David A Largaespada

David A Largaespada

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David A Largaespada

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CRISPR/Cas9-Based Positive Screens for Cancer-Related Traits.

Methods Mol Biol 2019 ;1907:137-144

Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1007/978-1-4939-8967-6_11DOI Listing
July 2019

HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism.

Mol Cancer Res 2019 Jul 11;17(7):1582-1593. Epub 2019 Apr 11.

State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation), The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-1127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610579PMC
July 2019

A comparison of risk factors for metastasis at diagnosis in humans and dogs with osteosarcoma.

Cancer Med 2019 Jun 21;8(6):3216-3226. Epub 2019 Apr 21.

Division of Pediatric Epidemiology and Clinical Research, School of Medicine, University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1002/cam4.2177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558582PMC
June 2019

Evaluating the landscape of gene cooperativity with receptor tyrosine kinases in liver tumorigenesis using transposon-mediated mutagenesis.

J Hepatol 2019 Mar 6;70(3):470-482. Epub 2018 Dec 6.

Aix Marseille Univ, CNRS, Developmental Biology Institute of Marseille (IBDM) UMR 7288, Parc Scientifique de Luminy, Marseille, France. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2018.11.027DOI Listing
March 2019

Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation.

Biomed Pharmacother 2019 Mar 18;111:68-75. Epub 2018 Dec 18.

The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183763
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http://dx.doi.org/10.1016/j.biopha.2018.12.019DOI Listing
March 2019

Screen Identifies and Other Genetic Drivers in Human B-cell Lymphoma.

Mol Cancer Res 2019 02 24;17(2):567-582. Epub 2018 Oct 24.

Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1158/1541-7786.MCR-18-0582DOI Listing
February 2019

Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice.

Hepatology 2018 03 26;67(3):924-939. Epub 2018 Jan 26.

Department of Anatomy & Cell Biology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA.

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http://dx.doi.org/10.1002/hep.29565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826818PMC
March 2018

CRISPR/Cas9 library screening for drug target discovery.

J Hum Genet 2018 Feb 20;63(2):179-186. Epub 2017 Nov 20.

Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1038/s10038-017-0376-9DOI Listing
February 2018

Transposons As Tools for Functional Genomics in Vertebrate Models.

Trends Genet 2017 11 6;33(11):784-801. Epub 2017 Sep 6.

Division of Medical Biotechnology, Paul Ehrlich Institute, Langen, Germany; These authors contributed equally to this work.. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2017.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682939PMC
November 2017

Multiphoton fluorescence lifetime imaging of chemotherapy distribution in solid tumors.

J Biomed Opt 2017 Nov;22(11):1-9

University of Minnesota, Department of Biomedical Engineering, Minneapolis, Minnesota, United States.

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http://dx.doi.org/10.1117/1.JBO.22.11.116010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712660PMC
November 2017

Transcriptomic analysis of gene signatures associated with sickle pain.

Sci Data 2017 05 16;4:170051. Epub 2017 May 16.

Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1038/sdata.2017.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749120PMC
May 2017

CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin.

Oncotarget 2016 Aug;7(33):53191-53203

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.18632/oncotarget.10668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288178PMC
August 2016

An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors.

EBioMedicine 2016 Jul 4;9:110-119. Epub 2016 Jun 4.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45229-0713, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972548PMC
July 2016

Case-oriented pathways analysis in pancreatic adenocarcinoma using data from a sleeping beauty transposon mutagenesis screen.

BMC Med Genomics 2016 Apr 1;9:16. Epub 2016 Apr 1.

Masonic Cancer Center, University of Minnesota, 425 E River Pkwy, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1186/s12920-016-0176-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818883PMC
April 2016

Divergent clonal selection dominates medulloblastoma at recurrence.

Authors:
A Sorana Morrissy Livia Garzia David J H Shih Scott Zuyderduyn Xi Huang Patryk Skowron Marc Remke Florence M G Cavalli Vijay Ramaswamy Patricia E Lindsay Salomeh Jelveh Laura K Donovan Xin Wang Betty Luu Kory Zayne Yisu Li Chelsea Mayoh Nina Thiessen Eloi Mercier Karen L Mungall Yusanne Ma Kane Tse Thomas Zeng Karey Shumansky Andrew J L Roth Sohrab Shah Hamza Farooq Noriyuki Kijima Borja L Holgado John J Y Lee Stuart Matan-Lithwick Jessica Liu Stephen C Mack Alex Manno K A Michealraj Carolina Nor John Peacock Lei Qin Juri Reimand Adi Rolider Yuan Y Thompson Xiaochong Wu Trevor Pugh Adrian Ally Mikhail Bilenky Yaron S N Butterfield Rebecca Carlsen Young Cheng Eric Chuah Richard D Corbett Noreen Dhalla An He Darlene Lee Haiyan I Li William Long Michael Mayo Patrick Plettner Jenny Q Qian Jacqueline E Schein Angela Tam Tina Wong Inanc Birol Yongjun Zhao Claudia C Faria José Pimentel Sofia Nunes Tarek Shalaby Michael Grotzer Ian F Pollack Ronald L Hamilton Xiao-Nan Li Anne E Bendel Daniel W Fults Andrew W Walter Toshihiro Kumabe Teiji Tominaga V Peter Collins Yoon-Jae Cho Caitlin Hoffman David Lyden Jeffrey H Wisoff James H Garvin Duncan S Stearns Luca Massimi Ulrich Schüller Jaroslav Sterba Karel Zitterbart Stephanie Puget Olivier Ayrault Sandra E Dunn Daniela P C Tirapelli Carlos G Carlotti Helen Wheeler Andrew R Hallahan Wendy Ingram Tobey J MacDonald Jeffrey J Olson Erwin G Van Meir Ji-Yeoun Lee Kyu-Chang Wang Seung-Ki Kim Byung-Kyu Cho Torsten Pietsch Gudrun Fleischhack Stephan Tippelt Young Shin Ra Simon Bailey Janet C Lindsey Steven C Clifford Charles G Eberhart Michael K Cooper Roger J Packer Maura Massimino Maria Luisa Garre Ute Bartels Uri Tabori Cynthia E Hawkins Peter Dirks Eric Bouffet James T Rutka Robert J Wechsler-Reya William A Weiss Lara S Collier Adam J Dupuy Andrey Korshunov David T W Jones Marcel Kool Paul A Northcott Stefan M Pfister David A Largaespada Andrew J Mungall Richard A Moore Nada Jabado Gary D Bader Steven J M Jones David Malkin Marco A Marra Michael D Taylor

Nature 2016 Jan 13;529(7586):351-7. Epub 2016 Jan 13.

Developmental &Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.

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http://dx.doi.org/10.1038/nature16478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936195PMC
January 2016

Understanding the Osteosarcoma Pathobiology: A Comparative Oncology Approach.

Vet Sci 2016 Jan 18;3(1). Epub 2016 Jan 18.

Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.3390/vetsci3010003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644613PMC
January 2016

HomeRun Vector Assembly System: a flexible and standardized cloning system for assembly of multi-modular DNA constructs.

PLoS One 2014 24;9(6):e100948. Epub 2014 Jun 24.

Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, United States of America; Center for Genome Engineering and Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100948PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069157PMC
November 2015

Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma.

World J Gastroenterol 2015 Nov;21(42):12157-70

Amy P Chiu, Lilian H Lo, Vincent W Keng, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.

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http://dx.doi.org/10.3748/wjg.v21.i42.12157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641133PMC
November 2015

Coping with cancer genes altered by copy number.

Oncotarget 2015 Nov;6(34):35155-6

Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Twin Cities, MN, USA.

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http://dx.doi.org/10.18632/oncotarget.6215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742095PMC
November 2015

Decreased affinity for efflux transporters increases brain penetrance and molecular targeting of a PI3K/mTOR inhibitor in a mouse model of glioblastoma.

Neuro Oncol 2015 Sep 12;17(9):1210-9. Epub 2015 May 12.

Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota (C.M.B., S.J.M., D.M.M., J.R.O., W.F.E); Brain Tumor Program, University of Minnesota, Minneapolis, Minnesota (C.M.B., R.K.O., S.J.M., D.M.M., J.R.O., D.A.L., W.F.E); Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota (R.K.O., W.F.E); Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota (J.R.O., D.A.L); Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (D.H.P., J.L.P., D.H.B., J.N.S); Brain Barriers Research Center, University of Minnesota, Minneapolis, Minnesota 

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http://dx.doi.org/10.1093/neuonc/nov081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588756PMC
September 2015

Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor.

Mol Cancer Res 2015 Aug 20;13(8):1238-47. Epub 2015 May 20.

Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, Minnesota. Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. Department of Genetic, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0674-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543426PMC
August 2015

Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.

Bioorg Med Chem 2015 Aug 30;23(15):4737-45. Epub 2015 May 30.

Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA; Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.05.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697833PMC
August 2015

Simple and efficient methods for enrichment and isolation of endonuclease modified cells.

PLoS One 2014 5;9(5):e96114. Epub 2014 May 5.

Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, United States of America; Center for Genome Engineering and Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, United States of America; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America; Discovery Genomics, Inc, Minneapolis, Minnesota, United States of America; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096114PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010432PMC
June 2015

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.

Nat Genet 2015 Jun 11;47(6):615-24. Epub 2015 May 11.

1] Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA. [2] Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, USA. [3] Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA. [4] Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1038/ng.3293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767150PMC
June 2015

Parthenolide prodrug LC-1 slows growth of intracranial glioma.

Bioorg Med Chem Lett 2015 Jun 25;25(12):2493-5. Epub 2015 Apr 25.

Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA; Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X150039
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http://dx.doi.org/10.1016/j.bmcl.2015.04.058DOI Listing
June 2015

Sleeping Beauty transposon insertional mutagenesis based mouse models for cancer gene discovery.

Curr Opin Genet Dev 2015 Feb 4;30:66-72. Epub 2015 Jun 4.

Department of Pediatrics, University of Minnesota Minneapolis, MN 55455, United States; Center for Genome Engineering, University of Minnesota Minneapolis, MN 55455, United States; Masonic Cancer Center, University of Minnesota Minneapolis, MN 55455, United States; Department of Genetics, Cell Biology, and Development, University of Minnesota Minneapolis, MN 55455, United States. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2015.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900178PMC
February 2015

Genetic signature of histiocytic sarcoma revealed by a sleeping beauty transposon genetic screen in mice.

PLoS One 2014 14;9(5):e97280. Epub 2014 May 14.

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America; Obstetrics, Gynecology, and Women's Health, University of Minnesota, Minneapolis, Minnesota, United States of America; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097280PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020815PMC
January 2015

NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia.

Blood 2014 Nov 14;124(22):3274-83. Epub 2014 Oct 14.

Department of Genetics, Cell Biology and Development, and Masonic Cancer Center, University of Minnesota, Minneapolis, MN; Center for Genome Engineering and Department of Pediatrics, University of Minnesota, Minneapolis, MN.

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http://dx.doi.org/10.1182/blood-2013-08-521708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239336PMC
November 2014

Antigen-specific culture of memory-like CD8 T cells for adoptive immunotherapy.

Cancer Immunol Res 2014 Sep 22;2(9):839-45. Epub 2014 May 22.

Masonic Cancer Center, Brain Tumor Program, Departments of Pediatrics, Genetics, Cell Biology and Development, and Center for Genome Engineering, and

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156517PMC
September 2014

PVT1 dependence in cancer with MYC copy-number increase.

Nature 2014 Aug 22;512(7512):82-6. Epub 2014 Jun 22.

1] Department of Genetics, Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA [2] Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1038/nature13311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767149PMC
August 2014

Using RNA-seq and targeted nucleases to identify mechanisms of drug resistance in acute myeloid leukemia.

Sci Rep 2014 Aug 13;4:6048. Epub 2014 Aug 13.

1] Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA [2] Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA [3] Center for Genome Engineering, University of Minnesota, Minneapolis, MN, USA [4] Brain Tumor Program, University of Minnesota, Minneapolis, MN, USA [5] Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.

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http://www.nature.com/articles/srep06048
Publisher Site
http://dx.doi.org/10.1038/srep06048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131221PMC
August 2014

Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis.

Am J Pathol 2014 Jul 13;184(7):2082-98. Epub 2014 May 13.

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota; Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota; Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota; Brain Tumor Program, University of Minnesota, Minneapolis, Minnesota; Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1016/j.ajpath.2014.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076465PMC
July 2014

Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies.

Semin Cell Dev Biol 2014 Mar 24;27:86-95. Epub 2014 Jan 24.

Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2014.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035448PMC
March 2014

Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination.

Oncoimmunology 2013 Oct 15;2(10):e26294. Epub 2013 Oct 15.

Masonic Cancer Center; University of Minnesota; Minneapolis; MN USA ; Brain Tumor Program; University of Minnesota; Minneapolis, MN USA ; Department of Pediatrics; University of Minnesota; Minneapolis, MN USA.

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http://dx.doi.org/10.4161/onci.26294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827073PMC
October 2013

Retrotransposons: a new and credible source of inherited and somatically acquired hepatocellular carcinoma mutations.

J Hepatol 2013 Sep 9;59(3):616-7. Epub 2013 May 9.

Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.jhep.2013.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079105PMC
September 2013

MMuFLR: missense mutation and frameshift location reporter.

Bioinformatics 2013 Sep 3;29(18):2353-4. Epub 2013 Jul 3.

Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1093/bioinformatics/btt385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036437PMC
September 2013

Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy.

Transl Res 2013 Apr 10;161(4):265-83. Epub 2013 Jan 10.

Department of Genetics Cell Biology and Development, Center for Genome Engineering and Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.trsl.2012.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602164PMC
April 2013

Modular assembly of transposon integratable multigene vectors using RecWay assembly.

Nucleic Acids Res 2013 Apr 26;41(8):e92. Epub 2013 Feb 26.

Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1093/nar/gkt115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632113PMC
April 2013

PML-RARα co-operates with Sox4 in acute myeloid leukemia development in mice.

Haematologica 2013 Mar 9;98(3):424-7. Epub 2012 Nov 9.

Helen Diller Family Comprehensive Cancer Center and Department of Laboratory Medicine, University of California San Francisco, USA.

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http://dx.doi.org/10.3324/haematol.2011.057067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659942PMC
March 2013

Review: In vivo models for defining molecular subtypes of the primitive neuroectodermal tumor genome: current challenges and solutions.

In Vivo 2012 Jul-Aug;26(4):487-500

The Center For Genome Engineering and Masonic Cancer Center, University of Minnesota, 6-160 Jackson Hall, 321 Church Street South East, Minneapolis, MN 55455, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516387PMC
January 2013

Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.

Sarcoma 2012 18;2012:620834. Epub 2012 Dec 18.

Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA ; Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA ; Center for Genome Engineering, University of Minnesota, Minneapolis, MN 55455, USA ; Brain Tumor Program, University of Minnesota, Minneapolis, MN 55455, USA ; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.

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http://www.hindawi.com/journals/sarcoma/2012/620834/
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http://dx.doi.org/10.1155/2012/620834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539440PMC
January 2013

Extensive somatic L1 retrotransposition in colorectal tumors.

Genome Res 2012 Dec 11;22(12):2328-38. Epub 2012 Sep 11.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1101/gr.145235.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514663PMC
December 2012

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.

Authors:
Andrew V Biankin Nicola Waddell Karin S Kassahn Marie-Claude Gingras Lakshmi B Muthuswamy Amber L Johns David K Miller Peter J Wilson Ann-Marie Patch Jianmin Wu David K Chang Mark J Cowley Brooke B Gardiner Sarah Song Ivon Harliwong Senel Idrisoglu Craig Nourse Ehsan Nourbakhsh Suzanne Manning Shivangi Wani Milena Gongora Marina Pajic Christopher J Scarlett Anthony J Gill Andreia V Pinho Ilse Rooman Matthew Anderson Oliver Holmes Conrad Leonard Darrin Taylor Scott Wood Qinying Xu Katia Nones J Lynn Fink Angelika Christ Tim Bruxner Nicole Cloonan Gabriel Kolle Felicity Newell Mark Pinese R Scott Mead Jeremy L Humphris Warren Kaplan Marc D Jones Emily K Colvin Adnan M Nagrial Emily S Humphrey Angela Chou Venessa T Chin Lorraine A Chantrill Amanda Mawson Jaswinder S Samra James G Kench Jessica A Lovell Roger J Daly Neil D Merrett Christopher Toon Krishna Epari Nam Q Nguyen Andrew Barbour Nikolajs Zeps Nipun Kakkar Fengmei Zhao Yuan Qing Wu Min Wang Donna M Muzny William E Fisher F Charles Brunicardi Sally E Hodges Jeffrey G Reid Jennifer Drummond Kyle Chang Yi Han Lora R Lewis Huyen Dinh Christian J Buhay Timothy Beck Lee Timms Michelle Sam Kimberly Begley Andrew Brown Deepa Pai Ami Panchal Nicholas Buchner Richard De Borja Robert E Denroche Christina K Yung Stefano Serra Nicole Onetto Debabrata Mukhopadhyay Ming-Sound Tsao Patricia A Shaw Gloria M Petersen Steven Gallinger Ralph H Hruban Anirban Maitra Christine A Iacobuzio-Donahue Richard D Schulick Christopher L Wolfgang Richard A Morgan Rita T Lawlor Paola Capelli Vincenzo Corbo Maria Scardoni Giampaolo Tortora Margaret A Tempero Karen M Mann Nancy A Jenkins Pedro A Perez-Mancera David J Adams David A Largaespada Lodewyk F A Wessels Alistair G Rust Lincoln D Stein David A Tuveson Neal G Copeland Elizabeth A Musgrove Aldo Scarpa James R Eshleman Thomas J Hudson Robert L Sutherland David A Wheeler John V Pearson John D McPherson Richard A Gibbs Sean M Grimmond

Nature 2012 Nov 24;491(7424):399-405. Epub 2012 Oct 24.

The Kinghorn Cancer Centre, 370 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia.

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http://dx.doi.org/10.1038/nature11547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530898PMC
November 2012

Why men are at higher risk for hepatocellular carcinoma?

J Hepatol 2012 Aug 13;57(2):453-4. Epub 2012 Mar 13.

Masonic Cancer Center, University of Minnesota, MN 55455, USA.

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http://dx.doi.org/10.1016/j.jhep.2012.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506003PMC
August 2012

TAPDANCE: an automated tool to identify and annotate transposon insertion CISs and associations between CISs from next generation sequence data.

BMC Bioinformatics 2012 Jun 29;13:154. Epub 2012 Jun 29.

Biostatistics and Bioinformatics Masonic Cancer Center, University of Minnesota, Minneapolis, USA.

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http://dx.doi.org/10.1186/1471-2105-13-154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461456PMC
June 2012

Efficient non-viral integration and stable gene expression in multipotent adult progenitor cells.

Stem Cells Int 2011 2;2011:717069. Epub 2011 Oct 2.

Center for Genome Engineering, Gene Therapy Program, Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.4061/2011/717069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184415PMC
November 2011

A Comprehensive Guide to Sleeping Beauty-Based Somatic Transposon Mutagenesis in the Mouse.

Curr Protoc Mouse Biol 2011 Sep 1;1(3):347-68. Epub 2011 Sep 1.

Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1002/9780470942390.mo110087DOI Listing
September 2011

A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis.

Proc Natl Acad Sci U S A 2011 Apr 21;108(14):5765-70. Epub 2011 Mar 21.

Department of Genetics, Cell Biology and Development, Center for Genome Engineering, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1073/pnas.1018012108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078351PMC
April 2011

Modeling hepatitis B virus X-induced hepatocellular carcinoma in mice with the Sleeping Beauty transposon system.

Hepatology 2011 Mar 3;53(3):781-90. Epub 2011 Jan 3.

Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1002/hep.24091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079950PMC
March 2011

A transposon and transposase system for human application.

Mol Ther 2010 Apr 26;18(4):674-83. Epub 2010 Jan 26.

Department of Genetics, Cell Biology, and Development, Center for Genome Engineering, Institute of Human Genetics, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S152500161632323
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http://dx.doi.org/10.1038/mt.2010.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862530PMC
April 2010

Efficient transposition of Tol2 in the mouse germline.

Genetics 2009 Dec 5;183(4):1565-73. Epub 2009 Oct 5.

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA

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http://dx.doi.org/10.1534/genetics.109.100768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787440PMC
December 2009

Transposon-mediated mutagenesis of somatic cells in the mouse for cancer gene identification.

Methods 2009 Nov 14;49(3):282-6. Epub 2009 Jul 14.

Masonic Cancer Center University of Minnesota, Department of Genetics, Arnold and Mabel Beckman Center for Genome Engineering, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1016/j.ymeth.2009.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806649PMC
November 2009

A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice.

Cancer Res 2009 Oct 6;69(20):8150-6. Epub 2009 Oct 6.

Department of Anatomy and Cell Biology, Center for Bioinformatics, Computational Biology and Biomedical Engineering, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700628PMC
October 2009

Developmental origins of cancer.

Cancer Res 2009 Aug 4;69(16):6375-7. Epub 2009 Aug 4.

Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1391DOI Listing
August 2009

Transposon mutagenesis in mice.

Methods Mol Biol 2009 ;530:379-90

University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, MN, USA.

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http://dx.doi.org/10.1007/978-1-59745-471-1_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984597PMC
May 2009

A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene.

Blood 2009 Jan 23;113(5):1075-85. Epub 2008 Oct 23.

Masonic Cancer Center and Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-03-14
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http://dx.doi.org/10.1182/blood-2008-03-144436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635073PMC
January 2009

RAS oncogene suppression induces apoptosis followed by more differentiated and less myelosuppressive disease upon relapse of acute myeloid leukemia.

Blood 2009 Jan 24;113(5):1086-96. Epub 2008 Oct 24.

Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, USA.

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http://dx.doi.org/10.1182/blood-2008-01-132316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635074PMC
January 2009

De novo induction of genetically engineered brain tumors in mice using plasmid DNA.

Cancer Res 2009 Jan;69(2):431-9

Departments of Pediatrics, Center for Allied Health Programs, Laboratory Medicine and Pathology, and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701484PMC
January 2009