David A Jaffray

David A Jaffray

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David A Jaffray

Publications by authors named "David A Jaffray"

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Automatic classification of dental artifact status for efficient image veracity checks: effects of image resolution and convolutional neural network depth.

Phys Med Biol 2020 Jan 10;65(1):015005. Epub 2020 Jan 10.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. The Techna Institute for the Advancement of Technology for Health, Toronto, Ontario, Canada. Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1088/1361-6560/ab5427DOI Listing
January 2020

Feasibility Study of Navigated Endoscopy for the Placement of High Dose Rate Brachytherapy Applicators in the Esophagus and Lung.

Med Phys 2019 Dec 28. Epub 2019 Dec 28.

Department of Radiation Oncology, University of Toronto, Toronto, M5T 1P5, Canada.

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http://dx.doi.org/10.1002/mp.13997DOI Listing
December 2019

The image-guided operating room-Utility and impact on surgeon's performance in the head and neck surgery.

Head Neck 2019 09 9;41(9):3372-3382. Epub 2019 Jul 9.

Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/hed.25864DOI Listing
September 2019

Scale-up of radiotherapy for cervical cancer in the era of human papillomavirus vaccination in low-income and middle-income countries: a model-based analysis of need and economic impact.

Lancet Oncol 2019 Jul 28;20(7):915-923. Epub 2019 May 28.

Radiation Medicine Program, Princess Margaret Cancer Centre Toronto, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/S1470-2045(19)30308-0DOI Listing
July 2019

Intraoperative Near-Infrared Fluorescence-Guided Peripheral Lung Tumor Localization in Rabbit Models.

Ann Thorac Surg 2019 01 6;107(1):248-256. Epub 2018 Oct 6.

Division of Thoracic Surgery, Toronto General Hospital, University of Toronto, University Health Network, Toronto, Ontario, Canada; Guided Therapeutics, TECHNA Institute, University Health Network, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00034975183136
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http://dx.doi.org/10.1016/j.athoracsur.2018.08.020DOI Listing
January 2019

Vulnerabilities of radiomic signature development: The need for safeguards.

Radiother Oncol 2019 01 8;130:2-9. Epub 2018 Nov 8.

Department of Medical Biophysics, University of Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada; IBBME, University of Toronto, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada; The Techna Institute for the Advancement of Technology for Health, Toronto, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2018.10.027DOI Listing
January 2019

Editorial. Leksell Gamma Knife Society and radiosurgery: a legacy and a vision for the future.

J Neurosurg 2018 12;129(Suppl1):2-4

7Departments of Radiation Oncology and Medical Biophysics, University of Toronto, and Department of Medical Physics, Radiation Medicine Program, Princess Margaret Cancer Centre/University Health Network, Toronto, Canada.

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http://dx.doi.org/10.3171/2018.7.GKS181992DOI Listing
December 2018

Radiation and Heat Improve the Delivery and Efficacy of Nanotherapeutics by Modulating Intratumoral Fluid Dynamics.

ACS Nano 2018 08 20;12(8):7583-7600. Epub 2018 Jul 20.

Department of Medical Biophysics , University of Toronto , Toronto , ON M5G 1L7 , Canada.

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http://dx.doi.org/10.1021/acsnano.7b06301DOI Listing
August 2018

Dosimetric impact of intrafraction changes in MR-guided high-dose-rate (HDR) brachytherapy for prostate cancer.

Brachytherapy 2018 Jan - Feb;17(1):59-67. Epub 2017 Jul 29.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brachy.2017.06.001DOI Listing
July 2018

Quality control methods for linear accelerator radiation and mechanical axes alignment.

Med Phys 2018 Jun 3;45(6):2388-2398. Epub 2018 May 3.

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, M5G 2M9, Canada.

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http://dx.doi.org/10.1002/mp.12910DOI Listing
June 2018

How Advances in Imaging Will Affect Precision Radiation Oncology.

Int J Radiat Oncol Biol Phys 2018 06 31;101(2):292-298. Epub 2018 Jan 31.

The D-Lab: Decision Support for Precision Medicine, GROW -School for Oncology, Maastricht University Medical Centre+, Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.ijrobp.2018.01.047DOI Listing
June 2018

Spatial frequency performance limitations of radiation dose optimization and beam positioning.

Phys Med Biol 2018 06 11;63(12):125006. Epub 2018 Jun 11.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada. Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1088/1361-6560/aac501DOI Listing
June 2018

2D-3D registration for cranial radiation therapy using a 3D kV CBCT and a single limited field-of-view 2D kV radiograph.

Med Phys 2018 May 24;45(5):1794-1810. Epub 2018 Mar 24.

Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, M5G-2M9, Canada.

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http://doi.wiley.com/10.1002/mp.12823
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http://dx.doi.org/10.1002/mp.12823DOI Listing
May 2018

Monte Carlo analysis of beam blocking grid design parameters: Scatter estimation and the importance of electron backscatter.

Med Phys 2018 Mar 11;45(3):1059-1070. Epub 2018 Feb 11.

Techna Institute and Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1002/mp.12756DOI Listing
March 2018

Serial 4DCT/4DPET imaging to predict and monitor response for locally-advanced non-small cell lung cancer chemo-radiotherapy.

Radiother Oncol 2018 02 12;126(2):347-354. Epub 2017 Dec 12.

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada; Department of Biostatistics, University Health Network, Canada; Techna Institute, Toronto, Canada.

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http://dx.doi.org/10.1016/j.radonc.2017.11.023DOI Listing
February 2018

Monte Carlo simulation of radiation transport and dose deposition from locally released gold nanoparticles labeled with In, Lu or Y incorporated into tissue implantable depots.

Phys Med Biol 2017 Oct 27;62(22):8581-8599. Epub 2017 Oct 27.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. TECHNA Institute/Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://stacks.iop.org/0031-9155/62/i=22/a=8581?key=crossref.
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http://dx.doi.org/10.1088/1361-6560/aa9106DOI Listing
October 2017

Tumor microenvironment determines response to a heat-activated thermosensitive liposome formulation of cisplatin in cervical carcinoma.

J Control Release 2017 Sep 29;262:182-191. Epub 2017 Jul 29.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.07.039DOI Listing
September 2017

Radiosensitization by gold nanoparticles: Will they ever make it to the clinic?

Radiother Oncol 2017 09 4;124(3):344-356. Epub 2017 Aug 4.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Canada; STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2017.07.007DOI Listing
September 2017

The Exploitation of Low-Energy Electrons in Cancer Treatment.

Radiat Res 2017 08 30;188(2):123-143. Epub 2017 May 30.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Ontario Cancer Institute and Campbell Family Institute for Cancer Research and Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1667/RR14727.1DOI Listing
August 2017

Fully automated treatment planning for head and neck radiotherapy using a voxel-based dose prediction and dose mimicking method.

Phys Med Biol 2017 Jul 6;62(15):5926-5944. Epub 2017 Jul 6.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network (UHN), Toronto, ON, Canada. TECHNA Institute, UHN, Toronto, ON, Canada.

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http://dx.doi.org/10.1088/1361-6560/aa71f8DOI Listing
July 2017

Editorial: Radiomics: The New World or Another Road to El Dorado?

J Natl Cancer Inst 2017 Jul;109(7)

Affiliations of authors: Department of Medical Biophysics (MLW, DAJ), Department of Radiation Oncology (DAJ), and IBBME (DAJ), University of Toronto, Toronto, Ontario, Canada; Techna Institute for the Advancement of Technology for Health (MLW, DAJ) and Radiation Medicine Program, Princess Margaret Cancer Centre (DAJ), University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/jnci/djx116DOI Listing
July 2017

Improved outcomes with dose escalation in localized prostate cancer treated with precision image-guided radiotherapy.

Radiother Oncol 2017 06 20;123(3):459-465. Epub 2017 Apr 20.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Department of Radiation Oncology, University of Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2017.04.003DOI Listing
June 2017

The correction of time and temperature effects in MR-based 3D Fricke xylenol orange dosimetry.

Phys Med Biol 2017 04 6;62(8):3221-3236. Epub 2017 Feb 6.

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1088/1361-6560/aa5e63DOI Listing
April 2017

A novel field emission microscopy method to study field emission characteristics of freestanding carbon nanotube arrays.

Nanotechnology 2017 Apr 17;28(15):155704. Epub 2017 Feb 17.

Department of Systems Design Engineering, University of Waterloo, 200 University Ave. West, Waterloo, ON, N2L 3G1, Canada.

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http://dx.doi.org/10.1088/1361-6528/aa613eDOI Listing
April 2017

Significant Radiation Enhancement Effects by Gold Nanoparticles in Combination with Cisplatin in Triple Negative Breast Cancer Cells and Tumor Xenografts.

Radiat Res 2017 02 13;187(2):147-160. Epub 2017 Jan 13.

Departments of a   Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy.

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http://dx.doi.org/10.1667/RR14578.1DOI Listing
February 2017

Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements.

Adv Drug Deliv Rev 2017 01 19;109:84-101. Epub 2015 Dec 19.

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada; STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2015.12.012DOI Listing
January 2017

Radiotherapy for Cancer: Present and Future.

Adv Drug Deliv Rev 2017 Jan;109:1-2

Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Department of Radiation Physics, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; STTARR Innovation Centre, Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Techna Institute, University Health Network, Toronto, Ontario, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.addr.2017.01.004DOI Listing
January 2017

Quantifying hypoxia in human cancers using static PET imaging.

Phys Med Biol 2016 11 25;61(22):7957-7974. Epub 2016 Oct 25.

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. Techna Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1088/0031-9155/61/22/7957DOI Listing
November 2016

The Use of Cone Beam Computed Tomography for Image Guided Gamma Knife Stereotactic Radiosurgery: Initial Clinical Evaluation.

Int J Radiat Oncol Biol Phys 2016 09 19;96(1):214-20. Epub 2016 Apr 19.

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2016.04.011DOI Listing
September 2016

Robotic path-finding in inverse treatment planning for stereotactic radiosurgery with continuous dose delivery.

Med Phys 2016 Aug;43(8):4545

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1118/1.4955177DOI Listing
August 2016

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors.

J Vis Exp 2016 08 18(114). Epub 2016 Aug 18.

Department of Medical Biophysics, University of Toronto; Leslie Dan Faculty of Pharmacy, University of Toronto; STTARR Innovation Centre, Princess Margaret Cancer Centre; Institute of Biomaterials and Biomedical Engineering, University of Toronto; Techna Institute, University Health Network; Radiation Medicine Program, Princess Margaret Cancer Centre.

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http://dx.doi.org/10.3791/54226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5091925PMC
August 2016

How long does it take? An analysis of volumetric image assessment time.

Radiother Oncol 2016 04 6;119(1):150-3. Epub 2016 Feb 6.

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01678140160004
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http://dx.doi.org/10.1016/j.radonc.2016.01.015DOI Listing
April 2016

In Vitro and In Vivo Studies of a New Class of Anticancer Molecules for Targeted Radiotherapy of Cancer.

Mol Cancer Ther 2016 04 26;15(4):640-50. Epub 2016 Feb 26.

Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario, Canada. Departments of Biology and Chemistry, University of Waterloo, Waterloo, Ontario, Canada.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0862DOI Listing
April 2016

Wide-field tissue polarimetry allows efficient localized mass spectrometry imaging of biological tissues.

Chem Sci 2016 Mar 15;7(3):2162-2169. Epub 2015 Dec 15.

Techna Institute for the Advancement of Technology for Health , University Health Network , Toronto , ON M5G-1P5 , Canada . Email:

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http://dx.doi.org/10.1039/c5sc03782dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090527PMC
March 2016

Development and Implementation of an Electronic Learning Module for Volumetric Image-Guided Radiation Therapy.

J Med Imaging Radiat Sci 2016 Mar 11;47(1):43-48. Epub 2016 Jan 11.

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario; Department of Radiation Oncology, University of Toronto, Toronto, Ontario.

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http://dx.doi.org/10.1016/j.jmir.2015.12.001DOI Listing
March 2016

Improved accuracy of quantitative parameter estimates in dynamic contrast-enhanced CT study with low temporal resolution.

Med Phys 2016 Jan;43(1):388

Radiation Medicine Program, Princess Margaret Hospital/University Health Network, Toronto, Ontario M5G 2M9, Canada; Department of Medical Physics, Stronach Regional Cancer Centre, Southlake Regional Health Centre, Newmarket, Ontario L3Y 2P9, Canada; and Department of Radiation Oncology, University of Toronto, Toronto, Ontario M5G 2M9, Canada.

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http://doi.wiley.com/10.1118/1.4937600
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http://dx.doi.org/10.1118/1.4937600DOI Listing
January 2016

Longitudinal tumor hypoxia imaging with [(18)F]FAZA-PET provides early prediction of nanoliposomal irinotecan (nal-IRI) treatment activity.

EJNMMI Res 2015 Dec 19;5(1):57. Epub 2015 Oct 19.

TECHNA Institute for the Advancement of Technology for Health, University Health Network, 101 College Street, Rm 7-302, Toronto, Ontario, M5G 1L7, Canada.

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http://dx.doi.org/10.1186/s13550-015-0135-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610963PMC
December 2015

Online virtual isocenter based radiation field targeting for high performance small animal microirradiation.

Phys Med Biol 2015 Dec 5;60(23):9031-46. Epub 2015 Nov 5.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON M5S 3E2, Canada. Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada.

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http://dx.doi.org/10.1088/0031-9155/60/23/9031DOI Listing
December 2015

Global Task Force on Radiotherapy for Cancer Control.

Lancet Oncol 2015 Sep;16(10):1144-6

Princess Margaret Cancer Centre, 610 University Avenue, M5G 2M9, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(15)00285-5DOI Listing
September 2015

The intra-tumoral relationship between microcirculation, interstitial fluid pressure and liposome accumulation.

J Control Release 2015 Aug 10;211:163-70. Epub 2015 Jun 10.

Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, ON, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Techna Institute, University Health Network, Toronto, ON, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01683659150061
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http://dx.doi.org/10.1016/j.jconrel.2015.06.008DOI Listing
August 2015

Contrast Agent Mass Spectrometry Imaging Reveals Tumor Heterogeneity.

Anal Chem 2015 Aug 15;87(15):7683-9. Epub 2015 Jul 15.

†Techna Institute for the Advancement of Technology for Health, University Health Network, Toronto, Ontario M5G-1P5, Canada.

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http://dx.doi.org/10.1021/acs.analchem.5b01992DOI Listing
August 2015

Spatial and temporal mapping of heterogeneity in liposome uptake and microvascular distribution in an orthotopic tumor xenograft model.

J Control Release 2015 Jun 8;207:101-11. Epub 2015 Apr 8.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01683659150022
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http://dx.doi.org/10.1016/j.jconrel.2015.04.006DOI Listing
June 2015

Treatment age, dose and sex determine neuroanatomical outcome in irradiated juvenile mice.

Radiat Res 2015 May 4;183(5):541-9. Epub 2015 May 4.

a  Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1667/RR13854.1DOI Listing
May 2015

Automatic learning-based beam angle selection for thoracic IMRT.

Med Phys 2015 Apr;42(4):1992-2005

Philips Healthcare, Markham, Ontario L6C 2S3, Canada.

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http://dx.doi.org/10.1118/1.4908000DOI Listing
April 2015

Noise distribution and denoising of current density images.

J Med Imaging (Bellingham) 2015 Apr 14;2(2):024005. Epub 2015 May 14.

Ryerson University , Electrical and Computer Engineering Department, 350 Victoria Street, Toronto, Ontario, M5B 2K3, Canada.

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http://dx.doi.org/10.1117/1.JMI.2.2.024005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478962PMC
April 2015

MR-guided prostate biopsy for planning of focal salvage after radiation therapy.

Radiology 2015 Jan 8;274(1):181-91. Epub 2014 Sep 8.

From the Radiation Medicine Program (C.M., D.I., J.P., J.L., J.A., A.S., W.D.F., M.M., C.C., R.B., A.B., D.A.J., P.C., K.K.B.) and Department of Biostatistics (E.G.A.), Princess Margaret Cancer Centre, 610 University Ave, Room 5-809, Toronto, ON, Canada M4X 1C3; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada (C.M., D.I., A.S., M.M., C.C., G.M., R.B., A.B., D.A.J., P.C., K.K.B.); Department of Radiation Oncology, Wellington Cancer Centre, Wellington, New Zealand (D.I.), Departments of Anesthesia (G.O.) and Pathology (A.J.E.), University Health Network, University of Toronto, Toronto, Ontario, Canada; Department of Radiation Oncology, Odette Cancer Center, Toronto, Ontario, Canada (G.M.); Department of Radiation Oncology, Wellington Cancer Centre, Wellington, New Zealand (D.I.); and Joint Department of Medical Imaging, University Health Network and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada (M.A.H.).

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http://dx.doi.org/10.1148/radiol.14122681DOI Listing
January 2015

Multileaf collimator performance monitoring and improvement using semiautomated quality control testing and statistical process control.

Med Phys 2014 Dec;41(12):121713

Radiation Medicine Program, Princess Margaret Cancer Center, Toronto, Ontario M5G 2M9, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario M5S 3E2, Canada; and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1118/1.4901520DOI Listing
December 2014

Hypoxia and cellular localization influence the radiosensitizing effect of gold nanoparticles (AuNPs) in breast cancer cells.

Radiat Res 2014 Nov 31;182(5):475-88. Epub 2014 Oct 31.

a  Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

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http://www.bioone.org/doi/10.1667/RR13642.1
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http://dx.doi.org/10.1667/RR13642.1DOI Listing
November 2014

Harmonic analysis for the characterization and correction of geometric distortion in MRI.

Med Phys 2014 Nov;41(11):112303

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto M5G 2M9, Canada and Department of Radiation Oncology, University of Toronto, Toronto M5S 3E2, Canada.

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http://dx.doi.org/10.1118/1.4898582DOI Listing
November 2014

Integration of optical imaging with a small animal irradiator.

Med Phys 2014 Oct;41(10):102701

Radiation Medicine Program, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada; Techna Institute, University Health Network, 124-100 College Street, Toronto, Ontario M5G 1P5, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario M5S 1A1, Canada; Ontario Cancer Institute, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada; and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 1A1, Canada.

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http://dx.doi.org/10.1118/1.4894730DOI Listing
October 2014

Dosimetrically triggered adaptive intensity modulated radiation therapy for cervical cancer.

Int J Radiat Oncol Biol Phys 2014 Sep 8;90(1):147-54. Epub 2014 Jul 8.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2014.05.039DOI Listing
September 2014

A mathematical model of the enhanced permeability and retention effect for liposome transport in solid tumors.

PLoS One 2013 2;8(12):e81157. Epub 2013 Dec 2.

Department of Medical Biophysics, University of Toronto, Ontario, Canada ; STTARR Innovation Centre, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081157PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846845PMC
August 2014

Bringing global access to radiation therapy: time for a change in approach.

Int J Radiat Oncol Biol Phys 2014 Jul;89(3):446-7

Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Union for International Cancer Control, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.ijrobp.2014.05.019DOI Listing
July 2014

Heat-activated thermosensitive liposomal cisplatin (HTLC) results in effective growth delay of cervical carcinoma in mice.

J Control Release 2014 Mar 15;178:69-78. Epub 2014 Jan 15.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada; STTARR Innovation Center, University Health Network, Toronto, ON M5G 1L7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.01.009DOI Listing
March 2014

Macromolecule extravasation-xenograft size matters: a systematic study using probe-based confocal laser endomicroscopy (pCLE).

Mol Imaging Biol 2013 Dec;15(6):693-702

Tumor Pathophysiology, OncoRay-National Center for Radiation Research in Oncology, Medical Faculty Carl Gustav Carus, Fetscherstraße 74, P.O. Box 41 , 01307, TU Dresden, Germany.

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http://dx.doi.org/10.1007/s11307-013-0641-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826054PMC
December 2013

Tumor perfusion imaging predicts the intra-tumoral accumulation of liposomes.

J Control Release 2013 Nov 7;172(1):351-357. Epub 2013 Sep 7.

TECHNA Institute and Ontario Cancer Institute, University Health Network, Toronto, Canada; Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Canada; Departments of Radiation Oncology, Medical Biophysics, and IBBME, University of Toronto, Canada.

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http://dx.doi.org/10.1016/j.jconrel.2013.08.296DOI Listing
November 2013

Design and fabrication of carbon nanotube field-emission cathode with coaxial gate and ballast resistor.

Small 2013 Oct 8;9(20):3385-9. Epub 2013 May 8.

Department of Systems Design Engineering, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.

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http://dx.doi.org/10.1002/smll.201300553DOI Listing
October 2013

Two-dimensional inverse planning and delivery with a preclinical image guided microirradiator.

Med Phys 2013 Oct;40(10):101709

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3E2, Canada and Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1118/1.4819935DOI Listing
October 2013

Automated treatment planning for a dedicated multi-source intra-cranial radiosurgery treatment unit accounting for overlapping structures and dose homogeneity.

Med Phys 2013 Sep;40(9):091715

Department of Mechanical and Industrial Engineering, University of Toronto, Ontario M5S 3G8, Canada.

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http://dx.doi.org/10.1118/1.4817555DOI Listing
September 2013

A method for online verification of adapted fields using an independent dose monitor.

Med Phys 2013 Jul;40(7):072104

Department of Radiation Physics, Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1118/1.4811204DOI Listing
July 2013

Multicenter collaborative quality assurance program for the province of Ontario, Canada: first-year results.

Int J Radiat Oncol Biol Phys 2013 May 22;86(1):164-9. Epub 2013 Feb 22.

Radiation Medicine Program, Princess Margaret Cancer Center, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2012.12.003DOI Listing
May 2013

Comparison of computed tomography- and optical image-based assessment of liposome distribution.

Mol Imaging 2013 May;12(3):148-60

Leslie Dan Faculty of Pharmacy, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

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May 2013

Changes in apparent diffusion coefficient and T2 relaxation during radiotherapy for prostate cancer.

J Magn Reson Imaging 2013 Apr 23;37(4):909-16. Epub 2012 Oct 23.

Radiation Medicine Program, Princess Margaret Hospital, and Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/jmri.23885DOI Listing
April 2013

Safety considerations for IGRT: Executive summary.

Pract Radiat Oncol 2013 Jul - Sep;3(3):167-170. Epub 2013 Apr 15.

Department of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, California.

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https://linkinghub.elsevier.com/retrieve/pii/S18798500130000
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http://dx.doi.org/10.1016/j.prro.2013.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808747PMC
April 2013

3D image-guided robotic needle positioning system for small animal interventions.

Med Phys 2013 Jan;40(1):011909

Biomedical Engineering Graduate Program, The University of Western Ontario, London, Ontario, Canada.

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http://dx.doi.org/10.1118/1.4771958DOI Listing
January 2013

Image-guided radiotherapy: from current concept to future perspectives.

Authors:
David A Jaffray

Nat Rev Clin Oncol 2012 Dec 20;9(12):688-99. Epub 2012 Nov 20.

Radiation Medicine Program, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario, Canada.

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http://www.nature.com/articles/nrclinonc.2012.194
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http://dx.doi.org/10.1038/nrclinonc.2012.194DOI Listing
December 2012

Impact of immobilization on intrafraction motion for spine stereotactic body radiotherapy using cone beam computed tomography.

Int J Radiat Oncol Biol Phys 2012 Oct 6;84(2):520-6. Epub 2012 Mar 6.

Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2011.12.039DOI Listing
October 2012

Displaying 3D radiation dose on endoscopic video for therapeutic assessment and surgical guidance.

Phys Med Biol 2012 Oct 25;57(20):6601-14. Epub 2012 Sep 25.

Radiation Medicine Program, Princess Margaret Hospital, 610 University Ave, Toronto, ON M5G 2M9, Canada.

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http://dx.doi.org/10.1088/0031-9155/57/20/6601DOI Listing
October 2012

Feasibility study of a synchronized-moving-grid (SMOG) system to improve image quality in cone-beam computed tomography (CBCT).

Med Phys 2012 Aug;39(8):5099-110

Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://doi.wiley.com/10.1118/1.4736826
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http://dx.doi.org/10.1118/1.4736826DOI Listing
August 2012

Simultaneous nonrigid registration, segmentation, and tumor detection in MRI guided cervical cancer radiation therapy.

IEEE Trans Med Imaging 2012 Jun 6;31(6):1213-27. Epub 2012 Feb 6.

Department of Electrical Engineering, School of Engineering and Applied Science, Yale University, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1109/TMI.2012.2186976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889159PMC
June 2012

Monte Carlo simulation on a gold nanoparticle irradiated by electron beams.

Phys Med Biol 2012 Jun 9;57(11):3323-31. Epub 2012 May 9.

Department of Radiation Oncology, University of Toronto, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1088/0031-9155/57/11/3323DOI Listing
June 2012

Electron transfer-based combination therapy of cisplatin with tetramethyl-p-phenylenediamine for ovarian, cervical, and lung cancers.

Proc Natl Acad Sci U S A 2012 Jun 8;109(26):10175-80. Epub 2012 Jun 8.

Department of Physics and Astronomy, University of Waterloo, Waterloo, ON, Canada N2L 3G1.

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http://dx.doi.org/10.1073/pnas.1203451109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387118PMC
June 2012

Automated treatment planning for a dedicated multi-source intracranial radiosurgery treatment unit using projected gradient and grassfire algorithms.

Med Phys 2012 Jun;39(6):3134-41

Department of Mechanical and Industrial Engineering, University of Toronto, 5 King's College Road, Toronto, Ontario M5S 3G8, Canada.

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http://dx.doi.org/10.1118/1.4709603DOI Listing
June 2012

A feature-based approach for refinement of model-based segmentation of low contrast structures.

Conf Proc IEEE Eng Med Biol Soc 2011 ;2011:7977-80

Princess Margaret Hospital, Toronto, Canada.

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http://dx.doi.org/10.1109/IEMBS.2011.6091967DOI Listing
May 2012

Auto-segmentation of normal and target structures in head and neck CT images: a feature-driven model-based approach.

Med Phys 2011 Nov;38(11):6160-70

Princess Margaret Hospital, Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1118/1.3654160DOI Listing
November 2011

A method for patient dose reduction in dynamic contrast enhanced CT study.

Med Phys 2011 Sep;38(9):5094-103

Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1118/1.3622611DOI Listing
September 2011