David A van Heel

David A van Heel

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David A van Heel

David A van Heel

Publications by authors named "David A van Heel"

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Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.

Authors:
Philip C Haycock Stephen Burgess Aayah Nounu Jie Zheng George N Okoli Jack Bowden Kaitlin Hazel Wade Nicholas J Timpson David M Evans Peter Willeit Abraham Aviv Tom R Gaunt Gibran Hemani Massimo Mangino Hayley Patricia Ellis Kathreena M Kurian Karen A Pooley Rosalind A Eeles Jeffrey E Lee Shenying Fang Wei V Chen Matthew H Law Lisa M Bowdler Mark M Iles Qiong Yang Bradford B Worrall Hugh Stephen Markus Rayjean J Hung Chris I Amos Amanda B Spurdle Deborah J Thompson Tracy A O'Mara Brian Wolpin Laufey Amundadottir Rachael Stolzenberg-Solomon Antonia Trichopoulou N Charlotte Onland-Moret Eiliv Lund Eric J Duell Federico Canzian Gianluca Severi Kim Overvad Marc J Gunter Rosario Tumino Ulrika Svenson Andre van Rij Annette F Baas Matthew J Bown Nilesh J Samani Femke N G van t'Hof Gerard Tromp Gregory T Jones Helena Kuivaniemi James R Elmore Mattias Johansson James Mckay Ghislaine Scelo Robert Carreras-Torres Valerie Gaborieau Paul Brennan Paige M Bracci Rachel E Neale Sara H Olson Steven Gallinger Donghui Li Gloria M Petersen Harvey A Risch Alison P Klein Jiali Han Christian C Abnet Neal D Freedman Philip R Taylor John M Maris Katja K Aben Lambertus A Kiemeney Sita H Vermeulen John K Wiencke Kyle M Walsh Margaret Wrensch Terri Rice Clare Turnbull Kevin Litchfield Lavinia Paternoster Marie Standl Gonçalo R Abecasis John Paul SanGiovanni Yong Li Vladan Mijatovic Yadav Sapkota Siew-Kee Low Krina T Zondervan Grant W Montgomery Dale R Nyholt David A van Heel Karen Hunt Dan E Arking Foram N Ashar Nona Sotoodehnia Daniel Woo Jonathan Rosand Mary E Comeau W Mark Brown Edwin K Silverman John E Hokanson Michael H Cho Jennie Hui Manuel A Ferreira Philip J Thompson Alanna C Morrison Janine F Felix Nicholas L Smith Angela M Christiano Lynn Petukhova Regina C Betz Xing Fan Xuejun Zhang Caihong Zhu Carl D Langefeld Susan D Thompson Feijie Wang Xu Lin David A Schwartz Tasha Fingerlin Jerome I Rotter Mary Frances Cotch Richard A Jensen Matthias Munz Henrik Dommisch Arne S Schaefer Fang Han Hanna M Ollila Ryan P Hillary Omar Albagha Stuart H Ralston Chenjie Zeng Wei Zheng Xiao-Ou Shu Andre Reis Steffen Uebe Ulrike Hüffmeier Yoshiya Kawamura Takeshi Otowa Tsukasa Sasaki Martin Lloyd Hibberd Sonia Davila Gang Xie Katherine Siminovitch Jin-Xin Bei Yi-Xin Zeng Asta Försti Bowang Chen Stefano Landi Andre Franke Annegret Fischer David Ellinghaus Carlos Flores Imre Noth Shwu-Fan Ma Jia Nee Foo Jianjun Liu Jong-Won Kim David G Cox Olivier Delattre Olivier Mirabeau Christine F Skibola Clara S Tang Merce Garcia-Barcelo Kai-Ping Chang Wen-Hui Su Yu-Sun Chang Nicholas G Martin Scott Gordon Tracey D Wade Chaeyoung Lee Michiaki Kubo Pei-Chieng Cha Yusuke Nakamura Daniel Levy Masayuki Kimura Shih-Jen Hwang Steven Hunt Tim Spector Nicole Soranzo Ani W Manichaikul R Graham Barr Bratati Kahali Elizabeth Speliotes Laura M Yerges-Armstrong Ching-Yu Cheng Jost B Jonas Tien Yin Wong Isabella Fogh Kuang Lin John F Powell Kenneth Rice Caroline L Relton Richard M Martin George Davey Smith

JAMA Oncol 2017 May;3(5):636-651

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England2School of Social and Community Medicine, University of Bristol, Bristol, England.

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http://dx.doi.org/10.1001/jamaoncol.2016.5945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638008PMC
May 2017

DNAJC21 Mutations Link a Cancer-Prone Bone Marrow Failure Syndrome to Corruption in 60S Ribosome Subunit Maturation.

Am J Hum Genet 2016 07 23;99(1):115-24. Epub 2016 Jun 23.

Centre for Genomics and Child Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005432PMC
July 2016

Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease.

Nat Genet 2015 Jun 20;47(6):577-8. Epub 2015 Apr 20.

1] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands. [2] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://www.nature.com/articles/ng.3268
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http://dx.doi.org/10.1038/ng.3268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449296PMC
June 2015

Genetic insights into common pathways and complex relationships among immune-mediated diseases.

Nat Rev Genet 2013 Sep 6;14(9):661-73. Epub 2013 Aug 6.

1] Inflammatory Bowel Disease Research Group, Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, UK. [2].

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http://www.nature.com/articles/nrg3502
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http://dx.doi.org/10.1038/nrg3502DOI Listing
September 2013

Comparative methylomics reveals gene-body H3K36me3 in Drosophila predicts DNA methylation and CpG landscapes in other invertebrates.

Genome Res 2011 Nov 22;21(11):1841-50. Epub 2011 Sep 22.

The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, United Kingdom.

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http://dx.doi.org/10.1101/gr.121640.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205569PMC
November 2011

Inflammatory skin and bowel disease linked to ADAM17 deletion.

N Engl J Med 2011 Oct;365(16):1502-8

Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

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http://dx.doi.org/10.1056/NEJMoa1100721DOI Listing
October 2011

A genetic perspective on coeliac disease.

Trends Mol Med 2010 Nov 12;16(11):537-50. Epub 2010 Oct 12.

Department of Genetics, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1016/j.molmed.2010.09.003DOI Listing
November 2010

Multiple common variants for celiac disease influencing immune gene expression.

Nat Genet 2010 Apr 28;42(4):295-302. Epub 2010 Feb 28.

Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1038/ng.543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847618PMC
April 2010

Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing.

Hum Mol Genet 2010 Jan;19(1):122-34

Centre for Digestive Diseases, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1093/hmg/ddp473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792152PMC
January 2010

Genetics and pathogenesis of coeliac disease.

Semin Immunol 2009 Dec 13;21(6):346-54. Epub 2009 May 13.

Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London E1 2AT, United Kingdom.

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http://dx.doi.org/10.1016/j.smim.2009.04.001DOI Listing
December 2009

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.

Nat Genet 2009 Nov 11;41(11):1182-90. Epub 2009 Oct 11.

Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108459PMC
November 2009

Analysis of HLA and non-HLA alleles can identify individuals at high risk for celiac disease.

Gastroenterology 2009 Sep 18;137(3):834-40, 840.e1-3. Epub 2009 May 18.

Department of Genetics, University Medical Centre of Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2009.05.040DOI Listing
September 2009

The genetics of chronic inflammatory diseases.

Hum Mol Genet 2009 Apr;18(R1):R101-6

Centre for Gastroenterology, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London, UK.

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http://dx.doi.org/10.1093/hmg/ddp001DOI Listing
April 2009

Recent advances in coeliac disease genetics.

Gut 2009 Apr;58(4):473-6

Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, 4 Newark St, Whitechapel, London E1 2AT, UK.

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http://dx.doi.org/10.1136/gut.2008.155879DOI Listing
April 2009

Shared and distinct genetic variants in type 1 diabetes and celiac disease.

N Engl J Med 2008 Dec 10;359(26):2767-77. Epub 2008 Dec 10.

Juvenile Diabetes Research Foundation-Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://www.nejm.org/doi/abs/10.1056/NEJMoa0807917
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http://dx.doi.org/10.1056/NEJMoa0807917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840835PMC
December 2008

New susceptibility genes for ulcerative colitis.

Nat Genet 2008 Jun;40(6):686-8

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http://dx.doi.org/10.1038/ng0608-686DOI Listing
June 2008

NOD2 activity modulates the phenotype of LPS-stimulated dendritic cells to promote the development of T-helper type 2-like lymphocytes - Possible implications for NOD2-associated Crohn's disease.

J Crohns Colitis 2007 Dec 27;1(2):106-15. Epub 2007 Sep 27.

Department of Gastroenterology, Imperial College London, Faculty of Medicine, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1016/j.crohns.2007.08.006DOI Listing
December 2007

Human pancreatic secretory trypsin inhibitor stabilizes intestinal mucosa against noxious agents.

Am J Pathol 2007 Nov;171(5):1462-73

Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts and The London School of Medicine, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.2353/ajpath.2007.070192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043508PMC
November 2007

A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease.

Immunity 2007 Jul 12;27(1):23-34. Epub 2007 Jul 12.

The Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia.

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http://dx.doi.org/10.1016/j.immuni.2007.05.015DOI Listing
July 2007

Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo.

Am J Respir Crit Care Med 2007 Mar 18;175(6):595-603. Epub 2007 Jan 18.

Department of Critical Care, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK.

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http://dx.doi.org/10.1164/rccm.200608-1103OCDOI Listing
March 2007

TUCAN (CARD8) genetic variants and inflammatory bowel disease.

Gastroenterology 2006 Oct 5;131(4):1190-6. Epub 2006 Aug 5.

Wellcome Trust Centre for Human Genetics, University of Oxford, Drive, Headington, Oxford OX3 7BN, England, UK.

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http://dx.doi.org/10.1053/j.gastro.2006.08.008DOI Listing
October 2006

Detection of muramyl dipeptide-sensing pathway defects in patients with Crohn's disease.

Inflamm Bowel Dis 2006 Jul;12(7):598-605

Institute of Cell and Molecular Science, Barts & The London, Queen Mary's School of Medicine & Dentistry, London, UK.

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http://dx.doi.org/10.1097/01.ibd.0000225344.21979.89DOI Listing
July 2006

Modulation of dendritic cell phenotype and function in an in vitro model of the intestinal epithelium.

Eur J Immunol 2006 Apr;36(4):864-74

Department of Gastroenterology, Imperial College London Faculty of Medicine, London, UK.

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http://dx.doi.org/10.1002/eji.200535497DOI Listing
April 2006

Synergistic enhancement of Toll-like receptor responses by NOD1 activation.

Eur J Immunol 2005 Aug;35(8):2471-6

Intestinal Inflammation and Repair Group, Department of Gastroenterology, Imperial College London Hammersmith Campus, London, UK.

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http://dx.doi.org/10.1002/eji.200526296DOI Listing
August 2005

Genetics in coeliac disease.

Best Pract Res Clin Gastroenterol 2005 Jun;19(3):323-39

Department of Gastroenterology, Imperial College London, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1016/j.bpg.2005.01.001DOI Listing
June 2005

Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease.

Hum Mol Genet 2005 May 24;14(10):1245-50. Epub 2005 Mar 24.

Thw Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, UK.

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http://dx.doi.org/10.1093/hmg/ddi135DOI Listing
May 2005

A common CTLA4 haplotype associated with coeliac disease.

Eur J Hum Genet 2005 Apr;13(4):440-4

Department of Gastroenterology, Imperial College London, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1038/sj.ejhg.5201357DOI Listing
April 2005

Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs.

Hum Mol Genet 2004 Apr 19;13(7):763-70. Epub 2004 Feb 19.

Department of Gastoenterology, Imperial College London, UK.

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http://dx.doi.org/10.1093/hmg/ddh090DOI Listing
April 2004

The IBD6 Crohn's disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants.

Hum Mol Genet 2003 Oct 19;12(20):2569-75. Epub 2003 Aug 19.

Wellcome Trust Centre for Human Genetics and Gastoenterology Unit, University of Oxford, UK.

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http://dx.doi.org/10.1093/hmg/ddg281DOI Listing
October 2003

Role of NOD2 variants in spondylarthritis.

Arthritis Rheum 2002 Jun;46(6):1629-33

Spondylitis and Bone Disease Research Group, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington OX3 7BN, Oxford, UK.

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http://dx.doi.org/10.1002/art.10329DOI Listing
June 2002