David A Hughes

David A Hughes

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David A Hughes

David A Hughes

Publications by authors named "David A Hughes"

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Common variation at 16p11.2 is associated with glycosuria in pregnancy: Findings from a genome-wide association study in European women.

Hum Mol Genet 2020 Mar 30. Epub 2020 Mar 30.

Medical Research Council Integrative Epidemiology Unit, Avon Longitudinal Study of Parents and Children, Population Health Science, Bristol Medical School, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.

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http://dx.doi.org/10.1093/hmg/ddaa054DOI Listing
March 2020

Reply to: Retesting the influences of mutation accumulation and antagonistic pleiotropy on human senescence and disease.

Nat Ecol Evol 2019 07 24;3(7):994-995. Epub 2019 Jun 24.

Institute of Evolutionary Biology (UPF-CSIC), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain.

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http://dx.doi.org/10.1038/s41559-019-0926-yDOI Listing
July 2019

methylation in mothers and newborns is associated with maternal exposure to war trauma.

Clin Epigenetics 2017 30;9:68. Epub 2017 Jun 30.

Department of Anthropology and University of Florida Genetics Institute, University of Florida, Gainesville, FL USA.

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http://clinicalepigeneticsjournal.biomedcentral.com/articles
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http://dx.doi.org/10.1186/s13148-017-0367-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493129PMC
April 2018

DNA methylation of methylation complex genes in relation to stress and genome-wide methylation in mother-newborn dyads.

Am J Phys Anthropol 2018 01 13;165(1):173-182. Epub 2017 Oct 13.

University of Florida, Gainesville, Florida 32611.

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http://dx.doi.org/10.1002/ajpa.23341DOI Listing
January 2018

Antagonistic pleiotropy and mutation accumulation influence human senescence and disease.

Nat Ecol Evol 2017 Jan 30;1(3):55. Epub 2017 Jan 30.

Institute of Evolutionary Biology (UPF-CSIC), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Catalonia 08003, Spain.

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http://dx.doi.org/10.1038/s41559-016-0055DOI Listing
January 2017

Evaluating intra- and inter-individual variation in the human placental transcriptome.

Genome Biol 2015 Mar 19;16:54. Epub 2015 Mar 19.

Max-Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, 04103, Germany.

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http://dx.doi.org/10.1186/s13059-015-0627-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404591PMC
March 2015

Acoustic devices for particle and cell manipulation and sensing.

Sensors (Basel) 2014 Aug 13;14(8):14806-38. Epub 2014 Aug 13.

Institute for Medical Science and Technology, University of Dundee, 1 Wurzburg Loan, Dundee DD2 1FD, UK.

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http://dx.doi.org/10.3390/s140814806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179044PMC
August 2014

RasGAP mediates neuronal survival in Drosophila through direct regulation of Rab5-dependent endocytosis.

J Cell Sci 2014 Jul 9;127(Pt 13):2849-61. Epub 2014 May 9.

The Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK

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http://dx.doi.org/10.1242/jcs.139329DOI Listing
July 2014

Human metabolic transformation of quercetin blocks its capacity to decrease endothelial nitric oxide synthase (eNOS) expression and endothelin-1 secretion by human endothelial cells.

J Agric Food Chem 2013 Sep 28;61(36):8589-96. Epub 2013 Aug 28.

Food and Health Programme, Institute of Food Research , Norwich Research Park, Norwich NR4 7UA, United Kingdom.

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http://dx.doi.org/10.1021/jf402511cDOI Listing
September 2013

Human quercetin conjugated metabolites attenuate TNF-α-induced changes in vasomodulatory molecules in an HUASMCs/HUVECs co-culture model.

Planta Med 2012 Sep 3;78(14):1571-3. Epub 2012 Aug 3.

Food and Health Programme, Institute of Food Research, Norwich Research Park, Norwich, UK.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0032-1315148
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http://dx.doi.org/10.1055/s-0032-1315148DOI Listing
September 2012

Methylation changes at NR3C1 in newborns associate with maternal prenatal stress exposure and newborn birth weight.

Epigenetics 2012 Aug 19;7(8):853-7. Epub 2012 Jul 19.

Department of Anthropology, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.4161/epi.21180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427280PMC
August 2012

Genetic and neural dissociation of individual responses to emotional expressions in human infants.

Dev Cogn Neurosci 2011 Jan 30;1(1):57-66. Epub 2010 Jul 30.

Centre for Brain and Cognitive Development, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.

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http://dx.doi.org/10.1016/j.dcn.2010.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987571PMC
January 2011

Physiologically relevant metabolites of quercetin have no effect on adhesion molecule or chemokine expression in human vascular smooth muscle cells.

Atherosclerosis 2009 Feb 1;202(2):431-8. Epub 2008 May 1.

Phytochemicals and Health Programme, Institute of Food Research, Norwich Research Park, Norwich, Norfolk, NR4 7UA, UK.

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http://dx.doi.org/10.1016/j.atherosclerosis.2008.04.040DOI Listing
February 2009

Natural selection and the molecular basis of electrophoretic variation at the coagulation F13B locus.

Eur J Hum Genet 2009 Feb 20;17(2):219-27. Epub 2008 Aug 20.

Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.

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http://dx.doi.org/10.1038/ejhg.2008.137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2986062PMC
February 2009

Increased constraints on MC4R during primate and human evolution.

Hum Genet 2009 Jan 15;124(6):633-47. Epub 2008 Nov 15.

Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.

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http://dx.doi.org/10.1007/s00439-008-0591-8DOI Listing
January 2009

Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis.

BMC Evol Biol 2009 Jan 7;9. Epub 2009 Jan 7.

Max-Planck-Institute for Evolutionary Anthropology, Department of Evolutionary Genetics, Leipzig, Germany.

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http://dx.doi.org/10.1186/1471-2148-9-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627829PMC
January 2009

Lack of association of colonic epithelium telomere length and oxidative DNA damage in Type 2 diabetes under good metabolic control.

BMC Endocr Disord 2008 Oct 10;8:12. Epub 2008 Oct 10.

Department of Gastroenterology, Norfolk and Norwich University Hospital Colney Lane, Norwich NR4 7UY, UK.

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http://dx.doi.org/10.1186/1472-6823-8-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572056PMC
October 2008

A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro.

Biochem Pharmacol 2008 Sep 1;76(5):645-53. Epub 2008 Jul 1.

Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Medical School, University of Nottingham, Nottingham NG7 2UH, UK.

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http://dx.doi.org/10.1016/j.bcp.2008.06.010DOI Listing
September 2008

An ancient look at UCP1.

Biochim Biophys Acta 2008 Jul-Aug;1777(7-8):637-41. Epub 2008 Mar 18.

Technische Universität München, Molecular Nutritional Medicine, Else Kröner-Fresenius Center, Freising-Weihenstephan, Germany.

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http://dx.doi.org/10.1016/j.bbabio.2008.03.006DOI Listing
August 2008

Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells.

Atherosclerosis 2008 Mar 18;197(1):50-6. Epub 2007 Sep 18.

Phytochemicals and Health Programme, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK.

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http://dx.doi.org/10.1016/j.atherosclerosis.2007.07.040DOI Listing
March 2008

Parallel selection on TRPV6 in human populations.

PLoS One 2008 Feb 27;3(2):e1686. Epub 2008 Feb 27.

Max Plank Institute for Evolutionary Anthropology, Leipzig, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001686PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246018PMC
February 2008

Drosophila Rho-kinase (DRok) is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis.

Dev Biol 2006 Sep 19;297(2):417-32. Epub 2006 May 19.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.ydbio.2006.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504748PMC
September 2006

Monocyte telomere shortening and oxidative DNA damage in type 2 diabetes.

Diabetes Care 2006 Feb;29(2):283-9

Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospital National Health Service Trust, Norwich NR4 7UA, UK.

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http://dx.doi.org/10.2337/diacare.29.02.06.dc05-1715DOI Listing
February 2006

Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis.

Biochem J 2006 Jan;393(Pt 1):303-9

Faculty of Life Sciences, University of Manchester, Jackson's Mill, P.O. Box 88, Manchester M60 1QD, UK.

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http://dx.doi.org/10.1042/BJ20051238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1383689PMC
January 2006

Effect of a beta-3 agonist on food intake in two strains of rats that differ in susceptibility to obesity.

Physiol Behav 2004 Sep;82(2-3):489-96

Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA.

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http://dx.doi.org/10.1016/j.physbeh.2004.04.059DOI Listing
September 2004

p120 Ras GTPase-activating protein associates with fibroblast growth factor receptors in Drosophila.

Biochem J 2004 Jun;380(Pt 3):767-74

Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, PO Box 88, Manchester M60 1QD, UK.

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http://dx.doi.org/10.1042/BJ20031848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224229PMC
June 2004

Plasma matrix metalloproteinases, low density lipoprotein oxidisability and soluble adhesion molecules after a glucose load in Type 2 diabetes.

Cardiovasc Diabetol 2004 Jun 18;3. Epub 2004 Jun 18.

Bertram Diabetes Research Unit, Norfolk and Norwich University Hospital NHS Trust, Norwich, NR1 3SR, UK.

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http://dx.doi.org/10.1186/1475-2840-3-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC441397PMC
June 2004

Humans.

Curr Biol 2004 May;14(10):R367-9

Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.cub.2004.05.005DOI Listing
May 2004

Significant presence of terminally differentiated T cells and altered NF-kappaB and I-kappaBalpha interactions in healthy ageing.

Exp Gerontol 2004 Apr;39(4):567-76

Immunology Group, Nutrition Division, Institute of Food Research, Norwich Research Park, Norwich, East Anglia, UK.

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http://dx.doi.org/10.1016/j.exger.2003.09.025DOI Listing
April 2004

Quantitative PCR for DNA identification based on genome-specific interspersed repetitive elements.

Genomics 2004 Mar;83(3):518-27

Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge, LA 70803, USA.

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http://dx.doi.org/10.1016/j.ygeno.2003.09.003DOI Listing
March 2004

DNA damage and susceptibility to oxidative damage in lymphocytes: effects of carotenoids in vitro and in vivo.

Br J Nutr 2004 Jan;91(1):53-61

Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK.

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http://dx.doi.org/10.1079/bjn20031028DOI Listing
January 2004

Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid.

J Biol Chem 2003 Dec 8;278(51):51340-6. Epub 2003 Oct 8.

School of Biological Sciences, University of East Anglia, and Bertram Diabetes Research Unit, Norfolk & Norwich University Hospital NHS Trust, Norwich, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M310865200DOI Listing
December 2003

Quantitative intra-short interspersed element PCR for species-specific DNA identification.

Anal Biochem 2003 May;316(2):259-69

Department of Biological Sciences, Biological Computation and Visualization Center, Louisiana State University, 202 Life Sciences Building, Baton Rouge 70803, USA.

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http://dx.doi.org/10.1016/s0003-2697(03)00095-2DOI Listing
May 2003

Increased expression of a scavenger receptor (CD36) in monocytes from subjects with Type 2 diabetes.

Atherosclerosis 2003 Mar;167(1):129-34

Bertram Diabetes Research Unit, Department of Endocrinology and Diabetes, Norfolk and Norwich University Hospital NHS Trust, UK.

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http://dx.doi.org/10.1016/s0021-9150(02)00421-5DOI Listing
March 2003

Monocyte matrix metalloproteinase production in Type 2 diabetes and controls--a cross sectional study.

Cardiovasc Diabetol 2003 Mar 10;2. Epub 2003 Mar 10.

Bertram Diabetes Research Unit, Norfolk and Norwich University Hospital NHS Trust, Norwich NR4 7UY, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152657PMC
http://dx.doi.org/10.1186/1475-2840-2-3DOI Listing
March 2003

Alpha-lipoic acid modulates NF-kappaB activity in human monocytic cells by direct interaction with DNA.

Exp Gerontol 2002 Jan-Mar;37(2-3):401-10

Immunology Group, Nutrition and Consumer Science Division, Institute of Food Research, Norwich Research Park, Colney, Norwich, Norfolk NR4 7UA, UK.

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http://dx.doi.org/10.1016/s0531-5565(01)00207-8DOI Listing
April 2002

Plasma F2 isoprostanes: direct evidence of increased free radical damage during acute hyperglycemia in type 2 diabetes.

Diabetes Care 2002 Mar;25(3):537-41

Bertram Diabetes Research Unit, Norfolk and Norwich University Hospital National Health Service Trust, Norwich, UK.

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http://dx.doi.org/10.2337/diacare.25.3.537DOI Listing
March 2002

HISTOPATHOLOGIC EFFECTS OF CHRONIC INTRACORPOREAL RADIATION AS RELATED TO IMPLANTABLE NUCLEAR-FUELED LEFT VENTRICULAR ASSIST DEVICES.

Cardiovasc Dis 1977 ;4(2):199-207

Cardiovascular Surgical Research Laboratories, Texas Heart Institute of St. Luke's Episcopal and Texas Children's Hospitals, Texas Medical Center, Houston, Texas.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC287655PMC
January 1977

BIOCHEMICAL, HEMATOLOGIC AND COAGULATION VALUES IN THE HEREFORD CALF.

Cardiovasc Dis 1975 ;2(4):417-424

Cardiovascular Surgical Research Laboratories, Texas Heart Institute of St. Luke's Episcopal and Texas Children's Hospitals, and the Department of Pathology, St. Luke's Episcopal Hospital, Texas Medical Center, Houston, Texas.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC345743PMC
January 1975