David B Savage

David B Savage

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Recent developments in lipodystrophy.

Authors:
Audrey Melvin Anna Stears David B Savage

Curr Opin Lipidol 2019 Aug;30(4):284-290

Metabolic Research Laboratories, Wellcome Trust - MRC Institute of Metabolic Science, University of Cambridge.

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http://dx.doi.org/10.1097/MOL.0000000000000613DOI Listing
August 2019

What lipodystrophies teach us about the metabolic syndrome.

Authors:
Jake P Mann David B Savage

J Clin Invest 2019 Aug 5;130. Epub 2019 Aug 5.

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http://dx.doi.org/10.1172/JCI129190DOI Listing
August 2019

Accumulation of saturated intramyocellular lipid is associated with insulin resistance.

Authors:
David B Savage Laura Watson Katie Carr Claire Adams Soren Brage Krishna K Chatterjee Leanne Hodson Chris Boesch Graham J Kemp Alison Sleigh

J Lipid Res 2019 Jul 2;60(7):1323-1332. Epub 2019 May 2.

Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, United Kingdom

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http://dx.doi.org/10.1194/jlr.M091942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602127PMC
July 2019

Long-term effectiveness and safety of metreleptin in the treatment of patients with partial lipodystrophy.

Authors:
Elif A Oral Phillip Gorden Elaine Cochran David Araújo-Vilar David B Savage Alison Long Gregory Fine Taylor Salinardi Rebecca J Brown

Endocrine 2019 Jun 25;64(3):500-511. Epub 2019 Feb 25.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s12020-019-01862-8DOI Listing
June 2019

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.

Authors:
Satish Patel Anna Alvarez-Guaita Audrey Melvin Debra Rimmington Alessia Dattilo Emily L Miedzybrodzka Irene Cimino Anne-Catherine Maurin Geoffrey P Roberts Claire L Meek Samuel Virtue Lauren M Sparks Stephanie A Parsons Leanne M Redman George A Bray Alice P Liou Rachel M Woods Sion A Parry Per B Jeppesen Anders J Kolnes Heather P Harding David Ron Antonio Vidal-Puig Frank Reimann Fiona M Gribble Carl J Hulston I Sadaf Farooqi Pierre Fafournoux Steven R Smith Jorgen Jensen Danna Breen Zhidan Wu Bei B Zhang Anthony P Coll David B Savage Stephen O'Rahilly

Cell Metab 2019 Mar 10;29(3):707-718.e8. Epub 2019 Jan 10.

Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183075
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http://dx.doi.org/10.1016/j.cmet.2018.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408327PMC
March 2019

Dual binding motifs underpin the hierarchical association of perilipins1-3 with lipid droplets.

Authors:
Dalila Ajjaji Kalthoum Ben M'barek Michael L Mimmack Cheryl England Haya Herscovitz Liang Dong Richard G Kay Satish Patel Vladimir Saudek Donald M Small David B Savage Abdou Rachid Thiam

Mol Biol Cell 2019 03 16;30(5):703-716. Epub 2019 Jan 16.

Laboratoire de Physique de l'Ecole Normale Supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris-Diderot, Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1091/mbc.E18-08-0534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589688PMC
March 2019

European paediatric non-alcoholic fatty liver disease registry (EU-PNAFLD): Design and rationale.

Authors:
Jake P Mann Anita Vreugdenhil Piotr Socha Wojciech Jańczyk Ulrich Baumann Sanjay Rajwal Thomas Casswall Claude Marcus Indra van Mourik Stephen O'Rahilly David B Savage Gabriele Noble-Jamieson Florence Lacaille Myriam Dabbas Béatrice Dubern Deirdre A Kelly Valerio Nobili Quentin M Anstee

Contemp Clin Trials 2018 12 5;75:67-71. Epub 2018 Nov 5.

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom; Liver Unit, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, United Kingdom.

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https://www.journals.elsevier.com/contemporary-clinical-tria
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https://linkinghub.elsevier.com/retrieve/pii/S15517144183042
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http://dx.doi.org/10.1016/j.cct.2018.11.003DOI Listing
December 2018

Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.

Authors:
Luca A Lotta Laura B L Wittemans Verena Zuber Isobel D Stewart Stephen J Sharp Jian'an Luan Felix R Day Chen Li Nicholas Bowker Lina Cai Emanuella De Lucia Rolfe Kay-Tee Khaw John R B Perry Stephen O'Rahilly Robert A Scott David B Savage Stephen Burgess Nicholas J Wareham Claudia Langenberg

JAMA 2018 12;320(24):2553-2563

MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1001/jama.2018.19329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583513PMC
December 2018

Association of Genetically Enhanced Lipoprotein Lipase-Mediated Lipolysis and Low-Density Lipoprotein Cholesterol-Lowering Alleles With Risk of Coronary Disease and Type 2 Diabetes.

Authors:
Luca A Lotta Isobel D Stewart Stephen J Sharp Felix R Day Stephen Burgess Jian'an Luan Nicholas Bowker Lina Cai Chen Li Laura B L Wittemans Nicola D Kerrison Kay-Tee Khaw Mark I McCarthy Stephen O'Rahilly Robert A Scott David B Savage John R B Perry Claudia Langenberg Nicholas J Wareham

JAMA Cardiol 2018 Oct;3(10):957-966

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.

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http://cardiology.jamanetwork.com/article.aspx?doi=10.1001/j
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http://dx.doi.org/10.1001/jamacardio.2018.2866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217943PMC
October 2018

PLIN1 Haploinsufficiency Is Not Associated With Lipodystrophy.

Authors:
Thomas W Laver Kashyap A Patel Kevin Colclough Jacqueline Curran Jane Dale Nikki Davis David B Savage Sarah E Flanagan Sian Ellard Andrew T Hattersley Michael N Weedon

J Clin Endocrinol Metab 2018 09;103(9):3225-3230

Institute of Biomedical & Clinical Science, University of Exeter, Exeter, United Kingdom.

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http://dx.doi.org/10.1210/jc.2017-02662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126890PMC
September 2018

Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice.

Authors:
Amandine Girousse Samuel Virtue Dan Hart Antonio Vidal-Puig Peter R Murgatroyd Etienne Mouisel Coralie Sengenès David B Savage

Mol Metab 2018 07 16;13:24-29. Epub 2018 May 16.

University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Cambridge, CB2 0QQ, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026316PMC
July 2018

A Pharmacogenetic Approach to the Treatment of Patients With Mutations.

Authors:
Maura Agostini Erik Schoenmakers Junaid Beig Louise Fairall Istvan Szatmari Odelia Rajanayagam Frederick W Muskett Claire Adams A David Marais Stephen O'Rahilly Robert K Semple Laszlo Nagy Amit R Majithia John W R Schwabe Dirk J Blom Rinki Murphy Krishna Chatterjee David B Savage

Diabetes 2018 06 5;67(6):1086-1092. Epub 2018 Apr 5.

The University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, U.K.

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db17
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http://dx.doi.org/10.2337/db17-1236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967605PMC
June 2018

Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy.

Authors:
Rebecca J Brown Elif A Oral Elaine Cochran David Araújo-Vilar David B Savage Alison Long Gregory Fine Taylor Salinardi Phillip Gorden

Endocrine 2018 06 12;60(3):479-489. Epub 2018 Apr 12.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/s12020-018-1589-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936645PMC
June 2018

PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress.

Authors:
Afreen Haider Yu-Chen Wei Koini Lim Antonio D Barbosa Che-Hsiung Liu Ursula Weber Marek Mlodzik Kadri Oras Simon Collier M Mahmood Hussain Liang Dong Satish Patel Anna Alvarez-Guaita Vladimir Saudek Benjamin J Jenkins Albert Koulman Marcus K Dymond Roger C Hardie Symeon Siniossoglou David B Savage

Dev Cell 2018 05 10;45(4):481-495.e8. Epub 2018 May 10.

Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971203PMC
May 2018

Compositional marker in vivo reveals intramyocellular lipid turnover during fasting-induced lipolysis.

Authors:
Ajay Thankamony Graham J Kemp Albert Koulman Vlada Bokii David B Savage Chris Boesch Leanne Hodson David B Dunger Alison Sleigh

Sci Rep 2018 02 9;8(1):2750. Epub 2018 Feb 9.

Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.

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http://dx.doi.org/10.1038/s41598-018-21170-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807358PMC
February 2018

Roux-en-Y Gastric Bypass Surgery in the Management of Familial Partial Lipodystrophy Type 1.

Authors:
Audrey Melvin Claire Adams Catherine Flanagan Lisa Gaff Barbara Gratton Fiona Gribble Geoffrey Roberts Robert K Semple Stephen O'Rahilly Francesco Rubino Anna Stears David B Savage

J Clin Endocrinol Metab 2017 10;102(10):3616-3620

National Severe Insulin Resistance Service, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2017-01235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630252PMC
October 2017

Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression.

Authors:
Nuno Rocha David A Bulger Andrea Frontini Hannah Titheradge Sigrid Bjerge Gribsholt Rachel Knox Matthew Page Julie Harris Felicity Payne Claire Adams Alison Sleigh John Crawford Anette Prior Gjesing Jette Bork-Jensen Oluf Pedersen Inês Barroso Torben Hansen Helen Cox Mary Reilly Alex Rossor Rebecca J Brown Simeon I Taylor Duncan McHale Martin Armstrong Elif A Oral Vladimir Saudek Stephen O'Rahilly Eamonn R Maher Bjørn Richelsen David B Savage Robert K Semple

Elife 2017 04 19;6. Epub 2017 Apr 19.

The University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, United Kingdom.

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https://elifesciences.org/articles/23813
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http://dx.doi.org/10.7554/eLife.23813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422073PMC
April 2017

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.

Authors:
Luca A Lotta Pawan Gulati Felix R Day Felicity Payne Halit Ongen Martijn van de Bunt Kyle J Gaulton John D Eicher Stephen J Sharp Jian'an Luan Emanuella De Lucia Rolfe Isobel D Stewart Eleanor Wheeler Sara M Willems Claire Adams Hanieh Yaghootkar Nita G Forouhi Kay-Tee Khaw Andrew D Johnson Robert K Semple Timothy Frayling John R B Perry Emmanouil Dermitzakis Mark I McCarthy Inês Barroso Nicholas J Wareham David B Savage Claudia Langenberg Stephen O'Rahilly Robert A Scott

Nat Genet 2017 01 14;49(1):17-26. Epub 2016 Nov 14.

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

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http://www2.wolfson.cam.ac.uk/files/misc/Lotta-Wareham-news-
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http://www2.wolfson.cam.ac.uk/files/misc/Nature-genetics-371
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http://dx.doi.org/10.1038/ng.3714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774584PMC
January 2017

Corrigendum: Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance.

Authors:
Luca A Lotta Pawan Gulati Felix R Day Felicity Payne Halit Ongen Martijn van de Bunt Kyle J Gaulton John D Eicher Stephen J Sharp Jian'an Luan Emanuella De Lucia Rolfe Isobel D Stewart Eleanor Wheeler Sara M Willems Claire Adams Hanieh Yaghootkar Nita G Forouhi Kay-Tee Khaw Andrew D Johnson Robert K Semple Timothy Frayling John R B Perry Emmanouil Dermitzakis Mark I McCarthy Inês Barroso Nicholas J Wareham David B Savage Claudia Langenberg Stephen O'Rahilly Robert A Scott

Nat Genet 2017 01;49(2):317

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http://dx.doi.org/10.1038/ng0217-317cDOI Listing
January 2017

Prospective functional classification of all possible missense variants in PPARG.

Authors:
Amit R Majithia Ben Tsuda Maura Agostini Keerthana Gnanapradeepan Robert Rice Gina Peloso Kashyap A Patel Xiaolan Zhang Marjoleine F Broekema Nick Patterson Marc Duby Ted Sharpe Eric Kalkhoven Evan D Rosen Inês Barroso Sian Ellard Sekar Kathiresan Stephen O'Rahilly Krishna Chatterjee Jose C Florez Tarjei Mikkelsen David B Savage David Altshuler

Nat Genet 2016 12 17;48(12):1570-1575. Epub 2016 Oct 17.

Program in Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/ng.3700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131844PMC
December 2016

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.

Authors:
Luca A Lotta Robert A Scott Stephen J Sharp Stephen Burgess Jian'an Luan Therese Tillin Amand F Schmidt Fumiaki Imamura Isobel D Stewart John R B Perry Luke Marney Albert Koulman Edward D Karoly Nita G Forouhi Rasmus J O Sjögren Erik Näslund Juleen R Zierath Anna Krook David B Savage Julian L Griffin Nishi Chaturvedi Aroon D Hingorani Kay-Tee Khaw Inês Barroso Mark I McCarthy Stephen O'Rahilly Nicholas J Wareham Claudia Langenberg

PLoS Med 2016 Nov 29;13(11):e1002179. Epub 2016 Nov 29.

MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.1002179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127513PMC
November 2016

Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis.

Authors:
Luca A Lotta Stephen J Sharp Stephen Burgess John R B Perry Isobel D Stewart Sara M Willems Jian'an Luan Eva Ardanaz Larraitz Arriola Beverley Balkau Heiner Boeing Panos Deloukas Nita G Forouhi Paul W Franks Sara Grioni Rudolf Kaaks Timothy J Key Carmen Navarro Peter M Nilsson Kim Overvad Domenico Palli Salvatore Panico Jose-Ramón Quirós Elio Riboli Olov Rolandsson Carlotta Sacerdote Elena C Salamanca Nadia Slimani Annemieke Mw Spijkerman Anne Tjonneland Rosario Tumino Daphne L van der A Yvonne T van der Schouw Mark I McCarthy Inês Barroso Stephen O'Rahilly David B Savage Naveed Sattar Claudia Langenberg Robert A Scott Nicholas J Wareham

JAMA 2016 Oct;316(13):1383-1391

MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1001/jama.2016.14568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386134PMC
October 2016

Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations.

Authors:
Isabel Huang-Doran Patsy Tomlinson Felicity Payne Alexandra Gast Alison Sleigh William Bottomley Julie Harris Allan Daly Nuno Rocha Simon Rudge Jonathan Clark Albert Kwok Stefano Romeo Emma McCann Barbara Müksch Mehul Dattani Stefano Zucchini Michael Wakelam Lazaros C Foukas David B Savage Rinki Murphy Stephen O'Rahilly Inês Barroso Robert K Semple

JCI Insight 2016 Oct 20;1(17):e88766. Epub 2016 Oct 20.

The University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, United Kingdom.

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http://dx.doi.org/10.1172/jci.insight.88766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070960PMC
October 2016

Seipin is required for converting nascent to mature lipid droplets.

Authors:
Huajin Wang Michel Becuwe Benjamin E Housden Chandramohan Chitraju Ashley J Porras Morven M Graham Xinran N Liu Abdou Rachid Thiam David B Savage Anil K Agarwal Abhimanyu Garg Maria-Jesus Olarte Qingqing Lin Florian Fröhlich Hans Kristian Hannibal-Bach Srigokul Upadhyayula Norbert Perrimon Tomas Kirchhausen Christer S Ejsing Tobias C Walther Robert V Farese

Elife 2016 Aug 26;5. Epub 2016 Aug 26.

Department of Genetics and Complex Diseases, Harvard T H Chan School of Public Health, Boston, United States.

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http://dx.doi.org/10.7554/eLife.16582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035145PMC
August 2016

Mechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes.

Authors:
Michael Eiden Albert Koulman Mensud Hatunic James A West Steven Murfitt Michael Osei Claire Adams Xinzhu Wang Yajing Chu Luke Marney Lee D Roberts Stephen O'Rahilly Robert K Semple David B Savage Julian L Griffin

Genome Med 2015 28;7:63. Epub 2015 Jun 28.

MRC Human Nutrition Research, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL UK ; Department of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge, UK.

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http://dx.doi.org/10.1186/s13073-015-0179-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535665PMC
May 2016

Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3.

Authors:
Emily R Rowe Michael L Mimmack Antonio D Barbosa Afreen Haider Iona Isaac Myriam M Ouberai Abdou Rachid Thiam Satish Patel Vladimir Saudek Symeon Siniossoglou David B Savage

J Biol Chem 2016 Mar 7;291(13):6664-78. Epub 2016 Jan 7.

From the University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom,

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http://dx.doi.org/10.1074/jbc.M115.691048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807253PMC
March 2016

31P magnetization transfer measurements of Pi→ATP flux in exercising human muscle.

Authors:
Alison Sleigh David B Savage Guy B Williams David Porter T Adrian Carpenter Kevin M Brindle Graham J Kemp

J Appl Physiol (1985) 2016 Mar 7;120(6):649-56. Epub 2016 Jan 7.

Magnetic Resonance and Image Analysis Research Centre, University of Liverpool, United Kingdom; and Department of Musculoskeletal Biology and MRC - Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing, Institute of Ageing and Chronic Disease, University of Liverpool, United Kingdom.

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http://dx.doi.org/10.1152/japplphysiol.00871.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796179PMC
March 2016

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Authors:
Tuomas O Kilpeläinen Jayne F Martin Carli Alicja A Skowronski Qi Sun Jennifer Kriebel Mary F Feitosa Åsa K Hedman Alexander W Drong James E Hayes Jinghua Zhao Tune H Pers Ursula Schick Niels Grarup Zoltán Kutalik Stella Trompet Massimo Mangino Kati Kristiansson Marian Beekman Leo-Pekka Lyytikäinen Joel Eriksson Peter Henneman Jari Lahti Toshiko Tanaka Jian'an Luan Fabiola Del Greco M Dorota Pasko Frida Renström Sara M Willems Anubha Mahajan Lynda M Rose Xiuqing Guo Yongmei Liu Marcus E Kleber Louis Pérusse Tom Gaunt Tarunveer S Ahluwalia Yun Ju Sung Yolande F Ramos Najaf Amin Antoinette Amuzu Inês Barroso Claire Bellis John Blangero Brendan M Buckley Stefan Böhringer Yii-Der I Chen Anton J N de Craen David R Crosslin Caroline E Dale Zari Dastani Felix R Day Joris Deelen Graciela E Delgado Ayse Demirkan Francis M Finucane Ian Ford Melissa E Garcia Christian Gieger Stefan Gustafsson Göran Hallmans Susan E Hankinson Aki S Havulinna Christian Herder Dena Hernandez Andrew A Hicks David J Hunter Thomas Illig Erik Ingelsson Andreea Ioan-Facsinay John-Olov Jansson Nancy S Jenny Marit E Jørgensen Torben Jørgensen Magnus Karlsson Wolfgang Koenig Peter Kraft Joanneke Kwekkeboom Tiina Laatikainen Karl-Heinz Ladwig Charles A LeDuc Gordon Lowe Yingchang Lu Pedro Marques-Vidal Christa Meisinger Cristina Menni Andrew P Morris Richard H Myers Satu Männistö Mike A Nalls Lavinia Paternoster Annette Peters Aruna D Pradhan Tuomo Rankinen Laura J Rasmussen-Torvik Wolfgang Rathmann Treva K Rice J Brent Richards Paul M Ridker Naveed Sattar David B Savage Stefan Söderberg Nicholas J Timpson Liesbeth Vandenput Diana van Heemst Hae-Won Uh Marie-Claude Vohl Mark Walker Heinz-Erich Wichmann Elisabeth Widén Andrew R Wood Jie Yao Tanja Zeller Yiying Zhang Ingrid Meulenbelt Margreet Kloppenburg Arne Astrup Thorkild I A Sørensen Mark A Sarzynski D C Rao Pekka Jousilahti Erkki Vartiainen Albert Hofman Fernando Rivadeneira André G Uitterlinden Eero Kajantie Clive Osmond Aarno Palotie Johan G Eriksson Markku Heliövaara Paul B Knekt Seppo Koskinen Antti Jula Markus Perola Risto K Huupponen Jorma S Viikari Mika Kähönen Terho Lehtimäki Olli T Raitakari Dan Mellström Mattias Lorentzon Juan P Casas Stefanie Bandinelli Winfried März Aaron Isaacs Ko W van Dijk Cornelia M van Duijn Tamara B Harris Claude Bouchard Matthew A Allison Daniel I Chasman Claes Ohlsson Lars Lind Robert A Scott Claudia Langenberg Nicholas J Wareham Luigi Ferrucci Timothy M Frayling Peter P Pramstaller Ingrid B Borecki Dawn M Waterworth Sven Bergmann Gérard Waeber Peter Vollenweider Henrik Vestergaard Torben Hansen Oluf Pedersen Frank B Hu P Eline Slagboom Harald Grallert Tim D Spector J W Jukema Robert J Klein Erik E Schadt Paul W Franks Cecilia M Lindgren Rudolph L Leibel Ruth J F Loos

Nat Commun 2016 Feb 1;7:10494. Epub 2016 Feb 1.

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1038/ncomms10494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740377PMC
February 2016

Simple and effective exercise design for assessing in vivo mitochondrial function in clinical applications using (31)P magnetic resonance spectroscopy.

Authors:
Alison Sleigh Victoria Lupson Ajay Thankamony David B Dunger David B Savage T Adrian Carpenter Graham J Kemp

Sci Rep 2016 Jan 11;6:19057. Epub 2016 Jan 11.

Magnetic Resonance &Image Analysis Research Centre, Department of Musculoskeletal Biology and MRC - Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing, University of Liverpool, Liverpool, L69 3GE, UK.

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http://dx.doi.org/10.1038/srep19057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707472PMC
January 2016

Truncation of POC1A associated with short stature and extreme insulin resistance.

Authors:
Jian-Hua Chen Maria Segni Felicity Payne Isabel Huang-Doran Alison Sleigh Claire Adams David B Savage Stephen O'Rahilly Robert K Semple Inês Barroso

J Mol Endocrinol 2015 Oct;55(2):147-58

The University of Cambridge Metabolic Research Laboratories Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK The National Institute for Health Research Cambridge Biomedical Research Centre Cambridge, UK Department of Pediatrics Sapienza University, Rome, Italy Metabolic Disease Group Wellcome Trust Sanger Institute, Cambridge, UK Wolfson Brain Imaging Centre University of Cambridge, Cambridge, UK National Institute for Health Research/Wellcome Trust Clinical Research Facility Cambridge, UK The University of Cambridge Metabolic Research Laboratories Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK The National Institute for Health Research Cambridge Biomedical Research Centre Cambridge, UK Department of Pediatrics Sapienza University, Rome, Italy Metabolic Disease Group Wellcome Trust Sanger Institute, Cambridge, UK Wolfson Brain Imaging Centre University of Cambridge, Cambridge, UK National Institute for Health Research/Wellcome Trust Clinical Research Facility Cambridge, UK The University of Cambridge Metabolic Research Laboratories Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK The National Institute for Health Research Cambridge Biomedical Research Centre Cambridge, UK Department of Pediatrics Sapienza University, Rome, Italy Metabolic Disease Group Wellcome Trust Sanger Institute, Cambridge, UK Wolfson Brain Imaging Centre University of Cambridge, Cambridge, UK National Institute for Health Research/Wellcome Trust Clinical Research Facility Cambridge, UK

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http://dx.doi.org/10.1530/JME-15-0090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722288PMC
October 2015

Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis.

Authors:
Kevin T Nead Stephen J Sharp Deborah J Thompson Jodie N Painter David B Savage Robert K Semple Adam Barker John R B Perry John Attia Alison M Dunning Douglas F Easton Elizabeth Holliday Luca A Lotta Tracy O'Mara Mark McEvoy Paul D P Pharoah Rodney J Scott Amanda B Spurdle Claudia Langenberg Nicholas J Wareham Robert A Scott

J Natl Cancer Inst 2015 Sep 1;107(9). Epub 2015 Jul 1.

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK (KTN, SJS, AB, JRBP, LAL, CL, NJW, RAS); Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (KTN); Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (DJT, DFE, PDPP); Queensland Institute of Medical Research, Brisbane, Australia (JNP, ANECS, TO, ABS); University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Cambridge, UK (DBS, RKS); Hunter Medical Research Institute, John Hunter Hospital, Newcastle, Australia (JA, EH, RJS); Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, The University of Newcastle, Newcastle, Australia (JA, MM); Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (AMD, DFE, PDPP); Centre for Information Based Medicine, School of Medicine and Public Health, University of Newcastle, Australia (EH, RJS).

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http://dx.doi.org/10.1093/jnci/djv178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572886PMC
September 2015

Lipid droplet-organelle interactions: emerging roles in lipid metabolism.

Authors:
Antonio Daniel Barbosa David B Savage Symeon Siniossoglou

Curr Opin Cell Biol 2015 Aug 15;35:91-7. Epub 2015 May 15.

Cambridge Institute for Medical Research, University of Cambridge, CB2 0XY Cambridge, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2015.04.017DOI Listing
August 2015

Acquired generalized lipodystrophy associated with peripheral T cell lymphoma with cutaneous infiltration.

Authors:
Arif Aslam David B Savage Ian H Coulson

Int J Dermatol 2015 Jul 29;54(7):827-9. Epub 2013 Oct 29.

Department of Dermatology, Burnley General Hospital, East Lancashire Hospitals National Health Service (NHS) Trust, Burnley, UK.

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http://dx.doi.org/10.1111/ijd.12185DOI Listing
July 2015

The genetics of lipid storage and human lipodystrophies.

Authors:
Ann L Robbins David B Savage

Trends Mol Med 2015 Jul 12;21(7):433-8. Epub 2015 May 12.

University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2015.04.004DOI Listing
July 2015

Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice.

Authors:
Linkang Zhou Shi-Young Park Li Xu Xiayu Xia Jing Ye Lu Su Kyeong-Hoon Jeong Jang Ho Hur Hyunhee Oh Yoshikazu Tamori Cristina M Zingaretti Saverio Cinti Jesús Argente Miao Yu Lizhen Wu Shenghong Ju Feifei Guan Hongyuan Yang Cheol Soo Choi David B Savage Peng Li

Nat Commun 2015 Jan 7;6:5949. Epub 2015 Jan 7.

MOE Key Laboratory of Bioinformatics and Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1038/ncomms6949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354252PMC
January 2015

Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity.

Authors:
Robert A Scott Tove Fall Dorota Pasko Adam Barker Stephen J Sharp Larraitz Arriola Beverley Balkau Aurelio Barricarte Inês Barroso Heiner Boeing Françoise Clavel-Chapelon Francesca L Crowe Jacqueline M Dekker Guy Fagherazzi Ele Ferrannini Nita G Forouhi Paul W Franks Diana Gavrila Vilmantas Giedraitis Sara Grioni Leif C Groop Rudolf Kaaks Timothy J Key Tilman Kühn Luca A Lotta Peter M Nilsson Kim Overvad Domenico Palli Salvatore Panico J Ramón Quirós Olov Rolandsson Nina Roswall Carlotta Sacerdote Núria Sala María-José Sánchez Matthias B Schulze Afshan Siddiq Nadia Slimani Ivonne Sluijs Annemieke Mw Spijkerman Anne Tjonneland Rosario Tumino Daphne L van der A Hanieh Yaghootkar Mark I McCarthy Robert K Semple Elio Riboli Mark Walker Erik Ingelsson Tim M Frayling David B Savage Claudia Langenberg Nicholas J Wareham

Diabetes 2014 Dec 19;63(12):4378-4387. Epub 2014 Jun 19.

MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.2337/db14-0319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241116PMC
December 2014

Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease.

Authors:
Felicity Payne Koini Lim Amandine Girousse Rebecca J Brown Nora Kory Ann Robbins Yali Xue Alison Sleigh Elaine Cochran Claire Adams Arundhati Dev Borman David Russel-Jones Phillip Gorden Robert K Semple Vladimir Saudek Stephen O'Rahilly Tobias C Walther Inês Barroso David B Savage

Proc Natl Acad Sci U S A 2014 Jun 2;111(24):8901-6. Epub 2014 Jun 2.

University of Cambridge, Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1408523111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066527PMC
June 2014

Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis.

Authors:
Satish Patel Wei Yang Kristina Kozusko Vladimir Saudek David B Savage

Proc Natl Acad Sci U S A 2014 Jun 9;111(25):9163-8. Epub 2014 Jun 9.

University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom

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http://dx.doi.org/10.1073/pnas.1318791111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078844PMC
June 2014

Human congenital perilipin deficiency and insulin resistance.

Authors:
Kristina Kozusko Satish Patel David B Savage

Endocr Dev 2013 1;24:150-5. Epub 2013 Feb 1.

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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August 2013

An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy.

Authors:
Michael N Weedon Sian Ellard Marc J Prindle Richard Caswell Hana Lango Allen Richard Oram Koumudi Godbole Chittaranjan S Yajnik Paolo Sbraccia Giuseppe Novelli Peter Turnpenny Emma McCann Kim Jee Goh Yukai Wang Jonathan Fulford Laura J McCulloch David B Savage Stephen O'Rahilly Katarina Kos Lawrence A Loeb Robert K Semple Andrew T Hattersley

Nat Genet 2013 Aug 16;45(8):947-50. Epub 2013 Jun 16.

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, UK.

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http://www.nature.com/articles/ng.2670
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http://dx.doi.org/10.1038/ng.2670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785143PMC
August 2013

Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals.

Authors:
Francis M Finucane Stephen J Sharp Mensud Hatunic Alison Sleigh Ema De Lucia Rolfe Avan Aihie Sayer Cyrus Cooper Simon J Griffin David B Savage Nicholas J Wareham

Int J Endocrinol 2013 2;2013:870487. Epub 2013 May 2.

MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, P.O. Box 285 Hills Road, Cambridge CB20QQ, UK ; Galway Diabetes Research Centre, School of Medicine, Clinical Science Institute, NUI Galway, Galway, Ireland.

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http://dx.doi.org/10.1155/2013/870487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659510PMC
June 2013

Early Diagnosis of Werner's Syndrome Using Exome-Wide Sequencing in a Single, Atypical Patient.

Authors:
Eleanor Raffan Liam A Hurst Saeed Al Turki Gillian Carpenter Carol Scott Allan Daly Alison Coffey Sanjeev Bhaskar Eleanor Howard Naz Khan Helen Kingston Aarno Palotie David B Savage Mark O'Driscoll Claire Smith Stephen O'Rahilly Inês Barroso Robert K Semple

Front Endocrinol (Lausanne) 2011 29;2. Epub 2011 Mar 29.

Institute of Metabolic Science, University of Cambridge Metabolic Research Laboratories Cambridge, UK.

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http://dx.doi.org/10.3389/fendo.2011.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356119PMC
August 2012

Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA.

Authors:
Marjorie J Lindhurst Victoria E R Parker Felicity Payne Julie C Sapp Simon Rudge Julie Harris Alison M Witkowski Qifeng Zhang Matthijs P Groeneveld Carol E Scott Allan Daly Susan M Huson Laura L Tosi Michael L Cunningham Thomas N Darling Joseph Geer Zoran Gucev V Reid Sutton Christos Tziotzios Adrian K Dixon Timothy Helliwell Stephen O'Rahilly David B Savage Michael J O Wakelam Inês Barroso Leslie G Biesecker Robert K Semple

Nat Genet 2012 Jun 24;44(8):928-33. Epub 2012 Jun 24.

The National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/ng.2332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461408PMC
June 2012

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

Authors:
Alisa K Manning Marie-France Hivert Robert A Scott Jonna L Grimsby Nabila Bouatia-Naji Han Chen Denis Rybin Ching-Ti Liu Lawrence F Bielak Inga Prokopenko Najaf Amin Daniel Barnes Gemma Cadby Jouke-Jan Hottenga Erik Ingelsson Anne U Jackson Toby Johnson Stavroula Kanoni Claes Ladenvall Vasiliki Lagou Jari Lahti Cecile Lecoeur Yongmei Liu Maria Teresa Martinez-Larrad May E Montasser Pau Navarro John R B Perry Laura J Rasmussen-Torvik Perttu Salo Naveed Sattar Dmitry Shungin Rona J Strawbridge Toshiko Tanaka Cornelia M van Duijn Ping An Mariza de Andrade Jeanette S Andrews Thor Aspelund Mustafa Atalay Yurii Aulchenko Beverley Balkau Stefania Bandinelli Jacques S Beckmann John P Beilby Claire Bellis Richard N Bergman John Blangero Mladen Boban Michael Boehnke Eric Boerwinkle Lori L Bonnycastle Dorret I Boomsma Ingrid B Borecki Yvonne Böttcher Claude Bouchard Eric Brunner Danijela Budimir Harry Campbell Olga Carlson Peter S Chines Robert Clarke Francis S Collins Arturo Corbatón-Anchuelo David Couper Ulf de Faire George V Dedoussis Panos Deloukas Maria Dimitriou Josephine M Egan Gudny Eiriksdottir Michael R Erdos Johan G Eriksson Elodie Eury Luigi Ferrucci Ian Ford Nita G Forouhi Caroline S Fox Maria Grazia Franzosi Paul W Franks Timothy M Frayling Philippe Froguel Pilar Galan Eco de Geus Bruna Gigante Nicole L Glazer Anuj Goel Leif Groop Vilmundur Gudnason Göran Hallmans Anders Hamsten Ola Hansson Tamara B Harris Caroline Hayward Simon Heath Serge Hercberg Andrew A Hicks Aroon Hingorani Albert Hofman Jennie Hui Joseph Hung Marjo-Riitta Jarvelin Min A Jhun Paul C D Johnson J Wouter Jukema Antti Jula W H Kao Jaakko Kaprio Sharon L R Kardia Sirkka Keinanen-Kiukaanniemi Mika Kivimaki Ivana Kolcic Peter Kovacs Meena Kumari Johanna Kuusisto Kirsten Ohm Kyvik Markku Laakso Timo Lakka Lars Lannfelt G Mark Lathrop Lenore J Launer Karin Leander Guo Li Lars Lind Jaana Lindstrom Stéphane Lobbens Ruth J F Loos Jian'an Luan Valeriya Lyssenko Reedik Mägi Patrik K E Magnusson Michael Marmot Pierre Meneton Karen L Mohlke Vincent Mooser Mario A Morken Iva Miljkovic Narisu Narisu Jeff O'Connell Ken K Ong Ben A Oostra Lyle J Palmer Aarno Palotie James S Pankow John F Peden Nancy L Pedersen Marina Pehlic Leena Peltonen Brenda Penninx Marijana Pericic Markus Perola Louis Perusse Patricia A Peyser Ozren Polasek Peter P Pramstaller Michael A Province Katri Räikkönen Rainer Rauramaa Emil Rehnberg Ken Rice Jerome I Rotter Igor Rudan Aimo Ruokonen Timo Saaristo Maria Sabater-Lleal Veikko Salomaa David B Savage Richa Saxena Peter Schwarz Udo Seedorf Bengt Sennblad Manuel Serrano-Rios Alan R Shuldiner Eric J G Sijbrands David S Siscovick Johannes H Smit Kerrin S Small Nicholas L Smith Albert Vernon Smith Alena Stančáková Kathleen Stirrups Michael Stumvoll Yan V Sun Amy J Swift Anke Tönjes Jaakko Tuomilehto Stella Trompet Andre G Uitterlinden Matti Uusitupa Max Vikström Veronique Vitart Marie-Claude Vohl Benjamin F Voight Peter Vollenweider Gerard Waeber Dawn M Waterworth Hugh Watkins Eleanor Wheeler Elisabeth Widen Sarah H Wild Sara M Willems Gonneke Willemsen James F Wilson Jacqueline C M Witteman Alan F Wright Hanieh Yaghootkar Diana Zelenika Tatijana Zemunik Lina Zgaga Nicholas J Wareham Mark I McCarthy Ines Barroso Richard M Watanabe Jose C Florez Josée Dupuis James B Meigs Claudia Langenberg

Nat Genet 2012 May 13;44(6):659-69. Epub 2012 May 13.

Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.2274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613127PMC
May 2012

Metabolic insights from extreme human insulin resistance phenotypes.

Authors:
Anna Stears Stephen O'Rahilly Robert K Semple David B Savage

Best Pract Res Clin Endocrinol Metab 2012 Apr;26(2):145-57

Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, University of Cambridge, UK.

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http://dx.doi.org/10.1016/j.beem.2011.09.003DOI Listing
April 2012

Mitochondrial oxidative phosphorylation is impaired in patients with congenital lipodystrophy.

Authors:
Alison Sleigh Anna Stears Kerrie Thackray Laura Watson Alessandra Gambineri Sath Nag V Irene Campi Nadia Schoenmakers Soren Brage T Adrian Carpenter Peter R Murgatroyd Stephen O'Rahilly Graham J Kemp David B Savage

J Clin Endocrinol Metab 2012 Mar 11;97(3):E438-42. Epub 2012 Jan 11.

Wolfson Brain Imaging Centre, Metabolic Research Laboratories and National Institute for Health Research Cambridge Biomedical Research Centre, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2011-2587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380089PMC
March 2012

Human frame shift mutations affecting the carboxyl terminus of perilipin increase lipolysis by failing to sequester the adipose triglyceride lipase (ATGL) coactivator AB-hydrolase-containing 5 (ABHD5).

Authors:
Sheetal Gandotra Koini Lim Amandine Girousse Vladimir Saudek Stephen O'Rahilly David B Savage

J Biol Chem 2011 Oct 12;286(40):34998-5006. Epub 2011 Jul 12.

Institute of Metabolic Science Metabolic Research Laboratories and the Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M111.278853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186430PMC
October 2011

Genetic syndromes of severe insulin resistance.

Authors:
Robert K Semple David B Savage Elaine K Cochran Phillip Gorden Stephen O'Rahilly

Endocr Rev 2011 Aug 2;32(4):498-514. Epub 2011 May 2.

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1210/er.2010-0020DOI Listing
August 2011

Mitochondrial dysfunction in patients with primary congenital insulin resistance.

Authors:
Alison Sleigh Philippa Raymond-Barker Kerrie Thackray David Porter Mensud Hatunic Alessandra Vottero Christine Burren Catherine Mitchell Martin McIntyre Soren Brage T Adrian Carpenter Peter R Murgatroyd Kevin M Brindle Graham J Kemp Stephen O'Rahilly Robert K Semple David B Savage

J Clin Invest 2011 Jun 9;121(6):2457-61. Epub 2011 May 9.

Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1172/JCI46405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104774PMC
June 2011

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

Authors:
Tuomas O Kilpeläinen M Carola Zillikens Alena Stančákova Francis M Finucane Janina S Ried Claudia Langenberg Weihua Zhang Jacques S Beckmann Jian'an Luan Liesbeth Vandenput Unnur Styrkarsdottir Yanhua Zhou Albert Vernon Smith Jing-Hua Zhao Najaf Amin Sailaja Vedantam So-Youn Shin Talin Haritunians Mao Fu Mary F Feitosa Meena Kumari Bjarni V Halldorsson Emmi Tikkanen Massimo Mangino Caroline Hayward Ci Song Alice M Arnold Yurii S Aulchenko Ben A Oostra Harry Campbell L Adrienne Cupples Kathryn E Davis Angela Döring Gudny Eiriksdottir Karol Estrada José Manuel Fernández-Real Melissa Garcia Christian Gieger Nicole L Glazer Candace Guiducci Albert Hofman Steve E Humphries Bo Isomaa Leonie C Jacobs Antti Jula David Karasik Magnus K Karlsson Kay-Tee Khaw Lauren J Kim Mika Kivimäki Norman Klopp Brigitte Kühnel Johanna Kuusisto Yongmei Liu Osten Ljunggren Mattias Lorentzon Robert N Luben Barbara McKnight Dan Mellström Braxton D Mitchell Vincent Mooser José Maria Moreno Satu Männistö Jeffery R O'Connell Laura Pascoe Leena Peltonen Belén Peral Markus Perola Bruce M Psaty Veikko Salomaa David B Savage Robert K Semple Tatjana Skaric-Juric Gunnar Sigurdsson Kijoung S Song Timothy D Spector Ann-Christine Syvänen Philippa J Talmud Gudmar Thorleifsson Unnur Thorsteinsdottir André G Uitterlinden Cornelia M van Duijn Antonio Vidal-Puig Sarah H Wild Alan F Wright Deborah J Clegg Eric Schadt James F Wilson Igor Rudan Samuli Ripatti Ingrid B Borecki Alan R Shuldiner Erik Ingelsson John-Olov Jansson Robert C Kaplan Vilmundur Gudnason Tamara B Harris Leif Groop Douglas P Kiel Fernando Rivadeneira Mark Walker Inês Barroso Peter Vollenweider Gérard Waeber John C Chambers Jaspal S Kooner Nicole Soranzo Joel N Hirschhorn Kari Stefansson H-Erich Wichmann Claes Ohlsson Stephen O'Rahilly Nicholas J Wareham Elizabeth K Speliotes Caroline S Fox Markku Laakso Ruth J F Loos

Nat Genet 2011 Jun 26;43(8):753-60. Epub 2011 Jun 26.

Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262230PMC
June 2011

An amino acid profile to predict diabetes?

Authors:
Claudia Langenberg David B Savage

Nat Med 2011 Apr;17(4):418-20

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http://dx.doi.org/10.1038/nm0411-418DOI Listing
April 2011

Congenital syndromes of severe insulin resistance.

Authors:
Isabel Huang-Doran David B Savage

Pediatr Endocrinol Rev 2011 Mar;8(3):190-9

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, UK.

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March 2011

Perilipin deficiency and autosomal dominant partial lipodystrophy.

Authors:
Sheetal Gandotra Caroline Le Dour William Bottomley Pascale Cervera Philippe Giral Yves Reznik Guillaume Charpentier Martine Auclair Marc Delépine Inês Barroso Robert K Semple Mark Lathrop Olivier Lascols Jacqueline Capeau Stephen O'Rahilly Jocelyne Magré David B Savage Corinne Vigouroux

N Engl J Med 2011 Feb;364(8):740-8

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://www.nejm.org/doi/abs/10.1056/NEJMoa1007487
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http://dx.doi.org/10.1056/NEJMoa1007487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773916PMC
February 2011

Lipodystrophy: metabolic insights from a rare disorder.

Authors:
Isabel Huang-Doran Alison Sleigh Justin J Rochford Stephen O'Rahilly David B Savage

J Endocrinol 2010 Dec 24;207(3):245-55. Epub 2010 Sep 24.

Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK.

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http://dx.doi.org/10.1677/JOE-10-0272DOI Listing
December 2010

Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance.

Authors:
David B Savage Robert K Semple

Curr Opin Lipidol 2010 Aug;21(4):329-36

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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http://pdfs.journals.lww.com/co-lipidology/2010/08000/Recent
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http://dx.doi.org/10.1097/MOL.0b013e32833b7782DOI Listing
August 2010

Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia.

Authors:
Catherine S Mitchell David B Savage Sylvie Dufour Nadia Schoenmakers Peter Murgatroyd Douglas Befroy David Halsall Samantha Northcott Philippa Raymond-Barker Suzanne Curran Elana Henning Julia Keogh Penny Owen John Lazarus Douglas L Rothman I Sadaf Farooqi Gerald I Shulman Krishna Chatterjee Kitt Falk Petersen

J Clin Invest 2010 Apr 8;120(4):1345-54. Epub 2010 Mar 8.

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1172/JCI38793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846038PMC
April 2010

Mouse models of inherited lipodystrophy.

Authors:
David B Savage

Dis Model Mech 2009 Nov-Dec;2(11-12):554-62

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.1242/dmm.002907DOI Listing
February 2010

Sex hormone-binding globulin and risk of type 2 diabetes.

Authors:
Robert Semple David B Savage Steven O'Rahilly

N Engl J Med 2009 Dec;361(27):2677; author reply 2677-8

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December 2009

Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC.

Authors:
Oscar Rubio-Cabezas Vishwajeet Puri Incoronata Murano Vladimir Saudek Robert K Semple Satya Dash Caroline S S Hyden William Bottomley Corinne Vigouroux Jocelyne Magré Philippa Raymond-Barker Peter R Murgatroyd Anil Chawla Jeremy N Skepper V Krishna Chatterjee Sara Suliman Ann-Marie Patch Anil K Agarwal Abhimanyu Garg Inês Barroso Saverio Cinti Michael P Czech Jesús Argente Stephen O'Rahilly David B Savage

EMBO Mol Med 2009 Aug;1(5):280-7

Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.

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http://dx.doi.org/10.1002/emmm.200900037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891108PMC
August 2009

A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia.

Authors:
Satya Dash Hiroyuki Sano Justin J Rochford Robert K Semple Giles Yeo Caroline S S Hyden Maria A Soos James Clark Andrew Rodin Claudia Langenberg Celine Druet Katherine A Fawcett Y C Loraine Tung Nicolas J Wareham Inês Barroso Gustav E Lienhard Stephen O'Rahilly David B Savage

Proc Natl Acad Sci U S A 2009 Jun 22;106(23):9350-5. Epub 2009 May 22.

Departments of Medicine and Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0900909106
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http://dx.doi.org/10.1073/pnas.0900909106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695078PMC
June 2009

Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial.

Authors:
Francis M Finucane Jessica Horton Lisa R Purslow David B Savage Soren Brage Hervé Besson Kenneth Horton Ema De Lucia Rolfe Alison Sleigh Stephen J Sharp Helen J Martin Avan Aihie Sayer Cyrus Cooper Ulf Ekelund Simon J Griffin Nicholas J Wareham

BMC Endocr Disord 2009 Jun 19;9:15. Epub 2009 Jun 19.

MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.

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http://bmcendocrdisord.biomedcentral.com/articles/10.1186/14
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http://dx.doi.org/10.1186/1472-6823-9-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708167PMC
June 2009

Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis.

Authors:
Robert K Semple Alison Sleigh Peter R Murgatroyd Claire A Adams Les Bluck Sarah Jackson Alessandra Vottero Dipak Kanabar Valentine Charlton-Menys Paul Durrington Maria A Soos T Adrian Carpenter David J Lomas Elaine K Cochran Phillip Gorden Stephen O'Rahilly David B Savage

J Clin Invest 2009 Feb 26;119(2):315-22. Epub 2009 Jan 26.

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://dx.doi.org/10.1172/JCI37432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631303PMC
February 2009

Complement abnormalities in acquired lipodystrophy revisited.

Authors:
David B Savage Robert K Semple Menna R Clatworthy Paul A Lyons B Paul Morgan Elaine K Cochran Phillip Gorden Philippa Raymond-Barker Peter R Murgatroyd Claire Adams Ian Scobie Ghulam J Mufti Graeme J M Alexander Sathia Thiru Incoronata Murano Saverio Cinti Afzal N Chaudhry Kenneth G C Smith Stephen O'Rahilly

J Clin Endocrinol Metab 2009 Jan 14;94(1):10-6. Epub 2008 Oct 14.

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2008-1703DOI Listing
January 2009

Fatty acid metabolism in patients with PPARgamma mutations.

Authors:
Garry D Tan David B Savage Barbara A Fielding Jenny Collins Leanne Hodson Sandy M Humphreys Stephen O'Rahilly Krishna Chatterjee Keith N Frayn Fredrik Karpe

J Clin Endocrinol Metab 2008 Nov 19;93(11):4462-70. Epub 2008 Aug 19.

Oxford Centre for Diabetes, Endocrinology, and Metabolism, Oxford OX3 7LJ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2007-2356DOI Listing
November 2008

Plasma adiponectin as a marker of insulin receptor dysfunction: clinical utility in severe insulin resistance.

Authors:
Robert K Semple Elaine K Cochran Maria A Soos Keith A Burling David B Savage Phillip Gorden Stephen O'Rahilly

Diabetes Care 2008 May 25;31(5):977-9. Epub 2008 Feb 25.

Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.2337/dc07-2194DOI Listing
May 2008

A clinical approach to severe insulin resistance.

Authors:
David B Savage Robert K Semple V Krishna K Chatterjee Jeremy K H Wales Richard J M Ross Stephen O'Rahilly

Endocr Dev 2007 ;11:122-132

Departments of Clinical Biochemistry and Medicine, University of Cambridge, Cambridge,UK.

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http://dx.doi.org/10.1159/000111067DOI Listing
February 2008

A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice.

Authors:
David B Savage Lanmin Zhai Balasubramanian Ravikumar Cheol Soo Choi Johanna E Snaar Amanda C McGuire Sung-Eun Wou Gemma Medina-Gomez Sheene Kim Cheryl B Bock Dyann M Segvich Bhavana Solanky Dinesh Deelchand Antonio Vidal-Puig Nicholas J Wareham Gerald I Shulman Fredrik Karpe Roy Taylor Bartholomew A Pederson Peter J Roach Stephen O'Rahilly Anna A DePaoli-Roach

PLoS Med 2008 Jan;5(1):e27

Department of Clinical Biochemistry and Medicine, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.0050027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2214798PMC
January 2008

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity.

Authors:
Cheol Soo Choi David B Savage Lutfi Abu-Elheiga Zhen-Xiang Liu Sheene Kim Ameya Kulkarni Alberto Distefano Yu-Jin Hwang Richard M Reznick Roberto Codella Dongyan Zhang Gary W Cline Salih J Wakil Gerald I Shulman

Proc Natl Acad Sci U S A 2007 Oct 8;104(42):16480-5. Epub 2007 Oct 8.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1073/pnas.0706794104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034222PMC
October 2007

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.

Authors:
Cheol Soo Choi David B Savage Ameya Kulkarni Xing Xian Yu Zhen-Xiang Liu Katsutaro Morino Sheene Kim Alberto Distefano Varman T Samuel Susanne Neschen Dongyan Zhang Amy Wang Xian-Man Zhang Mario Kahn Gary W Cline Sanjay K Pandey John G Geisler Sanjay Bhanot Brett P Monia Gerald I Shulman

J Biol Chem 2007 Aug 27;282(31):22678-88. Epub 2007 May 27.

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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August 2007

TCF7L2 polymorphisms modulate proinsulin levels and beta-cell function in a British Europid population.

Authors:
Ruth J F Loos Paul W Franks Richard W Francis Inês Barroso Fiona M Gribble David B Savage Ken K Ong Stephen O'Rahilly Nicholas J Wareham

Diabetes 2007 Jul 6;56(7):1943-7. Epub 2007 Apr 6.

Medical Research Council Epidemiology Unit, Strangeways Research Laboratory, Cambridge, UK.

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http://dx.doi.org/10.2337/db07-0055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668957PMC
July 2007

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome.

Authors:
Kitt Falk Petersen Sylvie Dufour David B Savage Stefan Bilz Gina Solomon Shin Yonemitsu Gary W Cline Douglas Befroy Laura Zemany Barbara B Kahn Xenophon Papademetris Douglas L Rothman Gerald I Shulman

Proc Natl Acad Sci U S A 2007 Jul 18;104(31):12587-94. Epub 2007 Jul 18.

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536, USA.

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http://dx.doi.org/10.1073/pnas.0705408104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924794PMC
July 2007

Disordered lipid metabolism and the pathogenesis of insulin resistance.

Authors:
David B Savage Kitt Falk Petersen Gerald I Shulman

Physiol Rev 2007 Apr;87(2):507-20

Department of Internal Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536-8012, USA.

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http://www.physiology.org/doi/10.1152/physrev.00024.2006
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http://dx.doi.org/10.1152/physrev.00024.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995548PMC
April 2007

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

Authors:
David B Savage Cheol Soo Choi Varman T Samuel Zhen-Xiang Liu Dongyan Zhang Amy Wang Xian-Man Zhang Gary W Cline Xing Xian Yu John G Geisler Sanjay Bhanot Brett P Monia Gerald I Shulman

J Clin Invest 2006 Mar 16;116(3):817-24. Epub 2006 Feb 16.

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1172/JCI27300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366503PMC
March 2006

Mechanisms of insulin resistance in humans and possible links with inflammation.

Authors:
David B Savage Kitt F Petersen Gerald I Shulman

Hypertension 2005 May 11;45(5):828-33. Epub 2005 Apr 11.

Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn 06510, USA.

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http://dx.doi.org/10.1161/01.HYP.0000163475.04421.e4DOI Listing
May 2005

Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma.

Authors:
Ulf Risérus Garry D Tan Barbara A Fielding Matt J Neville Jenny Currie David B Savage V Krishna Chatterjee Keith N Frayn Stephen O'Rahilly Fredrik Karpe

Diabetes 2005 May;54(5):1379-84

Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, OX3 7LJ, UK.

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http://dx.doi.org/10.2337/diabetes.54.5.1379DOI Listing
May 2005

Energy expenditure and adaptive responses to an acute hypercaloric fat load in humans with lipodystrophy.

Authors:
David B Savage Peter R Murgatroyd V Krishna Chatterjee Stephen O'Rahilly

J Clin Endocrinol Metab 2005 Mar 21;90(3):1446-52. Epub 2004 Dec 21.

Department of Clinical Biochemistry and Medicine, Level 4, Box 232, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2004-1494DOI Listing
March 2005

PPAR gamma as a metabolic regulator: insights from genomics and pharmacology.

Authors:
David B Savage

Expert Rev Mol Med 2005 Jan 25;7(1):1-16. Epub 2005 Jan 25.

Department of Medicine, University of Cambridge, UK.

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http://dx.doi.org/10.1017/S1462399405008793DOI Listing
January 2005

Proteinuric nephropathy in acquired and congenital generalized lipodystrophy: baseline characteristics and course during recombinant leptin therapy.

Authors:
Edward D Javor Stephanie Ann Moran Janice Ryan Young Elaine K Cochran Alex M DePaoli Elif Arioglu Oral Martin A Turman Piers R Blackett David B Savage Stephen O'Rahilly James E Balow Phillip Gorden

J Clin Endocrinol Metab 2004 Jul;89(7):3199-207

National Institute of Diabetes and Digestive and Kidney Diseases/NIH, 10 Center Drive, Room 8D20, Bethesda, MD 20892-1770, USA.

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http://dx.doi.org/10.1210/jc.2003-032140DOI Listing
July 2004

Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma.

Authors:
Maura Agostini Mark Gurnell David B Savage Emily M Wood Aaron G Smith Odelia Rajanayagam Keith T Garnes Sidney H Levinson H Eric Xu John W R Schwabe Timothy M Willson Stephen O'Rahilly V Krishna Chatterjee

Endocrinology 2004 Apr 4;145(4):1527-38. Epub 2003 Dec 4.

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, United Kingdom.

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http://dx.doi.org/10.1210/en.2003-1271DOI Listing
April 2004

The metabolic syndrome: peroxisome proliferator-activated receptor gamma and its therapeutic modulation.

Authors:
Mark Gurnell David B Savage V Krishna K Chatterjee Stephen O'Rahilly

J Clin Endocrinol Metab 2003 Jun;88(6):2412-21

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom.

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http://dx.doi.org/10.1210/jc.2003-030435DOI Listing
June 2003

Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma.

Authors:
David B Savage Garry D Tan Carlo L Acerini Susan A Jebb Maura Agostini Mark Gurnell Rachel L Williams A Margot Umpleby E Louise Thomas Jimmy D Bell Adrian K Dixon Fidelma Dunne Romina Boiani Saverio Cinti Antonio Vidal-Puig Fredrik Karpe V Krishna K Chatterjee Stephen O'Rahilly

Diabetes 2003 Apr;52(4):910-7

Department of Medicine, Addenbrooke's Hospital, Cambridge, UK.

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http://dx.doi.org/10.2337/diabetes.52.4.910DOI Listing
April 2003

Digenic inheritance of severe insulin resistance in a human pedigree.

Authors:
David B Savage Maura Agostini Inês Barroso Mark Gurnell Jian'an Luan Aline Meirhaeghe Anne-Helen Harding Gudrun Ihrke Odelia Rajanayagam Maria A Soos Stella George Dirk Berger E Louise Thomas Jimmy D Bell Karim Meeran Richard J Ross Antonio Vidal-Puig Nicholas J Wareham Stephen O'Rahilly V Krishna K Chatterjee Alan J Schafer

Nat Genet 2002 Aug 15;31(4):379-84. Epub 2002 Jul 15.

Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK.

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http://dx.doi.org/10.1038/ng926DOI Listing
August 2002

Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization.

Authors:
Terry P Combs John A Wagner Joel Berger Tom Doebber Wen-Jun Wang Bei B Zhang Michael Tanen Anders H Berg Stephen O'Rahilly David B Savage Krishna Chatterjee Stuart Weiss Patrick J Larson Keith M Gottesdiener Barry J Gertz Maureen J Charron Philipp E Scherer David E Moller

Endocrinology 2002 Mar;143(3):998-1007

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1210/endo.143.3.8662DOI Listing
March 2002