David A Sinclair

David A Sinclair

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Frailty biomarkers in humans and rodents: Current approaches and future advances.

Mech Ageing Dev 2019 Jun 17;180:117-128. Epub 2019 Apr 17.

Department of Genetics, Harvard Medical School, Boston, MA, USA; Department of Pharmacology, The University of New South Wales, Sydney, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00476374193003
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http://dx.doi.org/10.1016/j.mad.2019.03.007DOI Listing
June 2019

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice.

Redox Biol 2019 Apr 10;24:101192. Epub 2019 Apr 10.

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary; Department of Public Health, Semmelweis University, Budapest, Hungary; Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2019.101192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477631PMC
April 2019

Assays for NAD-Dependent Reactions and NAD Metabolites.

Methods Mol Biol 2018 ;1813:77-90

Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-8588-3_6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409209PMC
March 2019

Multiple basal cell carcinomas in a patient with myotonic dystrophy type 1.

BMJ Case Rep 2019 Mar 8;12(3). Epub 2019 Mar 8.

Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22723
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http://dx.doi.org/10.1136/bcr-2018-227233DOI Listing
March 2019

Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease.

Cell Metab 2019 Mar 20. Epub 2019 Mar 20.

Department of Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA; Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.03.001DOI Listing
March 2019

Epigenetic changes during aging and their reprogramming potential.

Crit Rev Biochem Mol Biol 2019 Feb 1;54(1):61-83. Epub 2019 Mar 1.

a Department of Genetics , Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.1080/10409238.2019.1570075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424622PMC
February 2019

Molecular and Cellular Characterization of SIRT1 Allosteric Activators.

Methods Mol Biol 2019 ;1983:133-149

Department of Genetics, Blavatnik Institute, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-9434-2_8DOI Listing
January 2019

Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice.

Cell Rep 2018 Nov;25(8):2234-2243.e6

Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia; Aging and Alzheimers Institute, ANZAC Research Institute, Centre for Education and Research on Ageing, Concord, NSW 2139, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.10.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296764PMC
November 2018

Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions.

Mol Cell 2018 09;71(5):718-732.e9

Wisconsin Institute for Discovery and Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health-Madison, Madison, WI 53715, USA; Morgridge Institute for Research, Madison, WI 53715, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.07.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188669PMC
September 2018

Sirtuins and NAD in the Development and Treatment of Metabolic and Cardiovascular Diseases.

Circ Res 2018 Sep;123(7):868-885

From the Department of Genetics, Harvard Medical School, Boston, MA (A.E.K., D.A.S.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31249
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http://dx.doi.org/10.1161/CIRCRESAHA.118.312498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206880PMC
September 2018

Sirtuin activators and inhibitors: Promises, achievements, and challenges.

Pharmacol Ther 2018 08 22;188:140-154. Epub 2018 Mar 22.

Department of Biochemistry and Research Center for Bio-Macromolecules, University of Bayreuth, 95440 Bayreuth, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2018.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342514PMC
August 2018

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.

Cell Metab 2018 03;27(3):529-547

Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Laboratory for Ageing Research, Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183012
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http://dx.doi.org/10.1016/j.cmet.2018.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342515PMC
March 2018

Impairment of an Endothelial NAD-HS Signaling Network Is a Reversible Cause of Vascular Aging.

Cell 2018 03;173(1):74-89.e20

Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Laboratory for Ageing Research, Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884172PMC
March 2018

Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance.

Mol Metab 2018 01 6;7:1-11. Epub 2017 Nov 6.

Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA; Pennington Biomedical Research Center, Baton Rouge, LA, USA; Translational Research Institute for Metabolism and Diabetes, Orlando, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784330PMC
January 2018

Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach.

Metabolomics 2017 12 23;14(1):15. Epub 2017 Dec 23.

Faculty of Medicine, School of Psychiatry, Centre for Healthy Brain Ageing, University of New South Wales Sydney, Sydney, Australia.

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http://dx.doi.org/10.1007/s11306-017-1310-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519110PMC
December 2017

Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise.

Sci Rep 2017 Nov 8;7(1):15063. Epub 2017 Nov 8.

Department of Pharmacology, School of Medical Sciences, UNSW Sydney, Sydney, NSW-2032, Australia.

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http://dx.doi.org/10.1038/s41598-017-14866-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678092PMC
November 2017

Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease.

Metab Syndr Relat Disord 2017 02 21;15(1):6-17. Epub 2016 Nov 21.

4 Division of Diabetes, Endocrinology, and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland.

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http://dx.doi.org/10.1089/met.2016.0108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326984PMC
February 2017

Response to: "If the Metabolic Winter Is Coming, When Will It Be Summer?" (Metab Syndr Relat Disord 2017;15:3).

Metab Syndr Relat Disord 2017 02 6;15(1):4-5. Epub 2017 Feb 6.

4 Division of Diabetes, Endocrinology, and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland.

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http://dx.doi.org/10.1089/met.2017.0004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335752PMC
February 2017

Slowing ageing by design: the rise of NAD and sirtuin-activating compounds.

Nat Rev Mol Cell Biol 2016 11 24;17(11):679-690. Epub 2016 Aug 24.

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrm.2016.93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107309PMC
November 2016

Restoring stem cells - all you need is NAD(.).

Cell Res 2016 Sep 24;26(9):971-2. Epub 2016 Jun 24.

School of Medical Sciences, UNSW Australia, Sydney 2052, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034109PMC
http://dx.doi.org/10.1038/cr.2016.80DOI Listing
September 2016

Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice.

Front Pharmacol 2016 19;7:258. Epub 2016 Aug 19.

Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW Australia.

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http://dx.doi.org/10.3389/fphar.2016.00258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990541PMC
September 2016

Why NAD(+) Declines during Aging: It's Destroyed.

Cell Metab 2016 Jun;23(6):965-966

Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Pharmacology, University of New South Wales, Sydney 2052, Australia. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088772PMC
http://dx.doi.org/10.1016/j.cmet.2016.05.022DOI Listing
June 2016

Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability.

Nucleic Acids Res 2016 Apr 19;44(7):e64. Epub 2015 Dec 19.

Laboratory for Receptor Biology and Gene Expression, National Cancer Institute, 41 Library Drive, Bethesda, MD 20892, USA

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http://dx.doi.org/10.1093/nar/gkv1482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838352PMC
April 2016

C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins.

Mech Ageing Dev 2016 Mar 22;154:30-42. Epub 2016 Feb 22.

Department of Neuroscience, Brown University, 185 Meeting Street, Providence, RI 02912, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mad.2016.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789167PMC
March 2016

When stem cells grow old: phenotypes and mechanisms of stem cell aging.

Development 2016 Jan;143(1):3-14

Paul F. Glenn Center for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA

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http://dx.doi.org/10.1242/dev.130633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725211PMC
January 2016

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside.

Eur Heart J 2015 Dec 25;36(48):3404-12. Epub 2015 Jun 25.

Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland Zurich Center of Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland

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http://dx.doi.org/10.1093/eurheartj/ehv290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4685177PMC
December 2015

Oogonial stem cells as a model to study age-associated infertility in women.

Reprod Fertil Dev 2015 Jul;27(6):969-74

Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1071/RD14461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851909PMC
July 2015

The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice.

Stem Cell Res 2015 Jul 22;15(1):130-40. Epub 2015 May 22.

Oregon Stem Cell Center, Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1016/j.scr.2015.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516677PMC
July 2015

Measuring PGC-1α and its acetylation status in mouse primary myotubes.

Methods Mol Biol 2015 ;1241:49-57

Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA.

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http://link.springer.com/10.1007/978-1-4939-1875-1_5
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http://dx.doi.org/10.1007/978-1-4939-1875-1_5DOI Listing
June 2015

The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.

Eur Heart J 2015 Jan 6;36(1):51-9. Epub 2014 Mar 6.

Cardiovascular Research, Institute of Physiology, University of Zurich and University Heart Center, Cardiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland Zurich Center of Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland

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http://dx.doi.org/10.1093/eurheartj/ehu095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286317PMC
January 2015

Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism.

Aging Cell 2014 Dec 25;13(6):1075-85. Epub 2014 Sep 25.

Department of Genetics and Complex Diseases, Division of Biological Sciences, Harvard School of Public Health, Boston, MA, USA; Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Genetics, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA, USA.

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http://dx.doi.org/10.1111/acel.12273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244309PMC
December 2014

Small-molecule allosteric activators of sirtuins.

Annu Rev Pharmacol Toxicol 2014 16;54:363-80. Epub 2013 Oct 16.

Glenn Laboratories for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115; email:

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http://dx.doi.org/10.1146/annurev-pharmtox-010611-134657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018738PMC
September 2014

Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy.

PLoS One 2014 8;9(1):e85031. Epub 2014 Jan 8.

Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Manton Center for Orphan Disease Research, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085031PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885684PMC
September 2014

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.

EMBO J 2014 Jul 12;33(13):1438-53. Epub 2014 May 12.

Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston, MA, USA Department of Pharmacology, School of Medicine The University of New South Wales, Sydney, NSW, Australia

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http://emboj.embopress.org/content/embojnl/33/13/1438.full.p
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http://emboj.embopress.org/cgi/doi/10.15252/embj.201386907
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http://dx.doi.org/10.15252/embj.201386907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194088PMC
July 2014

Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells.

Stem Cell Reports 2014 Jul 6;3(1):44-59. Epub 2014 Jun 6.

Department of Developmental & Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA ; Developmental and Stem Cell Biology Multidisciplinary Training Area, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA ; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA ; Division of Hematology and Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA ; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://www.cell.com/stem-cell-reports/pdf/S2213-6711(14)0012
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http://linkinghub.elsevier.com/retrieve/pii/S221367111400122
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http://dx.doi.org/10.1016/j.stemcr.2014.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110778PMC
July 2014

SIRT2 controls the pentose phosphate switch.

EMBO J 2014 Jun 13;33(12):1287-8. Epub 2014 May 13.

Laboratory for Ageing Research, Department of Pharmacology, School of Medical Sciences, UNSW Australia, Sydney, NSW, Australia Glenn Labs for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA, Australia.

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http://dx.doi.org/10.15252/embj.201488713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194117PMC
June 2014

Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay.

Methods Mol Biol 2013 ;1077:167-77

Department of Genetics, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-62703-637-5_11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4727966PMC
April 2014

Studying the replicative life span of yeast cells.

Authors:
David A Sinclair

Methods Mol Biol 2013 ;1048:49-63

Paul F. Glenn Laboratories for the Molecular Biology of Aging, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-62703-556-9_5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775250PMC
March 2014

Small molecule SIRT1 activators for the treatment of aging and age-related diseases.

Trends Pharmacol Sci 2014 Mar 16;35(3):146-54. Epub 2014 Jan 16.

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01656147130023
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http://dx.doi.org/10.1016/j.tips.2013.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970218PMC
March 2014

GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.

Proc Natl Acad Sci U S A 2014 Mar 20;111(10):3781-6. Epub 2014 Feb 20.

Department of Genetics, Harvard Medical School, Boston, MA 02115.

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http://dx.doi.org/10.1073/pnas.1400705111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956149PMC
March 2014

The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet.

Cell Rep 2014 Mar 27;6(5):836-43. Epub 2014 Feb 27.

Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010117PMC
March 2014

Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis.

Cancer Cell 2014 Jan;25(1):12-9

Laboratory for Ageing Research, Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia; Paul F. Glenn Labs for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2013.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970212PMC
January 2014

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.

Cell 2013 Dec;155(7):1624-38

Glenn Labs for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney NSW 2052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2013.11.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076149PMC
December 2013

Germline energetics, aging, and female infertility.

Cell Metab 2013 Jun;17(6):838-50

Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://www.cell.com/cell-metabolism/pdf/S1550-4131(13)00197-
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http://dx.doi.org/10.1016/j.cmet.2013.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756096PMC
June 2013

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.

Mol Cell Biol 2013 Apr 4;33(8):1487-502. Epub 2013 Feb 4.

Department of Genetics and The Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, Massachusetts, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00971-12
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http://dx.doi.org/10.1128/MCB.00971-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624249PMC
April 2013

Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway.

Circulation 2013 Apr 27;127(16):1692-701. Epub 2013 Mar 27.

Department of Cell Biology & Molecular Medicine, University of Medicine & Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.001212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980473PMC
April 2013

Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene.

Cell Cycle 2013 Jan 15;12(2):263-70. Epub 2012 Jan 15.

Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.

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http://dx.doi.org/10.4161/cc.23056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575455PMC
January 2013

Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin.

Mol Cell Biol 2012 Aug 29;32(15):2966-78. Epub 2012 May 29.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://mcb.asm.org/content/early/2012/05/22/MCB.05688-11.ful
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http://mcb.asm.org/content/32/15/2966.full.pdf
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http://mcb.asm.org/cgi/doi/10.1128/MCB.05688-11
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http://dx.doi.org/10.1128/MCB.05688-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434519PMC
August 2012

Sirtuin 1 and sirtuin 3: physiological modulators of metabolism.

Physiol Rev 2012 Jul;92(3):1479-514

Department of Physiology, School of Medicine-Instituto de Investigaciones Sanitarias, University of Santiago de Compostela, Santiago de Compostela, Spain.

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http://dx.doi.org/10.1152/physrev.00022.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746174PMC
July 2012

The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction.

Aging (Albany NY) 2012 Jul;4(7):499-508

Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.

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http://www.aging-us.com/article/100474
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http://dx.doi.org/10.18632/aging.100474DOI Listing
July 2012

The intersection between aging and cardiovascular disease.

Circ Res 2012 Apr;110(8):1097-108

Glenn Laboratories for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA, USA.

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April 2012

Guidelines for the use and interpretation of assays for monitoring autophagy.

Authors:
Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli Lotta Agholme Maria Agnello Patrizia Agostinis Julio A Aguirre-Ghiso Hyung Jun Ahn Ouardia Ait-Mohamed Slimane Ait-Si-Ali Takahiko Akematsu Shizuo Akira Hesham M Al-Younes Munir A Al-Zeer Matthew L Albert Roger L Albin Javier Alegre-Abarrategui Maria Francesca Aleo Mehrdad Alirezaei Alexandru Almasan Maylin Almonte-Becerril Atsuo Amano Ravi Amaravadi Shoba Amarnath Amal O Amer Nathalie Andrieu-Abadie Vellareddy Anantharam David K Ann Shailendra Anoopkumar-Dukie Hiroshi Aoki Nadezda Apostolova Giuseppe Arancia John P Aris Katsuhiko Asanuma Nana Y O Asare Hisashi Ashida Valerie Askanas David S Askew Patrick Auberger Misuzu Baba Steven K Backues Eric H Baehrecke Ben A Bahr Xue-Yuan Bai Yannick Bailly Robert Baiocchi Giulia Baldini Walter Balduini Andrea Ballabio Bruce A Bamber Edward T W Bampton Gábor Bánhegyi Clinton R Bartholomew Diane C Bassham Robert C Bast Henri Batoko Boon-Huat Bay Isabelle Beau Daniel M Béchet Thomas J Begley Christian Behl Christian Behrends Soumeya Bekri Bryan Bellaire Linda J Bendall Luca Benetti Laura Berliocchi Henri Bernardi Francesca Bernassola Sébastien Besteiro Ingrid Bhatia-Kissova Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Lawrence H Boise Paolo Bonaldo David L Boone Beat C Bornhauser Karina R Bortoluci Ioannis Bossis Frédéric Bost Jean-Pierre Bourquin Patricia Boya Michaël Boyer-Guittaut Peter V Bozhkov Nathan R Brady Claudio Brancolini Andreas Brech Jay E Brenman Ana Brennand Emery H Bresnick Patrick Brest Dave Bridges Molly L Bristol Paul S Brookes Eric J Brown John H Brumell Nicola Brunetti-Pierri Ulf T Brunk Dennis E Bulman Scott J Bultman Geert Bultynck Lena F Burbulla Wilfried Bursch Jonathan P Butchar Wanda Buzgariu Sergio P Bydlowski Ken Cadwell Monika Cahová Dongsheng Cai Jiyang Cai Qian Cai Bruno Calabretta Javier Calvo-Garrido Nadine Camougrand Michelangelo Campanella Jenny Campos-Salinas Eleonora Candi Lizhi Cao Allan B Caplan Simon R Carding Sandra M Cardoso Jennifer S Carew Cathleen R Carlin Virginie Carmignac Leticia A M Carneiro Serena Carra Rosario A Caruso Giorgio Casari Caty Casas Roberta Castino Eduardo Cebollero Francesco Cecconi Jean Celli Hassan Chaachouay Han-Jung Chae Chee-Yin Chai David C Chan Edmond Y Chan Raymond Chuen-Chung Chang Chi-Ming Che Ching-Chow Chen Guang-Chao Chen Guo-Qiang Chen Min Chen Quan Chen Steve S-L Chen WenLi Chen Xi Chen Xiangmei Chen Xiequn Chen Ye-Guang Chen Yingyu Chen Yongqiang Chen Yu-Jen Chen Zhixiang Chen Alan Cheng Christopher H K Cheng Yan Cheng Heesun Cheong Jae-Ho Cheong Sara Cherry Russ Chess-Williams Zelda H Cheung Eric Chevet Hui-Ling Chiang Roberto Chiarelli Tomoki Chiba Lih-Shen Chin Shih-Hwa Chiou Francis V Chisari Chi Hin Cho Dong-Hyung Cho Augustine M K Choi DooSeok Choi Kyeong Sook Choi Mary E Choi Salem Chouaib Divaker Choubey Vinay Choubey Charleen T Chu Tsung-Hsien Chuang Sheau-Huei Chueh Taehoon Chun Yong-Joon Chwae Mee-Len Chye Roberto Ciarcia Maria R Ciriolo Michael J Clague Robert S B Clark Peter G H Clarke Robert Clarke Patrice Codogno Hilary A Coller María I Colombo Sergio Comincini Maria Condello Fabrizio Condorelli Mark R Cookson Graham H Coombs Isabelle Coppens Ramon Corbalan Pascale Cossart Paola Costelli Safia Costes Ana Coto-Montes Eduardo Couve Fraser P Coxon James M Cregg José L Crespo Marianne J Cronjé Ana Maria Cuervo Joseph J Cullen Mark J Czaja Marcello D'Amelio Arlette Darfeuille-Michaud Lester M Davids Faith E Davies Massimo De Felici John F de Groot Cornelis A M de Haan Luisa De Martino Angelo De Milito Vincenzo De Tata Jayanta Debnath Alexei Degterev Benjamin Dehay Lea M D Delbridge Francesca Demarchi Yi Zhen Deng Jörn Dengjel Paul Dent Donna Denton Vojo Deretic Shyamal D Desai Rodney J Devenish Mario Di Gioacchino Gilbert Di Paolo Chiara Di Pietro Guillermo Díaz-Araya Inés Díaz-Laviada Maria T Diaz-Meco Javier Diaz-Nido Ivan Dikic Savithramma P Dinesh-Kumar Wen-Xing Ding Clark W Distelhorst Abhinav Diwan Mojgan Djavaheri-Mergny Svetlana Dokudovskaya Zheng Dong Frank C Dorsey Victor Dosenko James J Dowling Stephen Doxsey Marlène Dreux Mark E Drew Qiuhong Duan Michel A Duchosal Karen Duff Isabelle Dugail Madeleine Durbeej Michael Duszenko Charles L Edelstein Aimee L Edinger Gustavo Egea Ludwig Eichinger N Tony Eissa Suhendan Ekmekcioglu Wafik S El-Deiry Zvulun Elazar Mohamed Elgendy Lisa M Ellerby Kai Er Eng Anna-Mart Engelbrecht Simone Engelender Jekaterina Erenpreisa Ricardo Escalante Audrey Esclatine Eeva-Liisa Eskelinen Lucile Espert Virginia Espina Huizhou Fan Jia Fan Qi-Wen Fan Zhen Fan Shengyun Fang Yongqi Fang Manolis Fanto Alessandro Fanzani Thomas Farkas Jean-Claude Farré Mathias Faure Marcus Fechheimer Carl G Feng Jian Feng Qili Feng Youji Feng László Fésüs Ralph Feuer Maria E Figueiredo-Pereira Gian Maria Fimia Diane C Fingar Steven Finkbeiner Toren Finkel Kim D Finley Filomena Fiorito Edward A Fisher Paul B Fisher Marc Flajolet Maria L Florez-McClure Salvatore Florio Edward A Fon Francesco Fornai Franco Fortunato Rati Fotedar Daniel H Fowler Howard S Fox Rodrigo Franco Lisa B Frankel Marc Fransen José M Fuentes Juan Fueyo Jun Fujii Kozo Fujisaki Eriko Fujita Mitsunori Fukuda Ruth H Furukawa Matthias Gaestel Philippe Gailly Malgorzata Gajewska Brigitte Galliot Vincent Galy Subramaniam Ganesh Barry Ganetzky Ian G Ganley Fen-Biao Gao George F Gao Jinming Gao Lorena Garcia Guillermo Garcia-Manero Mikel Garcia-Marcos Marjan Garmyn Andrei L Gartel Evelina Gatti Mathias Gautel Thomas R Gawriluk Matthew E Gegg Jiefei Geng Marc Germain Jason E Gestwicki David A Gewirtz Saeid Ghavami Pradipta Ghosh Anna M Giammarioli Alexandra N Giatromanolaki Spencer B Gibson Robert W Gilkerson Michael L Ginger Henry N Ginsberg Jakub Golab Michael S Goligorsky Pierre Golstein Candelaria Gomez-Manzano Ebru Goncu Céline Gongora Claudio D Gonzalez Ramon Gonzalez Cristina González-Estévez Rosa Ana González-Polo Elena Gonzalez-Rey Nikolai V Gorbunov Sharon Gorski Sandro Goruppi Roberta A Gottlieb Devrim Gozuacik Giovanna Elvira Granato Gary D Grant Kim N Green Aleš Gregorc Frédéric Gros Charles Grose Thomas W Grunt Philippe Gual Jun-Lin Guan Kun-Liang Guan Sylvie M Guichard Anna S Gukovskaya Ilya Gukovsky Jan Gunst Asa B Gustafsson Andrew J Halayko Amber N Hale Sandra K Halonen Maho Hamasaki Feng Han Ting Han Michael K Hancock Malene Hansen Hisashi Harada Masaru Harada Stefan E Hardt J Wade Harper Adrian L Harris James Harris Steven D Harris Makoto Hashimoto Jeffrey A Haspel Shin-ichiro Hayashi Lori A Hazelhurst Congcong He You-Wen He Marie-Joseé Hébert Kim A Heidenreich Miep H Helfrich Gudmundur V Helgason Elizabeth P Henske Brian Herman Paul K Herman Claudio Hetz Sabine Hilfiker Joseph A Hill Lynne J Hocking Paul Hofman Thomas G Hofmann Jörg Höhfeld Tessa L Holyoake Ming-Huang Hong David A Hood Gökhan S Hotamisligil Ewout J Houwerzijl Maria Høyer-Hansen Bingren Hu Chien-An A Hu Hong-Ming Hu Ya Hua Canhua Huang Ju Huang Shengbing Huang Wei-Pang Huang Tobias B Huber Won-Ki Huh Tai-Ho Hung Ted R Hupp Gang Min Hur James B Hurley Sabah N A Hussain Patrick J Hussey Jung Jin Hwang Seungmin Hwang Atsuhiro Ichihara Shirin Ilkhanizadeh Ken Inoki Takeshi Into Valentina Iovane Juan L Iovanna Nancy Y Ip Yoshitaka Isaka Hiroyuki Ishida Ciro Isidoro Ken-ichi Isobe Akiko Iwasaki Marta Izquierdo Yotaro Izumi Panu M Jaakkola Marja Jäättelä George R Jackson William T Jackson Bassam Janji Marina Jendrach Ju-Hong Jeon Eui-Bae Jeung Hong Jiang Hongchi Jiang Jean X Jiang Ming Jiang Qing Jiang Xuejun Jiang Xuejun Jiang Alberto Jiménez Meiyan Jin Shengkan Jin Cheol O Joe Terje Johansen Daniel E Johnson Gail V W Johnson Nicola L Jones Bertrand Joseph Suresh K Joseph Annie M Joubert Gábor Juhász Lucienne Juillerat-Jeanneret Chang Hwa Jung Yong-Keun Jung Kai Kaarniranta Allen Kaasik Tomohiro Kabuta Motoni Kadowaki Katarina Kagedal Yoshiaki Kamada Vitaliy O Kaminskyy Harm H Kampinga Hiromitsu Kanamori Chanhee Kang Khong Bee Kang Kwang Il Kang Rui Kang Yoon-A Kang Tomotake Kanki Thirumala-Devi Kanneganti Haruo Kanno Anumantha G Kanthasamy Arthi Kanthasamy Vassiliki Karantza Gur P Kaushal Susmita Kaushik Yoshinori Kawazoe Po-Yuan Ke John H Kehrl Ameeta Kelekar Claus Kerkhoff David H Kessel Hany Khalil Jan A K W Kiel Amy A Kiger Akio Kihara Deok Ryong Kim Do-Hyung Kim Dong-Hou Kim Eun-Kyoung Kim Hyung-Ryong Kim Jae-Sung Kim Jeong Hun Kim Jin Cheon Kim John K Kim Peter K Kim Seong Who Kim Yong-Sun Kim Yonghyun Kim Adi Kimchi Alec C Kimmelman Jason S King Timothy J Kinsella Vladimir Kirkin Lorrie A Kirshenbaum Katsuhiko Kitamoto Kaio Kitazato Ludger Klein Walter T Klimecki Jochen Klucken Erwin Knecht Ben C B Ko Jan C Koch Hiroshi Koga Jae-Young Koh Young Ho Koh Masato Koike Masaaki Komatsu Eiki Kominami Hee Jeong Kong Wei-Jia Kong Viktor I Korolchuk Yaichiro Kotake Michael I Koukourakis Juan B Kouri Flores Attila L Kovács Claudine Kraft Dimitri Krainc Helmut Krämer Carole Kretz-Remy Anna M Krichevsky Guido Kroemer Rejko Krüger Oleg Krut Nicholas T Ktistakis Chia-Yi Kuan Roza Kucharczyk Ashok Kumar Raj Kumar Sharad Kumar Mondira Kundu Hsing-Jien Kung Tino Kurz Ho Jeong Kwon Albert R La Spada Frank Lafont Trond Lamark Jacques Landry Jon D Lane Pierre Lapaquette Jocelyn F Laporte Lajos László Sergio Lavandero Josée N Lavoie Robert Layfield Pedro A Lazo Weidong Le Laurent Le Cam Daniel J Ledbetter Alvin J X Lee Byung-Wan Lee Gyun Min Lee Jongdae Lee Ju-Hyun Lee Michael Lee Myung-Shik Lee Sug Hyung Lee Christiaan Leeuwenburgh Patrick Legembre Renaud Legouis Michael Lehmann Huan-Yao Lei Qun-Ying Lei David A Leib José Leiro John J Lemasters Antoinette Lemoine Maciej S Lesniak Dina Lev Victor V Levenson Beth Levine Efrat Levy Faqiang Li Jun-Lin Li Lian Li Sheng Li Weijie Li Xue-Jun Li Yan-bo Li Yi-Ping Li Chengyu Liang Qiangrong Liang Yung-Feng Liao Pawel P Liberski Andrew Lieberman Hyunjung J Lim Kah-Leong Lim Kyu Lim Chiou-Feng Lin Fu-Cheng Lin Jian Lin Jiandie D Lin Kui Lin Wan-Wan Lin Weei-Chin Lin Yi-Ling Lin Rafael Linden Paul Lingor Jennifer Lippincott-Schwartz Michael P Lisanti Paloma B Liton Bo Liu Chun-Feng Liu Kaiyu Liu Leyuan Liu Qiong A Liu Wei Liu Young-Chau Liu Yule Liu Richard A Lockshin Chun-Nam Lok Sagar Lonial Benjamin Loos Gabriel Lopez-Berestein Carlos López-Otín Laura Lossi Michael T Lotze Peter Lőw Binfeng Lu Bingwei Lu Bo Lu Zhen Lu Frédéric Luciano Nicholas W Lukacs Anders H Lund Melinda A Lynch-Day Yong Ma Fernando Macian Jeff P MacKeigan Kay F Macleod Frank Madeo Luigi Maiuri Maria Chiara Maiuri Davide Malagoli May Christine V Malicdan Walter Malorni Na Man Eva-Maria Mandelkow Stéphen Manon Irena Manov Kai Mao Xiang Mao Zixu Mao Philippe Marambaud Daniela Marazziti Yves L Marcel Katie Marchbank Piero Marchetti Stefan J Marciniak Mateus Marcondes Mohsen Mardi Gabriella Marfe Guillermo Mariño Maria Markaki Mark R Marten Seamus J Martin Camille Martinand-Mari Wim Martinet Marta Martinez-Vicente Matilde Masini Paola Matarrese Saburo Matsuo Raffaele Matteoni Andreas Mayer Nathalie M Mazure David J McConkey Melanie J McConnell Catherine McDermott Christine McDonald Gerald M McInerney Sharon L McKenna BethAnn McLaughlin Pamela J McLean Christopher R McMaster G Angus McQuibban Alfred J Meijer Miriam H Meisler Alicia Meléndez Thomas J Melia Gerry Melino Maria A Mena Javier A Menendez Rubem F S Menna-Barreto Manoj B Menon Fiona M Menzies Carol A Mercer Adalberto Merighi Diane E Merry Stefania Meschini Christian G Meyer Thomas F Meyer Chao-Yu Miao Jun-Ying Miao Paul A M Michels Carine Michiels Dalibor Mijaljica Ana Milojkovic Saverio Minucci Clelia Miracco Cindy K Miranti Ioannis Mitroulis Keisuke Miyazawa Noboru Mizushima Baharia Mograbi Simin Mohseni Xavier Molero Bertrand Mollereau Faustino Mollinedo Takashi Momoi Iryna Monastyrska Martha M Monick Mervyn J Monteiro Michael N Moore Rodrigo Mora Kevin Moreau Paula I Moreira Yuji Moriyasu Jorge Moscat Serge Mostowy Jeremy C Mottram Tomasz Motyl Charbel E-H Moussa Sylke Müller Sylviane Muller Karl Münger Christian Münz Leon O Murphy Maureen E Murphy Antonio Musarò Indira Mysorekar Eiichiro Nagata Kazuhiro Nagata Aimable Nahimana Usha Nair Toshiyuki Nakagawa Kiichi Nakahira Hiroyasu Nakano Hitoshi Nakatogawa Meera Nanjundan Naweed I Naqvi Derek P Narendra Masashi Narita Miguel Navarro Steffan T Nawrocki Taras Y Nazarko Andriy Nemchenko Mihai G Netea Thomas P Neufeld Paul A Ney Ioannis P Nezis Huu Phuc Nguyen Daotai Nie Ichizo Nishino Corey Nislow Ralph A Nixon Takeshi Noda Angelika A Noegel Anna Nogalska Satoru Noguchi Lucia Notterpek Ivana Novak Tomoyoshi Nozaki Nobuyuki Nukina Thorsten Nürnberger Beat Nyfeler Keisuke Obara Terry D Oberley Salvatore Oddo Michinaga Ogawa Toya Ohashi Koji Okamoto Nancy L Oleinick F Javier Oliver Laura J Olsen Stefan Olsson Onya Opota Timothy F Osborne Gary K Ostrander Kinya Otsu Jing-hsiung James Ou Mireille Ouimet Michael Overholtzer Bulent Ozpolat Paolo Paganetti Ugo Pagnini Nicolas Pallet Glen E Palmer Camilla Palumbo Tianhong Pan Theocharis Panaretakis Udai Bhan Pandey Zuzana Papackova Issidora Papassideri Irmgard Paris Junsoo Park Ohkmae K Park Jan B Parys Katherine R Parzych Susann Patschan Cam Patterson Sophie Pattingre John M Pawelek Jianxin Peng David H Perlmutter Ida Perrotta George Perry Shazib Pervaiz Matthias Peter Godefridus J Peters Morten Petersen Goran Petrovski James M Phang Mauro Piacentini Philippe Pierre Valérie Pierrefite-Carle Gérard Pierron Ronit Pinkas-Kramarski Antonio Piras Natik Piri Leonidas C Platanias Stefanie Pöggeler Marc Poirot Angelo Poletti Christian Poüs Mercedes Pozuelo-Rubio Mette Prætorius-Ibba Anil Prasad Mark Prescott Muriel Priault Nathalie Produit-Zengaffinen Ann Progulske-Fox Tassula Proikas-Cezanne Serge Przedborski Karin Przyklenk Rosa Puertollano Julien Puyal Shu-Bing Qian Liang Qin Zheng-Hong Qin Susan E Quaggin Nina Raben Hannah Rabinowich Simon W Rabkin Irfan Rahman Abdelhaq Rami Georg Ramm Glenn Randall Felix Randow V Ashutosh Rao Jeffrey C Rathmell Brinda Ravikumar Swapan K Ray Bruce H Reed John C Reed Fulvio Reggiori Anne Régnier-Vigouroux Andreas S Reichert John J Reiners Russel J Reiter Jun Ren José L Revuelta Christopher J Rhodes Konstantinos Ritis Elizete Rizzo Jeffrey Robbins Michel Roberge Hernan Roca Maria C Roccheri Stephane Rocchi H Peter Rodemann Santiago Rodríguez de Córdoba Bärbel Rohrer Igor B Roninson Kirill Rosen Magdalena M Rost-Roszkowska Mustapha Rouis Kasper M A Rouschop Francesca Rovetta Brian P Rubin David C Rubinsztein Klaus Ruckdeschel Edmund B Rucker Assaf Rudich Emil Rudolf Nelson Ruiz-Opazo Rossella Russo Tor Erik Rusten Kevin M Ryan Stefan W Ryter David M Sabatini Junichi Sadoshima Tapas Saha Tatsuya Saitoh Hiroshi Sakagami Yasuyoshi Sakai Ghasem Hoseini Salekdeh Paolo Salomoni Paul M Salvaterra Guy Salvesen Rosa Salvioli Anthony M J Sanchez José A Sánchez-Alcázar Ricardo Sánchez-Prieto Marco Sandri Uma Sankar Poonam Sansanwal Laura Santambrogio Shweta Saran Sovan Sarkar Minnie Sarwal Chihiro Sasakawa Ausra 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Efthimios Sivridis Vojtech Skop Vladimir P Skulachev Ruth S Slack Soraya S Smaili Duncan R Smith Maria S Soengas Thierry Soldati Xueqin Song Anil K Sood Tuck Wah Soong Federica Sotgia Stephen A Spector Claudia D Spies Wolfdieter Springer Srinivasa M Srinivasula Leonidas Stefanis Joan S Steffan Ruediger Stendel Harald Stenmark Anastasis Stephanou Stephan T Stern Cinthya Sternberg Björn Stork Peter Strålfors Carlos S Subauste Xinbing Sui David Sulzer Jiaren Sun Shi-Yong Sun Zhi-Jun Sun Joseph J Y Sung Kuninori Suzuki Toshihiko Suzuki Michele S Swanson Charles Swanton Sean T Sweeney Lai-King Sy Gyorgy Szabadkai Ira Tabas Heinrich Taegtmeyer Marco Tafani Krisztina Takács-Vellai Yoshitaka Takano Kaoru Takegawa Genzou Takemura Fumihiko Takeshita Nicholas J Talbot Kevin S W Tan Keiji Tanaka Kozo Tanaka Daolin Tang Dingzhong Tang Isei Tanida Bakhos A Tannous Nektarios Tavernarakis Graham S Taylor Gregory A Taylor J Paul Taylor Lance S Terada Alexei Terman Gianluca Tettamanti Karin Thevissen Craig B Thompson Andrew Thorburn Michael Thumm FengFeng Tian Yuan Tian Glauco Tocchini-Valentini Aviva M Tolkovsky Yasuhiko Tomino Lars Tönges Sharon A Tooze Cathy Tournier John Tower Roberto Towns Vladimir Trajkovic Leonardo H Travassos Ting-Fen Tsai Mario P Tschan Takeshi Tsubata Allan Tsung Boris Turk Lorianne S Turner Suresh C Tyagi Yasuo Uchiyama Takashi Ueno Midori Umekawa Rika Umemiya-Shirafuji Vivek K Unni Maria I Vaccaro Enza Maria Valente Greet Van den Berghe Ida J van der Klei Wouter van Doorn Linda F van Dyk Marjolein van Egmond Leo A van Grunsven Peter Vandenabeele Wim P Vandenberghe Ilse Vanhorebeek Eva C Vaquero Guillermo Velasco Tibor Vellai Jose Miguel Vicencio Richard D Vierstra Miquel Vila Cécile Vindis Giampietro Viola Maria Teresa Viscomi Olga V Voitsekhovskaja Clarissa von Haefen Marcela Votruba Keiji Wada Richard Wade-Martins Cheryl L Walker Craig M Walsh Jochen Walter Xiang-Bo Wan Aimin Wang Chenguang Wang Dawei Wang Fan Wang Fen Wang Guanghui Wang Haichao Wang Hong-Gang Wang Horng-Dar Wang Jin Wang Ke Wang Mei Wang Richard C Wang Xinglong Wang Xuejun Wang Ying-Jan Wang Yipeng Wang Zhen Wang Zhigang Charles Wang Zhinong Wang Derick G Wansink Diane M Ward Hirotaka Watada Sarah L Waters Paul Webster Lixin Wei Conrad C Weihl William A Weiss Scott M Welford Long-Ping Wen Caroline A Whitehouse J Lindsay Whitton Alexander J Whitworth Tom Wileman John W Wiley Simon Wilkinson Dieter Willbold Roger L Williams Peter R Williamson Bradly G Wouters Chenghan Wu Dao-Cheng Wu William K K Wu Andreas Wyttenbach Ramnik J Xavier Zhijun Xi Pu Xia Gengfu Xiao Zhiping Xie Zhonglin Xie Da-zhi Xu Jianzhen Xu Liang Xu Xiaolei Xu Ai Yamamoto Akitsugu Yamamoto Shunhei Yamashina Michiaki Yamashita Xianghua Yan Mitsuhiro Yanagida Dun-Sheng Yang Elizabeth Yang Jin-Ming Yang Shi Yu Yang Wannian Yang Wei Yuan Yang Zhifen Yang Meng-Chao Yao Tso-Pang Yao Behzad Yeganeh Wei-Lien Yen Jia-jing Yin Xiao-Ming Yin Ook-Joon Yoo Gyesoon Yoon Seung-Yong Yoon Tomohiro Yorimitsu Yuko 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Autophagy 2012 Apr;8(4):445-544

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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An unSIRTain role in longevity.

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Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase.

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Aging: past, present and future.

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