David A Flockhart

David A Flockhart

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David A Flockhart

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Influence of Oral Progesterone Administration on Drug-Induced QT Interval Lengthening: A Randomized, Double-Blind, Placebo-Controlled Crossover Study.

JACC Clin Electrophysiol 2016 Dec;2(7):765-774

Krannert Institute of Cardiology, Department of Medicine, School of Medicine, Indiana University, Indianapolis, Indiana.

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http://dx.doi.org/10.1016/j.jacep.2016.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403156PMC
December 2016

Inhibition of Cytochrome P450 2B6 Activity by Voriconazole Profiled Using Efavirenz Disposition in Healthy Volunteers.

Antimicrob Agents Chemother 2016 11 21;60(11):6813-6822. Epub 2016 Oct 21.

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1128/AAC.01000-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075090PMC
November 2016

A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors ╬▒ and ╬▓.

Bioorg Med Chem 2016 11 31;24(21):5400-5409. Epub 2016 Aug 31.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and The Purdue University Center for Cancer Research, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, United States. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065788PMC
http://dx.doi.org/10.1016/j.bmc.2016.08.064DOI Listing
November 2016

Aromatase inhibitors augment nociceptive behaviors in rats and enhance the excitability of sensory neurons.

Exp Neurol 2016 07 9;281:53-65. Epub 2016 Apr 9.

Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2016.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877294PMC
July 2016

Comparative risk of severe hypoglycemia among concomitant users of thiazolidinedione antidiabetic agents and antihyperlipidemics.

Diabetes Res Clin Pract 2016 May 14;115:60-7. Epub 2016 Mar 14.

Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, United States; Center for Pharmacoepidemiology Research and Training, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, United States; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine at the University of Pennsylvania, 34th Street & Civic Center Boulevard, Philadelphia, PA 19104, United States.

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http://dx.doi.org/10.1016/j.diabres.2016.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4890073PMC
May 2016

Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers.

Drug Metab Pharmacokinet 2016 Apr 29;31(2):107-16. Epub 2015 Jul 29.

Indiana University School of Medicine, Department of Medicine, Division of Clinical Pharmacology, Indianapolis, IN 46202, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dmpk.2015.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974081PMC
April 2016

Pharmacogenomically actionable medications in a safety net health care system.

SAGE Open Med 2016 7;4:2050312115624333. Epub 2016 Jan 7.

Department of Medicine, Indiana University, Indianapolis, IN, USA.

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http://dx.doi.org/10.1177/2050312115624333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724767PMC
February 2016

Synthesis of Triphenylethylene Bisphenols as Aromatase Inhibitors That Also Modulate Estrogen Receptors.

J Med Chem 2016 Jan 24;59(1):157-70. Epub 2015 Dec 24.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and The Purdue University Center for Cancer Research, Purdue University , West Lafayette, Indiana 47907, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126733PMC
January 2016

FDA's draft guidance on laboratory-developed tests increases clinical and economic risk to adoption of pharmacogenetic testing.

J Clin Pharmacol 2015 Jul;55(7):725-7

Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1002/jcph.492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719776PMC
July 2015

Cypiripi: exact genotyping of CYP2D6 using high-throughput sequencing data.

Bioinformatics 2015 Jun;31(12):i27-34

School of Computing Science, Simon Fraser University, Burnaby, BC V5A 1S6, Canada, Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA and School of Informatics and Computing, Indiana University, Bloomington, IN 47401, USA School of Computing Science, Simon Fraser University, Burnaby, BC V5A 1S6, Canada, Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA and School of Informatics and Computing, Indiana University, Bloomington, IN 47401, USA.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btv232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542776PMC
June 2015

Report of new haplotype for ABCC2 gene: rs17222723 and rs8187718 in cis.

J Mol Diagn 2015 Mar 29;17(2):201-5. Epub 2014 Dec 29.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.

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http://dx.doi.org/10.1016/j.jmoldx.2014.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348475PMC
March 2015

Comparative risk of ischemic stroke among users of clopidogrel together with individual proton pump inhibitors.

Stroke 2015 Mar 5;46(3):722-31. Epub 2015 Feb 5.

From the Center for Clinical Epidemiology and Biostatistics (C.E.L., W.B.B., C.M.B., C.P.F., S.E. Kimmel, S.H.), Center for Pharmacoepidemiology Research and Training (C.E.L., W.B.B., D.A.F., C.P.F., S.E. Kimmel, S.H.), Department of Psychiatry (W.B.B.), Department of Neurology (S.E. Kasner), Division of Cardiovascular Medicine, Department of Medicine (S.E. Kimmel), and Department of Systems Pharmacology and Translational Therapeutics (S.H.), Perelman School of Medicine at the University of Pennsylvania, Philadelphia; and Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis (D.A.F.).

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http://dx.doi.org/10.1161/STROKEAHA.114.006866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342326PMC
March 2015

Design and synthesis of norendoxifen analogues with dual aromatase inhibitory and estrogen receptor modulatory activities.

J Med Chem 2015 Mar 9;58(6):2623-48. Epub 2015 Mar 9.

ÔÇáDepartment of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, and The Purdue University Center for Cancer Research, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana 47907, United States.

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http://dx.doi.org/10.1021/jm501218eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687028PMC
March 2015

Is personalized medicine achievable in obstetrics?

Semin Perinatol 2014 Dec 3;38(8):534-40. Epub 2014 Oct 3.

Department of Medicine, Department of Medical Genetics, and Department of Pharmacology; Indiana Institute of Personalized Medicine, Indiana University School of Medicine, Indianapolis, IN.

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http://dx.doi.org/10.1053/j.semperi.2014.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252827PMC
December 2014

Substantial effect of efavirenz monotherapy on bilirubin levels in healthy volunteers.

Curr Ther Res Clin Exp 2014 Dec 27;76:64-9. Epub 2014 Sep 27.

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

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http://dx.doi.org/10.1016/j.curtheres.2014.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209507PMC
December 2014

Patient-reported symptoms and discontinuation of adjuvant aromatase inhibitor therapy.

Cancer 2014 Aug 6;120(16):2403-11. Epub 2014 May 6.

Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan.

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http://dx.doi.org/10.1002/cncr.28756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126845PMC
August 2014

Editors' report, November 2013.

Br J Clin Pharmacol 2014 Mar;77(3):401-2

Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, Australia.

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http://dx.doi.org/10.1111/bcp.12317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952714PMC
March 2014

PharmGKB summary: ifosfamide pathways, pharmacokinetics and pharmacodynamics.

Pharmacogenet Genomics 2014 Feb;24(2):133-8

Departments of aGenetics bBioengineering, Stanford University Medical Center, Stanford, California cDepartments of Medicine, Indiana University Simon Cancer Center, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084804PMC
February 2014

Cytochrome P450 3A4*22, PPAR-╬▒, and ARNT polymorphisms and clopidogrel response.

Clin Pharmacol 2013 9;5:185-92. Epub 2013 Dec 9.

Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.2147/CPAA.S53151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862586PMC
December 2013

PharmGKB summary: tamoxifen pathway, pharmacokinetics.

Pharmacogenet Genomics 2013 Nov;23(11):643-7

Departments of aGenetics bBioengineering, Stanford University Medical Center, Stanford, California cDepartment of Medicine, Indiana University Simon Cancer Center, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1097/FPC.0b013e3283656bc1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084801PMC
November 2013

Regulation of microRNA expression by rifampin in human hepatocytes.

Drug Metab Dispos 2013 Oct 9;41(10):1763-8. Epub 2013 Aug 9.

Department of Medicine, Division of Clinical Pharmacology (A.R., S.P., Z.D., D.A.F., T.C.S.), and Department of Medical and Molecular Genetics (A.R., Y.L., H.L., C.G., L.L.), Indiana University School of Medicine, Indianapolis, Indiana; and Division of Clinical Pharmacology and Innovative Therapeutics, the Children's Mercy Hospital and Clinics, Kansas City, Missouri (A.G.).

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http://dx.doi.org/10.1124/dmd.113.052886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781376PMC
October 2013

Inhibition of cytochrome p450 enzymes by the e- and z-isomers of norendoxifen.

Drug Metab Dispos 2013 Sep 3;41(9):1715-20. Epub 2013 Jul 3.

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indiana Institute for Personalized Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1124/dmd.113.052506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876808PMC
September 2013

Synthesis of mixed (E,Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities.

J Med Chem 2013 Jun 3;56(11):4611-8. Epub 2013 Jun 3.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy and The Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA.

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http://dx.doi.org/10.1021/jm400364hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043309PMC
June 2013

C-reactive protein and fibrin clot strength measured by thrombelastography after coronary stenting.

Blood Coagul Fibrinolysis 2013 Apr;24(3):321-6

Krannert Institute of Cardiology, Indiana University School of Medicine, 1800 N. Capitol Avenue, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1097/MBC.0b013e32835cc193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028117PMC
April 2013

Genetic associations with toxicity-related discontinuation of aromatase inhibitor therapy for breast cancer.

Breast Cancer Res Treat 2013 Apr 2;138(3):807-16. Epub 2013 Apr 2.

Breast Oncology Program, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Med Inn Bldg C450, Ann Arbor, MI 48109-5843, USA.

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http://dx.doi.org/10.1007/s10549-013-2504-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646626PMC
April 2013

Is (+)-[13C]-pantoprazole better than (┬▒)-[13C]-pantoprazole for the breath test to evaluate CYP2C19 enzyme activity?

J Breath Res 2013 Mar 21;7(1):016001. Epub 2012 Dec 21.

Indiana University School of Medicine, Indiana University, Indianapolis, IN, USA.

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http://dx.doi.org/10.1088/1752-7155/7/1/016001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587180PMC
March 2013

Comparison of changes in the lipid profile of postmenopausal women with early stage breast cancer treated with exemestane or letrozole.

J Clin Pharmacol 2012 Dec 15;52(12):1852-60. Epub 2011 Dec 15.

Division of Clinical Pharmacology, Wishard Memorial Hospital, WD Myers Bldg, W7123, 1001 West 10th St, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1177/0091270011424153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616612PMC
December 2012

Pharmacogenetics and healthcare outcomes in patients with chronic heart failure.

Eur J Clin Pharmacol 2012 Nov 29;68(11):1483-91. Epub 2012 Apr 29.

Department of Anesthesiology and Pain Medicine, Inje University Sanggye Paik Hospital, 761-1, Sanggye 7-dong, Nowon-gu, Seoul, Korea.

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http://dx.doi.org/10.1007/s00228-012-1280-zDOI Listing
November 2012

Dietary restrictions and drug interactions with monoamine oxidase inhibitors: an update.

J Clin Psychiatry 2012 ;73 Suppl 1:17-24

Indiana Insitute for Personalized Medicine and Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.4088/JCP.11096su1c.03DOI Listing
November 2012

Impact of the Interaction between 3'-UTR SNPs and microRNA on the Expression of Human Xenobiotic Metabolism Enzyme and Transporter Genes.

Front Genet 2012 21;3:248. Epub 2012 Nov 21.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University West Lafayette, IN, USA.

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http://dx.doi.org/10.3389/fgene.2012.00248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502871PMC
November 2012

Whole genome amplification of DNA for genotyping pharmacogenetics candidate genes.

Front Pharmacol 2012 30;3:54. Epub 2012 Mar 30.

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine Indianapolis, IN, USA.

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http://journal.frontiersin.org/article/10.3389/fphar.2012.00
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http://dx.doi.org/10.3389/fphar.2012.00054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315790PMC
October 2012

Enhanced sensitivity to drug-induced QT interval lengthening in patients with heart failure due to left ventricular systolic dysfunction.

J Clin Pharmacol 2012 Sep 1;52(9):1296-305. Epub 2011 Nov 1.

Department of Pharmacy Practice, College of Pharmacy, Purdue University, W7555 Myers Building, WHS, 1001 West 10th Street, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1177/0091270011416939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857021PMC
September 2012

Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response.

Clin Pharmacol 2012 20;4:13-20. Epub 2012 Feb 20.

Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.2147/CPAA.S27822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304338PMC
August 2012

Protease activated receptor-1 (PAR-1) mediated platelet aggregation is dependent on clopidogrel response.

Thromb Res 2012 Aug 28;130(2):198-202. Epub 2012 Mar 28.

Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1016/j.thromres.2012.02.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965578PMC
August 2012

Reduced methadone clearance during aromatase inhibition.

J Clin Psychopharmacol 2012 Aug;32(4):511-7

Division of Clinical Pharmacology, Indiana Institute for Personalized Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/JCP.0b013e31825d0b54DOI Listing
August 2012

The tamoxifen metabolite norendoxifen is a potent and selective inhibitor of aromatase (CYP19) and a potential lead compound for novel therapeutic agents.

Breast Cancer Res Treat 2012 May 4;133(1):99-109. Epub 2011 Aug 4.

Division of Clinical Pharmacology, Department of Pharmacology and Toxicology, Indiana University Simon Cancer Center, Indiana University School of Medicine, 1001 West 10th Street, Room 7123, Myers Building, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1007/s10549-011-1699-4DOI Listing
May 2012

Functional characterization of a genetic polymorphism in the promoter of the ESR2 gene.

Horm Cancer 2012 Apr;3(1-2):37-43

Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, 46202, USA.

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http://link.springer.com/10.1007/s12672-011-0086-2
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http://dx.doi.org/10.1007/s12672-011-0086-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402208PMC
April 2012

In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4╬▒ expression.

Drug Metab Dispos 2012 Apr 9;40(4):726-33. Epub 2012 Jan 9.

Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.111.040329
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http://dx.doi.org/10.1124/dmd.111.040329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310421PMC
April 2012

Comparison of breast cancer recurrence risk and cardiovascular disease incidence risk among postmenopausal women with breast cancer.

Breast Cancer Res Treat 2012 Feb 1;131(3):907-14. Epub 2011 Nov 1.

Breast Cancer Program, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Bunting-Blaustein Cancer Research Building 1, Room 144, 1650 Orleans Street, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1007/s10549-011-1843-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582017PMC
February 2012

Tamoxifen metabolites as active inhibitors of aromatase in the treatment of breast cancer.

Breast Cancer Res Treat 2012 Jan 9;131(2):473-81. Epub 2011 Mar 9.

Division of Clinical Pharmacology, Department of Pharmacology and Toxicology, Indiana University Simon Cancer Center, Indiana University School of Medicine, 1001 West 10th Street, Room 7123, Myers Building, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1007/s10549-011-1428-zDOI Listing
January 2012

Tamoxifen and its metabolites cause acute vasorelaxation of aortic rings by inducing vasodilator prostanoid synthesis.

J Cardiovasc Pharmacol 2011 Dec;58(6):647-53

Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.

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http://dx.doi.org/10.1097/FJC.0b013e31823171baDOI Listing
December 2011

Stereoselective pharmacokinetics of stable isotope (+/-)-[13C]-pantoprazole: Implications for a rapid screening phenotype test of CYP2C19 activity.

Chirality 2011 Nov 20;23(10):904-9. Epub 2011 Sep 20.

Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Wishard Memorial Hospital, Indianapolis, Indiana.

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http://dx.doi.org/10.1002/chir.21011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409653PMC
November 2011

Methadone adverse reaction presenting with large increase in plasma methadone binding: a case series.

J Med Case Rep 2011 Oct 10;5:513. Epub 2011 Oct 10.

Division of Clinical Pharmacology, Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://jmedicalcasereports.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/1752-1947-5-513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201932PMC
October 2011

Morbid obesity and metabolic syndrome in Ossabaw miniature swine are associated with increased platelet reactivity.

Diabetes Metab Syndr Obes 2011 15;4:99-105. Epub 2011 Mar 15.

Krannert Institute of Cardiology, Indiana University School of Medicine, IN, USA.

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http://dx.doi.org/10.2147/DMSO.S17105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107692PMC
June 2011

In vitro cytochrome P450-mediated metabolism of exemestane.

Drug Metab Dispos 2011 Jan 28;39(1):98-105. Epub 2010 Sep 28.

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1124/dmd.110.032276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014267PMC
January 2011

Methadone: a substrate and mechanism-based inhibitor of CYP19 (aromatase).

Drug Metab Dispos 2010 Aug 21;38(8):1308-13. Epub 2010 Apr 21.

Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1124/dmd.110.032474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913626PMC
August 2010

Differential quantification of CYP2D6 gene copy number by four different quantitative real-time PCR assays.

Pharmacogenet Genomics 2010 Jul;20(7):451-4

Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32833a1083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411953PMC
July 2010

Composite functional genetic and comedication CYP2D6 activity score in predicting tamoxifen drug exposure among breast cancer patients.

J Clin Pharmacol 2010 Apr 15;50(4):450-8. Epub 2010 Jan 15.

Division of Biostatistics/Clinical Pharmacology, Indiana University, School of Medicine, 410 W. 10th St., HITS 3000, Indianapolis, IN 46202; e-mail:

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http://dx.doi.org/10.1177/0091270009359182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816977PMC
April 2010

Pharmacotherapy and pregnancy: highlights from the Second International Conference for Individualized Pharmacotherapy in Pregnancy.

Clin Transl Sci 2009 Dec;2(6):439-43

Indiana University School of Medicine, PREGMED, The Indiana University Center for Pharmacogenetics and Therapeutics Research in Maternal and Child Health, Indiana, USA.

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http://dx.doi.org/10.1111/j.1752-8062.2009.00166.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641763PMC
December 2009

Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro.

Cancer Chemother Pharmacol 2009 Oct 7;64(5):867-75. Epub 2009 Feb 7.

Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1007/s00280-009-0935-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774495PMC
October 2009

Exploratory study evaluating the association of polymorphisms of angiogenesis genes with hot flashes.

Breast Cancer Res Treat 2009 Aug 11;116(3):543-9. Epub 2008 Sep 11.

Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1007/s10549-008-0178-zDOI Listing
August 2009

Estrogen receptor genotype is associated with risk of venous thromboembolism during tamoxifen therapy.

Breast Cancer Res Treat 2009 Jun 12;115(3):643-50. Epub 2008 Dec 12.

Department of Hematology/Oncology, Marshfield Clinic Weston Center, 3501 Cranberry Boulevard, Weston, WI 54476, USA.

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http://dx.doi.org/10.1007/s10549-008-0264-2DOI Listing
June 2009

Identification of genetic variants in the human indoleamine 2,3-dioxygenase (IDO1) gene, which have altered enzyme activity.

Pharmacogenet Genomics 2009 Jun;19(6):464-76

Department of medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

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June 2009

Assessment of vascular effects of tamoxifen and its metabolites on the rat perfused hindquarter vascular bed.

Basic Clin Pharmacol Toxicol 2009 May;104(5):400-7

Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.

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http://dx.doi.org/10.1111/j.1742-7843.2009.00377.xDOI Listing
May 2009

Pharmacotherapy and pregnancy: Highlights from the first International Conference for Individualized Pharmacotherapy in Pregnancy.

Clin Transl Sci 2009 Feb;2(1):11-4

Indiana University School of Medicine, PREGMED, The Indiana University Center for Pharmacogenetics and Therapeutics Research in Maternal and Child Health, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1111/j.1752-8062.2009.00079.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350789PMC
February 2009

Pharmacogenetics of tamoxifen: who should undergo CYP2D6 genetic testing?

J Natl Compr Canc Netw 2009 Feb;7(2):203-13

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland 21231-1000, USA.

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February 2009

Pharmacokinetics of ibutilide in patients with heart failure due to left ventricular systolic dysfunction.

Pharmacotherapy 2008 Dec;28(12):1461-70

Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Purdue University, 1001 W 10th Street, Indianapolis, IN, USA.

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http://dx.doi.org/10.1592/phco.28.12.1461DOI Listing
December 2008

Drug interactions and pharmacogenomics in the treatment of breast cancer and depression.

Am J Psychiatry 2008 Oct;165(10):1251-5

Breast Oncology Program, University of Michigan Comprehensive Cancer Center, 300 North Ingalls St., Bldg. 3A04, Ann Arbor, MI 48109-5419, USA.

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http://dx.doi.org/10.1176/appi.ajp.2008.08040482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742969PMC
October 2008

VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans.

Pharmacogenomics 2008 Oct;9(10):1445-58

Department of Neurology, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC-312, Birmingham AL 35294-0021, USA.

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http://dx.doi.org/10.2217/14622416.9.10.1445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586955PMC
October 2008