Publications by authors named "David Brocks"

16Publications

Mobile genomics: tools and techniques for tackling transposons.

Authors:
Kathryn O'Neill David Brocks Molly Gale Hammell

Philos Trans R Soc Lond B Biol Sci 2020 03 10;375(1795):20190345. Epub 2020 Feb 10.

Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

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March 2020

Integrative Analysis Defines Distinct Prognostic Subgroups of Intrahepatic Cholangiocarcinoma.

Authors:
Benjamin Goeppert Reka Toth Stephan Singer Thomas Albrecht Daniel B Lipka Pavlo Lutsik David Brocks Marion Baehr Oliver Muecke Yassen Assenov Lei Gu Volker Endris Albrecht Stenzinger Arianeb Mehrabi Peter Schirmacher Christoph Plass Dieter Weichenhan Stephanie Roessler

Hepatology 2019 05 28;69(5):2091-2106. Epub 2019 Feb 28.

Institute of Pathology, University Clinic of Heidelberg, Heidelberg, Germany.

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May 2019

Combination treatment of acute myeloid leukemia cells with DNMT and HDAC inhibitors: predominant synergistic gene downregulation associated with gene body demethylation.

Authors:
Nadja Blagitko-Dorfs Pascal Schlosser Gabriele Greve Dietmar Pfeifer Ruth Meier Annika Baude David Brocks Christoph Plass Michael Lübbert

Leukemia 2019 04 23;33(4):945-956. Epub 2018 Nov 23.

Division of Hematology, Oncology and Stem Cell Transplantation, Department of Internal Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.

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April 2019

Reactivation of endogenous retroviral elements via treatment with DNMT- and HDAC-inhibitors.

Authors:
Michael Daskalakis David Brocks Yi-Hua Sheng Md Saiful Islam Alzbeta Ressnerova Yassen Assenov Till Milde Ina Oehme Olaf Witt Ashish Goyal Alexander Kühn Mark Hartmann Dieter Weichenhan Manfred Jung Christoph Plass

Cell Cycle 2018 30;17(7):811-822. Epub 2018 Apr 30.

a Division of Epigenomics and Cancer Risk Factors , German Cancer Research Center , Heidelberg , Germany.

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December 2019

Intratumor heterogeneity in epigenetic patterns.

Authors:
Yassen Assenov David Brocks Clarissa Gerhäuser

Semin Cancer Biol 2018 08 31;51:12-21. Epub 2018 Jan 31.

Epigenomics and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

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August 2018

RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia.

Authors:
Daniel B Lipka Tania Witte Reka Toth Jing Yang Manuel Wiesenfarth Peter Nöllke Alexandra Fischer David Brocks Zuguang Gu Jeongbin Park Brigitte Strahm Marcin Wlodarski Ayami Yoshimi Rainer Claus Michael Lübbert Hauke Busch Melanie Boerries Mark Hartmann Maximilian Schönung Umut Kilik Jens Langstein Justyna A Wierzbinska Caroline Pabst Swati Garg Albert Catalá Barbara De Moerloose Michael Dworzak Henrik Hasle Franco Locatelli Riccardo Masetti Markus Schmugge Owen Smith Jan Stary Marek Ussowicz Marry M van den Heuvel-Eibrink Yassen Assenov Matthias Schlesner Charlotte Niemeyer Christian Flotho Christoph Plass

Nat Commun 2017 12 19;8(1):2126. Epub 2017 Dec 19.

Cancer Epigenetics Group, Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), INF 280, 69120, Heidelberg, Germany.

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December 2017

Erratum: DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats.

Authors:
David Brocks Christopher R Schmidt Michael Daskalakis Hyo Sik Jang Nakul M Shah Daofeng Li Jing Li Bo Zhang Yiran Hou Sara Laudato Daniel B Lipka Johanna Schott Holger Bierhoff Yassen Assenov Monika Helf Alzbeta Ressnerova Md Saiful Islam Anders M Lindroth Simon Haas Marieke Essers Charles D Imbusch Benedikt Brors Ina Oehme Olaf Witt Michael Lübbert Jan-Philipp Mallm Karsten Rippe Rainer Will Dieter Weichenhan Georg Stoecklin Clarissa Gerhäuser Christopher C Oakes Ting Wang Christoph Plass

Nat Genet 2017 10;49(11):1661

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October 2017

DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats.

Authors:
David Brocks Christopher R Schmidt Michael Daskalakis Hyo Sik Jang Nakul M Shah Daofeng Li Jing Li Bo Zhang Yiran Hou Sara Laudato Daniel B Lipka Johanna Schott Holger Bierhoff Yassen Assenov Monika Helf Alzbeta Ressnerova Md Saiful Islam Anders M Lindroth Simon Haas Marieke Essers Charles D Imbusch Benedikt Brors Ina Oehme Olaf Witt Michael Lübbert Jan-Philipp Mallm Karsten Rippe Rainer Will Dieter Weichenhan Georg Stoecklin Clarissa Gerhäuser Christopher C Oakes Ting Wang Christoph Plass

Nat Genet 2017 Jul 12;49(7):1052-1060. Epub 2017 Jun 12.

Division of Epigenomics and Cancer Risk Factors, DKFZ, Heidelberg, Germany.

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July 2017

DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia.

Authors:
Christopher C Oakes Marc Seifert Yassen Assenov Lei Gu Martina Przekopowitz Amy S Ruppert Qi Wang Charles D Imbusch Andrius Serva Sandra D Koser David Brocks Daniel B Lipka Olga Bogatyrova Dieter Weichenhan Benedikt Brors Laura Rassenti Thomas J Kipps Daniel Mertens Marc Zapatka Peter Lichter Hartmut Döhner Ralf Küppers Thorsten Zenz Stephan Stilgenbauer John C Byrd Christoph Plass

Nat Genet 2016 Mar 18;48(3):253-64. Epub 2016 Jan 18.

Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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March 2016

Musical patterns for comparative epigenomics.

Authors:
David Brocks

Clin Epigenetics 2015 8;7:94. Epub 2015 Sep 8.

Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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September 2015

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.

Authors:
Dagmar Walter Amelie Lier Anja Geiselhart Frederic B Thalheimer Sina Huntscha Mirko C Sobotta Bettina Moehrle David Brocks Irem Bayindir Paul Kaschutnig Katja Muedder Corinna Klein Anna Jauch Timm Schroeder Hartmut Geiger Tobias P Dick Tim Holland-Letz Peter Schmezer Steven W Lane Michael A Rieger Marieke A G Essers David A Williams Andreas Trumpp Michael D Milsom

Nature 2015 Apr 18;520(7548):549-52. Epub 2015 Feb 18.

1] Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany [2] Deutsches Krebsforschungszentrum (DKFZ), Division of Stem Cells and Cancer, Experimental Hematology Group, 69120 Heidelberg, Germany.

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April 2015

Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing.

Authors:
Daniel B Lipka Qi Wang Nina Cabezas-Wallscheid Daniel Klimmeck Dieter Weichenhan Carl Herrmann Amelie Lier David Brocks Lisa von Paleske Simon Renders Peer Wünsche Petra Zeisberger Lei Gu Simon Haas Marieke Ag Essers Benedikt Brors Roland Eils Andreas Trumpp Michael D Milsom Christoph Plass

Cell Cycle 2014 ;13(22):3476-87

a Division of Epigenomics and Cancer Risk Factors , German Cancer Research Center (DKFZ) ; Heidelberg , Germany.

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September 2015

Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis.

Authors:
Nina Cabezas-Wallscheid Daniel Klimmeck Jenny Hansson Daniel B Lipka Alejandro Reyes Qi Wang Dieter Weichenhan Amelie Lier Lisa von Paleske Simon Renders Peer Wünsche Petra Zeisberger David Brocks Lei Gu Carl Herrmann Simon Haas Marieke A G Essers Benedikt Brors Roland Eils Wolfgang Huber Michael D Milsom Christoph Plass Jeroen Krijgsveld Andreas Trumpp

Cell Stem Cell 2014 Oct 21;15(4):507-522. Epub 2014 Aug 21.

Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address:

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October 2014

Intratumor DNA methylation heterogeneity reflects clonal evolution in aggressive prostate cancer.

Authors:
David Brocks Yassen Assenov Sarah Minner Olga Bogatyrova Ronald Simon Christina Koop Christopher Oakes Manuela Zucknick Daniel Bernhard Lipka Joachim Weischenfeldt Lars Feuerbach Richard Cowper-Sal Lari Mathieu Lupien Benedikt Brors Jan Korbel Thorsten Schlomm Amos Tanay Guido Sauter Clarissa Gerhäuser Christoph Plass

Cell Rep 2014 Aug 24;8(3):798-806. Epub 2014 Jul 24.

Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; The German Cancer Consortium, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

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August 2014

Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing.

Authors:
Holger Bierhoff Marcel Andre Dammert David Brocks Silvia Dambacher Gunnar Schotta Ingrid Grummt

Mol Cell 2014 May 24;54(4):675-82. Epub 2014 Apr 24.

Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany. Electronic address:

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May 2014

Evolution of DNA methylation is linked to genetic aberrations in chronic lymphocytic leukemia.

Authors:
Christopher C Oakes Rainer Claus Lei Gu Yassen Assenov Jennifer Hüllein Manuela Zucknick Matthias Bieg David Brocks Olga Bogatyrova Christopher R Schmidt Laura Rassenti Thomas J Kipps Daniel Mertens Peter Lichter Hartmut Döhner Stephan Stilgenbauer John C Byrd Thorsten Zenz Christoph Plass

Cancer Discov 2014 Mar 19;4(3):348-61. Epub 2013 Dec 19.

Divisions of 1Epigenomics and Cancer Risk Factors, 2Theoretical Bioinformatics, 3Biostatistics, and 4Molecular Genetics; 5Department of Translational Oncology, National Center for Tumor Diseases (NCT), The German Cancer Research Center (DKFZ); 6Department of Medicine V, University of Heidelberg, Heidelberg; 7Department of Medicine, University of Freiburg Medical Center, Freiburg; 8Department of Internal Medicine III, University of Ulm, Ulm; 9The German Cancer Consortium, Germany; 10Department of Medicine, University of California at San Diego Moores Cancer Center, La Jolla, California; and 11Division of Hematology, The Ohio State University, Columbus, Ohio.

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March 2014