David A Kass

David A Kass

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David A Kass

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Myocardial Phosphodiesterases and their Role in cGMP Regulation.

J Cardiovasc Pharmacol 2019 Oct 21. Epub 2019 Oct 21.

Department of Medicine, Division of Cardiology and Department of Pharmacology and Molecular Sciences Baltimore, MD.

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http://Insights.ovid.com/crossref?an=00005344-900000000-9847
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http://dx.doi.org/10.1097/FJC.0000000000000773DOI Listing
October 2019

Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway.

J Am Coll Cardiol 2019 Jun;73(21):2705-2718

Interdisciplinary Stem Cell Institute, University of Miami Leonard M. Miller School of Medicine, Miami, Florida; Department of Medicine, Division of Cardiology, University of Miami Leonard M. Miller School of Medicine, Miami, Florida; Vascular Biology Institute and Peggy and Harold Katz Family Drug Discovery Center, University of Miami Leonard M. Miller School of Medicine, Miami, Florida. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2019.02.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546303PMC
June 2019

Leveraging Signaling Pathways to Treat Heart Failure With Reduced Ejection Fraction.

Circ Res 2019 May;124(11):1618-1632

From the Division of Cardiology, Department of Medicine (M.P.-V., V.S.H., D.A.K.), The Johns Hopkins University, Baltimore MD.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.313682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534150PMC
May 2019

Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury.

J Mol Cell Cardiol 2019 Apr 9;129:236-246. Epub 2019 Mar 9.

Department of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, USA; Heart, Lung and Vascular Institute, Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2019.03.006DOI Listing
April 2019

Chronic Atrial and Ventricular Pacing in the Mouse.

Circ Heart Fail 2019 02;12(2):e005655

Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD (M.S., R.N., D.B., G.Z., B.L.L., A.S., D.I.L., D.A.K.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513021PMC
February 2019

Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition.

Circulation 2018 10;138(18):1974-1987

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (T.H., G.E.K., R.S.T., T.A., S.H., R.N., G.Z., D.I.L., D.A.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.030490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205901PMC
October 2018

Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease.

JCI Insight 2018 08 9;3(15). Epub 2018 Aug 9.

Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1172/jci.insight.121739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6129132PMC
August 2018

Pulmonary Effective Arterial Elastance as a Measure of Right Ventricular Afterload and Its Prognostic Value in Pulmonary Hypertension Due to Left Heart Disease.

Circ Heart Fail 2018 04;11(4):e004436

Division of Cardiology (E.T., B.W.K., E.K.K., D.A.K., R.J.T.) and Division of Pulmonary and Critical Care Medicine (T.M.K., R.D., S.C.M., P.M.H.), Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD. Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S., H.H.P.). Division of Cardiology, Mayo Clinic, Rochester, MN (B.A.B., W.L.M.). Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle (P.J.L.). Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston (B.A.H., R.J.T.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901761PMC
April 2018

Prevention of PKG-1α Oxidation Suppresses Antihypertrophic/Antifibrotic Effects From PDE5 Inhibition but not sGC Stimulation.

Circ Heart Fail 2018 03;11(3):e004740

From the Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD (T.N., G.Z., M.J.R., K.K.-S., M.Z., G.E.K., D.A.K.); and Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Japan (T.N., K.T.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858464PMC
March 2018

Transient receptor potential channel 6 regulates abnormal cardiac S-nitrosylation in Duchenne muscular dystrophy.

Proc Natl Acad Sci U S A 2017 12 29;114(50):E10763-E10771. Epub 2017 Nov 29.

Advanced Clinical BioSystems Research Institute, Heart Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048;

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http://dx.doi.org/10.1073/pnas.1712623114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740634PMC
December 2017

Cardiac Phosphodiesterases and Their Modulation for Treating Heart Disease.

Handb Exp Pharmacol 2017 ;243:249-269

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/164_2016_82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665023PMC
October 2017

Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo.

Circ Heart Fail 2017 Sep;10(9)

From the Division of Cardiology, Department of Pediatrics (Y.L., N.O., A.H., G.R.-C., A.M.M.), Division of Cardiology, Department of Medicine (G.Z., N.P., C.T., G.K., D.A.K.), Department of Pharmacology and Molecular Sciences, Department of Biomedical Engineering (D.A.K.), and Deparment of Ophthalmology (P.Z.), Johns Hopkins University, Baltimore, MD; and Istanbul Faculty of Medicine, Istanbul University, Turkey (N.O.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.003850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612410PMC
September 2017

Inorganic Nitrates: for Heart Failure With Preserved Ejection Fraction?

Circ Res 2017 03;120(7):1057-1059

From the Division of Cardiology, Department of Medicine and Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1161/CIRCRESAHA.117.310699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398899PMC
March 2017

Nanodomain Regulation of Cardiac Cyclic Nucleotide Signaling by Phosphodiesterases.

Annu Rev Pharmacol Toxicol 2017 01 12;57:455-479. Epub 2016 Oct 12.

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; email:

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http://dx.doi.org/10.1146/annurev-pharmtox-010716-104756DOI Listing
January 2017

Cellular and Molecular Aspects of Dyssynchrony and Resynchronization.

Heart Fail Clin 2017 Jan;13(1):29-41

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Ross Research Building, Room 858, 720 Rutland Avenue, Baltimore, MD 21205, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15517136163006
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http://dx.doi.org/10.1016/j.hfc.2016.07.003DOI Listing
January 2017

Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy.

Cell Rep 2017 01;18(2):571-582

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.12.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5232412PMC
January 2017

A Simple Adaptive Transfer Function for Deriving the Central Blood Pressure Waveform from a Radial Blood Pressure Waveform.

Sci Rep 2016 09 14;6:33230. Epub 2016 Sep 14.

Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA.

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http://dx.doi.org/10.1038/srep33230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021949PMC
September 2016

Old dog, new tricks: novel cardiac targets and stress regulation by protein kinase G.

Cardiovasc Res 2016 07 13;111(2):154-62. Epub 2016 Jun 13.

Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

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http://dx.doi.org/10.1093/cvr/cvw107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937204PMC
July 2016

Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap.

Circulation 2016 Jul;134(1):73-90

From Division of Cardiology, Department of Medicine, and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL (S.J.S.); Sections on Cardiovascular Medicine and Geriatrics, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.); Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN, (B.A.B.); Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands (L.v.H., W.J.P.); Department of Cardiology, Onze Lieve Vrouw Gasthuis, Amsterdam, The Netherlands (L.v.H.); Department of Medicine, Medical University of South Carolina (MUSC) and the RHJ Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); and Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD (D.A.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.021884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930115PMC
July 2016

Right Ventricular Functional Reserve in Pulmonary Arterial Hypertension.

Circulation 2016 Jun 11;133(24):2413-22. Epub 2016 May 11.

From Divisions of Cardiology (S.H., B.A.H., E.T., A.C.B., P.S.R., D.A.K., R.J.T.), Pulmonary and Critical Care (S.C.M., R.L.D., T.M.K., P.M.H.), and Rheumatology (L.K.H., A.A.S., Z.M., F.M.W.), Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD; and Departments of Radiology (C.P.C.-V., S.L.Z.) and Biomedical Engineering (D.A.K.), Johns Hopkins Medical Institutions, Baltimore, MD.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.022082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907868PMC
June 2016

Novel, single-beat approach for determining both end-systolic pressure-dimension relationship and preload recruitable stroke work.

Open Heart 2016 15;3(1):e000451. Epub 2016 Jun 15.

Department of Pediatric Cardiology , Saitama Medical Center, Saitama Medical University , Kawagoe , Japan.

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http://dx.doi.org/10.1136/openhrt-2016-000451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916631PMC
June 2016

Association Between Left Atrial Stiffness Index and Atrial Fibrillation Recurrence in Patients Undergoing Left Atrial Ablation.

Circ Arrhythm Electrophysiol 2016 Mar;9(3)

From the Departments of Cardiology (I.M.K., F.M., R.D.B., J.E.M., D.D.S., H.A., D.A.K., H.C., S.N.) and Radiology and Radiological Sciences (S.L.Z.), The Johns Hopkins University School of Medicine, Baltimore, MD; and Departments of Biostatistics (V.Z.) and Epidemiology (S.N.), Johns Hopkins University, Baltimore, MD.

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http://dx.doi.org/10.1161/CIRCEP.115.003163DOI Listing
March 2016

Can Nitrite AMPk Up Sirt-ainty to Treat Heart Failure With Preserved Ejection Fraction?

Circulation 2016 Feb 26;133(8):692-4. Epub 2016 Jan 26.

From Division of Cardiology (S.H., D.A.K.), Department of Medicine, Department of Biomedical Engineering (D.A.K.), and Department of Pharmacology and Molecular Sciences (D.A.K.), Johns Hopkins Medical Institutions, Baltimore, MD.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.021409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835360PMC
February 2016

Cellular and Molecular Aspects of Dyssynchrony and Resynchronization.

Card Electrophysiol Clin 2015 Dec;7(4):585-97

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Ross Research Building, Room 858, 720 Rutland Avenue, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.ccep.2015.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660268PMC
December 2015

Citrullination of myofilament proteins in heart failure.

Cardiovasc Res 2015 Nov 25;108(2):232-42. Epub 2015 Jun 25.

The Heart Institute and Department of Medicine, Cedars-Sinai Medical Center, Advanced Clinical BioSystems Research Institute, Advanced Health Science Building, 9229, Los Angeles, CA, USA Bayview Proteomics Center, Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1093/cvr/cvv185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614685PMC
November 2015

Outcomes and worsening renal function in patients hospitalized with heart failure with preserved ejection fraction.

Am J Cardiol 2015 Nov 31;116(10):1534-40. Epub 2015 Aug 31.

Division of Cardiology, Department of Medicine, The Johns Hopkins Hospital, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2015.08.019DOI Listing
November 2015

Molecular Screen Identifies Cardiac Myosin-Binding Protein-C as a Protein Kinase G-Iα Substrate.

Circ Heart Fail 2015 Nov 18;8(6):1115-22. Epub 2015 Oct 18.

From the Molecular Cardiology Research Institute (R.T., G.-R.W., T.D.C., R.M.B.) and Division of Cardiology (R.M.B.), Tufts Medical Center, Boston, MA; Tufts University School of Medicine, Boston, MA (S. Giovanni); Department of Cell and Molecular Physiology, Health Sciences Division, Loyola University Chicago, Maywood, IL (S. Govindan, S.S.); Johns Hopkins Medical Institutions, Baltimore, MD (D.I.L., E.T., D.A.K.); and Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan (E.T.).

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651836PMC
November 2015

Transcriptional Landscape of Cardiomyocyte Maturation.

Cell Rep 2015 Nov 12;13(8):1705-16. Epub 2015 Nov 12.

Division of Cardiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; The Johns Hopkins Institute for Cell Engineering, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.10.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662925PMC
November 2015

Dual Labeling Biotin Switch Assay to Reduce Bias Derived From Different Cysteine Subpopulations: A Method to Maximize S-Nitrosylation Detection.

Circ Res 2015 Oct 3;117(10):846-57. Epub 2015 Sep 3.

From the Department of Biological Chemistry (H.S.C., C.I.M., R.N.C., J.E.V.E.), Division of Cardiology, Department of Medicine (V.V., P.P.R., D.A.K., J.E.V.E.), The Johns Hopkins NHLBI Proteomics Innovation Center on Heart Failure (H.S.C., V.V., D.A.K., J.E.V.E.), Department of Medicine, Mass Spectrometry and Proteomic Core Facility (R.N.C.), Johns Hopkins University School of Medicine, Baltimore, MD; Thermo Fisher Scientific, Rockford, IL (R.D.B., J.C.R.); Advanced Clinical Biosystems Research Institute, Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (V.V., E.L.C., J.E.V.E.); Department of Medicine, Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, FL (W.B., J.M.H.); Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada (C.I.M.); and Division of Cardiology, Medical University of Graz, Austria (P.P.R.).

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http://dx.doi.org/10.1161/CIRCRESAHA.115.307336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979977PMC
October 2015

Stressed hearts inflame the body (in a good way).

Proc Natl Acad Sci U S A 2015 Jun 21;112(23):7113-4. Epub 2015 May 21.

Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205

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http://dx.doi.org/10.1073/pnas.1507821112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466727PMC
June 2015

Cardiac resynchronization therapy restores sympathovagal balance in the failing heart by differential remodeling of cholinergic signaling.

Circ Res 2015 May 2;116(10):1691-9. Epub 2015 Mar 2.

From the Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.305268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577523PMC
May 2015

Molecular imaging of inflammation in the ApoE -/- mouse model of atherosclerosis with IodoDPA.

Biochem Biophys Res Commun 2015 May 6;461(1):70-5. Epub 2015 Apr 6.

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.bbrc.2015.03.171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426030PMC
May 2015

Natural killer cells limit cardiac inflammation and fibrosis by halting eosinophil infiltration.

Am J Pathol 2015 Mar 23;185(3):847-61. Epub 2015 Jan 23.

The W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2014.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348473PMC
March 2015

Soluble guanylate cyclase is required for systemic vasodilation but not positive inotropy induced by nitroxyl in the mouse.

Hypertension 2015 Feb 1;65(2):385-92. Epub 2014 Dec 1.

From the Department of Medicine, Division of Cardiology, Johns Hopkins School of Medicine, Baltimore MD (G.Z., M.J.R., T.N., E.T., N.P., D.A.K.); Institut of Vegetative Physiology, Julius Maximilians-Universität Würzburg, Würzburg, Germany (D.G., A.F.); and Departments of Anesthesia (G.S., D.E.B.) and Surgery (D.H.), Johns Hopkins Medical Institutions, Baltimore MD.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289094PMC
February 2015

Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation.

Proc Natl Acad Sci U S A 2015 Feb 12;112(6):1880-5. Epub 2015 Jan 12.

Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205; Dipartimento di Medicina Clinica e Sperimentale, Universita' di Perugia, 06132 Perugia, Italy

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http://www.pnas.org/content/112/6/1880.full.pdf
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http://www.pnas.org/lookup/doi/10.1073/pnas.1417949112
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http://dx.doi.org/10.1073/pnas.1417949112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330748PMC
February 2015

Glycoproteins identified from heart failure and treatment models.

Proteomics 2015 Jan 9;15(2-3):567-79. Epub 2014 Oct 9.

Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1002/pmic.201400151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492696PMC
January 2015

Response to letter from Villa-Abrille et al.

Circ Res 2015 Jan;116(1):e12

Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1161/CIRCRESAHA.114.305576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381802PMC
January 2015

Efficacy of cardiac resynchronization in acutely infarcted canine hearts with electromechanical dyssynchrony.

Heart Rhythm 2014 Oct 2;11(10):1819-26. Epub 2014 Jun 2.

Division of Cardiology, Johns Hopkins Medical Institutions, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2014.05.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188793PMC
October 2014

Sildenafil does not improve cardiomyopathy in Duchenne/Becker muscular dystrophy.

Ann Neurol 2014 Oct 10;76(4):541-9. Epub 2014 Jul 10.

Hugo W. Moser Research Institute, Kennedy Krieger Institute, Baltimore, MD; Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1002/ana.24214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191982PMC
October 2014

Dynamic gene expression patterns in animal models of early and late heart failure reveal biphasic-bidirectional transcriptional activation of signaling pathways.

Physiol Genomics 2014 Oct 26;46(20):779-87. Epub 2014 Aug 26.

Department of Medicine, Division of Cardiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland

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http://dx.doi.org/10.1152/physiolgenomics.00054.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200378PMC
October 2014

Remodeling of the sarcomeric cytoskeleton in cardiac ventricular myocytes during heart failure and after cardiac resynchronization therapy.

J Mol Cell Cardiol 2014 Jul 20;72:186-95. Epub 2014 Mar 20.

Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA; Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077200PMC
July 2014

Severity of systemic sclerosis-associated pulmonary arterial hypertension in African Americans.

Medicine (Baltimore) 2014 Jul;93(5):177-85

Divisions of Pulmonary and Critical Care Medicine (IB, SCM, DB, TMK, HC, TH, NC, ALZ, RD, REG, PMH), General Internal Medicine (MS, FMW), Rheumatology (LKH), and Cardiology (RJT, DAK), Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) (IB), Barcelona, Spain; and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES) (IB), Spain.

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http://dx.doi.org/10.1097/MD.0000000000000032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602454PMC
July 2014

Inhibition of glycosphingolipid synthesis ameliorates atherosclerosis and arterial stiffness in apolipoprotein E-/- mice and rabbits fed a high-fat and -cholesterol diet.

Circulation 2014 Jun 7;129(23):2403-13. Epub 2014 Apr 7.

From the Departments of Pediatrics (S.C., S.M., C.A., M.R.), Medicine (D. Bedja, D.A.K.), and Anesthesiology and Critical Care Medicine (D. Berkowitz), Johns Hopkins University School of Medicine, Baltimore, MD; and Australian School of Advanced Medicine, Macquarie University, Sydney, Australia (D. Bedja, A.A.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.007559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053506PMC
June 2014

Cardiac fibroblasts mediate IL-17A-driven inflammatory dilated cardiomyopathy.

J Exp Med 2014 Jun 16;211(7):1449-64. Epub 2014 Jun 16.

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Department of Pathology, and Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

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http://dx.doi.org/10.1084/jem.20132126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076595PMC
June 2014

Heart failure with preserved ejection fraction: mechanisms, clinical features, and therapies.

Circ Res 2014 Jun;115(1):79-96

From the Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1161/CIRCRESAHA.115.302922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146618PMC
June 2014

Cardiomyocyte-specific transforming growth factor β suppression blocks neutrophil infiltration, augments multiple cytoprotective cascades, and reduces early mortality after myocardial infarction.

Circ Res 2014 Apr 26;114(8):1246-57. Epub 2014 Feb 26.

From the Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD (P.P.R., S.H., D.I.L., N.K., D.A.K.); Division of Cardiology, Medical University of Graz, Austria (P.P.R.); Department of Pediatrics, Cincinnati Children's Hospital, University of Cincinnati, Cincinnati, OH (D.V., J.D.M.); Howard Hughes Medical Institute, University of Cincinnati, Cincinnati, OH (J.D.M.); and Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, Gunma, Japan (N.K.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.114.30265
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http://dx.doi.org/10.1161/CIRCRESAHA.114.302653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997999PMC
April 2014

Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors.

Elife 2014 Apr 24;3:e02164. Epub 2014 Apr 24.

Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, United States Institute for Cell Engineering, Johns Hopkins University, Baltimore, United States

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007206PMC
http://dx.doi.org/10.7554/eLife.02164DOI Listing
April 2014

Hyperactive adverse mechanical stress responses in dystrophic heart are coupled to transient receptor potential canonical 6 and blocked by cGMP-protein kinase G modulation.

Circ Res 2014 Feb 21;114(5):823-32. Epub 2014 Jan 21.

From the Division of Cardiology, Department of Medicine (K.S., P.P.R., D.-i.L., S.H., D.B., O.H.C., D.A.K.) and Department of Biomedical Engineering (D.A.K.), The Johns Hopkins Medical Institutions, Baltimore, MD; Division of Cardiology, Medical University of Graz, Graz, Austria (P.P.R.); and National Institute of Environmental Health Science, Research Triangle Park, NC (L.B.).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963144PMC
February 2014

Et Tu PDE2?

Authors:
David A Kass

J Am Coll Cardiol 2013 Oct 26;62(17):1607-9. Epub 2013 Jun 26.

Division of Cardiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland. Electronic address:

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October 2013

Hypertrophy signaling pathways in experimental chronic aortic regurgitation.

J Cardiovasc Transl Res 2013 Oct 26;6(5):852-60. Epub 2013 Jul 26.

Division of Cardiology, Johns Hopkins Medical Institutions, 600 N Wolfe St., Carnegie 568, Baltimore, MD, 21287, USA.

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October 2013

Ventricular-arterial coupling, remodeling, and prognosis in chronic heart failure.

J Am Coll Cardiol 2013 Sep 13;62(13):1165-72. Epub 2013 Jun 13.

Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S073510971302247
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http://dx.doi.org/10.1016/j.jacc.2013.03.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943424PMC
September 2013

Electromechanical dyssynchrony and resynchronization of the failing heart.

Circ Res 2013 Aug;113(6):765-76

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.113.300270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874431PMC
August 2013

Protein kinase g positively regulates proteasome-mediated degradation of misfolded proteins.

Circulation 2013 Jul 14;128(4):365-76. Epub 2013 Jun 14.

Division of Basic Biomedical Sciences, University of South Dakota, 414 E Clark St, Vermillion, SD 57069, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.001971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3761383PMC
July 2013

Nitric oxide synthases in heart failure.

Antioxid Redox Signal 2013 Mar 20;18(9):1078-99. Epub 2012 Sep 20.

Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1089/ars.2012.4824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567782PMC
March 2013

Redox and nitrosative regulation of cardiac remodeling.

Antioxid Redox Signal 2013 Mar 16;18(9):1021-3. Epub 2012 Nov 16.

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http://dx.doi.org/10.1089/ars.2012.4942DOI Listing
March 2013

Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart.

Circulation 2012 Oct 12;126(15):1828-37. Epub 2012 Sep 12.

Department of Medicine, Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.096388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733556PMC
October 2012

Protein kinase g iα inhibits pressure overload-induced cardiac remodeling and is required for the cardioprotective effect of sildenafil in vivo.

J Am Heart Assoc 2012 Oct 25;1(5):e003731. Epub 2012 Oct 25.

Molecular Cardiology Research Institute and Division of Cardiology, Tufts Medical Center, Boston, MA 02111, USA.

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http://dx.doi.org/10.1161/JAHA.112.003731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541610PMC
October 2012

Cardiac role of cyclic-GMP hydrolyzing phosphodiesterase type 5: from experimental models to clinical trials.

Authors:
David A Kass

Curr Heart Fail Rep 2012 Sep;9(3):192-9

Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Ross Building, Room 858, 720 Rutland Avenue, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1007/s11897-012-0101-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408604PMC
September 2012

Heart failure: a PKGarious balancing act.

Authors:
David A Kass

Circulation 2012 Aug 17;126(7):797-9. Epub 2012 Jul 17.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.112.124909DOI Listing
August 2012

Phosphodiesterases and cyclic GMP regulation in heart muscle.

Physiology (Bethesda) 2012 Aug;27(4):248-58

Division of Cardiology, Department of Medicine, The Johns Hopkins University Medical Institutions, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1152/physiol.00011.2012DOI Listing
August 2012