperm.

Dev Cell 2012 Mar;22(3):469-70

Division of Biology, California Institute of Technology, and the Howard Hughes Medical Institute, Pasadena, CA 91125, USA.

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March 2012

Parkin uses the UPS to ship off dysfunctional mitochondria.

Autophagy 2011 Jul 1;7(7):771-2. Epub 2011 Jul 1.

Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA, USA.

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July 2011

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy.

Hum Mol Genet 2011 May 4;20(9):1726-37. Epub 2011 Feb 4.

Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

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May 2011

Improving safety and eliminating redundant tests: cutting costs in U.S. hospitals.

Health Aff (Millwood) 2009 Sep-Oct;28(5):1475-84

Harvard School of Public Health (HSPH), Boston, Massachusetts, USA.

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April 2011

piRNAs meet mitochondria.

Dev Cell 2011 Mar;20(3):287-8

California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.

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March 2011

Quantitative risk stratification in Markov chains with limiting conditional distributions.

Med Decis Making 2009 Jul-Aug;29(4):532-40. Epub 2009 Mar 31.

Department of Economics, Massachusetts Institute of Technology, Cambridge, MA, USA.

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September 2010

Physiological functions of mitochondrial fusion.

Ann N Y Acad Sci 2010 Jul;1201:21-5

Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.

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July 2010

OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation.

Hum Mol Genet 2010 Jun 25;19(11):2113-22. Epub 2010 Feb 25.

Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

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June 2010

Patient, physician, and payment predictors of statin adherence.

Med Care 2010 Mar;48(3):196-202

Department of Medicine, Division of General Internal Medicine, Brigham and Women's Hospital, Boston, MA, USA.

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March 2010

Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases.

Hum Mol Genet 2009 Oct;18(R2):R169-76

Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA.

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October 2009

Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion.

Mol Biol Cell 2009 Aug 28;20(15):3525-32. Epub 2009 May 28.

Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

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August 2009

Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A.

Hum Mol Genet 2008 Feb 24;17(3):367-75. Epub 2007 Oct 24.

Division of Biology, California Institute of Technology, 1200 East California Boulevard, MC114-96, Pasadena, CA 91125, USA.

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February 2008

Heart failure disease management programs: a cost-effectiveness analysis.

Am Heart J 2008 Feb 19;155(2):332-8. Epub 2007 Nov 19.

Brigham and Women's Hospital, Boston, MA 02115, USA.

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February 2008

Functions and dysfunctions of mitochondrial dynamics.

Nat Rev Mol Cell Biol 2007 Nov;8(11):870-9

Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.

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November 2007

Structural basis for recruitment of mitochondrial fission complexes by Fis1.

Proc Natl Acad Sci U S A 2007 Nov 12;104(47):18526-30. Epub 2007 Nov 12.

Division of Biology, California Institute of Technology, 1200 East California Boulevard, MC 114-96, Pasadena, CA 91125, USA.

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November 2007

Mitochondrial fusion protects against neurodegeneration in the cerebellum.

Cell 2007 Aug;130(3):548-62

Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

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August 2007

New insights into mitochondrial fusion.

FEBS Lett 2007 May 20;581(11):2168-73. Epub 2007 Feb 20.

Division of Biology, California Institute of Technology, MC114-96, Pasadena, CA 91125, USA.

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May 2007

Mitochondrial dynamics in disease.

Authors:
David C Chan

N Engl J Med 2007 Apr;356(17):1707-9

California Institute of Technology, Pasadena, USA.

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April 2007

Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations.

J Cell Biol 2007 Feb;176(4):405-14

Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

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February 2007

Mitochondrial fusion and fission in mammals.

Authors:
David C Chan

Annu Rev Cell Dev Biol 2006 ;22:79-99

Division of Biology, California Institute of Technology, Pasadena, California, USA.

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December 2006

A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis.

Nat Cell Biol 2006 Nov 8;8(11):1255-62. Epub 2006 Oct 8.

Graduate Program in Molecular and Cellular Biology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794-5140, USA.

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November 2006

Dissecting mitochondrial fusion.

Authors:
David C Chan

Dev Cell 2006 Nov;11(5):592-4

Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.

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November 2006

Molecular mechanism of mitochondrial membrane fusion.

Biochim Biophys Acta 2006 May-Jun;1763(5-6):482-9. Epub 2006 Mar 9.

Division of Biology, California Institute of Technology, 1200 East California Blvd., MC114-96, Pasadena, CA 91125, USA.

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September 2006

Analysis of complexes of inhibitors with Cryptosporidium hominis DHFR leads to a new trimethoprim derivative.

Bioorg Med Chem Lett 2006 Aug 5;16(16):4366-70. Epub 2006 Jun 5.

Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA.

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August 2006

Critical dependence of neurons on mitochondrial dynamics.

Curr Opin Cell Biol 2006 Aug 14;18(4):453-9. Epub 2006 Jun 14.

Division of Biology, California Institute of Technology, 1200 East California Blvd, MC114-96, Pasadena, CA 91125, United States.

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August 2006

Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion.

J Biol Chem 2006 Jun 19;281(24):16599-606. Epub 2006 Apr 19.

Division of Biology, California Institute of Technology, 1200 E. California Boulevard, Pasadena, CA 91125, USA.

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June 2006

Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-gamma coactivator-1 alpha, estrogen-related receptor-alpha, and mitofusin 2.

Diabetes 2006 Jun;55(6):1783-91

Institute for Research in Biomedicine (IRB), Scientífic Park of Barcelona, Departament of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barelona, Spain.

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http://dx.doi.org/10.2337/db05-0509DOI Listing
June 2006

Mitochondria: dynamic organelles in disease, aging, and development.

Authors:
David C Chan

Cell 2006 Jun;125(7):1241-52

Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

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June 2006

Emerging functions of mammalian mitochondrial fusion and fission.

Hum Mol Genet 2005 Oct;14 Spec No. 2:R283-9

Division of Biology, California Institute of Technology, 1200 E. California Boulevard, MC114-96, Pasadena, CA 91125, USA.

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October 2005

Disruption of fusion results in mitochondrial heterogeneity and dysfunction.

J Biol Chem 2005 Jul 17;280(28):26185-92. Epub 2005 May 17.

Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.

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July 2005

The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria.

J Cell Biol 2005 Jul 11;170(2):237-48. Epub 2005 Jul 11.

Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171414PMC
July 2005

Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain.

J Med Chem 2005 Jun;48(13):4420-31

Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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June 2005

The fusion activity of HIV-1 gp41 depends on interhelical interactions.

J Biol Chem 2005 May 16;280(20):19852-7. Epub 2005 Mar 16.

Division of Biology, California Institute of Technology, Pasadena, 91125, USA.

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May 2005

Synthesis of the lipophilic antifolate piritrexim via a palladium(0)-catalyzed cross-coupling reaction.

J Org Chem 2005 Feb;70(4):1364-8

Dana-Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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February 2005

Structural basis of mitochondrial tethering by mitofusin complexes.

Science 2004 Aug;305(5685):858-62

Division of Biology, California Institute of Technology, 1200 East California Boulevard, MC114-96, Pasadena, CA 91125, USA.

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August 2004

Synthesis of 2,4-diamino-6-[2'-O-(omega-carboxyalkyl)oxydibenz[b,f]azepin-5-yl]methylpteridines as potent and selective inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase.

J Med Chem 2004 May;47(10):2475-85

Dana-Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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May 2004

Mitochondrial dynamics in mammals.

Curr Top Dev Biol 2004 ;59:119-44

Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1016/S0070-2153(04)59005-1DOI Listing
April 2004

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis.

J Cell Biol 2004 Feb 9;164(4):493-9. Epub 2004 Feb 9.

Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.jcb.org/lookup/doi/10.1083/jcb.200309082
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http://dx.doi.org/10.1083/jcb.200309082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172000PMC
February 2004

Interferon-alpha/beta-receptor interactions: a complex story unfolding.

Curr Pharm Des 2002 ;8(24):2131-7

Toronto General Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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February 2003

The prefusogenic intermediate of HIV-1 gp41 contains exposed C-peptide regions.

J Biol Chem 2003 Feb 13;278(9):7573-9. Epub 2002 Dec 13.

Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M211154200
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http://dx.doi.org/10.1074/jbc.M211154200DOI Listing
February 2003

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development.

J Cell Biol 2003 Jan 13;160(2):189-200. Epub 2003 Jan 13.

Division of Biology, Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1083/jcb.200211046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172648PMC
January 2003

Structural studies on bioactive compounds. Part 36: design, synthesis and biological evaluation of pyrimethamine-based antifolates against Pneumocystis carinii.

Bioorg Med Chem 2002 Sep;10(9):3001-10

Cancer Research Laboratories, School of Pharmaceutical Sciences, University of Nottingham, Nottingham NG7 2RD, UK.

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September 2002