David Botstein

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA. Department of Chemistry, Princeton University, Princeton, NJ 08544, USA.

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October 2016

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells.

Authors:

Henrik D Møller Rasmus K Bojsen Chris Tachibana Lance Parsons David Botstein Birgitte Regenberg

J Vis Exp 2016 Apr 4(110):e54239 |. Epub 2016 Apr 4.

Department of Biology, University of Copenhagen;

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April 2016

Analysis of Polygenic Mutants Suggests a Role for Mediator in Regulating Transcriptional Activation Distance in Saccharomyces cerevisiae.

Authors:

Caitlin T Reavey Mark J Hickman Krista C Dobi David Botstein Fred Winston

Genetics 2015 Oct 17;201(2):599-612. Epub 2015 Aug 17.

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115

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October 2015

Extrachromosomal circular DNA is common in yeast.

Authors:

Henrik D Møller Lance Parsons Tue S Jørgensen David Botstein Birgitte Regenberg

Proc Natl Acad Sci U S A 2015 Jun 2;112(24):E3114-22. Epub 2015 Jun 2.

Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark;

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June 2015

Characterizing the in vivo role of trehalose in Saccharomyces cerevisiae using the AGT1 transporter.

Authors:

Patrick A Gibney Ariel Schieler Jonathan C Chen Joshua D Rabinowitz David Botstein

Proc Natl Acad Sci U S A 2015 May 27;112(19):6116-21. Epub 2015 Apr 27.

Lewis-Sigler Institute for Integrative Genomics and Departments of Molecular Biology and

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May 2015

Lasker∼Koshland to genetics pioneer.

Authors:

David Botstein

Cell 2014 Sep;158(6):1230-1232

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA. Electronic address:

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September 2014

Synthetic biology tools for programming gene expression without nutritional perturbations in Saccharomyces cerevisiae.

Authors:

R Scott McIsaac Patrick A Gibney Sunil S Chandran Kirsten R Benjamin David Botstein

Nucleic Acids Res 2014 Apr 20;42(6):e48. Epub 2014 Jan 20.

The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA, Amyris, Inc., Emeryville, CA 94608, USA, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.

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April 2014

Rapid synthesis and screening of chemically activated transcription factors with GFP-based reporters.

Authors:

R Scott McIsaac Benjamin L Oakes David Botstein Marcus B Noyes

J Vis Exp 2013 Nov 26(81):e51153. Epub 2013 Nov 26.

The Lewis-Sigler Institute for Integrative Genomics, Princeton University.

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November 2013

Yeast metabolic and signaling genes are required for heat-shock survival and have little overlap with the heat-induced genes.

Authors:

Patrick A Gibney Charles Lu Amy A Caudy David C Hess David Botstein

Proc Natl Acad Sci U S A 2013 Nov 28;110(46):E4393-402. Epub 2013 Oct 28.

Lewis-Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544.

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November 2013

Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations.

Authors:

Gregory I Lang Daniel P Rice Mark J Hickman Erica Sodergren George M Weinstock David Botstein Michael M Desai

Nature 2013 Aug 21;500(7464):571-4. Epub 2013 Jul 21.

Lewis-Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.

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August 2013

A new system for comparative functional genomics of Saccharomyces yeasts.

Authors:

Amy A Caudy Yuanfang Guan Yue Jia Christina Hansen Chris DeSevo Alicia P Hayes Joy Agee Juan R Alvarez-Dominguez Hugo Arellano Daniel Barrett Cynthia Bauerle Namita Bisaria Patrick H Bradley J Scott Breunig Erin Bush David Cappel Emily Capra Walter Chen John Clore Peter A Combs Christopher Doucette Olukunle Demuren Peter Fellowes Sam Freeman Evgeni Frenkel Daniel Gadala-Maria Richa Gawande David Glass Samuel Grossberg Anita Gupta Latanya Hammonds-Odie Aaron Hoisos Jenny Hsi Yu-Han Huang Hsu Sachi Inukai Konrad J Karczewski Xiaobo Ke Mina Kojima Samuel Leachman Danny Lieber Anna Liebowitz Julia Liu Yufei Liu Trevor Martin Jose Mena Rosa Mendoza Cameron Myhrvold Christian Millian Sarah Pfau Sandeep Raj Matt Rich Joe Rokicki William Rounds Michael Salazar Matthew Salesi Rajani Sharma Sanford Silverman Cara Singer Sandhya Sinha Max Staller Philip Stern Hanlin Tang Sharon Weeks Maxwell Weidmann Ashley Wolf Carmen Young Jie Yuan Christopher Crutchfield Megan McClean Coleen T Murphy Manuel Llinás David Botstein Olga G Troyanskaya Maitreya J Dunham

Genetics 2013 Sep 12;195(1):275-87. Epub 2013 Jul 12.

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada.

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September 2013

Visualization and analysis of mRNA molecules using fluorescence in situ hybridization in Saccharomyces cerevisiae.

Authors:

R Scott McIsaac Sanford J Silverman Lance Parsons Ping Xu Ryan Briehof Megan N McClean David Botstein

J Vis Exp 2013 Jun 14(76):e50382. Epub 2013 Jun 14.

The Lewis-Sigler Institute for Integrative Genomics, Princeton University.

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June 2013

Phylogenetic portrait of the Saccharomyces cerevisiae functional genome.

Authors:

Patrick A Gibney Mark J Hickman Patrick H Bradley John C Matese David Botstein

G3 (Bethesda) 2013 Aug 7;3(8):1335-40. Epub 2013 Aug 7.

The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA.

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August 2013

Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case.

Authors:

Cyrielle Reisser Cynthia Dick Leonid Kruglyak David Botstein Joseph Schacherer David C Hess

G3 (Bethesda) 2013 04 9;3(4):733-740. Epub 2013 Apr 9.

Department of Biology, Santa Clara University, Santa Clara, California 95053

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April 2013

Automating the construction of gene ontologies.

Authors:

Kara Dolinski David Botstein

Nat Biotechnol 2013 Jan;31(1):34-5

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA.

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January 2013

Synthetic gene expression perturbation systems with rapid, tunable, single-gene specificity in yeast.

Authors:

R Scott McIsaac Benjamin L Oakes Xin Wang Krysta A Dummit David Botstein Marcus B Noyes

Nucleic Acids Res 2013 Feb 28;41(4):e57. Epub 2012 Dec 28.

The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.

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February 2013

TOR and RAS pathways regulate desiccation tolerance in Saccharomyces cerevisiae.

Authors:

Aaron Z Welch Patrick A Gibney David Botstein Douglas E Koshland

Mol Biol Cell 2013 Jan 21;24(2):115-28. Epub 2012 Nov 21.

Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA.

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January 2013

Decoupling nutrient signaling from growth rate causes aerobic glycolysis and deregulation of cell size and gene expression.

Authors:

Nikolai Slavov David Botstein

Mol Biol Cell 2013 Jan 7;24(2):157-68. Epub 2012 Nov 7.

Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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January 2013

Why we need more basic biology research, not less.

Authors:

David Botstein

Mol Biol Cell 2012 Nov;23(21):4160-1

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.

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November 2012

Loss of a 20S proteasome activator in Saccharomyces cerevisiae downregulates genes important for genomic integrity, increases DNA damage, and selectively sensitizes cells to agents with diverse mechanisms of action.

Authors:

Kevin M Doherty Leah D Pride James Lukose Brian E Snydsman Ronald Charles Ajay Pramanik Eric G Muller David Botstein Carol Wood Moore

G3 (Bethesda) 2012 Aug 1;2(8):943-59. Epub 2012 Aug 1.

Department of Microbiology and Immunology, City University of New York Sophie Davis School of Biomedical Education, City College, New York, NY 10031-9101, USA.

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August 2012

Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway.

Authors:

R Scott McIsaac Allegra A Petti Harmen J Bussemaker David Botstein

Mol Biol Cell 2012 Aug 13;23(15):2993-3007. Epub 2012 Jun 13.

The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.

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August 2012

Combinatorial control of diverse metabolic and physiological functions by transcriptional regulators of the yeast sulfur assimilation pathway.

Authors:

Allegra A Petti R Scott McIsaac Olivia Ho-Shing Harmen J Bussemaker David Botstein

Mol Biol Cell 2012 Aug 13;23(15):3008-24. Epub 2012 Jun 13.

The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.

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August 2012

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