Publications by authors named "David B Savage"

89Publications

Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance.

Authors:
Anthony P Coll Michael Chen Pranali Taskar Debra Rimmington Satish Patel John A Tadross Irene Cimino Ming Yang Paul Welsh Samuel Virtue Deborah A Goldspink Emily L Miedzybrodzka Adam R Konopka Raul Ruiz Esponda Jeffrey T-J Huang Y C Loraine Tung Sergio Rodriguez-Cuenca Rute A Tomaz Heather P Harding Audrey Melvin Giles S H Yeo David Preiss Antonio Vidal-Puig Ludovic Vallier K Sreekumaran Nair Nicholas J Wareham David Ron Fiona M Gribble Frank Reimann Naveed Sattar David B Savage Bernard B Allan Stephen O'Rahilly

Nature 2020 Feb;578(7796):E24

MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

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February 2020

European lipodystrophy registry: background and structure.

Authors:
Julia von Schnurbein Claire Adams Baris Akinci Giovanni Ceccarini Maria Rosaria D'Apice Alessandra Gambineri Raoul C M Hennekam Isabelle Jeru Giovanna Lattanzi Konstanze Miehle Gabriele Nagel Giuseppe Novelli Ferruccio Santini Ermelinda Santos Silva David B Savage Paolo Sbraccia Jannik Schaaf Ekaterina Sorkina George Tanteles Marie-Christine Vantyghem Camille Vatier Corinne Vigouroux Elena Vorona David Araújo-Vilar Martin Wabitsch

Orphanet J Rare Dis 2020 01 15;15(1):17. Epub 2020 Jan 15.

Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics and Adolescent Medicine, Centre for Rare Endocrine Disorders, Ulm University Medical Centre, Eythstraße 24, 89075, Ulm, Germany.

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January 2020

GDF15 mediates the effects of metformin on body weight and energy balance.

Authors:
Anthony P Coll Michael Chen Pranali Taskar Debra Rimmington Satish Patel John A Tadross Irene Cimino Ming Yang Paul Welsh Samuel Virtue Deborah A Goldspink Emily L Miedzybrodzka Adam R Konopka Raul Ruiz Esponda Jeffrey T-J Huang Y C Loraine Tung Sergio Rodriguez-Cuenca Rute A Tomaz Heather P Harding Audrey Melvin Giles S H Yeo David Preiss Antonio Vidal-Puig Ludovic Vallier K Sreekumaran Nair Nicholas J Wareham David Ron Fiona M Gribble Frank Reimann Naveed Sattar David B Savage Bernard B Allan Stephen O'Rahilly

Nature 2020 02 25;578(7795):444-448. Epub 2019 Dec 25.

MRC Metabolic Diseases Unit, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

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February 2020

Diagnostic Challenge in PLIN1-Associated Familial Partial Lipodystrophy.

Authors:
Isabelle Jéru Marie-Christine Vantyghem Elise Bismuth Pascale Cervera Sara Barraud Martine Auclair Camille Vatier Olivier Lascols David B Savage Corinne Vigouroux

J Clin Endocrinol Metab 2019 12;104(12):6025-6032

Sorbonne University, Inserm U938, Saint-Antoine Research Centre and Institute of CardioMetabolism and Nutrition, Paris, France.

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December 2019

Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization.

Authors:
Antonio D Barbosa Koini Lim Muriel Mari James R Edgar Lihi Gal Peter Sterk Benjamin J Jenkins Albert Koulman David B Savage Maya Schuldiner Fulvio Reggiori Philip A Wigge Symeon Siniossoglou

Dev Cell 2019 09 15;50(6):755-766.e6. Epub 2019 Aug 15.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK. Electronic address:

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September 2019

What lipodystrophies teach us about the metabolic syndrome.

Authors:
Jake P Mann David B Savage

J Clin Invest 2019 08 5;129(10):4009-4021. Epub 2019 Aug 5.

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August 2019

Recent developments in lipodystrophy.

Authors:
Audrey Melvin Anna Stears David B Savage

Curr Opin Lipidol 2019 08;30(4):284-290

Metabolic Research Laboratories, Wellcome Trust - MRC Institute of Metabolic Science, University of Cambridge.

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August 2019

Accumulation of saturated intramyocellular lipid is associated with insulin resistance.

Authors:
David B Savage Laura Watson Katie Carr Claire Adams Soren Brage Krishna K Chatterjee Leanne Hodson Chris Boesch Graham J Kemp Alison Sleigh

J Lipid Res 2019 07 2;60(7):1323-1332. Epub 2019 May 2.

Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, United Kingdom

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July 2019

Lipase tug of war: PNPLA3 sequesters ABHD5 from ATGL.

Authors:
Stefano Romeo David B Savage

Nat Metab 2019 05;1(5):505-506

Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.

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May 2019

Long-term effectiveness and safety of metreleptin in the treatment of patients with partial lipodystrophy.

Authors:
Elif A Oral Phillip Gorden Elaine Cochran David Araújo-Vilar David B Savage Alison Long Gregory Fine Taylor Salinardi Rebecca J Brown

Endocrine 2019 06 25;64(3):500-511. Epub 2019 Feb 25.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

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June 2019

Dual binding motifs underpin the hierarchical association of perilipins1-3 with lipid droplets.

Authors:
Dalila Ajjaji Kalthoum Ben M'barek Michael L Mimmack Cheryl England Haya Herscovitz Liang Dong Richard G Kay Satish Patel Vladimir Saudek Donald M Small David B Savage Abdou Rachid Thiam

Mol Biol Cell 2019 03 16;30(5):703-716. Epub 2019 Jan 16.

Laboratoire de Physique de l'Ecole Normale Supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris-Diderot, Sorbonne Paris Cité, Paris, France.

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March 2019

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.

Authors:
Satish Patel Anna Alvarez-Guaita Audrey Melvin Debra Rimmington Alessia Dattilo Emily L Miedzybrodzka Irene Cimino Anne-Catherine Maurin Geoffrey P Roberts Claire L Meek Samuel Virtue Lauren M Sparks Stephanie A Parsons Leanne M Redman George A Bray Alice P Liou Rachel M Woods Sion A Parry Per B Jeppesen Anders J Kolnes Heather P Harding David Ron Antonio Vidal-Puig Frank Reimann Fiona M Gribble Carl J Hulston I Sadaf Farooqi Pierre Fafournoux Steven R Smith Jorgen Jensen Danna Breen Zhidan Wu Bei B Zhang Anthony P Coll David B Savage Stephen O'Rahilly

Cell Metab 2019 03 10;29(3):707-718.e8. Epub 2019 Jan 10.

Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address:

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March 2019

Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.

Authors:
Luca A Lotta Laura B L Wittemans Verena Zuber Isobel D Stewart Stephen J Sharp Jian'an Luan Felix R Day Chen Li Nicholas Bowker Lina Cai Emanuella De Lucia Rolfe Kay-Tee Khaw John R B Perry Stephen O'Rahilly Robert A Scott David B Savage Stephen Burgess Nicholas J Wareham Claudia Langenberg

JAMA 2018 12;320(24):2553-2563

MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.

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December 2018

European paediatric non-alcoholic fatty liver disease registry (EU-PNAFLD): Design and rationale.

Authors:
Jake P Mann Anita Vreugdenhil Piotr Socha Wojciech Jańczyk Ulrich Baumann Sanjay Rajwal Thomas Casswall Claude Marcus Indra van Mourik Stephen O'Rahilly David B Savage Gabriele Noble-Jamieson Florence Lacaille Myriam Dabbas Béatrice Dubern Deirdre A Kelly Valerio Nobili Quentin M Anstee

Contemp Clin Trials 2018 12 5;75:67-71. Epub 2018 Nov 5.

Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, United Kingdom; Liver Unit, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Newcastle upon Tyne, United Kingdom.

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December 2018

Association of Genetically Enhanced Lipoprotein Lipase-Mediated Lipolysis and Low-Density Lipoprotein Cholesterol-Lowering Alleles With Risk of Coronary Disease and Type 2 Diabetes.

Authors:
Luca A Lotta Isobel D Stewart Stephen J Sharp Felix R Day Stephen Burgess Jian'an Luan Nicholas Bowker Lina Cai Chen Li Laura B L Wittemans Nicola D Kerrison Kay-Tee Khaw Mark I McCarthy Stephen O'Rahilly Robert A Scott David B Savage John R B Perry Claudia Langenberg Nicholas J Wareham

JAMA Cardiol 2018 10;3(10):957-966

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.

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October 2018

PLIN1 Haploinsufficiency Is Not Associated With Lipodystrophy.

Authors:
Thomas W Laver Kashyap A Patel Kevin Colclough Jacqueline Curran Jane Dale Nikki Davis David B Savage Sarah E Flanagan Sian Ellard Andrew T Hattersley Michael N Weedon

J Clin Endocrinol Metab 2018 09;103(9):3225-3230

Institute of Biomedical & Clinical Science, University of Exeter, Exeter, United Kingdom.

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September 2018

Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice.

Authors:
Amandine Girousse Samuel Virtue Dan Hart Antonio Vidal-Puig Peter R Murgatroyd Etienne Mouisel Coralie Sengenès David B Savage

Mol Metab 2018 07 16;13:24-29. Epub 2018 May 16.

University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Cambridge, CB2 0QQ, United Kingdom. Electronic address:

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July 2018

PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress.

Authors:
Afreen Haider Yu-Chen Wei Koini Lim Antonio D Barbosa Che-Hsiung Liu Ursula Weber Marek Mlodzik Kadri Oras Simon Collier M Mahmood Hussain Liang Dong Satish Patel Anna Alvarez-Guaita Vladimir Saudek Benjamin J Jenkins Albert Koulman Marcus K Dymond Roger C Hardie Symeon Siniossoglou David B Savage

Dev Cell 2018 05 10;45(4):481-495.e8. Epub 2018 May 10.

Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address:

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May 2018

Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy.

Authors:
Rebecca J Brown Elif A Oral Elaine Cochran David Araújo-Vilar David B Savage Alison Long Gregory Fine Taylor Salinardi Phillip Gorden

Endocrine 2018 06 12;60(3):479-489. Epub 2018 Apr 12.

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.

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June 2018

A Pharmacogenetic Approach to the Treatment of Patients With Mutations.

Authors:
Maura Agostini Erik Schoenmakers Junaid Beig Louise Fairall Istvan Szatmari Odelia Rajanayagam Frederick W Muskett Claire Adams A David Marais Stephen O'Rahilly Robert K Semple Laszlo Nagy Amit R Majithia John W R Schwabe Dirk J Blom Rinki Murphy Krishna Chatterjee David B Savage

Diabetes 2018 06 5;67(6):1086-1092. Epub 2018 Apr 5.

The University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, U.K.

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June 2018