David B Savage

David B Savage

UNVERIFIED PROFILE

Are you David B Savage?   Register this Author

Register author
David B Savage

David B Savage

Publications by authors named "David B Savage"

Are you David B Savage?   Register this Author

83Publications

2211Reads

47Profile Views

Recent developments in lipodystrophy.

Curr Opin Lipidol 2019 Aug;30(4):284-290

Metabolic Research Laboratories, Wellcome Trust - MRC Institute of Metabolic Science, University of Cambridge.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOL.0000000000000613DOI Listing
August 2019

What lipodystrophies teach us about the metabolic syndrome.

J Clin Invest 2019 Aug 5;130. Epub 2019 Aug 5.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI129190DOI Listing
August 2019

Accumulation of saturated intramyocellular lipid is associated with insulin resistance.

J Lipid Res 2019 Jul 2;60(7):1323-1332. Epub 2019 May 2.

Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.M091942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602127PMC
July 2019

Long-term effectiveness and safety of metreleptin in the treatment of patients with partial lipodystrophy.

Endocrine 2019 Jun 25;64(3):500-511. Epub 2019 Feb 25.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12020-019-01862-8DOI Listing
June 2019

Dual binding motifs underpin the hierarchical association of perilipins1-3 with lipid droplets.

Mol Biol Cell 2019 03 16;30(5):703-716. Epub 2019 Jan 16.

Laboratoire de Physique de l'Ecole Normale Supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris-Diderot, Sorbonne Paris Cité, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1091/mbc.E18-08-0534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589688PMC
March 2019

European paediatric non-alcoholic fatty liver disease registry (EU-PNAFLD): Design and rationale.

Contemp Clin Trials 2018 12 5;75:67-71. Epub 2018 Nov 5.

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom; Liver Unit, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, United Kingdom.

View Article

Download full-text PDF

Source
https://www.journals.elsevier.com/contemporary-clinical-tria
Web Search
https://linkinghub.elsevier.com/retrieve/pii/S15517144183042
Publisher Site
http://dx.doi.org/10.1016/j.cct.2018.11.003DOI Listing
December 2018

PLIN1 Haploinsufficiency Is Not Associated With Lipodystrophy.

J Clin Endocrinol Metab 2018 09;103(9):3225-3230

Institute of Biomedical & Clinical Science, University of Exeter, Exeter, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2017-02662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126890PMC
September 2018

Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice.

Mol Metab 2018 07 16;13:24-29. Epub 2018 May 16.

University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Cambridge, CB2 0QQ, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmet.2018.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026316PMC
July 2018

Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy.

Endocrine 2018 06 12;60(3):479-489. Epub 2018 Apr 12.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12020-018-1589-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936645PMC
June 2018

Mechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes.

Genome Med 2015 28;7:63. Epub 2015 Jun 28.

MRC Human Nutrition Research, Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL UK ; Department of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13073-015-0179-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535665PMC
May 2016

Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1-3.

J Biol Chem 2016 Mar 7;291(13):6664-78. Epub 2016 Jan 7.

From the University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M115.691048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807253PMC
March 2016

31P magnetization transfer measurements of Pi→ATP flux in exercising human muscle.

J Appl Physiol (1985) 2016 Mar 7;120(6):649-56. Epub 2016 Jan 7.

Magnetic Resonance and Image Analysis Research Centre, University of Liverpool, United Kingdom; and Department of Musculoskeletal Biology and MRC - Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing, Institute of Ageing and Chronic Disease, University of Liverpool, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/japplphysiol.00871.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796179PMC
March 2016

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Authors:
Tuomas O Kilpeläinen Jayne F Martin Carli Alicja A Skowronski Qi Sun Jennifer Kriebel Mary F Feitosa Åsa K Hedman Alexander W Drong James E Hayes Jinghua Zhao Tune H Pers Ursula Schick Niels Grarup Zoltán Kutalik Stella Trompet Massimo Mangino Kati Kristiansson Marian Beekman Leo-Pekka Lyytikäinen Joel Eriksson Peter Henneman Jari Lahti Toshiko Tanaka Jian'an Luan Fabiola Del Greco M Dorota Pasko Frida Renström Sara M Willems Anubha Mahajan Lynda M Rose Xiuqing Guo Yongmei Liu Marcus E Kleber Louis Pérusse Tom Gaunt Tarunveer S Ahluwalia Yun Ju Sung Yolande F Ramos Najaf Amin Antoinette Amuzu Inês Barroso Claire Bellis John Blangero Brendan M Buckley Stefan Böhringer Yii-Der I Chen Anton J N de Craen David R Crosslin Caroline E Dale Zari Dastani Felix R Day Joris Deelen Graciela E Delgado Ayse Demirkan Francis M Finucane Ian Ford Melissa E Garcia Christian Gieger Stefan Gustafsson Göran Hallmans Susan E Hankinson Aki S Havulinna Christian Herder Dena Hernandez Andrew A Hicks David J Hunter Thomas Illig Erik Ingelsson Andreea Ioan-Facsinay John-Olov Jansson Nancy S Jenny Marit E Jørgensen Torben Jørgensen Magnus Karlsson Wolfgang Koenig Peter Kraft Joanneke Kwekkeboom Tiina Laatikainen Karl-Heinz Ladwig Charles A LeDuc Gordon Lowe Yingchang Lu Pedro Marques-Vidal Christa Meisinger Cristina Menni Andrew P Morris Richard H Myers Satu Männistö Mike A Nalls Lavinia Paternoster Annette Peters Aruna D Pradhan Tuomo Rankinen Laura J Rasmussen-Torvik Wolfgang Rathmann Treva K Rice J Brent Richards Paul M Ridker Naveed Sattar David B Savage Stefan Söderberg Nicholas J Timpson Liesbeth Vandenput Diana van Heemst Hae-Won Uh Marie-Claude Vohl Mark Walker Heinz-Erich Wichmann Elisabeth Widén Andrew R Wood Jie Yao Tanja Zeller Yiying Zhang Ingrid Meulenbelt Margreet Kloppenburg Arne Astrup Thorkild I A Sørensen Mark A Sarzynski D C Rao Pekka Jousilahti Erkki Vartiainen Albert Hofman Fernando Rivadeneira André G Uitterlinden Eero Kajantie Clive Osmond Aarno Palotie Johan G Eriksson Markku Heliövaara Paul B Knekt Seppo Koskinen Antti Jula Markus Perola Risto K Huupponen Jorma S Viikari Mika Kähönen Terho Lehtimäki Olli T Raitakari Dan Mellström Mattias Lorentzon Juan P Casas Stefanie Bandinelli Winfried März Aaron Isaacs Ko W van Dijk Cornelia M van Duijn Tamara B Harris Claude Bouchard Matthew A Allison Daniel I Chasman Claes Ohlsson Lars Lind Robert A Scott Claudia Langenberg Nicholas J Wareham Luigi Ferrucci Timothy M Frayling Peter P Pramstaller Ingrid B Borecki Dawn M Waterworth Sven Bergmann Gérard Waeber Peter Vollenweider Henrik Vestergaard Torben Hansen Oluf Pedersen Frank B Hu P Eline Slagboom Harald Grallert Tim D Spector J W Jukema Robert J Klein Erik E Schadt Paul W Franks Cecilia M Lindgren Rudolph L Leibel Ruth J F Loos

Nat Commun 2016 Feb 1;7:10494. Epub 2016 Feb 1.

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms10494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740377PMC
February 2016

Simple and effective exercise design for assessing in vivo mitochondrial function in clinical applications using (31)P magnetic resonance spectroscopy.

Sci Rep 2016 Jan 11;6:19057. Epub 2016 Jan 11.

Magnetic Resonance &Image Analysis Research Centre, Department of Musculoskeletal Biology and MRC - Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing, University of Liverpool, Liverpool, L69 3GE, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep19057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707472PMC
January 2016

Truncation of POC1A associated with short stature and extreme insulin resistance.

J Mol Endocrinol 2015 Oct;55(2):147-58

The University of Cambridge Metabolic Research Laboratories Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK The National Institute for Health Research Cambridge Biomedical Research Centre Cambridge, UK Department of Pediatrics Sapienza University, Rome, Italy Metabolic Disease Group Wellcome Trust Sanger Institute, Cambridge, UK Wolfson Brain Imaging Centre University of Cambridge, Cambridge, UK National Institute for Health Research/Wellcome Trust Clinical Research Facility Cambridge, UK The University of Cambridge Metabolic Research Laboratories Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK The National Institute for Health Research Cambridge Biomedical Research Centre Cambridge, UK Department of Pediatrics Sapienza University, Rome, Italy Metabolic Disease Group Wellcome Trust Sanger Institute, Cambridge, UK Wolfson Brain Imaging Centre University of Cambridge, Cambridge, UK National Institute for Health Research/Wellcome Trust Clinical Research Facility Cambridge, UK The University of Cambridge Metabolic Research Laboratories Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK The National Institute for Health Research Cambridge Biomedical Research Centre Cambridge, UK Department of Pediatrics Sapienza University, Rome, Italy Metabolic Disease Group Wellcome Trust Sanger Institute, Cambridge, UK Wolfson Brain Imaging Centre University of Cambridge, Cambridge, UK National Institute for Health Research/Wellcome Trust Clinical Research Facility Cambridge, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/JME-15-0090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722288PMC
October 2015

Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis.

J Natl Cancer Inst 2015 Sep 1;107(9). Epub 2015 Jul 1.

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK (KTN, SJS, AB, JRBP, LAL, CL, NJW, RAS); Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (KTN); Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (DJT, DFE, PDPP); Queensland Institute of Medical Research, Brisbane, Australia (JNP, ANECS, TO, ABS); University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Cambridge, UK (DBS, RKS); Hunter Medical Research Institute, John Hunter Hospital, Newcastle, Australia (JA, EH, RJS); Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, The University of Newcastle, Newcastle, Australia (JA, MM); Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK (AMD, DFE, PDPP); Centre for Information Based Medicine, School of Medicine and Public Health, University of Newcastle, Australia (EH, RJS).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnci/djv178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572886PMC
September 2015

Lipid droplet-organelle interactions: emerging roles in lipid metabolism.

Curr Opin Cell Biol 2015 Aug 15;35:91-7. Epub 2015 May 15.

Cambridge Institute for Medical Research, University of Cambridge, CB2 0XY Cambridge, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ceb.2015.04.017DOI Listing
August 2015

Acquired generalized lipodystrophy associated with peripheral T cell lymphoma with cutaneous infiltration.

Int J Dermatol 2015 Jul 29;54(7):827-9. Epub 2013 Oct 29.

Department of Dermatology, Burnley General Hospital, East Lancashire Hospitals National Health Service (NHS) Trust, Burnley, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijd.12185DOI Listing
July 2015

The genetics of lipid storage and human lipodystrophies.

Trends Mol Med 2015 Jul 12;21(7):433-8. Epub 2015 May 12.

University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmed.2015.04.004DOI Listing
July 2015

Perilipins 2 and 3 lack a carboxy-terminal domain present in perilipin 1 involved in sequestering ABHD5 and suppressing basal lipolysis.

Proc Natl Acad Sci U S A 2014 Jun 9;111(25):9163-8. Epub 2014 Jun 9.

University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1318791111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078844PMC
June 2014

Human congenital perilipin deficiency and insulin resistance.

Endocr Dev 2013 1;24:150-5. Epub 2013 Feb 1.

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/342511
Publisher Site
http://dx.doi.org/10.1159/000342511DOI Listing
August 2013

Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals.

Int J Endocrinol 2013 2;2013:870487. Epub 2013 May 2.

MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, P.O. Box 285 Hills Road, Cambridge CB20QQ, UK ; Galway Diabetes Research Centre, School of Medicine, Clinical Science Institute, NUI Galway, Galway, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2013/870487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659510PMC
June 2013

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

Authors:
Alisa K Manning Marie-France Hivert Robert A Scott Jonna L Grimsby Nabila Bouatia-Naji Han Chen Denis Rybin Ching-Ti Liu Lawrence F Bielak Inga Prokopenko Najaf Amin Daniel Barnes Gemma Cadby Jouke-Jan Hottenga Erik Ingelsson Anne U Jackson Toby Johnson Stavroula Kanoni Claes Ladenvall Vasiliki Lagou Jari Lahti Cecile Lecoeur Yongmei Liu Maria Teresa Martinez-Larrad May E Montasser Pau Navarro John R B Perry Laura J Rasmussen-Torvik Perttu Salo Naveed Sattar Dmitry Shungin Rona J Strawbridge Toshiko Tanaka Cornelia M van Duijn Ping An Mariza de Andrade Jeanette S Andrews Thor Aspelund Mustafa Atalay Yurii Aulchenko Beverley Balkau Stefania Bandinelli Jacques S Beckmann John P Beilby Claire Bellis Richard N Bergman John Blangero Mladen Boban Michael Boehnke Eric Boerwinkle Lori L Bonnycastle Dorret I Boomsma Ingrid B Borecki Yvonne Böttcher Claude Bouchard Eric Brunner Danijela Budimir Harry Campbell Olga Carlson Peter S Chines Robert Clarke Francis S Collins Arturo Corbatón-Anchuelo David Couper Ulf de Faire George V Dedoussis Panos Deloukas Maria Dimitriou Josephine M Egan Gudny Eiriksdottir Michael R Erdos Johan G Eriksson Elodie Eury Luigi Ferrucci Ian Ford Nita G Forouhi Caroline S Fox Maria Grazia Franzosi Paul W Franks Timothy M Frayling Philippe Froguel Pilar Galan Eco de Geus Bruna Gigante Nicole L Glazer Anuj Goel Leif Groop Vilmundur Gudnason Göran Hallmans Anders Hamsten Ola Hansson Tamara B Harris Caroline Hayward Simon Heath Serge Hercberg Andrew A Hicks Aroon Hingorani Albert Hofman Jennie Hui Joseph Hung Marjo-Riitta Jarvelin Min A Jhun Paul C D Johnson J Wouter Jukema Antti Jula W H Kao Jaakko Kaprio Sharon L R Kardia Sirkka Keinanen-Kiukaanniemi Mika Kivimaki Ivana Kolcic Peter Kovacs Meena Kumari Johanna Kuusisto Kirsten Ohm Kyvik Markku Laakso Timo Lakka Lars Lannfelt G Mark Lathrop Lenore J Launer Karin Leander Guo Li Lars Lind Jaana Lindstrom Stéphane Lobbens Ruth J F Loos Jian'an Luan Valeriya Lyssenko Reedik Mägi Patrik K E Magnusson Michael Marmot Pierre Meneton Karen L Mohlke Vincent Mooser Mario A Morken Iva Miljkovic Narisu Narisu Jeff O'Connell Ken K Ong Ben A Oostra Lyle J Palmer Aarno Palotie James S Pankow John F Peden Nancy L Pedersen Marina Pehlic Leena Peltonen Brenda Penninx Marijana Pericic Markus Perola Louis Perusse Patricia A Peyser Ozren Polasek Peter P Pramstaller Michael A Province Katri Räikkönen Rainer Rauramaa Emil Rehnberg Ken Rice Jerome I Rotter Igor Rudan Aimo Ruokonen Timo Saaristo Maria Sabater-Lleal Veikko Salomaa David B Savage Richa Saxena Peter Schwarz Udo Seedorf Bengt Sennblad Manuel Serrano-Rios Alan R Shuldiner Eric J G Sijbrands David S Siscovick Johannes H Smit Kerrin S Small Nicholas L Smith Albert Vernon Smith Alena Stančáková Kathleen Stirrups Michael Stumvoll Yan V Sun Amy J Swift Anke Tönjes Jaakko Tuomilehto Stella Trompet Andre G Uitterlinden Matti Uusitupa Max Vikström Veronique Vitart Marie-Claude Vohl Benjamin F Voight Peter Vollenweider Gerard Waeber Dawn M Waterworth Hugh Watkins Eleanor Wheeler Elisabeth Widen Sarah H Wild Sara M Willems Gonneke Willemsen James F Wilson Jacqueline C M Witteman Alan F Wright Hanieh Yaghootkar Diana Zelenika Tatijana Zemunik Lina Zgaga Nicholas J Wareham Mark I McCarthy Ines Barroso Richard M Watanabe Jose C Florez Josée Dupuis James B Meigs Claudia Langenberg

Nat Genet 2012 May 13;44(6):659-69. Epub 2012 May 13.

Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.2274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613127PMC
May 2012

Metabolic insights from extreme human insulin resistance phenotypes.

Best Pract Res Clin Endocrinol Metab 2012 Apr;26(2):145-57

Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, University of Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.beem.2011.09.003DOI Listing
April 2012

Mitochondrial oxidative phosphorylation is impaired in patients with congenital lipodystrophy.

J Clin Endocrinol Metab 2012 Mar 11;97(3):E438-42. Epub 2012 Jan 11.

Wolfson Brain Imaging Centre, Metabolic Research Laboratories and National Institute for Health Research Cambridge Biomedical Research Centre, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2011-2587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380089PMC
March 2012

Human frame shift mutations affecting the carboxyl terminus of perilipin increase lipolysis by failing to sequester the adipose triglyceride lipase (ATGL) coactivator AB-hydrolase-containing 5 (ABHD5).

J Biol Chem 2011 Oct 12;286(40):34998-5006. Epub 2011 Jul 12.

Institute of Metabolic Science Metabolic Research Laboratories and the Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M111.278853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186430PMC
October 2011

Genetic syndromes of severe insulin resistance.

Endocr Rev 2011 Aug 2;32(4):498-514. Epub 2011 May 2.

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/er.2010-0020DOI Listing
August 2011

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

Authors:
Tuomas O Kilpeläinen M Carola Zillikens Alena Stančákova Francis M Finucane Janina S Ried Claudia Langenberg Weihua Zhang Jacques S Beckmann Jian'an Luan Liesbeth Vandenput Unnur Styrkarsdottir Yanhua Zhou Albert Vernon Smith Jing-Hua Zhao Najaf Amin Sailaja Vedantam So-Youn Shin Talin Haritunians Mao Fu Mary F Feitosa Meena Kumari Bjarni V Halldorsson Emmi Tikkanen Massimo Mangino Caroline Hayward Ci Song Alice M Arnold Yurii S Aulchenko Ben A Oostra Harry Campbell L Adrienne Cupples Kathryn E Davis Angela Döring Gudny Eiriksdottir Karol Estrada José Manuel Fernández-Real Melissa Garcia Christian Gieger Nicole L Glazer Candace Guiducci Albert Hofman Steve E Humphries Bo Isomaa Leonie C Jacobs Antti Jula David Karasik Magnus K Karlsson Kay-Tee Khaw Lauren J Kim Mika Kivimäki Norman Klopp Brigitte Kühnel Johanna Kuusisto Yongmei Liu Osten Ljunggren Mattias Lorentzon Robert N Luben Barbara McKnight Dan Mellström Braxton D Mitchell Vincent Mooser José Maria Moreno Satu Männistö Jeffery R O'Connell Laura Pascoe Leena Peltonen Belén Peral Markus Perola Bruce M Psaty Veikko Salomaa David B Savage Robert K Semple Tatjana Skaric-Juric Gunnar Sigurdsson Kijoung S Song Timothy D Spector Ann-Christine Syvänen Philippa J Talmud Gudmar Thorleifsson Unnur Thorsteinsdottir André G Uitterlinden Cornelia M van Duijn Antonio Vidal-Puig Sarah H Wild Alan F Wright Deborah J Clegg Eric Schadt James F Wilson Igor Rudan Samuli Ripatti Ingrid B Borecki Alan R Shuldiner Erik Ingelsson John-Olov Jansson Robert C Kaplan Vilmundur Gudnason Tamara B Harris Leif Groop Douglas P Kiel Fernando Rivadeneira Mark Walker Inês Barroso Peter Vollenweider Gérard Waeber John C Chambers Jaspal S Kooner Nicole Soranzo Joel N Hirschhorn Kari Stefansson H-Erich Wichmann Claes Ohlsson Stephen O'Rahilly Nicholas J Wareham Elizabeth K Speliotes Caroline S Fox Markku Laakso Ruth J F Loos

Nat Genet 2011 Jun 26;43(8):753-60. Epub 2011 Jun 26.

Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262230PMC
June 2011

An amino acid profile to predict diabetes?

Nat Med 2011 Apr;17(4):418-20

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nm0411-418DOI Listing
April 2011

Congenital syndromes of severe insulin resistance.

Pediatr Endocrinol Rev 2011 Mar;8(3):190-9

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, UK.

View Article

Download full-text PDF

Source
March 2011

Lipodystrophy: metabolic insights from a rare disorder.

J Endocrinol 2010 Dec 24;207(3):245-55. Epub 2010 Sep 24.

Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1677/JOE-10-0272DOI Listing
December 2010

Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance.

Curr Opin Lipidol 2010 Aug;21(4):329-36

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/co-lipidology/2010/08000/Recent
Web Search
http://dx.doi.org/10.1097/MOL.0b013e32833b7782DOI Listing
August 2010

Mouse models of inherited lipodystrophy.

Authors:
David B Savage

Dis Model Mech 2009 Nov-Dec;2(11-12):554-62

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dmm.002907DOI Listing
February 2010

Sex hormone-binding globulin and risk of type 2 diabetes.

N Engl J Med 2009 Dec;361(27):2677; author reply 2677-8

View Article

Download full-text PDF

Source
December 2009

Complement abnormalities in acquired lipodystrophy revisited.

J Clin Endocrinol Metab 2009 Jan 14;94(1):10-6. Epub 2008 Oct 14.

Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2008-1703DOI Listing
January 2009

Fatty acid metabolism in patients with PPARgamma mutations.

J Clin Endocrinol Metab 2008 Nov 19;93(11):4462-70. Epub 2008 Aug 19.

Oxford Centre for Diabetes, Endocrinology, and Metabolism, Oxford OX3 7LJ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2007-2356DOI Listing
November 2008

Plasma adiponectin as a marker of insulin receptor dysfunction: clinical utility in severe insulin resistance.

Diabetes Care 2008 May 25;31(5):977-9. Epub 2008 Feb 25.

Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/dc07-2194DOI Listing
May 2008

A clinical approach to severe insulin resistance.

Endocr Dev 2007 ;11:122-132

Departments of Clinical Biochemistry and Medicine, University of Cambridge, Cambridge,UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000111067DOI Listing
February 2008

Disordered lipid metabolism and the pathogenesis of insulin resistance.

Physiol Rev 2007 Apr;87(2):507-20

Department of Internal Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536-8012, USA.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/physrev.00024.2006
Publisher Site
http://dx.doi.org/10.1152/physrev.00024.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995548PMC
April 2007

Mechanisms of insulin resistance in humans and possible links with inflammation.

Hypertension 2005 May 11;45(5):828-33. Epub 2005 Apr 11.

Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn 06510, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/01.HYP.0000163475.04421.e4DOI Listing
May 2005

Energy expenditure and adaptive responses to an acute hypercaloric fat load in humans with lipodystrophy.

J Clin Endocrinol Metab 2005 Mar 21;90(3):1446-52. Epub 2004 Dec 21.

Department of Clinical Biochemistry and Medicine, Level 4, Box 232, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 2QQ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2004-1494DOI Listing
March 2005

PPAR gamma as a metabolic regulator: insights from genomics and pharmacology.

Authors:
David B Savage

Expert Rev Mol Med 2005 Jan 25;7(1):1-16. Epub 2005 Jan 25.

Department of Medicine, University of Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S1462399405008793DOI Listing
January 2005

The metabolic syndrome: peroxisome proliferator-activated receptor gamma and its therapeutic modulation.

J Clin Endocrinol Metab 2003 Jun;88(6):2412-21

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2003-030435DOI Listing
June 2003