David A Tuveson

David A Tuveson

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David A Tuveson

Publications by authors named "David A Tuveson"

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Perspectives on the role of Wnt biology in cancer.

Sci Signal 2019 Jul 9;12(589). Epub 2019 Jul 9.

Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

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http://dx.doi.org/10.1126/scisignal.aay4494DOI Listing
July 2019

Generation and Culture of Human Pancreatic Ductal Adenocarcinoma Organoids from Resected Tumor Specimens.

Methods Mol Biol 2019 ;1882:97-115

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

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http://link.springer.com/10.1007/978-1-4939-8879-2_9
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http://dx.doi.org/10.1007/978-1-4939-8879-2_9DOI Listing
June 2019

Generation and Culture of Tumor and Metastatic Organoids from Murine Models of Pancreatic Ductal Adenocarcinoma.

Methods Mol Biol 2019 ;1882:117-133

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

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http://dx.doi.org/10.1007/978-1-4939-8879-2_10DOI Listing
June 2019

A FATal Combination: Fibroblast-Derived Lipids and Cancer-Derived Autotaxin Promote Pancreatic Cancer Growth.

Cancer Discov 2019 May;9(5):578-580

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-19-0273DOI Listing
May 2019

Organoid models for translational pancreatic cancer research.

Curr Opin Genet Dev 2019 Mar 4;54:7-11. Epub 2019 Mar 4.

Cold Spring Harbor Laboratory, NCI-designated Cancer Center, 1 Bungtown Rd., Cold Spring Harbor, NY 11724, United States. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2019.02.003DOI Listing
March 2019

Stromal biology and therapy in pancreatic cancer: ready for clinical translation?

Gut 2019 01 3;68(1):159-171. Epub 2018 Sep 3.

Department of Gastroenterology, Endocrinology, Metabolism and Infectiology, University Hospital Marburg, UKGM, Philipps University Marburg, Marburg, Germany.

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2018-316451
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http://dx.doi.org/10.1136/gutjnl-2018-316451DOI Listing
January 2019

Transcriptional Regulation by Nrf2.

Antioxid Redox Signal 2018 12 20;29(17):1727-1745. Epub 2017 Oct 20.

1 Cold Spring Harbor Laboratory , Cold Spring Harbor, New York.

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http://dx.doi.org/10.1089/ars.2017.7342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208165PMC
December 2018

Deciphering cancer fibroblasts.

J Exp Med 2018 Dec 23;215(12):2967-2968. Epub 2018 Nov 23.

Cancer Center at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

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http://www.jem.org/lookup/doi/10.1084/jem.20182069
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http://dx.doi.org/10.1084/jem.20182069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279394PMC
December 2018

Challenges and Opportunities in Modeling Pancreatic Cancer.

Cold Spring Harb Symp Quant Biol 2016 13;81:231-235. Epub 2017 Mar 13.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.

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http://dx.doi.org/10.1101/sqb.2016.81.031104DOI Listing
February 2018

Soils and Seeds That Initiate Pancreatic Cancer Metastasis.

Cancer Discov 2017 10;7(10):1067-1068

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0887DOI Listing
October 2017

Quid pro Quo: A Tumor is Not Alone.

Trends Mol Med 2017 05 10;23(5):375-376. Epub 2017 Apr 10.

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http://dx.doi.org/10.1016/j.molmed.2017.03.007DOI Listing
May 2017

ROS in Cancer: The Burning Question.

Trends Mol Med 2017 05 17;23(5):411-429. Epub 2017 Apr 17.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2017.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462452PMC
May 2017

ROS in translation: Chink in the armor.

Cell Cycle 2017 02 16;16(4):297-298. Epub 2016 Sep 16.

a Cold Spring Harbor Laboratory , Cold Spring Harbor , NY , USA.

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http://dx.doi.org/10.1080/15384101.2016.1232087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388435PMC
February 2017

Cancer: Double trouble for tumours.

Nature 2017 02 18;542(7639):34-35. Epub 2017 Jan 18.

Cancer Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

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http://dx.doi.org/10.1038/nature21117DOI Listing
February 2017

Untangling the genetics from the epigenetics in pancreatic cancer metastasis.

Nat Genet 2017 Feb;49(3):323-324

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

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http://dx.doi.org/10.1038/ng.3798DOI Listing
February 2017

Modeling pancreatic cancer with organoids.

Trends Cancer 2016 Apr;2(4):176-190

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Lustgarten Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724, USA; Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S24058033160004
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http://dx.doi.org/10.1016/j.trecan.2016.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847151PMC
April 2016

Pancreatic cancer.

Nat Rev Dis Primers 2016 04 21;2:16022. Epub 2016 Apr 21.

NIHR Pancreas Biomedical Research Unit, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Duncan Building, Daulby Street, Liverpool L69 3GA, UK.

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http://dx.doi.org/10.1038/nrdp.2016.22DOI Listing
April 2016

Preclinical models of pancreatic ductal adenocarcinoma.

J Pathol 2016 Jan 14;238(2):197-204. Epub 2015 Nov 14.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

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http://dx.doi.org/10.1002/path.4651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700534PMC
January 2016

Model organoids provide new research opportunities for ductal pancreatic cancer.

Mol Cell Oncol 2016 Jan 23;3(1):e1014757. Epub 2015 Feb 23.

Hubrecht Institute; Royal Netherlands Academy of Arts and Sciences (KNAW); University Medical Center Utrecht and Cancer Genomics ; Utrecht, the Netherlands.

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http://dx.doi.org/10.1080/23723556.2015.1014757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845167PMC
January 2016

Stromal biology and therapy in pancreatic cancer: a changing paradigm.

Gut 2015 Sep 20;64(9):1476-84. Epub 2015 May 20.

Department of Gastroenterology, Endocrinology, Infectiology and Metabolism, Philipps-University, Marburg, Germany.

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http://dx.doi.org/10.1136/gutjnl-2015-309304DOI Listing
September 2015

Mouse Models of Pancreatic Ductal Adenocarcinoma.

Hematol Oncol Clin North Am 2015 Aug 11;29(4):609-17. Epub 2015 Jun 11.

Cancer Biology, Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA; Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Medical College, Cornell University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.hoc.2015.04.010DOI Listing
August 2015

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1.

Cell 2015 Jul 2;162(2):259-270. Epub 2015 Jul 2.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506698PMC
July 2015

Identification of novel vascular projections with cellular trafficking abilities on the microvasculature of pancreatic ductal adenocarcinoma.

J Pathol 2015 Jun 17;236(2):142-154. Epub 2015 Feb 17.

State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200433, People's Republic of China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089710PMC
http://dx.doi.org/10.1002/path.4506DOI Listing
June 2015

A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules.

Sci Rep 2015 Jun 5;5:11061. Epub 2015 Jun 5.

Department of Oncology, University of Cambridge, CRUK Cambridge institute, Cambridge, CB2 0RE, UK.

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http://dx.doi.org/10.1038/srep11061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457145PMC
June 2015

p53 mutations change phosphatidylinositol acyl chain composition.

Cell Rep 2015 Jan 24;10(1):8-19. Epub 2014 Dec 24.

Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287966PMC
January 2015

ADAM8 as a drug target in pancreatic cancer.

Nat Commun 2015 Jan 28;6:6175. Epub 2015 Jan 28.

1] King's College London, Institute for Pharmaceutical Science and KCLDI, London SE1 9RT, UK [2] Department of Neurosurgery, Marburg University, , Baldingerstrasse, 35033 Marburg, Germany.

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http://dx.doi.org/10.1038/ncomms7175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014123PMC
January 2015

The RAS and YAP1 dance, who is leading?

EMBO J 2014 Nov 25;33(21):2437-8. Epub 2014 Sep 25.

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

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http://dx.doi.org/10.15252/embj.201490014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283400PMC
November 2014

The promise and perils of antioxidants for cancer patients.

N Engl J Med 2014 Jul;371(2):177-8

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http://dx.doi.org/10.1056/NEJMcibr1405701DOI Listing
July 2014

Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma.

Cancer Res 2014 Jun 8;74(12):3344-56. Epub 2014 Apr 8.

Authors' Affiliations: Faculty of Life Sciences and Department of Histopathology Medical School, University of Manchester, Manchester; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom; and Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-2941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058314PMC
June 2014

Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma.

Onco Targets Ther 2013 Dec 18;7:33-43. Epub 2013 Dec 18.

Department of Gastroenterology, Endocrinology, Infectiology and Metabolism, Philipps University Marburg, Marburg, Germany.

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http://www.dovepress.com/emerging-concepts-in-pancreatic-can
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http://dx.doi.org/10.2147/OTT.S38111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872146PMC
December 2013

Claudin-4-targeted optical imaging detects pancreatic cancer and its precursor lesions.

Gut 2013 Jul 7;62(7):1034-43. Epub 2012 Jun 7.

Department of Gastroenterology, Endocrinology and Metabolism, Philipps University Marburg, Marburg, Germany.

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http://dx.doi.org/10.1136/gutjnl-2012-302577DOI Listing
July 2013

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.

Authors:
Andrew V Biankin Nicola Waddell Karin S Kassahn Marie-Claude Gingras Lakshmi B Muthuswamy Amber L Johns David K Miller Peter J Wilson Ann-Marie Patch Jianmin Wu David K Chang Mark J Cowley Brooke B Gardiner Sarah Song Ivon Harliwong Senel Idrisoglu Craig Nourse Ehsan Nourbakhsh Suzanne Manning Shivangi Wani Milena Gongora Marina Pajic Christopher J Scarlett Anthony J Gill Andreia V Pinho Ilse Rooman Matthew Anderson Oliver Holmes Conrad Leonard Darrin Taylor Scott Wood Qinying Xu Katia Nones J Lynn Fink Angelika Christ Tim Bruxner Nicole Cloonan Gabriel Kolle Felicity Newell Mark Pinese R Scott Mead Jeremy L Humphris Warren Kaplan Marc D Jones Emily K Colvin Adnan M Nagrial Emily S Humphrey Angela Chou Venessa T Chin Lorraine A Chantrill Amanda Mawson Jaswinder S Samra James G Kench Jessica A Lovell Roger J Daly Neil D Merrett Christopher Toon Krishna Epari Nam Q Nguyen Andrew Barbour Nikolajs Zeps Nipun Kakkar Fengmei Zhao Yuan Qing Wu Min Wang Donna M Muzny William E Fisher F Charles Brunicardi Sally E Hodges Jeffrey G Reid Jennifer Drummond Kyle Chang Yi Han Lora R Lewis Huyen Dinh Christian J Buhay Timothy Beck Lee Timms Michelle Sam Kimberly Begley Andrew Brown Deepa Pai Ami Panchal Nicholas Buchner Richard De Borja Robert E Denroche Christina K Yung Stefano Serra Nicole Onetto Debabrata Mukhopadhyay Ming-Sound Tsao Patricia A Shaw Gloria M Petersen Steven Gallinger Ralph H Hruban Anirban Maitra Christine A Iacobuzio-Donahue Richard D Schulick Christopher L Wolfgang Richard A Morgan Rita T Lawlor Paola Capelli Vincenzo Corbo Maria Scardoni Giampaolo Tortora Margaret A Tempero Karen M Mann Nancy A Jenkins Pedro A Perez-Mancera David J Adams David A Largaespada Lodewyk F A Wessels Alistair G Rust Lincoln D Stein David A Tuveson Neal G Copeland Elizabeth A Musgrove Aldo Scarpa James R Eshleman Thomas J Hudson Robert L Sutherland David A Wheeler John V Pearson John D McPherson Richard A Gibbs Sean M Grimmond

Nature 2012 Nov 24;491(7424):399-405. Epub 2012 Oct 24.

The Kinghorn Cancer Centre, 370 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia.

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http://dx.doi.org/10.1038/nature11547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530898PMC
November 2012

Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice.

Gut 2012 Jun 9;61(6):877-84. Epub 2011 Dec 9.

Li Ka Shing Centre, Cancer Research UK Cambridge Research Institute, Cambridge, UK.

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http://dx.doi.org/10.1136/gutjnl-2011-300850DOI Listing
June 2012

What we have learned about pancreatic cancer from mouse models.

Gastroenterology 2012 May 8;142(5):1079-92. Epub 2012 Mar 8.

Li Ka Shing Centre, Cambridge Research Institute, and Department of Oncology, Cancer Research UK, Cambridge, England.

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http://linkinghub.elsevier.com/retrieve/pii/S001650851200315
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http://dx.doi.org/10.1053/j.gastro.2012.03.002DOI Listing
May 2012

Predictive in vivo animal models and translation to clinical trials.

Drug Discov Today 2012 Mar;17(5-6):253-60

Cancer Research UK, Cambridge Research Institute, UK.

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March 2012

Understanding metastasis in pancreatic cancer: a call for new clinical approaches.

Cell 2012 Jan;148(1-2):21-3

Li Ka Shing Centre, Cancer Research UK Cambridge Research Institute, Robinson Way, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1016/j.cell.2011.12.021DOI Listing
January 2012

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.

J Clin Invest 2011 Nov 3;121(11):4257-67. Epub 2011 Oct 3.

Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1172/JCI58509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223862PMC
November 2011

Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression.

Gastroenterology 2011 Oct 24;141(4):1486-97, 1497.e1-14. Epub 2011 Jun 24.

Centre for Tumor Biology, Barts Cancer Institute-a CR-UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, London, England.

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http://dx.doi.org/10.1053/j.gastro.2011.06.047DOI Listing
October 2011

C-Raf is required for the initiation of lung cancer by K-Ras(G12D).

Cancer Discov 2011 Jul 11;1(2):128-36. Epub 2011 May 11.

Li Ka Shing Centre, Cambridge Research Institute, Cancer Research UK, Cambridge, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-10-0044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203527PMC
July 2011

Stromal biology and therapy in pancreatic cancer.

Gut 2011 Jun 21;60(6):861-8. Epub 2010 Oct 21.

Li Ka Shing Centre, Cambridge Research Institute, Cancer Research UK, Cambridge, UK.

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http://gut.bmj.com/cgi/doi/10.1136/gut.2010.226092
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http://dx.doi.org/10.1136/gut.2010.226092DOI Listing
June 2011

Deploying mouse models of pancreatic cancer for chemoprevention studies.

Cancer Prev Res (Phila) 2010 Nov 2;3(11):1382-7. Epub 2010 Nov 2.

Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 303 East Superior Street, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-10-0258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242034PMC
November 2010

Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha.

Science 2010 Nov;330(6005):827-30

Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, UK.

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http://dx.doi.org/10.1126/science.1195300DOI Listing
November 2010

Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer.

Cancer Cell 2010 Nov 4;18(5):499-509. Epub 2010 Nov 4.

Department of Oncology and the Medical Research Council Cancer Cell Unit, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK.

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http://dx.doi.org/10.1016/j.ccr.2010.10.015DOI Listing
November 2010

C-Raf inhibits MAPK activation and transformation by B-Raf(V600E).

Mol Cell 2009 Nov;36(3):477-86

Li Ka Shing Centre, Cambridge Research Institute, Cancer Research UK, Robinson Way, Cambridge CB2 0RE, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S109727650900782
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http://dx.doi.org/10.1016/j.molcel.2009.10.017DOI Listing
November 2009

Finding and killing the CRABs of pancreatic cancer.

Gastroenterology 2009 Sep 28;137(3):782-5. Epub 2009 Jul 28.

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http://dx.doi.org/10.1053/j.gastro.2009.07.035DOI Listing
September 2009

RAS in cellular transformation and senescence.

Eur J Cancer 2009 Sep;45 Suppl 1:211-6

Li Ka Shing Centre, Cancer Research UK Cambridge Institute, Cambridge, UK.

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http://dx.doi.org/10.1016/S0959-8049(09)70036-XDOI Listing
September 2009

An shRNA silencing a non-toxic transgene reduces nutrient consumption and increases production of adenoviral vectors in a novel packaging cell.

J Cell Physiol 2009 May;219(2):365-71

Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

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http://dx.doi.org/10.1002/jcp.21679DOI Listing
May 2009

Modelling oncogenic Ras/Raf signalling in the mouse.

Curr Opin Genet Dev 2009 Feb 7;19(1):4-11. Epub 2009 Feb 7.

Li Ka Shing Centre, Cambridge Research Institute, Cancer Research UK, Robinson Way, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/j.gde.2008.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389704PMC
February 2009

K-Ras-driven pancreatic cancer mouse model for anticancer inhibitor analyses.

Methods Enzymol 2008 ;439:73-85

Department of Clinical Oncology, Addenbrookes NHS Trust, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/S0076-6879(07)00406-5DOI Listing
June 2008

Dynamics of the immune reaction to pancreatic cancer from inception to invasion.

Cancer Res 2007 Oct;67(19):9518-27

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0175DOI Listing
October 2007

Maximizing mouse cancer models.

Nat Rev Cancer 2007 Sep;7(9):645-58

Cambridge Research Institute, Cancer Research UK.

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http://dx.doi.org/10.1038/nrc2192DOI Listing
September 2007