David A Hafler

David A Hafler

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Corrigendum to "Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo" [Yjaut 96C (2019) 40-49].

J Autoimmun 2019 Aug 18;102:179. Epub 2019 May 18.

Department of Neurology, Yale School of Medicine, New Haven, CT, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2019.05.008DOI Listing
August 2019

Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice.

Nat Microbiol 2019 06 11;4(6):948-955. Epub 2019 Mar 11.

Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, USA.

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http://www.nature.com/articles/s41564-019-0385-x
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http://dx.doi.org/10.1038/s41564-019-0385-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533137PMC
June 2019

From Big Data to Precision Medicine.

Front Med (Lausanne) 2019 1;6:34. Epub 2019 Mar 1.

Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.

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https://www.frontiersin.org/article/10.3389/fmed.2019.00034/
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http://dx.doi.org/10.3389/fmed.2019.00034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405506PMC
March 2019

TIGIT signaling restores suppressor function of Th1 Tregs.

JCI Insight 2019 Feb 7;4(3). Epub 2019 Feb 7.

Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1172/jci.insight.124427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413794PMC
February 2019

Multiple sclerosis enters a grey area.

Nature 2019 02;566(7745):465-466

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http://dx.doi.org/10.1038/d41586-019-00563-6DOI Listing
February 2019

Fingolimod modulates T cell phenotype and regulatory T cell plasticity in vivo.

J Autoimmun 2019 01 16;96:40-49. Epub 2018 Aug 16.

Department of Neurology, Yale School of Medicine, New Haven, CT, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183029
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http://dx.doi.org/10.1016/j.jaut.2018.08.002DOI Listing
January 2019

Regulatory T cells in autoimmune disease.

Nat Immunol 2018 07 20;19(7):665-673. Epub 2018 Jun 20.

Department of Neurology, Yale School of Medicine, New Haven, CN, USA.

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http://dx.doi.org/10.1038/s41590-018-0120-4DOI Listing
July 2018

Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme.

PLoS One 2017 7;12(9):e0181538. Epub 2017 Sep 7.

Departments of Biological Engineering and Chemical Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0181538PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589094PMC
October 2017

Co-inhibitory blockade while preserving tolerance: checkpoint inhibitors for glioblastoma.

Immunol Rev 2017 03;276(1):9-25

Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1111/imr.12529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338636PMC
March 2017

Solving Immunology?

Trends Immunol 2017 02 13;38(2):116-127. Epub 2016 Dec 13.

Center for Advanced Research on Diagnostic Assays, Immunology Institute, Friedman Brain Institute, and Departments of Neurology, Neuroscience, Pharmacology, and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2016.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695553PMC
February 2017

The Link Between CD6 and Autoimmunity: Genetic and Cellular Associations.

Curr Drug Targets 2016 ;17(6):651-65

Department I of Internal Medicine, Faculty of Medicine, University of Cologne, 50931, Cologne, Germany.

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http://dx.doi.org/10.2174/1389450117666160201105934DOI Listing
December 2016

The Human Functional Genomics Project: Understanding Generation of Diversity.

Cell 2016 11;167(4):894-896

Departments of Immunobiology and Neurology, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.10.040DOI Listing
November 2016

AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease.

EMBO Rep 2016 08 16;17(8):1169-83. Epub 2016 Jun 16.

Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT, USA

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http://dx.doi.org/10.15252/embr.201541905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967959PMC
August 2016

National Heart, Lung, and Blood Institute Working Group Report on Salt in Human Health and Sickness: Building on the Current Scientific Evidence.

Hypertension 2016 08 20;68(2):281-8. Epub 2016 Jun 20.

From the Division of Cardiovascular Sciences (Y.S.O, Z.S.G., C.M.-B., E.T.) and Division of Intramural Research (N.N.M.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD; Department of Medicine, Johns Hopkins University, Baltimore, MD (L.J.A.); Department of Neurology and Department of Immunobiology, Yale University School of Medicine, New Haven, CT (A.L.H., D.A.H.); Department of Epidemiology, Tulane University, New Orleans, LA (J.H.); Department of Physiology and Pharmacology, University of Toledo, OH (B.J.); Department of Medicine and Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (S.A.K.); Department of Physiology, Medical College of Wisconsin, Milwaukee (D.M.); Department of Pathology and Immunology, Washington University in St. Louis, MO (G.R.); Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson (M.R.); Department of Medicine, Georgetown University, Washington, DC (K.S.); Department of Medicine, Vanderbilt University, Nashville, TN (J.T., D.G.H.); and Department of Physiology, University of Texas Health Science Center at San Antonio (G.M.T.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.07415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945367PMC
August 2016

Linking Genotype to Clinical Phenotype in Multiple Sclerosis: In Search of the Holy Grail.

JAMA Neurol 2016 07;73(7):777-8

Department of Neurology, Yale School of Medicine, New Haven, Connecticut3Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1001/jamaneurol.2016.1227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198230PMC
July 2016

Multiple sclerosis: genetics, biomarkers, treatments.

Curr Opin Neurol 2016 06;29(3):345-53

aDepartments of Neurology and Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA bCentre National de la Recherche Scientifique, U5282 cCentre de Physiopathologie Toulouse-Purpan, Université Toulouse 3 dINSERM, U1043, Toulouse, France eBroad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1097/WCO.0000000000000319DOI Listing
June 2016

CNS demyelination and enhanced myelin-reactive responses after ipilimumab treatment.

Neurology 2016 04 16;86(16):1553-6. Epub 2016 Mar 16.

From the Yale School of Medicine (Y.C., A.N., S.R., G.P., V.L.S.C., A.O.V., D.A.H., D.P.), New Haven, CT; Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology (B.A.G.), Cambridge; and University of Nebraska Medical Center (R.Z.), Omaha.

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http://dx.doi.org/10.1212/WNL.0000000000002594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573201PMC
April 2016

Evaluation of KIR4.1 as an Immune Target in Multiple Sclerosis.

N Engl J Med 2016 Apr;374(15):1495-6

Yale School of Medicine, New Haven, CT

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http://dx.doi.org/10.1056/NEJMc1513302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918464PMC
April 2016

PD-1 marks dysfunctional regulatory T cells in malignant gliomas.

JCI Insight 2016 Apr;1(5)

Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1172/jci.insight.85935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864991PMC
April 2016

Biomarkers in multiple sclerosis.

Clin Immunol 2015 Nov 2;161(1):51-8. Epub 2015 Jul 2.

Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2015.06.015DOI Listing
November 2015

Prospects of immune checkpoint modulators in the treatment of glioblastoma.

Nat Rev Neurol 2015 Sep 11;11(9):504-14. Epub 2015 Aug 11.

Division of Neurosurgery, 220 Sands Building, Research Drive, Duke University School of Medicine, Durham, NC 27705, USA.

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http://dx.doi.org/10.1038/nrneurol.2015.139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782584PMC
September 2015

Sodium-activated macrophages: the salt mine expands.

Cell Res 2015 Aug 28;25(8):885-6. Epub 2015 Jul 28.

Department of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA.

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http://dx.doi.org/10.1038/cr.2015.91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528060PMC
August 2015

Monoallelic expression of the human FOXP2 speech gene.

Proc Natl Acad Sci U S A 2015 Jun 24;112(22):6848-54. Epub 2014 Nov 24.

Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029; Fishberg Department of Neuroscience, Department of Genetics and Genomic Sciences, Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029

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http://dx.doi.org/10.1073/pnas.1411270111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460484PMC
June 2015

Editorial: T cell regulation by the environment.

Front Immunol 2015 13;6:229. Epub 2015 May 13.

MRC Centre for Inflammation Research , University of Edinburgh , UK.

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http://dx.doi.org/10.3389/fimmu.2015.00229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429623PMC
June 2015

Genetic basis of autoimmunity.

J Clin Invest 2015 Jun 1;125(6):2234-41. Epub 2015 Jun 1.

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http://dx.doi.org/10.1172/JCI78086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497748PMC
June 2015

Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli.

Sci Transl Med 2015 Jun;7(291):291ra93

Department of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA. Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa9223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574294PMC
June 2015

Corrigendum: multiple sclerosis-a quiet revolution.

Nat Rev Neurol 2015 May 24;11(5):246. Epub 2015 Mar 24.

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http://dx.doi.org/10.1038/nrneurol.2015.49DOI Listing
May 2015

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis.

Sci Transl Med 2015 May;7(287):287ra74

Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA. The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa8038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497538PMC
May 2015

Thymic selection: to thine own self be true.

Immunity 2015 May;42(5):788-9

Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA. Electronic address:

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http://www.cell.com/immunity/pdf/S1074-7613(15)00187-9.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S107476131500187
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http://dx.doi.org/10.1016/j.immuni.2015.05.007DOI Listing
May 2015

Multiple sclerosis-a quiet revolution.

Nat Rev Neurol 2015 Mar 17;11(3):134-42. Epub 2015 Feb 17.

Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1038/nrneurol.2015.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556342PMC
March 2015

Genetic and epigenetic fine mapping of causal autoimmune disease variants.

Nature 2015 Feb 29;518(7539):337-43. Epub 2014 Oct 29.

1] Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [2] Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA [3] Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA [4] Center for Systems Biology and Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nature13835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336207PMC
February 2015

TLR7 induces anergy in human CD4(+) T cells.

Nat Immunol 2015 Jan 17;16(1):118-28. Epub 2014 Nov 17.

Department of Neurology and Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/ni.3036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413902PMC
January 2015

Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells.

Eur J Immunol 2014 Sep 16;44(9):2703-2711. Epub 2014 Jun 16.

Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06520.

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http://dx.doi.org/10.1002/eji.201344392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165702PMC
September 2014

pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires.

Bioinformatics 2014 Jul 10;30(13):1930-2. Epub 2014 Mar 10.

Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA, Bioengineering Program, Faculty of Engineering, Bar-Ilan University, Ramat Gan 52900, Israel, Department of Pathology, Yale School of Medicine, New Haven, CT 06511, Department of Science Education, Hofstra North Shore-LIJ School of Medicine, Hofstra University, Hempstead, NY 11530, Department of Neurology, Yale School of Medicine, New Haven, CT 06511, Human and Translational Immunology Program, Yale School of Medicine, New Haven, CT 06511 and AbVitro Inc., Boston, MA 02210, USAInterdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511, USA, Bioengineering Program, Faculty of Engineering, Bar-Ilan University, Ramat Gan 52900, Israel, Department of Pathology, Yale School of Medicine, New Haven, CT 06511, Department of Science Education, Hofstra North Shore-LIJ School of Medicine, Hofstra University, Hempstead, NY 11530, Department of Neurology, Yale School of Medicine, New Haven, CT 06511, Human and Translational Immunology Program, Yale School of Medicine, New Haven, CT 06511 and AbVitro Inc., Boston, MA 02210, USA.

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http://dx.doi.org/10.1093/bioinformatics/btu138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071206PMC
July 2014

TLR-mediated STAT3 and ERK activation controls IL-10 secretion by human B cells.

Eur J Immunol 2014 Jul 16;44(7):2121-9. Epub 2014 Apr 16.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/eji.201344341DOI Listing
July 2014

Regulatory T cells in autoimmune neuroinflammation.

Immunol Rev 2014 May;259(1):231-44

Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Faculty of Medicine, Dresden University of Technology (TUD), Dresden, Germany.

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http://doi.wiley.com/10.1111/imr.12169
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http://dx.doi.org/10.1111/imr.12169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990868PMC
May 2014

Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses.

Immunity 2014 Apr;40(4):569-81

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070748PMC
April 2014

Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing data.

Front Immunol 2013 15;4:358. Epub 2013 Nov 15.

Bioengineering Program, Faculty of Engineering, Bar Ilan University , Ramat Gan , Israel ; Department of Pathology, Yale School of Medicine , New Haven, CT , USA.

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http://dx.doi.org/10.3389/fimmu.2013.00358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828525PMC
December 2013

Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus.

Neurology 2013 Nov 30;81(22):1891-9. Epub 2013 Oct 30.

From the Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry (L.O., I.Y.F., M.L., B.T.K., Z.X., P.L.D.), Department of Neurology, Partners MS Center, Center for Neurologic Diseases (B.C.H., T.C., S.J.K., H.L.W., P.L.D.), and Center for Neurological Imaging, Department of Radiology (C.R.G.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Program in Medical & Population Genetics (L.O., I.Y.F., M.L., B.T.K., Z.X., P.L.D.), Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge; and the Department of Neurology and Immunobiology (D.A.H.), Yale School of Medicine, New Haven, CT.

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http://dx.doi.org/10.1212/01.wnl.0000436612.66328.8aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843384PMC
November 2013

The plasticity of human Treg and Th17 cells and its role in autoimmunity.

Semin Immunol 2013 Nov 5;25(4):305-12. Epub 2013 Nov 5.

Department of Neurology, Yale School of Medicine, New Haven, CT, United States; Department of Immunobiology, Yale School of Medicine, New Haven, CT, United States; Broad Institute of MIT and Harvard, Cambridge, MA, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S10445323130009
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http://dx.doi.org/10.1016/j.smim.2013.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905679PMC
November 2013

Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects.

PLoS Genet 2013 Nov 21;9(11):e1003926. Epub 2013 Nov 21.

Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham & Women's Hospital, Boston, Massachusetts, United States of America ; Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America ; Harvard Medical School, Boston, Massachusetts, United States of America ; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836799PMC
November 2013

The CD226/CD155 interaction regulates the proinflammatory (Th1/Th17)/anti-inflammatory (Th2) balance in humans.

J Immunol 2013 Oct 26;191(7):3673-80. Epub 2013 Aug 26.

Department of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06520.

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http://dx.doi.org/10.4049/jimmunol.1300945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819731PMC
October 2013

Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis.

Neurology 2013 Sep 6;81(11):956-63. Epub 2013 Aug 6.

From the Department of Neurology (L.Q., P.L.C., M.A.B., C.C., D.A.H., J.-Y.L., K.C.O.), Human and Translational Immunology Program (D.A.H., K.C.O.), Department of Genetics (C.C.), Department of Pathology (S.H.K., G.Y.), and Department of Immunobiology (D.A.H.), Yale School of Medicine, New Haven, CT; Neuromuscular Diseases Unit (L.Q.), Hospital de la Santa Creu i Sant Pau, Universitat Autónoma de Barcelona, Spain; Medical and Population Genetics (C.C.), Broad Institute of MIT and Harvard, Cambridge, MA; Department of Neurology (A.H.C.), Washington University School of Medicine, St. Louis, MO; Interdepartmental Program in Computational Biology and Bioinformatics (S.H.K.), Yale University, New Haven, CT; and Department of Neurology (S.N.W.), Harvard Medical School and Brigham and Women's Hospital, Boston, MA. Simon N. Willis is currently affiliated with the Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.

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http://www.neurology.org/cgi/doi/10.1212/WNL.0b013e3182a43b4
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http://dx.doi.org/10.1212/WNL.0b013e3182a43b48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888197PMC
September 2013

Specific peripheral B cell tolerance defects in patients with multiple sclerosis.

J Clin Invest 2013 Jun 15;123(6):2737-41. Epub 2013 May 15.

Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06511, USA.

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http://dx.doi.org/10.1172/JCI68775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668812PMC
June 2013

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.

Nature 2013 Apr 6;496(7446):518-22. Epub 2013 Mar 6.

Departments of Neurology and Immunobiology, Yale School of Medicine, 15 York Street, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1038/nature11868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746493PMC
April 2013

Immune-mediated disease genetics: the shared basis of pathogenesis.

Trends Immunol 2013 Jan 29;34(1):22-6. Epub 2012 Sep 29.

Department of Neurology, Yale School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1016/j.it.2012.09.001DOI Listing
January 2013

Induction and molecular signature of pathogenic TH17 cells.

Nat Immunol 2012 Oct 9;13(10):991-9. Epub 2012 Sep 9.

Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ni.2416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459594PMC
October 2012

An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity.

Sci Transl Med 2012 Sep;4(153):153ra131

Program in Translational Neuropsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://stm.sciencemag.org/cgi/doi/10.1126/scitranslmed.30041
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http://dx.doi.org/10.1126/scitranslmed.3004186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753678PMC
September 2012

Class II MHC self-antigen presentation in human B and T lymphocytes.

PLoS One 2012 27;7(1):e29805. Epub 2012 Jan 27.

Program in Immunology, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029805PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267721PMC
July 2012

Regulatory T cells in the central nervous system.

Immunol Rev 2012 Jul;248(1):156-69

Department of Neurology, Yale School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.1111/j.1600-065X.2012.01130.xDOI Listing
July 2012

Prostaglandin E2 affects T cell responses through modulation of CD46 expression.

J Immunol 2012 Jun 27;188(11):5303-10. Epub 2012 Apr 27.

Centre for Inflammation Research, University of Edinburgh, Queen's Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1103090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758685PMC
June 2012

The TIGIT/CD226 axis regulates human T cell function.

J Immunol 2012 Apr 16;188(8):3869-75. Epub 2012 Mar 16.

Department of Neurology, Yale School of Medicine, New Haven, CT 06520-8018, USA.

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http://dx.doi.org/10.4049/jimmunol.1103627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324669PMC
April 2012

Multiple sclerosis.

J Clin Invest 2012 Apr 2;122(4):1180-8. Epub 2012 Apr 2.

Department of Neurology and Department of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1172/JCI58649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314452PMC
April 2012

Perspective: Deconstructing a disease.

Authors:
David A Hafler

Nature 2012 Apr;484(7393):S6

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http://dx.doi.org/10.1038/nature11100DOI Listing
April 2012

Polyfunctional responses by human T cells result from sequential release of cytokines.

Proc Natl Acad Sci U S A 2012 Jan 12;109(5):1607-12. Epub 2011 Dec 12.

Department of Chemical Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.1117194109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277116PMC
January 2012

Fingolimod for multiple sclerosis.

N Engl J Med 2012 Jan;366(4):339-47

Yale Multiple Sclerosis Center, Department of Neurology, Yale School of Medicine, New Haven, CT 06520-8018, USA.

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http://www.nejm.org/doi/abs/10.1056/NEJMct1101691
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http://dx.doi.org/10.1056/NEJMct1101691DOI Listing
January 2012

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.

Ann Neurol 2011 Dec;70(6):897-912

Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://doi.wiley.com/10.1002/ana.22609
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http://dx.doi.org/10.1002/ana.22609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247076PMC
December 2011

The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation.

J Immunol 2011 Sep 17;187(6):3286-91. Epub 2011 Aug 17.

Department of Neurology, Yale School of Medicine, New Haven, CT 06520, USA.

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http://dx.doi.org/10.4049/jimmunol.1100626DOI Listing
September 2011

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Authors:
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Nature 2011 Aug 10;476(7359):214-9. Epub 2011 Aug 10.

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http://dx.doi.org/10.1038/nature10251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182531PMC
August 2011

Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease.

Nat Med 2011 Jun 3;17(6):673-5. Epub 2011 May 3.

Department of Neurology and Immunobiology, Yale School of Medicine, New Haven, Connecticut, USA.

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http://dx.doi.org/10.1038/nm.2389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675886PMC
June 2011

Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments.

J Neuroimmunol 2011 Apr 27;233(1-2):168-74. Epub 2010 Nov 27.

Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.1016/j.jneuroim.2010.10.038DOI Listing
April 2011

Immunology. An innate role for IL-17.

Science 2011 Apr;332(6025):47-8

Department of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1205311
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April 2011

CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis.

J Immunol 2011 Mar 7;186(6):3317-26. Epub 2011 Feb 7.

Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.4049/jimmunol.1002502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467560PMC
March 2011

Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine.

Biosens Bioelectron 2011 Jan 15;26(5):2707-10. Epub 2010 Sep 15.

Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, 51 Blossom St., Boston, MA, USA.

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http://dx.doi.org/10.1016/j.bios.2010.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141325PMC
January 2011

Human regulatory T cells in autoimmune diseases.

Curr Opin Immunol 2010 Dec 24;22(6):753-60. Epub 2010 Sep 24.

Harvard Medical School, Boston, MA 02215, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S09527915100012
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http://dx.doi.org/10.1016/j.coi.2010.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997859PMC
December 2010