Publications by authors named "David A Lomas"

100Publications

Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin.

JCI Insight 2020 Jul 23;5(14). Epub 2020 Jul 23.

UCL Respiratory and the Institute of Structural and Molecular Biology, University College London, London, United Kingdom.

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http://dx.doi.org/10.1172/jci.insight.135459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453904PMC
July 2020

Alpha-Antitrypsin Deficiency.

N Engl J Med 2020 04;382(15):1443-1455

From the Department of Internal Medicine III, University Hospital RWTH (Rheinisch-Westfälisch Technische Hochschule) Aachen, Aachen, Germany (P.S.); the Irish Centre for Genetic Lung Disease, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin (N.G.M.); and UCL Respiratory, Division of Medicine, Rayne Institute, University College London, London (D.A.L.).

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http://dx.doi.org/10.1056/NEJMra1910234DOI Listing
April 2020

Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin.

Sci Rep 2019 11 21;9(1):17293. Epub 2019 Nov 21.

Centre for Respiratory Biology, UCL Respiratory, Rayne Building, University College London, 5 University Street, London, WC1E 6JF, UK.

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http://dx.doi.org/10.1038/s41598-019-53535-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872872PMC
November 2019

New Therapeutic Targets for Alpha-1 Antitrypsin Deficiency.

Authors:
David A Lomas

Chronic Obstr Pulm Dis 2018 Aug 6;5(4):233-243. Epub 2018 Aug 6.

UCL Respiratory, Division of Medicine, University College London, United Kingdom.

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http://dx.doi.org/10.15326/jcopdf.5.4.2017.0165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361470PMC
August 2018

Author Correction: α1-Antitrypsin deficiency.

Nat Rev Dis Primers 2018 Oct 29;4(1):40. Epub 2018 Oct 29.

Department of Medicine, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1038/s41572-018-0043-2DOI Listing
October 2018

In Vitro Approaches for the Assessment of Serpin Polymerization.

Methods Mol Biol 2018 ;1826:87-107

UCL Respiratory and the Institute of Structural and Molecular Biology, University College London, London, UK.

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http://dx.doi.org/10.1007/978-1-4939-8645-3_6DOI Listing
March 2019

Single-Inhaler Triple versus Dual Therapy in Patients with COPD.

N Engl J Med 2018 08;379(6):592-593

University College London, London, United Kingdom

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http://dx.doi.org/10.1056/NEJMc1807380DOI Listing
August 2018

α-Antitrypsin Polymerizes in Alveolar Macrophages of Smokers With and Without α-Antitrypsin Deficiency.

Chest 2018 09 12;154(3):607-616. Epub 2018 May 12.

Department of Cardiac, Thoracic, and Vascular Sciences, University of Padua, Padua, Italy; Respiratory Division, Meakins-Christie Laboratories, McGill University, Montreal, QC, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S00123692183072
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http://dx.doi.org/10.1016/j.chest.2018.04.039DOI Listing
September 2018

Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD.

N Engl J Med 2018 May 18;378(18):1671-1680. Epub 2018 Apr 18.

From GlaxoSmithKline, Collegeville (D.A. Lipson, J.B., S.J.P.), and the Perelman School of Medicine, University of Pennsylvania (D.A. Lipson), and Lewis Katz School of Medicine at Temple University (G.J.C.), Philadelphia - all in Pennsylvania; GlaxoSmithKline, Research Triangle Park, NC (F.B., C.E.J.); GlaxoSmithKline, Stockley Park West, Uxbridge (N.B., N.C.D., S.K., M.T.), the Department of Respiratory Medicine, Royal Devon and Exeter Hospital, Exeter (D.M.G.H.), UCL Respiratory, University College London, London (D.A. Lomas), and the Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester, Manchester University NHS Foundation Trust, Manchester (D.S.) - all in the United Kingdom; the Division of Pulmonary, Allergy, and Critical Care Medicine, Lung Health Center, University of Alabama at Birmingham, Birmingham (M.T.D.); the Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor (M.K.H.); the Department of Public Health, University of Copenhagen, Copenhagen (P.L.), and the Medical Department, Pulmonary Section, Herlev-Gentofte Hospital, Herlev (P.L.) - both in Denmark; New York-Presbyterian Hospital/Weill Cornell Medical Center, New York (F.J.M.); and the Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore (R.A.W.).

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http://www.nejm.org/doi/10.1056/NEJMoa1713901
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http://dx.doi.org/10.1056/NEJMoa1713901DOI Listing
May 2018

Heteropolymerization of α-1-antitrypsin mutants in cell models mimicking heterozygosity.

Hum Mol Genet 2018 05;27(10):1785-1793

Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.

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http://dx.doi.org/10.1093/hmg/ddy090DOI Listing
May 2018

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes.

Int J Parasitol Drugs Drug Resist 2018 04 2;8(1):8-21. Epub 2017 Dec 2.

Centre for Respiratory Biology, UCL Respiratory, Division of Medicine, University College London, Gower Street, London, WC1E 6BT, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ijpddr.2017.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734697PMC
April 2018

Liver: Taking out the JuNK to treat α1-antitrypsin deficiency.

Nat Rev Gastroenterol Hepatol 2017 04 8;14(4):201-202. Epub 2017 Mar 8.

UCL Respiratory, Division of Medicine, Rayne Building, University College London, London WC1E 6BN, UK.

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http://dx.doi.org/10.1038/nrgastro.2017.22DOI Listing
April 2017

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Nat Genet 2017 Mar 6;49(3):426-432. Epub 2017 Feb 6.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381275PMC
March 2017

Progressive myoclonus epilepsy associated with neuroserpin inclusion bodies (neuroserpinosis).

Epileptic Disord 2016 Sep;18(S2):103-110

Department of Genetics, University of Cambridge, UK, MedImmune Limited, Cambridge, United Kingdom.

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http://dx.doi.org/10.1684/epd.2016.0847DOI Listing
September 2016

An ECLIPSE View of Alpha-1 Antitrypsin Deficiency.

Authors:
David A Lomas

Ann Am Thorac Soc 2016 08;13 Suppl 4:S326-31

Wolfson Institute for Biomedical Research, Division of Medicine, University College London, United Kingdom.

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http://dx.doi.org/10.1513/AnnalsATS.201506-348KVDOI Listing
August 2016

Development of a Conceptual Model of Disease Progression for Use in Economic Modeling of Chronic Obstructive Pulmonary Disease.

Med Decis Making 2017 05 2;37(4):440-452. Epub 2016 Aug 2.

Wolfson Institute for Biomedical Research, University College London, London, UK (DAL).

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http://dx.doi.org/10.1177/0272989X16662009DOI Listing
May 2017

α1-Antitrypsin deficiency.

Nat Rev Dis Primers 2016 07 28;2:16051. Epub 2016 Jul 28.

Department of Medicine, Royal College of Surgeons in Ireland Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.

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http://dx.doi.org/10.1038/nrdp.2016.51DOI Listing
July 2016

An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour.

Biochem J 2016 10 12;473(19):3269-90. Epub 2016 Jul 12.

Centre for Respiratory Biology, UCL Respiratory, University College London, London WC1E 6JF, U.K. Institute of Structural and Molecular Biology/Birkbeck, University of London, London WC1E 7HX, U.K.

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http://dx.doi.org/10.1042/BCJ20160159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264506PMC
October 2016

Does Protease-Antiprotease Imbalance Explain Chronic Obstructive Pulmonary Disease?

Authors:
David A Lomas

Ann Am Thorac Soc 2016 04;13 Suppl 2:S130-7

Wolfson Institute for Biomedical Research, Division of Medicine, University College London, London, United Kingdom.

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http://dx.doi.org/10.1513/AnnalsATS.201504-196KVDOI Listing
April 2016

Update on alpha-1 antitrypsin deficiency: New therapies.

J Hepatol 2016 08 29;65(2):413-24. Epub 2016 Mar 29.

The London Alpha-1-Antitrypsin Deficiency Service, Royal Free London NHS Foundation Trust, London, UK; Institute of Structural and Molecular Biology, UCL/Birkbeck College, University of London, London WC1E 7HX, UK; Division of Asthma, Allergy and Lung Biology, King's College London, Guy's Hospital, 5th Floor, Tower Wing, London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S01688278163008
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http://dx.doi.org/10.1016/j.jhep.2016.03.010DOI Listing
August 2016

Polymers of Z α1-antitrypsin are secreted in cell models of disease.

Eur Respir J 2016 Mar 4;47(3):1005-9. Epub 2016 Feb 4.

Dept of Biology and Biotechnologies 'Charles Darwin', Sapienza University of Rome, Rome, Italy Pasteur Institute - Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy

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http://dx.doi.org/10.1183/13993003.00940-2015DOI Listing
March 2016

Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization.

Am J Respir Cell Mol Biol 2016 Jan;54(1):71-80

1 Wolfson Institute for Biomedical Research, University College London, London, United Kingdom.

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http://dx.doi.org/10.1165/rcmb.2015-0154OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742932PMC
January 2016

Genome-wide site-specific differential methylation in the blood of individuals with Klinefelter syndrome.

Mol Reprod Dev 2015 May 30;82(5):377-86. Epub 2015 Apr 30.

Channing Division of Network Medicine, Brigham & Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/mrd.22483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439255PMC
May 2015

One-year change in health status and subsequent outcomes in COPD.

Thorax 2015 May 17;70(5):420-5. Epub 2015 Mar 17.

Department of Research & Education, CIRO+, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands Faculty of Medicine and Life Sciences, REVAL-Rehabilitation Research Center, BIOMED-Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.

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http://thorax.bmj.com/content/early/2015/03/17/thoraxjnl-201
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http://dx.doi.org/10.1136/thoraxjnl-2014-205697DOI Listing
May 2015

A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity.

FASEB J 2015 Jun 10;29(6):2667-78. Epub 2015 Mar 10.

*Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge, United Kingdom; Department of Cell Biology, Genetics and Physiology, University of Malaga, Malaga, Spain; Wolfson Institute for Biomedical Research, University College London, London, United Kingdom; and Department of Biology and Biotechnologies, "Charles Darwin," and Pasteur Institute, Cenci Bolognetti Foundation, Sapienza University, Rome, Italy

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http://dx.doi.org/10.1096/fj.14-267351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548814PMC
June 2015

An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein.

Biochem J 2015 May;468(1):99-108

*Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BN, U.K.

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http://dx.doi.org/10.1042/BJ20141569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422257PMC
May 2015

Function of monocytes and monocyte-derived macrophages in α1-antitrypsin deficiency.

Eur Respir J 2015 Feb 16;45(2):365-76. Epub 2014 Oct 16.

Dept of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands

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http://dx.doi.org/10.1183/09031936.00046114DOI Listing
February 2015

The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans.

PLoS One 2014 31;9(7):e102985. Epub 2014 Jul 31.

Department of Genetics, University of Cambridge, Cambridge, United Kingdom; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102985PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117641PMC
October 2015

Evaluating the role of inflammation in chronic airways disease: the ERICA study.

COPD 2014 Sep 15;11(5):552-9. Epub 2014 May 15.

1NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust and Imperial College, London, UK.

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http://dx.doi.org/10.3109/15412555.2014.898031DOI Listing
September 2014

The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer's disease.

Dis Model Mech 2014 Apr 26;7(4):445-58. Epub 2014 Feb 26.

Department of Genetics, Downing Site, Cambridge, CB2 3EH, UK.

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http://dx.doi.org/10.1242/dmm.014134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974455PMC
April 2014

Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization.

Biochem J 2014 May;460(1):103-15

†Wolfson Institute for Biomedical Research, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, U.K.

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http://biochemj.org/lookup/doi/10.1042/BJ20131650
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http://dx.doi.org/10.1042/BJ20131650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080824PMC
May 2014

Genetic susceptibility.

Clin Chest Med 2014 Mar 12;35(1):29-38. Epub 2013 Dec 12.

University College London, 1st Floor, Maple House, 149 Tottenham Court Road, London W1T 7NF, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S02725231130015
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http://dx.doi.org/10.1016/j.ccm.2013.10.008DOI Listing
March 2014

The molecular and cellular pathology of α₁-antitrypsin deficiency.

Trends Mol Med 2014 Feb 25;20(2):116-27. Epub 2013 Dec 25.

Institute of Structural and Molecular Biology/Crystallography, Department of Biological Sciences, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, UK; Division of Medicine, University College London, 1st Floor, Maple House, 149, Tottenham Court Road, London, W1T 7NF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2013.10.007DOI Listing
February 2014

Lessons from ECLIPSE: a review of COPD biomarkers.

Thorax 2014 Jul 5;69(7):666-72. Epub 2013 Dec 5.

Fundació Investigació Sanitària Illes Balears (FISIB), Ciber Enfermedades Respiratorias (CIBERES), Barcelona, Catalunya, Spain Thorax Institute, Hospital Clinic, IDIBAPS, Univ. Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1136/thoraxjnl-2013-204778DOI Listing
July 2014

Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α1-antitrypsin.

Hum Mol Genet 2014 Feb 4;23(4):929-41. Epub 2013 Oct 4.

Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/Medical Research Council Building, Hills Road, Cambridge CB2 0XY, United Kingdom.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddt487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007119PMC
February 2014