Publications by authors named "David Brough"

93Publications

Inhibiting the NLRP3 Inflammasome.

Molecules 2020 Nov 25;25(23). Epub 2020 Nov 25.

Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

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November 2020

LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation.

Elife 2020 11 20;9. Epub 2020 Nov 20.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.

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November 2020

Loss of hepatocyte cell division leads to liver inflammation and fibrosis.

PLoS Genet 2020 11 4;16(11):e1009084. Epub 2020 Nov 4.

Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore.

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November 2020

Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification.

FEBS J 2020 Nov 3. Epub 2020 Nov 3.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, UK.

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November 2020

Anti-inflammatories in Alzheimer's disease-potential therapy or spurious correlate?

Brain Commun 2020 24;2(2):fcaa109. Epub 2020 Jul 24.

Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, School of Biological Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, UK.

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July 2020

Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes .

Front Immunol 2020 30;11:565924. Epub 2020 Sep 30.

Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

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September 2020

The NLRP3-inflammasome as a sensor of organelle dysfunction.

J Cell Biol 2020 Dec;219(12)

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

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December 2020

Inhibition of the NLRP3 inflammasome by HSP90 inhibitors.

Immunology 2021 Jan 30;162(1):84-91. Epub 2020 Oct 30.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

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January 2021

Mechanisms of NLRP3 priming in inflammaging and age related diseases.

Cytokine Growth Factor Rev 2020 10 24;55:15-25. Epub 2020 Aug 24.

Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

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October 2020

Anakinra in COVID-19: important considerations for clinical trials.

Lancet Rheumatol 2020 Jul 21;2(7):e379-e381. Epub 2020 May 21.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

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July 2020

The inflammatory microenvironment in vestibular schwannoma.

Neurooncol Adv 2020 Jan-Dec;2(1):vdaa023. Epub 2020 Feb 27.

Manchester Centre for Clinical Neurosciences, Salford Royal Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

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February 2020

Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture.

Immunology 2020 Sep 22;161(1):39-52. Epub 2020 Jun 22.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

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September 2020

Haematopoietic stem cell gene therapy with IL-1Ra rescues cognitive loss in mucopolysaccharidosis IIIA.

EMBO Mol Med 2020 03 14;12(3):e11185. Epub 2020 Feb 14.

Stem Cell and Neurotherapies, Division of Cell Matrix Biology & Regenerative Medicine, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

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March 2020

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation.

Authors:
Channabasavaiah B Gurumurthy Aidan R O'Brien Rolen M Quadros John Adams Pilar Alcaide Shinya Ayabe Johnathan Ballard Surinder K Batra Marie-Claude Beauchamp Kathleen A Becker Guillaume Bernas David Brough Francisco Carrillo-Salinas Wesley Chan Hanying Chen Ruby Dawson Victoria DeMambro Jinke D'Hont Katharine M Dibb James D Eudy Lin Gan Jing Gao Amy Gonzales Anyonya R Guntur Huiping Guo Donald W Harms Anne Harrington Kathryn E Hentges Neil Humphreys Shiho Imai Hideshi Ishii Mizuho Iwama Eric Jonasch Michelle Karolak Bernard Keavney Nay-Chi Khin Masamitsu Konno Yuko Kotani Yayoi Kunihiro Imayavaramban Lakshmanan Catherine Larochelle Catherine B Lawrence Lin Li Volkhard Lindner Xian-De Liu Gloria Lopez-Castejon Andrew Loudon Jenna Lowe Loydie A Jerome-Majewska Taiji Matsusaka Hiromi Miura Yoshiki Miyasaka Benjamin Morpurgo Katherine Motyl Yo-Ichi Nabeshima Koji Nakade Toshiaki Nakashiba Kenichi Nakashima Yuichi Obata Sanae Ogiwara Mariette Ouellet Leif Oxburgh Sandra Piltz Ilka Pinz Moorthy P Ponnusamy David Ray Ronald J Redder Clifford J Rosen Nikki Ross Mark T Ruhe Larisa Ryzhova Ane M Salvador Sabrina Shameen Alam Radislav Sedlacek Karan Sharma Chad Smith Katrien Staes Lora Starrs Fumihiro Sugiyama Satoru Takahashi Tomohiro Tanaka Andrew W Trafford Yoshihiro Uno Leen Vanhoutte Frederique Vanrockeghem Brandon J Willis Christian S Wright Yuko Yamauchi Xin Yi Kazuto Yoshimi Xuesong Zhang Yu Zhang Masato Ohtsuka Satyabrata Das Daniel J Garry Tino Hochepied Paul Thomas Jan Parker-Thornburg Antony D Adamson Atsushi Yoshiki Jean-Francois Schmouth Andrei Golovko William R Thompson K C Kent Lloyd Joshua A Wood Mitra Cowan Tomoji Mashimo Seiya Mizuno Hao Zhu Petr Kasparek Lucy Liaw Joseph M Miano Gaetan Burgio

Genome Biol 2019 08 26;20(1):171. Epub 2019 Aug 26.

Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, the Australian National University, Canberra, Australia.

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August 2019

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease.

J Vis Exp 2019 07 6(149). Epub 2019 Jul 6.

Division of Pharmacy and Optometry, School of Health Studies, Faculty of Biology, Medicine and Health, University of Manchester;

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July 2019

Primary aortoenteric fistula: a case of delayed diagnosis.

ANZ J Surg 2020 03 8;90(3):383-384. Epub 2019 May 8.

Department of Surgery, The Wesley Hospital, Auchenflower, Queensland, Australia.

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March 2020

Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome.

Stroke 2019 05;50(5):1232-1239

From the Division of Neuroscience and Experimental Psychology (E.L., J.B., G.C., S.M.A., D.B.), School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom.

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May 2019

Cathelicidin is a "fire alarm", generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa.

PLoS Pathog 2019 04 12;15(4):e1007694. Epub 2019 Apr 12.

Centre for Inflammation Research at the University of Edinburgh, Queens' Medical Research Institute, Edinburgh BioQuarter, Little France Crescent, Edinburgh, United Kingdom.

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April 2019

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes.

J Biol Chem 2019 05 2;294(21):8325-8335. Epub 2019 Apr 2.

From the Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester M13 9PT, United Kingdom

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May 2019

Small, Thin Graphene Oxide Is Anti-inflammatory Activating Nuclear Factor Erythroid 2-Related Factor 2 via Metabolic Reprogramming.

ACS Nano 2018 12 20;12(12):11949-11962. Epub 2018 Nov 20.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre , University of Manchester , AV Hill Building, Oxford Road , Manchester M13 9PT , United Kingdom.

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December 2018

Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming.

Proc Natl Acad Sci U S A 2018 10 19;115(40):E9371-E9380. Epub 2018 Sep 19.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, M13 9PT Manchester, United Kingdom;

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October 2018

USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation.

EMBO Rep 2018 10 11;19(10). Epub 2018 Sep 11.

Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, Manchester Collaborative Centre of Inflammation Research, Manchester Academic Health Science Centre, Core Technology Facility, School of Biological Sciences, University of Manchester, Manchester, UK

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October 2018

Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?

SLAS Discov 2018 12 3;23(10):991-1017. Epub 2018 Jul 3.

1 Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

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December 2018

Targeting the IL33-NLRP3 axis improves therapy for experimental cerebral malaria.

Proc Natl Acad Sci U S A 2018 07 28;115(28):7404-7409. Epub 2018 Jun 28.

School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PT, United Kingdom;

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July 2018

Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.

Sci Rep 2018 04 4;8(1):5667. Epub 2018 Apr 4.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK.

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April 2018

Redefining the ancestral origins of the interleukin-1 superfamily.

Nat Commun 2018 03 20;9(1):1156. Epub 2018 Mar 20.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK.

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March 2018

Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid.

Med Chem Res 2018;27(3):884-889. Epub 2017 Nov 13.

1Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT UK.

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November 2017

Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome.

ChemMedChem 2018 02 5;13(4):312-320. Epub 2018 Feb 5.

Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK.

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February 2018

Microglial Priming as Trained Immunity in the Brain.

Neuroscience 2019 05 29;405:47-54. Epub 2017 Dec 29.

Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester M13 9PT, UK.

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May 2019

CRISPR/Cas9 mediated mutation of mouse IL-1α nuclear localisation sequence abolishes expression.

Sci Rep 2017 12 6;7(1):17077. Epub 2017 Dec 6.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK.

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December 2017

Boron-Based Inhibitors of the NLRP3 Inflammasome.

Cell Chem Biol 2017 Nov 21;24(11):1321-1335.e5. Epub 2017 Sep 21.

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK. Electronic address:

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November 2017

An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1β.

J Cell Sci 2017 Oct 4;130(19):3197-3202. Epub 2017 Sep 4.

Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.

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October 2017

Salmonella typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and can occur in the absence of pyroptosis.

Sci Rep 2017 07 31;7(1):6861. Epub 2017 Jul 31.

Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.

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July 2017

Materials Knowledge Systems in Python - A Data Science Framework for Accelerated Development of Hierarchical Materials.

Integr Mater Manuf Innov 2017 Mar 15;6(1):36-53. Epub 2017 Mar 15.

School of Computational Science and Engineering, Georgia Institute of Technology, 30332, Atlanta, USA.

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March 2017

Unconventional Pathways of Secretion Contribute to Inflammation.

Int J Mol Sci 2017 Jan 5;18(1). Epub 2017 Jan 5.

Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.

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January 2017

Microstructure-based knowledge systems for capturing process-structure evolution linkages.

Acta Mater 2017 ;21

School of Computational Science and Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.

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January 2017

Extraction of Process-Structure Evolution Linkages from X-ray Scattering Measurements Using Dimensionality Reduction and Time Series Analysis.

Integr Mater Manuf Innov 2017 10;6(2):147-159. Epub 2017 Mar 10.

1School of Computational Science and Engineering, Georgia Institute of Technology, North Ave NW, Atlanta, 30332 USA.

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March 2017

Mini-symposium: Role of the inflammasome in brain pathogenesis: a potential therapeutic target? - introduction.

Brain Pathol 2017 03;27(2):190-191

Faculty of Biology, Medicine and Health University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT.

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March 2017

Inflammasomes as therapeutic targets for Alzheimer's disease.

Brain Pathol 2017 03;27(2):223-234

Faculty of Biology, Medicine and Health, University of Manchester, AV Hill Building, Oxford Road, Manchester, M13 9PT, UK.

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March 2017

P2X7 receptor-dependent tuning of gut epithelial responses to infection.

Immunol Cell Biol 2017 02 25;95(2):178-188. Epub 2016 Aug 25.

Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

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February 2017

Inflammasomes link vascular disease with neuroinflammation and brain disorders.

J Cereb Blood Flow Metab 2016 10 2;36(10):1668-1685. Epub 2016 Aug 2.

Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary

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October 2016

Investigating IL-1β Secretion Using Real-Time Single-Cell Imaging.

Methods Mol Biol 2016 ;1417:75-88

Faculty of Life Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester, UK.

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December 2017

Inhibiting the Inflammasome: A Chemical Perspective.

J Med Chem 2016 Mar 12;59(5):1691-710. Epub 2015 Oct 12.

Manchester Pharmacy School, Faculty of Medical and Human Sciences, The University of Manchester , Stopford Building, Oxford Road, Manchester M13 9PT, U.K.

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March 2016

Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways.

Eur J Immunol 2015 Oct 21;45(10):2758-61. Epub 2015 Sep 21.

Faculty of Life Sciences, University of Manchester, Manchester, UK.

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October 2015

Acid-dependent Interleukin-1 (IL-1) Cleavage Limits Available Pro-IL-1β for Caspase-1 Cleavage.

J Biol Chem 2015 Oct 31;290(42):25374-81. Epub 2015 Aug 31.

From the Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom.

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October 2015

Interleukin-1 as a pharmacological target in acute brain injury.

Exp Physiol 2015 Dec 14;100(12):1488-94. Epub 2015 Jul 14.

Faculty of Life Sciences, University of Manchester, Manchester, UK.

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December 2015

P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages.

Cytokine 2015 Aug 9;74(2):293-304. Epub 2015 Jun 9.

Faculty of Life Sciences, Smith Building, The University of Manchester, UK. Electronic address:

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August 2015

Consensus guidelines for the detection of immunogenic cell death.

Oncoimmunology 2014 Oct 13;3(9):e955691. Epub 2014 Dec 13.

Equipe 11 labellisée par la Ligue Nationale contre le Cancer; Center de Recherche des Cordeliers ; Paris, France ; INSERM; U1138 ; Paris, France ; Gustave Roussy Cancer Campus ; Villejuif, France ; Université Paris Descartes/Paris V; Sorbonne Paris Cité ; Paris, France.

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October 2014

Interleukin-1α and brain inflammation.

IUBMB Life 2015 May 23;67(5):323-30. Epub 2015 Apr 23.

Faculty of Life Sciences, University of Manchester, Manchester, UK.

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May 2015

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.

Proc Natl Acad Sci U S A 2015 Mar 16;112(13):4050-5. Epub 2015 Mar 16.

Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom; and

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March 2015

Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling.

J Immunol 2015 Feb 31;194(3):1261-73. Epub 2014 Dec 31.

Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom; and Unidad de Inflamación y Cirugía Experimental, Centro de Investigación Biomédica en Red en el Área Temática de Enfermedades Hepáticas y Digestivas, Hospital Clínico Universitario Virgen de la Arrixaca, Instituto Murciano de Investigación Biosanitaria-Arrixaca, 30120 Murcia, Spain

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February 2015

Novel perspectives on non-canonical inflammasome activation.

Immunotargets Ther 2015 24;4:131-41. Epub 2015 Jul 24.

Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (ASTAR), Singapore.

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July 2016

Dendritic cell IL-1α and IL-1β are polyubiquitinated and degraded by the proteasome.

J Biol Chem 2014 Dec 4;289(51):35582-92. Epub 2014 Nov 4.

From the Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom and.

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December 2014

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.

Nat Immunol 2014 Aug 22;15(8):738-48. Epub 2014 Jun 22.

1] Inflammation and Experimental Surgery Unit, CIBERehd, Institute for Bio-Health Research of Murcia, Clinical University Hospital Virgen de la Arrixaca, Murcia, Spain. [2] Faculty of Life Sciences, University of Manchester, Manchester, UK.

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August 2014

Release of interleukin-1α or interleukin-1β depends on mechanism of cell death.

J Biol Chem 2014 Jun 30;289(23):15942-50. Epub 2014 Apr 30.

From the Faculty of Life Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, United Kingdom

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June 2014

The role of inflammation and interleukin-1 in acute cerebrovascular disease.

J Inflamm Res 2013 Aug 20;6:121-8. Epub 2013 Aug 20.

Manchester Academic Health Sciences Center, Brain Injury Research Group, Clinical Sciences Building, Salford Royal Foundation Trust, Salford, UK.

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August 2013

Acidosis drives damage-associated molecular pattern (DAMP)-induced interleukin-1 secretion via a caspase-1-independent pathway.

J Biol Chem 2013 Oct 10;288(42):30485-94. Epub 2013 Sep 10.

From the Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom.

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October 2013

Inhibition of calpain blocks the phagosomal escape of Listeria monocytogenes.

PLoS One 2012 26;7(4):e35936. Epub 2012 Apr 26.

Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.

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September 2012

Obese mice exhibit an altered behavioural and inflammatory response to lipopolysaccharide.

Dis Model Mech 2012 Sep 10;5(5):649-59. Epub 2012 Feb 10.

AV Hill Building, Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK.

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September 2012

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.

Eur J Immunol 2012 Mar 27;42(3):716-25. Epub 2011 Dec 27.

Faculty of Life Sciences, University of Manchester, Manchester, UK.

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March 2012

Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing.

Nat Chem Biol 2011 Oct 23;7(12):902-8. Epub 2011 Oct 23.

Doctoral Training Centre, Integrative Systems Biology Molecules to Life, Manchester Centre for Integrative Systems Biology, Manchester Interdisciplinary Biocentre, The University of Manchester, Manchester, UK.

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October 2011

Understanding the mechanism of IL-1β secretion.

Cytokine Growth Factor Rev 2011 Aug 22;22(4):189-95. Epub 2011 Oct 22.

Faculty of Life Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.

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August 2011

Regulation of interleukin-1 in acute brain injury.

Trends Pharmacol Sci 2011 Oct 23;32(10):617-22. Epub 2011 Jul 23.

Faculty of Life Sciences, University of Manchester, AV Hill Building, Oxford Road, Manchester M13 9PT, UK.

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October 2011

Nuclear retention of IL-1 alpha by necrotic cells: a mechanism to dampen sterile inflammation.

Eur J Immunol 2009 Nov;39(11):2973-80

Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK.

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November 2009

Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc.

Eur J Immunol 2009 Feb;39(2):352-8

Faculty of Life Sciences, University of Manchester, Manchester, UK.

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February 2009

The dynamics and mechanisms of interleukin-1alpha and beta nuclear import.

Traffic 2009 Jan 7;10(1):16-25. Epub 2008 Oct 7.

Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK.

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January 2009

Neuronal injury induces the release of pro-interleukin-1beta from activated microglia in vitro.

Brain Res 2008 Oct 8;1236:1-7. Epub 2008 Aug 8.

Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK.

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October 2008

A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat.

Neuropharmacology 2007 Oct 10;53(5):638-42. Epub 2007 Aug 10.

Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.

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October 2007

Mechanisms of regulation for interleukin-1beta in neurodegenerative disease.

Neuropharmacology 2007 Jun 12;52(8):1563-9. Epub 2007 Mar 12.

Faculty of Life Sciences, C.2210 Michael Smith Building, University of Manchester, Manchester M13 9PT, UK.

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June 2007

Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death.

J Cell Sci 2007 Mar 6;120(Pt 5):772-81. Epub 2007 Feb 6.

Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.

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March 2007

Mobility of proteins associated with the plasma membrane by interaction with inositol lipids.

J Cell Sci 2005 Jul 28;118(Pt 14):3019-25. Epub 2005 Jun 28.

Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.

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July 2005

Agonist-induced regulation of mitochondrial and endoplasmic reticulum motility.

Biochem J 2005 Dec;392(Pt 2):291-7

Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.

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December 2005

Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo.

J Cereb Blood Flow Metab 2003 Mar;23(3):381-4

School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK.

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March 2003

Extracellular ATP and P2X7 receptors in neurodegeneration.

Eur J Pharmacol 2002 Jul;447(2-3):261-9

School of Biological Sciences, University of Manchester, Stopford Building 1.204, Oxford Road, Manchester, M13 9PT, UK.

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July 2002

Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism.

Mol Cell Neurosci 2002 Feb;19(2):272-80

Division of Neuroscience, School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom.

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February 2002

Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production.

J Biol Chem 2002 Feb 12;277(5):3210-8. Epub 2001 Nov 12.

School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom.

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February 2002