Publications by authors named "David A Hume"

100Publications

Network analysis of transcriptomic diversity amongst resident tissue macrophages and dendritic cells in the mouse mononuclear phagocyte system.

PLoS Biol 2020 Oct 8;18(10):e3000859. Epub 2020 Oct 8.

Mater Research Institute-University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1371/journal.pbio.3000859DOI Listing
October 2020

The equine mononuclear phagocyte system: The relevance of the horse as a model for understanding human innate immunity.

Equine Vet J 2020 Sep 2. Epub 2020 Sep 2.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.

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http://dx.doi.org/10.1111/evj.13341DOI Listing
September 2020

Measurement of serum Interleukin 34 (IL-34) and correlation with severity and pruritus scores in client-owned dogs with atopic dermatitis.

Vet Dermatol 2020 Aug 13. Epub 2020 Aug 13.

R(D)SVS and The Roslin Institute, Hospital for Small Animals, The University of Edinburgh, Edinburgh, EH25 9RG, Scotland, UK.

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http://dx.doi.org/10.1111/vde.12873DOI Listing
August 2020

Species-Specificity of Transcriptional Regulation and the Response to Lipopolysaccharide in Mammalian Macrophages.

Front Cell Dev Biol 2020 21;8:661. Epub 2020 Jul 21.

Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia.

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http://dx.doi.org/10.3389/fcell.2020.00661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386301PMC
July 2020

Immunohistochemical study of morphology and distribution of CD163 macrophages in the normal adult equine gastrointestinal tract.

Vet Immunol Immunopathol 2020 Aug 27;226:110073. Epub 2020 May 27.

The Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1016/j.vetimm.2020.110073DOI Listing
August 2020

Regulation and function of macrophage colony-stimulating factor (CSF1) in the chicken immune system.

Dev Comp Immunol 2020 04 20;105:103586. Epub 2019 Dec 20.

Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, QLD, 4104, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.dci.2019.103586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996135PMC
April 2020

A Mini-Atlas of Gene Expression for the Domestic Goat ().

Front Genet 2019 4;10:1080. Epub 2019 Nov 4.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.3389/fgene.2019.01080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844187PMC
November 2019

Developmental Stage-Specific Distribution of Macrophages in Mouse Mammary Gland.

Front Cell Dev Biol 2019 24;7:250. Epub 2019 Oct 24.

Faculty of Medicine, Mater Research Institute-The University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.3389/fcell.2019.00250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821639PMC
October 2019

Elimination of Reference Mapping Bias Reveals Robust Immune Related Allele-Specific Expression in Crossbred Sheep.

Front Genet 2019 19;10:863. Epub 2019 Sep 19.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh, United Kingdom.

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http://dx.doi.org/10.3389/fgene.2019.00863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761296PMC
September 2019

Functional evolution of the colony-stimulating factor 1 receptor (CSF1R) and its ligands in birds.

J Leukoc Biol 2020 02 5;107(2):237-250. Epub 2019 Sep 5.

The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom.

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http://dx.doi.org/10.1002/JLB.6MA0519-172RDOI Listing
February 2020

Analysis of the impact of CSF-1 administration in adult rats using a novel Csf1r-mApple reporter gene.

J Leukoc Biol 2020 02 8;107(2):221-235. Epub 2019 Aug 8.

Mater Research, The University of Queensland, Brisbane, Australia.

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http://dx.doi.org/10.1002/JLB.MA0519-149RDOI Listing
February 2020

Phenotypic impacts of CSF1R deficiencies in humans and model organisms.

J Leukoc Biol 2020 02 22;107(2):205-219. Epub 2019 Jul 22.

Mater Research Institute, University of Queensland, Woolloongabba, Queensland, Australia.

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http://dx.doi.org/10.1002/JLB.MR0519-143RDOI Listing
February 2020

The Effect of Race Training on the Basal Gene Expression of Alveolar Macrophages Derived From Standardbred Racehorses.

J Equine Vet Sci 2019 04 29;75:48-54. Epub 2019 Jan 29.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S07370806183072
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http://dx.doi.org/10.1016/j.jevs.2019.01.010DOI Listing
April 2019

Measurement of serum macrophage migration inhibitory factor (MIF) and correlation with severity and pruritus scores in client owned dogs with atopic dermatitis.

Vet Dermatol 2019 Jan 23. Epub 2019 Jan 23.

R(D)SVS and The Roslin Institute, Hospital for Small Animals, The University of Edinburgh, Edinburgh, EH25 9RG, Scotland, UK.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/vde.12721
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http://dx.doi.org/10.1111/vde.12721DOI Listing
January 2019

The Mononuclear Phagocyte System: The Relationship between Monocytes and Macrophages.

Trends Immunol 2019 02 19;40(2):98-112. Epub 2018 Dec 19.

University of Edinburgh Centre for Inflammation Research, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1016/j.it.2018.11.007DOI Listing
February 2019

Assembly of a parts list of the human mitotic cell cycle machinery.

J Mol Cell Biol 2019 08;11(8):703-718

The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, Scotland, UK.

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http://dx.doi.org/10.1093/jmcb/mjy063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788831PMC
August 2019

Immune Cell Gene Signatures for Profiling the Microenvironment of Solid Tumors.

Cancer Immunol Res 2018 11 28;6(11):1388-1400. Epub 2018 Sep 28.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom.

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http://cancerimmunolres.aacrjournals.org/lookup/doi/10.1158/
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http://dx.doi.org/10.1158/2326-6066.CIR-18-0342DOI Listing
November 2018

Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment.

Blood 2018 08 26;132(7):735-749. Epub 2018 Jun 26.

Mater Research Institute-The University of Queensland, Faculty of Medicine, The University of Queensland, Woolloongabba, QLD, Australia.

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http://dx.doi.org/10.1182/blood-2018-01-829663DOI Listing
August 2018

Cross-species inference of long non-coding RNAs greatly expands the ruminant transcriptome.

Genet Sel Evol 2018 04 24;50(1):20. Epub 2018 Apr 24.

The Roslin Institute, University of Edinburgh, Easter Bush Campus, Edinburgh, Midlothian, EH25 9RG, UK.

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http://dx.doi.org/10.1186/s12711-018-0391-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926538PMC
April 2018

The preterm labor associated ADAMTS2 gene is induced by glucocorticoids.

Am J Obstet Gynecol 2018 07 28;219(1):122-123. Epub 2018 Mar 28.

Monocytomics Research, Herrsching, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ajog.2018.03.024DOI Listing
July 2018

The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche.

Nat Commun 2018 03 28;9(1):1272. Epub 2018 Mar 28.

The Roslin Institute & Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.

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http://dx.doi.org/10.1038/s41467-018-03638-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871851PMC
March 2018

Effects of anti-inflammatory drugs on the expression of tryptophan-metabolism genes by human macrophages.

J Leukoc Biol 2018 04 26;103(4):681-692. Epub 2018 Jan 26.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh, Scotland, UK.

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http://doi.wiley.com/10.1002/JLB.3A0617-261R
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http://dx.doi.org/10.1002/JLB.3A0617-261RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918594PMC
April 2018

Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci.

Cell Rep 2017 Dec;21(11):3022-3031

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.11.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745231PMC
December 2017

A high resolution atlas of gene expression in the domestic sheep (Ovis aries).

PLoS Genet 2017 Sep 15;13(9):e1006997. Epub 2017 Sep 15.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, Scotland, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1006997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626511PMC
September 2017

FANTOM5 CAGE profiles of human and mouse samples.

Authors:
Shuhei Noguchi Takahiro Arakawa Shiro Fukuda Masaaki Furuno Akira Hasegawa Fumi Hori Sachi Ishikawa-Kato Kaoru Kaida Ai Kaiho Mutsumi Kanamori-Katayama Tsugumi Kawashima Miki Kojima Atsutaka Kubosaki Ri-Ichiroh Manabe Mitsuyoshi Murata Sayaka Nagao-Sato Kenichi Nakazato Noriko Ninomiya Hiromi Nishiyori-Sueki Shohei Noma Eri Saijyo Akiko Saka Mizuho Sakai Christophe Simon Naoko Suzuki Michihira Tagami Shoko Watanabe Shigehiro Yoshida Peter Arner Richard A Axton Magda Babina J Kenneth Baillie Timothy C Barnett Anthony G Beckhouse Antje Blumenthal Beatrice Bodega Alessandro Bonetti James Briggs Frank Brombacher Ailsa J Carlisle Hans C Clevers Carrie A Davis Michael Detmar Taeko Dohi Albert S B Edge Matthias Edinger Anna Ehrlund Karl Ekwall Mitsuhiro Endoh Hideki Enomoto Afsaneh Eslami Michela Fagiolini Lynsey Fairbairn Mary C Farach-Carson Geoffrey J Faulkner Carmelo Ferrai Malcolm E Fisher Lesley M Forrester Rie Fujita Jun-Ichi Furusawa Teunis B Geijtenbeek Thomas Gingeras Daniel Goldowitz Sven Guhl Reto Guler Stefano Gustincich Thomas J Ha Masahide Hamaguchi Mitsuko Hara Yuki Hasegawa Meenhard Herlyn Peter Heutink Kelly J Hitchens David A Hume Tomokatsu Ikawa Yuri Ishizu Chieko Kai Hiroshi Kawamoto Yuki I Kawamura Judith S Kempfle Tony J Kenna Juha Kere Levon M Khachigian Toshio Kitamura Sarah Klein S Peter Klinken Alan J Knox Soichi Kojima Haruhiko Koseki Shigeo Koyasu Weonju Lee Andreas Lennartsson Alan Mackay-Sim Niklas Mejhert Yosuke Mizuno Hiromasa Morikawa Mitsuru Morimoto Kazuyo Moro Kelly J Morris Hozumi Motohashi Christine L Mummery Yutaka Nakachi Fumio Nakahara Toshiyuki Nakamura Yukio Nakamura Tadasuke Nozaki Soichi Ogishima Naganari Ohkura Hiroshi Ohno Mitsuhiro Ohshima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry A Ovchinnikov Robert Passier Margaret Patrikakis Ana Pombo Swati Pradhan-Bhatt Xian-Yang Qin Michael Rehli Patrizia Rizzu Sugata Roy Antti Sajantila Shimon Sakaguchi Hiroki Sato Hironori Satoh Suzana Savvi Alka Saxena Christian Schmidl Claudio Schneider Gundula G Schulze-Tanzil Anita Schwegmann Guojun Sheng Jay W Shin Daisuke Sugiyama Takaaki Sugiyama Kim M Summers Naoko Takahashi Jun Takai Hiroshi Tanaka Hideki Tatsukawa Andru Tomoiu Hiroo Toyoda Marc van de Wetering Linda M van den Berg Roberto Verardo Dipti Vijayan Christine A Wells Louise N Winteringham Ernst Wolvetang Yoko Yamaguchi Masayuki Yamamoto Chiyo Yanagi-Mizuochi Misako Yoneda Yohei Yonekura Peter G Zhang Silvia Zucchelli Imad Abugessaisa Erik Arner Jayson Harshbarger Atsushi Kondo Timo Lassmann Marina Lizio Serkan Sahin Thierry Sengstag Jessica Severin Hisashi Shimoji Masanori Suzuki Harukazu Suzuki Jun Kawai Naoto Kondo Masayoshi Itoh Carsten O Daub Takeya Kasukawa Hideya Kawaji Piero Carninci Alistair R R Forrest Yoshihide Hayashizaki

Sci Data 2017 08 29;4:170112. Epub 2017 Aug 29.

RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1038/sdata.2017.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574368PMC
August 2017

Transcriptional mechanisms that control expression of the macrophage colony-stimulating factor receptor locus.

Clin Sci (Lond) 2017 Aug 31;131(16):2161-2182. Epub 2017 Jul 31.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush, Midlothian EH25 9RG, U.K, Developmental Biology Division.

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http://dx.doi.org/10.1042/CS20170238DOI Listing
August 2017

Identification of the macrophage-specific promoter signature in FANTOM5 mouse embryo developmental time course data.

J Leukoc Biol 2017 10 27;102(4):1081-1092. Epub 2017 Jul 27.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush Campus, Midlothian, United Kingdom; and

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http://dx.doi.org/10.1189/jlb.1A0417-150RRDOI Listing
October 2017

Integration of quantitated expression estimates from polyA-selected and rRNA-depleted RNA-seq libraries.

BMC Bioinformatics 2017 Jun 13;18(1):301. Epub 2017 Jun 13.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.

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http://dx.doi.org/10.1186/s12859-017-1714-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470212PMC
June 2017

Jmjd6, a JmjC Dioxygenase with Many Interaction Partners and Pleiotropic Functions.

Front Genet 2017 16;8:32. Epub 2017 Mar 16.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh Edinburgh, UK.

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http://dx.doi.org/10.3389/fgene.2017.00032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352680PMC
March 2017

Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes.

Genet Sel Evol 2016 Sep 29;48(1):74. Epub 2016 Sep 29.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041578PMC
http://dx.doi.org/10.1186/s12711-016-0252-7DOI Listing
September 2016

Macrophage colony-stimulating factor (CSF1) controls monocyte production and maturation and the steady-state size of the liver in pigs.

Am J Physiol Gastrointest Liver Physiol 2016 09 21;311(3):G533-47. Epub 2016 Jul 21.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Scotland, United Kingdom; and

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http://dx.doi.org/10.1152/ajpgi.00116.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076001PMC
September 2016

Transcriptional Regulation and Macrophage Differentiation.

Microbiol Spectr 2016 06;4(3)

University Hospital Regensburg, Department of Internal Medicine III, D-93047 Regensburg, Germany.

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http://dx.doi.org/10.1128/microbiolspec.MCHD-0024-2015DOI Listing
June 2016

Analysis of the function of IL-10 in chickens using specific neutralising antibodies and a sensitive capture ELISA.

Dev Comp Immunol 2016 10 22;63:206-12. Epub 2016 Apr 22.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.dci.2016.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947970PMC
October 2016

Functional annotation of the T-cell immunoglobulin mucin family in birds.

Immunology 2016 07;148(3):287-303

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK.

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http://dx.doi.org/10.1111/imm.12607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913284PMC
July 2016

Induction of interferon and cell death in response to cytosolic DNA in chicken macrophages.

Dev Comp Immunol 2016 Jun 29;59:145-52. Epub 2016 Jan 29.

School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Qld 4072, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.dci.2016.01.023DOI Listing
June 2016

Enhancer Turnover Is Associated with a Divergent Transcriptional Response to Glucocorticoid in Mouse and Human Macrophages.

J Immunol 2016 Jan 9;196(2):813-822. Epub 2015 Dec 9.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, The University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, Scotland, UK.

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http://dx.doi.org/10.4049/jimmunol.1502009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707550PMC
January 2016

Identification and annotation of conserved promoters and macrophage-expressed genes in the pig genome.

BMC Genomics 2015 Nov 18;16:970. Epub 2015 Nov 18.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, EH25 9RG, Edinburgh, UK.

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http://dx.doi.org/10.1186/s12864-015-2111-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652390PMC
November 2015

Dengue virus NS1 protein activates cells via Toll-like receptor 4 and disrupts endothelial cell monolayer integrity.

Sci Transl Med 2015 Sep;7(304):304ra142

Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia. Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.

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http://dx.doi.org/10.1126/scitranslmed.aaa3863DOI Listing
September 2015

Third Report on Chicken Genes and Chromosomes 2015.

Authors:
Michael Schmid Jacqueline Smith David W Burt Bronwen L Aken Parker B Antin Alan L Archibald Chris Ashwell Perry J Blackshear Clarissa Boschiero C Titus Brown Shane C Burgess Hans H Cheng William Chow Derrick J Coble Amanda Cooksey Richard P M A Crooijmans Joana Damas Richard V N Davis Dirk-Jan de Koning Mary E Delany Thomas Derrien Takele T Desta Ian C Dunn Matthew Dunn Hans Ellegren Lél Eöry Ionas Erb Marta Farré Mario Fasold Damarius Fleming Paul Flicek Katie E Fowler Laure Frésard David P Froman Valerie Garceau Paul P Gardner Almas A Gheyas Darren K Griffin Martien A M Groenen Thomas Haaf Olivier Hanotte Alan Hart Julien Häsler S Blair Hedges Jana Hertel Kerstin Howe Allen Hubbard David A Hume Pete Kaiser Darek Kedra Stephen J Kemp Christophe Klopp Kalmia E Kniel Richard Kuo Sandrine Lagarrigue Susan J Lamont Denis M Larkin Raman A Lawal Sarah M Markland Fiona McCarthy Heather A McCormack Marla C McPherson Akira Motegi Stefan A Muljo Andrea Münsterberg Rishi Nag Indrajit Nanda Michael Neuberger Anne Nitsche Cedric Notredame Harry Noyes Rebecca O'Connor Elizabeth A O'Hare Andrew J Oler Sheila C Ommeh Helio Pais Michael Persia Frédérique Pitel Likit Preeyanon Pablo Prieto Barja Elizabeth M Pritchett Douglas D Rhoads Charmaine M Robinson Michael N Romanov Max Rothschild Pierre-François Roux Carl J Schmidt Alisa-Sophia Schneider Matthew G Schwartz Steve M Searle Michael A Skinner Craig A Smith Peter F Stadler Tammy E Steeves Claus Steinlein Liang Sun Minoru Takata Igor Ulitsky Qing Wang Ying Wang Wesley C Warren Jonathan M D Wood David Wragg Huaijun Zhou

Cytogenet Genome Res 2015 14;145(2):78-179. Epub 2015 Jul 14.

Department of Human Genetics, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1159/000430927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120589PMC
October 2015

The Many Alternative Faces of Macrophage Activation.

Authors:
David A Hume

Front Immunol 2015 22;6:370. Epub 2015 Jul 22.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh , Edinburgh , UK.

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http://dx.doi.org/10.3389/fimmu.2015.00370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510422PMC
August 2015

Immune surveillance of the lung by migrating tissue monocytes.

Elife 2015 Jul 13;4:e07847. Epub 2015 Jul 13.

Centre d'Immunologie et des Maladies Infectieuses, University Pierre et Marie Curie, Sorbonne Universities, Paris, France.

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http://dx.doi.org/10.7554/eLife.07847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521583PMC
July 2015

A transcriptional perspective on human macrophage biology.

Semin Immunol 2015 Feb 3;27(1):44-50. Epub 2015 Apr 3.

Institute of Innate Immunity, University Hospitals, University of Bonn, 53127 Bonn, Germany; Division of Infectious Diseases and Immunology, UMass Medical School, Worcester, MA 01605, USA; German Center of Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany.

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http://dx.doi.org/10.1016/j.smim.2015.02.001DOI Listing
February 2015

Technical Advance: Transcription factor, promoter, and enhancer utilization in human myeloid cells.

J Leukoc Biol 2015 May 25;97(5):985-995. Epub 2015 Feb 25.

*The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Scotland, United Kingdom; RIKEN Preventive Medicine and Diagnosis Innovation Program, Tsurumi-ku, Yokohama, Japan; RIKEN Center for Life Science Technologies, Division of Genomic Technologies, Tsurumi-ku, Yokohama, Japan; Department of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden; Department of Dermatology and Allergy, Charité Universitätsmedizin Berlin, Germany; Department of Internal Medicine III, University Hospital, University of Regensburg, Germany; Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands; and **RIKEN Omics Science Center, Tsurumi-ku, Yokohama, Japan

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http://dx.doi.org/10.1189/jlb.6TA1014-477RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398258PMC
May 2015

Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells.

Authors:
Erik Arner Carsten O Daub Kristoffer Vitting-Seerup Robin Andersson Berit Lilje Finn Drabløs Andreas Lennartsson Michelle Rönnerblad Olga Hrydziuszko Morana Vitezic Tom C Freeman Ahmad M N Alhendi Peter Arner Richard Axton J Kenneth Baillie Anthony Beckhouse Beatrice Bodega James Briggs Frank Brombacher Margaret Davis Michael Detmar Anna Ehrlund Mitsuhiro Endoh Afsaneh Eslami Michela Fagiolini Lynsey Fairbairn Geoffrey J Faulkner Carmelo Ferrai Malcolm E Fisher Lesley Forrester Daniel Goldowitz Reto Guler Thomas Ha Mitsuko Hara Meenhard Herlyn Tomokatsu Ikawa Chieko Kai Hiroshi Kawamoto Levon M Khachigian S Peter Klinken Soichi Kojima Haruhiko Koseki Sarah Klein Niklas Mejhert Ken Miyaguchi Yosuke Mizuno Mitsuru Morimoto Kelly J Morris Christine Mummery Yutaka Nakachi Soichi Ogishima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry Ovchinnikov Robert Passier Margaret Patrikakis Ana Pombo Xian-Yang Qin Sugata Roy Hiroki Sato Suzana Savvi Alka Saxena Anita Schwegmann Daisuke Sugiyama Rolf Swoboda Hiroshi Tanaka Andru Tomoiu Louise N Winteringham Ernst Wolvetang Chiyo Yanagi-Mizuochi Misako Yoneda Susan Zabierowski Peter Zhang Imad Abugessaisa Nicolas Bertin Alexander D Diehl Shiro Fukuda Masaaki Furuno Jayson Harshbarger Akira Hasegawa Fumi Hori Sachi Ishikawa-Kato Yuri Ishizu Masayoshi Itoh Tsugumi Kawashima Miki Kojima Naoto Kondo Marina Lizio Terrence F Meehan Christopher J Mungall Mitsuyoshi Murata Hiromi Nishiyori-Sueki Serkan Sahin Sayaka Nagao-Sato Jessica Severin Michiel J L de Hoon Jun Kawai Takeya Kasukawa Timo Lassmann Harukazu Suzuki Hideya Kawaji Kim M Summers Christine Wells David A Hume Alistair R R Forrest Albin Sandelin Piero Carninci Yoshihide Hayashizaki

Science 2015 Feb 12;347(6225):1010-4. Epub 2015 Feb 12.

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http://dx.doi.org/10.1126/science.1259418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681433PMC
February 2015

Cell-autonomous sex differences in gene expression in chicken bone marrow-derived macrophages.

J Immunol 2015 Mar 30;194(5):2338-44. Epub 2015 Jan 30.

Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, Scotland, United Kingdom

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http://dx.doi.org/10.4049/jimmunol.1401982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337484PMC
March 2015

Transcriptomic analysis of mononuclear phagocyte differentiation and activation.

Immunol Rev 2014 Nov;262(1):74-84

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK.

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http://doi.wiley.com/10.1111/imr.12211
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http://dx.doi.org/10.1111/imr.12211DOI Listing
November 2014

Visualisation of chicken macrophages using transgenic reporter genes: insights into the development of the avian macrophage lineage.

Development 2014 Aug 25;141(16):3255-65. Epub 2014 Jul 25.

The Roslin Institute and Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK

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http://dx.doi.org/10.1242/dev.105593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197536PMC
August 2014

Homeostasis in the mononuclear phagocyte system.

Trends Immunol 2014 Aug 18;35(8):358-67. Epub 2014 Jul 18.

University of Edinburgh, The Roslin Institute and Royal (Dick) School of Veterinary Studies, Easter Bush Campus, Midlothian, EH25 9RG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.it.2014.06.006DOI Listing
August 2014

Design and development of exome capture sequencing for the domestic pig (Sus scrofa).

BMC Genomics 2014 Jul 3;15:550. Epub 2014 Jul 3.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, UK.

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http://dx.doi.org/10.1186/1471-2164-15-550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099480PMC
July 2014

Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators.

J Leukoc Biol 2014 Aug 10;96(2):167-83. Epub 2014 Apr 10.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Scotland, United Kingdom; and

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http://dx.doi.org/10.1189/jlb.6HI0313-169RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378362PMC
August 2014

A promoter-level mammalian expression atlas.

Authors:
Alistair R R Forrest Hideya Kawaji Michael Rehli J Kenneth Baillie Michiel J L de Hoon Vanja Haberle Timo Lassmann Ivan V Kulakovskiy Marina Lizio Masayoshi Itoh Robin Andersson Christopher J Mungall Terrence F Meehan Sebastian Schmeier Nicolas Bertin Mette Jørgensen Emmanuel Dimont Erik Arner Christian Schmidl Ulf Schaefer Yulia A Medvedeva Charles Plessy Morana Vitezic Jessica Severin Colin A Semple Yuri Ishizu Robert S Young Margherita Francescatto Intikhab Alam Davide Albanese Gabriel M Altschuler Takahiro Arakawa John A C Archer Peter Arner Magda Babina Sarah Rennie Piotr J Balwierz Anthony G Beckhouse Swati Pradhan-Bhatt Judith A Blake Antje Blumenthal Beatrice Bodega Alessandro Bonetti James Briggs Frank Brombacher A Maxwell Burroughs Andrea Califano Carlo V Cannistraci Daniel Carbajo Yun Chen Marco Chierici Yari Ciani Hans C Clevers Emiliano Dalla Carrie A Davis Michael Detmar Alexander D Diehl Taeko Dohi Finn Drabløs Albert S B Edge Matthias Edinger Karl Ekwall Mitsuhiro Endoh Hideki Enomoto Michela Fagiolini Lynsey Fairbairn Hai Fang Mary C Farach-Carson Geoffrey J Faulkner Alexander V Favorov Malcolm E Fisher Martin C Frith Rie Fujita Shiro Fukuda Cesare Furlanello Masaaki Furino Jun-ichi Furusawa Teunis B Geijtenbeek Andrew P Gibson Thomas Gingeras Daniel Goldowitz Julian Gough Sven Guhl Reto Guler Stefano Gustincich Thomas J Ha Masahide Hamaguchi Mitsuko Hara Matthias Harbers Jayson Harshbarger Akira Hasegawa Yuki Hasegawa Takehiro Hashimoto Meenhard Herlyn Kelly J Hitchens Shannan J Ho Sui Oliver M Hofmann Ilka Hoof Furni Hori Lukasz Huminiecki Kei Iida Tomokatsu Ikawa Boris R Jankovic Hui Jia Anagha Joshi Giuseppe Jurman Bogumil Kaczkowski Chieko Kai Kaoru Kaida Ai Kaiho Kazuhiro Kajiyama Mutsumi Kanamori-Katayama Artem S Kasianov Takeya Kasukawa Shintaro Katayama Sachi Kato Shuji Kawaguchi Hiroshi Kawamoto Yuki I Kawamura Tsugumi Kawashima Judith S Kempfle Tony J Kenna Juha Kere Levon M Khachigian Toshio Kitamura S Peter Klinken Alan J Knox Miki Kojima Soichi Kojima Naoto Kondo Haruhiko Koseki Shigeo Koyasu Sarah Krampitz Atsutaka Kubosaki Andrew T Kwon Jeroen F J Laros Weonju Lee Andreas Lennartsson Kang Li Berit Lilje Leonard Lipovich Alan Mackay-Sim Ri-ichiroh Manabe Jessica C Mar Benoit Marchand Anthony Mathelier Niklas Mejhert Alison Meynert Yosuke Mizuno David A de Lima Morais Hiromasa Morikawa Mitsuru Morimoto Kazuyo Moro Efthymios Motakis Hozumi Motohashi Christine L Mummery Mitsuyoshi Murata Sayaka Nagao-Sato Yutaka Nakachi Fumio Nakahara Toshiyuki Nakamura Yukio Nakamura Kenichi Nakazato Erik van Nimwegen Noriko Ninomiya Hiromi Nishiyori Shohei Noma Shohei Noma Tadasuke Noazaki Soichi Ogishima Naganari Ohkura Hiroko Ohimiya Hiroshi Ohno Mitsuhiro Ohshima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry A Ovchinnikov Arnab Pain Robert Passier Margaret Patrikakis Helena Persson Silvano Piazza James G D Prendergast Owen J L Rackham Jordan A Ramilowski Mamoon Rashid Timothy Ravasi Patrizia Rizzu Marco Roncador Sugata Roy Morten B Rye Eri Saijyo Antti Sajantila Akiko Saka Shimon Sakaguchi Mizuho Sakai Hiroki Sato Suzana Savvi Alka Saxena Claudio Schneider Erik A Schultes Gundula G Schulze-Tanzil Anita Schwegmann Thierry Sengstag Guojun Sheng Hisashi Shimoji Yishai Shimoni Jay W Shin Christophe Simon Daisuke Sugiyama Takaai Sugiyama Masanori Suzuki Naoko Suzuki Rolf K Swoboda Peter A C 't Hoen Michihira Tagami Naoko Takahashi Jun Takai Hiroshi Tanaka Hideki Tatsukawa Zuotian Tatum Mark Thompson Hiroo Toyodo Tetsuro Toyoda Elvind Valen Marc van de Wetering Linda M van den Berg Roberto Verado Dipti Vijayan Ilya E Vorontsov Wyeth W Wasserman Shoko Watanabe Christine A Wells Louise N Winteringham Ernst Wolvetang Emily J Wood Yoko Yamaguchi Masayuki Yamamoto Misako Yoneda Yohei Yonekura Shigehiro Yoshida Susan E Zabierowski Peter G Zhang Xiaobei Zhao Silvia Zucchelli Kim M Summers Harukazu Suzuki Carsten O Daub Jun Kawai Peter Heutink Winston Hide Tom C Freeman Boris Lenhard Vladimir B Bajic Martin S Taylor Vsevolod J Makeev Albin Sandelin David A Hume Piero Carninci Yoshihide Hayashizaki

Nature 2014 Mar;507(7493):462-70

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http://dx.doi.org/10.1038/nature13182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529748PMC
March 2014

Transcriptional switching in macrophages associated with the peritoneal foreign body response.

Immunol Cell Biol 2014 Jul 18;92(6):518-26. Epub 2014 Mar 18.

Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia.

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http://doi.wiley.com/10.1038/icb.2014.19
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http://dx.doi.org/10.1038/icb.2014.19DOI Listing
July 2014

Network analysis reveals distinct clinical syndromes underlying acute mountain sickness.

PLoS One 2014 22;9(1):e81229. Epub 2014 Jan 22.

Apex (Altitude Physiology Expeditions), c/o Dr. J. K. Baillie, Critical Care Medicine, University of Edinburgh, Royal Infirmary of Edinburgh, United Kingdom ; Division of Genetics and Genomics, Roslin Institute, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081229PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898916PMC
December 2014

Lentiviral vectors containing mouse Csf1r control elements direct macrophage-restricted expression in multiple species of birds and mammals.

Mol Ther Methods Clin Dev 2014 9;1:14010. Epub 2014 Apr 9.

The Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Scotland , UK.

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https://linkinghub.elsevier.com/retrieve/pii/S23290501163007
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http://dx.doi.org/10.1038/mtm.2014.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362345PMC
May 2015

CSF1R mutations in hereditary diffuse leukoencephalopathy with spheroids are loss of function.

Sci Rep 2013 Oct 22;3:3013. Epub 2013 Oct 22.

1] The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, Scotland, UK [2].

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http://dx.doi.org/10.1038/srep03013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804858PMC
October 2013

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1.

J Exp Med 2013 Oct 7;210(11):2477-91. Epub 2013 Oct 7.

Institute of Immunology and Infection Research, School of Biological Sciences; and 2 Medical Research Council Centre for Inflammation Research and 3 The Roslin Institute and Royal (Dick) School of Veterinary Studies, College of Medicine and Veterinary Medicine; University of Edinburgh, Edinburgh EH8 9YL, Scotland, UK.

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http://www.jem.org/lookup/doi/10.1084/jem.20121999
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http://dx.doi.org/10.1084/jem.20121999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804948PMC
October 2013

Production and characterisation of a monoclonal antibody that recognises the chicken CSF1 receptor and confirms that expression is restricted to macrophage-lineage cells.

Dev Comp Immunol 2014 Feb 29;42(2):278-85. Epub 2013 Sep 29.

The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.

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http://dx.doi.org/10.1016/j.dci.2013.09.011DOI Listing
February 2014

An expression atlas of human primary cells: inference of gene function from coexpression networks.

BMC Genomics 2013 Sep 20;14:632. Epub 2013 Sep 20.

The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush, Midlothian, Edinburgh EH25 9RG, UK.

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http://dx.doi.org/10.1186/1471-2164-14-632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849585PMC
September 2013