Publications by authors named "David A Frank"

93Publications

Cytosolic delivery of peptidic STAT3 SH2 domain inhibitors.

Bioorg Med Chem 2020 Jun 4;28(12):115542. Epub 2020 May 4.

Department of Chemistry, Tufts University, Medford, MA 02155, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2020.115542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294595PMC
June 2020

CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3.

Neoplasia 2020 01 22;22(1):47-59. Epub 2019 Nov 22.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2019.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881650PMC
January 2020

Inhibit versus Destroy: Are PROTAC Degraders the Solution to Targeting STAT3?

Cancer Cell 2019 11;36(5):459-461

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.10.010DOI Listing
November 2019

Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation.

Nature 2019 09 28;573(7772):139-143. Epub 2019 Aug 28.

Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.

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http://dx.doi.org/10.1038/s41586-019-1511-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6728214PMC
September 2019

The STAT3 Target Gene TNFRSF1A Modulates the NF-κB Pathway in Breast Cancer Cells.

Neoplasia 2018 05 2;20(5):489-498. Epub 2018 Apr 2.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2018.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916089PMC
May 2018

Targeting Oncogenic Transcription Factors: Therapeutic Implications of Endogenous STAT Inhibitors.

Trends Cancer 2017 12 10;3(12):816-827. Epub 2017 Nov 10.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2017.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727919PMC
December 2017

State of the Science: Cancer Complementary and Alternative Medicine Therapeutics Research-NCI Strategic Workshop Highlights of Discussion Report.

J Natl Cancer Inst Monogr 2017 11;2017(52)

Division of Cancer Treatment and Diagnosis, National Cancer Institute, Rockville, MD; National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD; Memorial Sloan Kettering Cancer Center, New York, NY; University of Kansas, Lawrence, KS; University of Florida, Gainsville, FL; Yale University, New Haven, CT; University of Iowa, Iowa City, IA; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; University of Rochester Medical Center, Rochester, NY; Columbia University Medical Center, New York, NY; The University of Texas MD Anderson Cancer Center, Houston, TX; Peking University Cancer Hospital, Beijing, China; University of Pittsburgh, Pittsburgh, PA; Weill Cornell Medicine at Cornell University, New York, NY; Bastyr University, Kenmore, WA; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD; Tsinghua University, Beijing, China.

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http://dx.doi.org/10.1093/jncimonographs/lgx003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061228PMC
November 2017

NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathways.

Cell Discov 2016 20;2:16030. Epub 2016 Sep 20.

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/celldisc.2016.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029543PMC
September 2016

Deregulation of SOCS5 suppresses dendritic cell function in chronic lymphocytic leukemia.

Oncotarget 2016 Jul;7(29):46301-46314

Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.18632/oncotarget.10093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216799PMC
July 2016

Targeting BCL6 and STAT3 in triple negative breast cancer: the one-two punch?

Oncoscience 2015 21;2(11):912. Epub 2015 Nov 21.

Department of Medical Oncology, Dana-Farber Cancer Institute and Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675785PMC
http://dx.doi.org/10.18632/oncoscience.270DOI Listing
December 2015

STAT3-Interacting Proteins as Modulators of Transcription Factor Function: Implications to Targeted Cancer Therapy.

ChemMedChem 2016 Apr 10;11(8):795-801. Epub 2015 Dec 10.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1002/cmdc.201500482DOI Listing
April 2016

Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways.

J Biol Chem 2015 Sep 4;290(39):23553-62. Epub 2015 Aug 4.

Advanced Institutes of Convergence Technology, Seoul National University, Suwon 443-270, Republic of Korea, WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Republic of Korea,

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http://dx.doi.org/10.1074/jbc.M115.662445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583007PMC
September 2015

Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity.

Mol Cell Biol 2015 Oct 13;35(19):3284-300. Epub 2015 Jul 13.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA Biophysical Collaborative Access Team/Illinois Institute of Technology, Sector 18ID (Advanced Photon Source, Argonne National Laboratory), Lemont, Illinois, USA Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA

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http://dx.doi.org/10.1128/MCB.00060-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561728PMC
October 2015

Granulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer.

Genes Cancer 2015 Mar;6(3-4):153-68

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA ; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://www.impactjournals.com/genesandcancer/index.php?abs=5
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426952PMC
http://dx.doi.org/10.18632/genesandcancer.58DOI Listing
March 2015

Mass-spectrometry-based molecular characterization of extracellular vesicles: lipidomics and proteomics.

J Proteome Res 2015 Jun 14;14(6):2367-84. Epub 2015 May 14.

⊥Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/pr501279tDOI Listing
June 2015

Inhibiting STAT5 by the BET bromodomain inhibitor JQ1 disrupts human dendritic cell maturation.

J Immunol 2015 Apr 27;194(7):3180-90. Epub 2015 Feb 27.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1401635
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http://dx.doi.org/10.4049/jimmunol.1401635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369449PMC
April 2015

STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b.

Cancers (Basel) 2014 Apr 23;6(2):958-68. Epub 2014 Apr 23.

Department of Medical Oncology, Dana-Farber Cancer Institute, and Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.3390/cancers6020958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074811PMC
April 2014

Fold change of nuclear NF-κB determines TNF-induced transcription in single cells.

Mol Cell 2014 Mar 13;53(6):867-79. Epub 2014 Feb 13.

Department of Cancer Biology and Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977799PMC
March 2014

JAK2-STAT5 signaling: A novel mechanism of resistance to targeted PI3K/mTOR inhibition.

JAKSTAT 2013 Oct 15;2(4):e24635. Epub 2013 Apr 15.

Department of Medical Oncology; Dana-Farber Cancer Institute; and Departments of Medicine; Brigham and Women's Hospital and Harvard Medical School; Boston, MA USA.

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http://dx.doi.org/10.4161/jkst.24635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891630PMC
October 2013

Targeting STAT5 in hematologic malignancies through inhibition of the bromodomain and extra-terminal (BET) bromodomain protein BRD2.

Mol Cancer Ther 2014 May 16;13(5):1194-205. Epub 2014 Jan 16.

Authors' Affiliations: Department of Medical Oncology, Dana-Farber Cancer Institute, and Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; and Department of Immunology, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, Brazil.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013223PMC
May 2014

Transcription factor STAT3 as a prognostic marker and therapeutic target in cancer.

Authors:
David A Frank

J Clin Oncol 2013 Dec 12;31(36):4560-1. Epub 2013 Nov 12.

Dana-Farber Cancer Institute; Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2013.52.8414DOI Listing
December 2013

Screening approaches to generating STAT inhibitors: Allowing the hits to identify the targets.

JAKSTAT 2012 Oct;1(4):292-9

Department of Medical Oncology; Dana-Farber Cancer Institute; and Department of Medicine; Brigham and Women's Hospital and Harvard Medical School; Boston, MA USA.

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http://dx.doi.org/10.4161/jkst.22662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670287PMC
October 2012

Targeting STATs for cancer therapy: "Undruggable" no more.

Authors:
David A Frank

JAKSTAT 2012 Oct;1(4):261-2

Department of Medical Oncology; Dana-Farber Cancer Institute; and Departments of Medicine; Brigham and Women's Hospital and Harvard Medical School; Boston, MA USA.

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http://dx.doi.org/10.4161/jkst.22528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670283PMC
October 2012

Targeting transcription factors: promising new strategies for cancer therapy.

Curr Opin Oncol 2013 Nov;25(6):652-8

aDepartment of Medical Oncology, Dana-Farber Cancer Institute, and Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA bDepartment of Immunology, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, Brazil.

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http://dx.doi.org/10.1097/01.cco.0000432528.88101.1aDOI Listing
November 2013

STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6.

Mol Cell Biol 2013 Aug 28;33(15):2879-90. Epub 2013 May 28.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1128/MCB.01620-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719667PMC
August 2013

Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer.

Mol Cell Endocrinol 2014 Jan 24;382(1):616-621. Epub 2013 Mar 24.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2013.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732813PMC
January 2014

STAT signaling in the pathogenesis and treatment of myeloid malignancies.

JAKSTAT 2012 Apr;1(2):55-64

Department of Medical Oncology; Dana-Farber Cancer Institute; and Departments of Medicine; Brigham and Women's Hospital and Harvard Medical School; Boston, MA USA.

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http://dx.doi.org/10.4161/jkst.20006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670294PMC
April 2012

STAT3 Inhibition by Microtubule-Targeted Drugs: Dual Molecular Effects of Chemotherapeutic Agents.

Mol Cell Pharmacol 2011 Jan;3(1):13-19

Department of Medical Oncology, Dana-Farber Cancer Institute, and Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177107PMC
January 2011

Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways.

Hum Mol Genet 2011 Nov 5;20(21):4143-54. Epub 2011 Aug 5.

Renal Division, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/hmg/ddr338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188991PMC
November 2011

STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers.

Clin Cancer Res 2011 Mar 10;17(6):1452-62. Epub 2011 Feb 10.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077111PMC
March 2011

Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling.

Mol Pharmacol 2010 Nov 6;78(5):903-8. Epub 2010 Aug 6.

Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1124/mol.110.066316DOI Listing
November 2010

STAT6 in PMBL: pathogenic or passenger?

Authors:
David A Frank

Blood 2009 Aug;114(6):1133-4

Dana-Farber Cancer Institute.

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http://dx.doi.org/10.1182/blood-2009-05-221770DOI Listing
August 2009

Reciprocal effects of STAT5 and STAT3 in breast cancer.

Mol Cancer Res 2009 Jun 2;7(6):966-76. Epub 2009 Jun 2.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://mcr.aacrjournals.org/content/early/2009/05/31/1541-77
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http://mcr.aacrjournals.org/cgi/doi/10.1158/1541-7786.MCR-08
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http://dx.doi.org/10.1158/1541-7786.MCR-08-0238DOI Listing
June 2009

CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy.

Clin Cancer Res 2009 Apr 7;15(8):2583-7. Epub 2009 Apr 7.

Division of Hematology-Oncology, Gwynne Hazen Cherry Memorial Laboratories, Mattel Children's Hospital UCLA, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-1137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883446PMC
April 2009

Targeting transcription factors for cancer therapy.

Authors:
David A Frank

IDrugs 2009 Jan;12(1):29-33

Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medical Oncology, Mayer 522B, 44 Binney Street, Boston, MA 02115, USA.

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January 2009

Review: Prophylactic use of granulocyte colony-stimulating factor reduces febrile neutropenia and short-term mortality in cancer.

Authors:
David A Frank

ACP J Club 2008 Jan-Feb;148(1)

Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.

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February 2008

Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy.

Clin Cancer Res 2007 Oct;13(19):5665-9

Division of Hematology/Oncology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-06-2491DOI Listing
October 2007

STAT1 expression is not required for polyp formation in Min mice.

Mol Carcinog 2008 Feb;47(2):75-9

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1002/mc.20371DOI Listing
February 2008

A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells.

Cancer Res 2007 Feb;67(3):1254-61

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-2439DOI Listing
February 2007

A STAT3 Gene Expression Signature in Gliomas is Associated with a Poor Prognosis.

Transl Oncogenomics 2007 11;2:99-105. Epub 2007 Nov 11.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634710PMC
http://dx.doi.org/10.4137/tog.s1903DOI Listing
May 2013

STAT3 as a central mediator of neoplastic cellular transformation.

Authors:
David A Frank

Cancer Lett 2007 Jun 28;251(2):199-210. Epub 2006 Nov 28.

Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.canlet.2006.10.017DOI Listing
June 2007

Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model.

J Natl Cancer Inst 2006 Sep;98(17):1238-47

Division of Hematology/Oncology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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http://jnci.oxfordjournals.org/content/98/17/1238.full.pdf
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http://jnci.oxfordjournals.org/cgi/doi/10.1093/jnci/djj334
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http://dx.doi.org/10.1093/jnci/djj334DOI Listing
September 2006

Monocyte 15-lipoxygenase expression is regulated by a novel cytosolic signaling complex with protein kinase C delta and tyrosine-phosphorylated Stat3.

J Immunol 2006 Sep;177(6):3771-81

Department of Cell Biology, Cleveland Clinic Foundation, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA.

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http://dx.doi.org/10.4049/jimmunol.177.6.3771DOI Listing
September 2006

Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.

J Biol Chem 2006 Sep 13;281(36):26216-24. Epub 2006 Jul 13.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M605001200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427032PMC
September 2006

Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants.

Biochemistry 2006 May;45(17):5599-605

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/bi0525674DOI Listing
May 2006

Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis.

Cancer Res 2006 Apr;66(7):3649-57

Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-3612DOI Listing
April 2006

A recombinant IL-4-Pseudomonas exotoxin inhibits protein synthesis and overcomes apoptosis resistance in human CLL B cells.

Leuk Res 2005 Sep 12;29(9):1009-18. Epub 2005 Apr 12.

Mayo Clinic, Stabile 628, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.leukres.2004.11.025DOI Listing
September 2005

The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells.

Blood 2005 Jul 31;106(2):690-7. Epub 2005 Mar 31.

Department of Medical Oncology, Mayer 522B, Dana-Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2004-11-4273DOI Listing
July 2005

Genome-wide analysis of STAT target genes: elucidating the mechanism of STAT-mediated oncogenesis.

Cancer Biol Ther 2004 Nov 22;3(11):1045-50. Epub 2004 Nov 22.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.4161/cbt.3.11.1172DOI Listing
November 2004

Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification.

J Biol Chem 2004 Dec 20;279(52):54724-30. Epub 2004 Oct 20.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M408464200DOI Listing
December 2004

IL-6-induced survival of colorectal carcinoma cells is inhibited by butyrate through down-regulation of the IL-6 receptor.

Carcinogenesis 2004 Nov 29;25(11):2247-55. Epub 2004 Jul 29.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/carcin/bgh246DOI Listing
November 2004

STAT1 mediates differentiation of chronic lymphocytic leukemia cells in response to Bryostatin 1.

Blood 2003 Oct 10;102(8):3016-24. Epub 2003 Jul 10.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney St, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2002-09-2972DOI Listing
October 2003

Sustained complete remission of CLL associated with the use of a Chinese herbal extract: case report and mechanistic analysis.

Leuk Res 2003 Sep;27(9):859-63

Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney St., Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s0145-2126(03)00009-2DOI Listing
September 2003

In vivo activation of signal transducer and activator of transcription 1 after CD154 gene therapy for chronic lymphocytic leukemia is associated with clinical and immunologic response.

Clin Cancer Res 2003 Jun;9(6):2166-72

Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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June 2003

StAT signaling in cancer: insights into pathogenesis and treatment strategies.

Authors:
David A Frank

Cancer Treat Res 2003 ;115:267-91

Department of Adult Oncology, Dana-Farber Cancer Institute, Departments of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1007/0-306-48158-8_11DOI Listing
July 2003