David A Fidock

David A Fidock

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David A Fidock

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Plasmodium falciparum resistance to piperaquine driven by PfCRT.

Lancet Infect Dis 2019 Nov;19(11):1168-1169

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York 10032, NY, USA; Division of Infectious Diseases in the Department of Medicine, Columbia University Irving Medical Center, New York 10032, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(19)30543-2DOI Listing
November 2019

Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery.

Cell Chem Biol 2019 Nov 29. Epub 2019 Nov 29.

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.11.009DOI Listing
November 2019

Blocking Development in Mosquitoes: A Powerful New Approach for Expanding Malaria Control Efforts.

Am J Trop Med Hyg 2019 Oct;101(4):734-735

Innovative Vector Control Consortium, Liverpool, United Kingdom.

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http://dx.doi.org/10.4269/ajtmh.19-0318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779223PMC
October 2019

Accelerated evolution and spread of multidrug-resistant Plasmodium falciparum takes down the latest first-line antimalarial drug in southeast Asia.

Lancet Infect Dis 2019 Sep 22;19(9):916-917. Epub 2019 Jul 22.

Department of Microbiology and Immunology, and Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1016/S1473-3099(19)30394-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754981PMC
September 2019

Elucidating Mechanisms of Drug-Resistant Plasmodium falciparum.

Cell Host Microbe 2019 Jul;26(1):35-47

Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2019.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639022PMC
July 2019

Pyronaridine-Artesunate Shows Promise as an Effective and Well-Tolerated Treatment for Artemisinin-Resistant Plasmodium falciparum Malaria.

Clin Infect Dis 2019 Jun 28. Epub 2019 Jun 28.

Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1093/cid/ciz583DOI Listing
June 2019

Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness.

MBio 2019 04 30;10(2). Epub 2019 Apr 30.

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA

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http://dx.doi.org/10.1128/mBio.02731-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6495381PMC
April 2019

Plasmodium falciparum In Vitro Drug Resistance Selections and Gene Editing.

Methods Mol Biol 2019 ;2013:123-140

Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1007/978-1-4939-9550-9_9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756925PMC
January 2019

Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors.

J Am Chem Soc 2018 09 29;140(36):11424-11437. Epub 2018 Aug 29.

Department of Pathology and Microbiology , University of Nebraska Medical Center , Omaha , Nebraska 68198 , United States.

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http://pubs.acs.org/doi/10.1021/jacs.8b06656
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http://dx.doi.org/10.1021/jacs.8b06656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407133PMC
September 2018

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine.

Nat Commun 2018 08 17;9(1):3314. Epub 2018 Aug 17.

Department of Microbiology and Immunology, Columbia University Irving Medical Center, 1502 Hammer Health Sciences Center, 701 W. 168th St., New York, NY, 10032, USA.

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http://www.nature.com/articles/s41467-018-05652-0
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http://dx.doi.org/10.1038/s41467-018-05652-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095916PMC
August 2018

A Breathprint for Malaria: New Opportunities for Noninterventional Diagnostics and Mosquito Traps?

Authors:
David A Fidock

J Infect Dis 2018 04;217(10):1512-1514

Department of Microbiology and Immunology, and Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York.

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https://academic.oup.com/jid/article/217/10/1512/4837252
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http://dx.doi.org/10.1093/infdis/jiy073DOI Listing
April 2018

Protein Degradation Systems as Antimalarial Therapeutic Targets.

Trends Parasitol 2017 09 5;33(9):731-743. Epub 2017 Jul 5.

Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pt.2017.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656264PMC
September 2017

Hydrogen peroxide dynamics in subcellular compartments of malaria parasites using genetically encoded redox probes.

Sci Rep 2017 09 5;7(1):10449. Epub 2017 Sep 5.

Biochemistry and Molecular Biology, Interdisciplinary Research Center, Justus Liebig University Giessen, 35392, Giessen, Germany.

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http://dx.doi.org/10.1038/s41598-017-10093-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585161PMC
September 2017

Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic.

Nat Med 2017 Aug;23(8):917-928

Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nm.4381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747363PMC
August 2017

Evidence of a Mild Mutator Phenotype in Cambodian Plasmodium falciparum Malaria Parasites.

PLoS One 2016 21;11(4):e0154166. Epub 2016 Apr 21.

Department of Microbiology and Immunology, Columbia University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154166PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839739PMC
April 2017

K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness .

MBio 2017 04 11;8(2). Epub 2017 Apr 11.

Department of Microbiology & Immunology, Columbia University College of Physicians and Surgeons, New York, New York, USA

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http://mbio.asm.org/lookup/doi/10.1128/mBio.00172-17
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http://dx.doi.org/10.1128/mBio.00172-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388803PMC
April 2017

Drug discovery: Chemical diversity targets malaria.

Authors:
David A Fidock

Nature 2016 10 12;538(7625):323-325. Epub 2016 Oct 12.

Departments of Microbiology and Immunology and of Medicine, Division of Infectious Diseases, Columbia University Medical Center, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/nature19481DOI Listing
October 2016

Artemisinin Action and Resistance in Plasmodium falciparum.

Trends Parasitol 2016 09 9;32(9):682-696. Epub 2016 Jun 9.

Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY, USA; Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pt.2016.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007624PMC
September 2016

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum.

Mol Biol Evol 2016 06 22;33(6):1554-70. Epub 2016 Feb 22.

Department of Microbiology and Immunology, Columbia University Medical Center, New York Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, NY

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http://dx.doi.org/10.1093/molbev/msw037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868112PMC
June 2016

Substrate and Inhibitor Specificity of the Plasmodium berghei Equilibrative Nucleoside Transporter Type 1.

Mol Pharmacol 2016 06 5;89(6):678-85. Epub 2016 Apr 5.

Departments of Physiology and Biophysics (A.A., R.D., Y.S., S.N.N., M.H.A.) and Neuroscience and Medicine (M.H.A.), Albert Einstein College of Medicine, Bronx, New York; and Departments Microbiology and Immunology (P.P.H., T.R.S.K., D.A.F.) and Medicine (D.A.F.), Columbia University Medical Center, New York, New York

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http://dx.doi.org/10.1124/mol.115.101386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885503PMC
June 2016

A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.

N Engl J Med 2016 06;374(25):2453-64

The authors' affiliations are listed in the Supplementary Appendix , available at NEJM.org.

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http://dx.doi.org/10.1056/NEJMoa1513137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955562PMC
June 2016

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.

Nat Commun 2016 05 18;7:11553. Epub 2016 May 18.

Department of Microbiology and Immunology, Columbia University Medical Center, Room 1502 HHSC, 701 West 168th Street, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/ncomms11553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873939PMC
May 2016

Luciferase-Based, High-Throughput Assay for Screening and Profiling Transmission-Blocking Compounds against Plasmodium falciparum Gametocytes.

Antimicrob Agents Chemother 2016 Apr 25;60(4):2097-107. Epub 2016 Mar 25.

Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia

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http://dx.doi.org/10.1128/AAC.01949-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808229PMC
April 2016

Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1.

BMC Genomics 2015 Dec 21;16:1090. Epub 2015 Dec 21.

Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, 10032, USA.

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http://dx.doi.org/10.1186/s12864-015-2320-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687325PMC
December 2015

Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt.

Proc Natl Acad Sci U S A 2015 Sep 10;112(37):11672-7. Epub 2015 Aug 10.

Laboratoire de parasitologie, WHO Collaborating Center for Surveillance of Anti-Malarial Drug Resistance, Centre National de Référence du paludisme, Laboratoire associé pour la région Antilles-Guyane, Institut Pasteur de la Guyane, 97300 Cayenne, French Guiana;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1507142112
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http://dx.doi.org/10.1073/pnas.1507142112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577156PMC
September 2015

Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum.

Cell Host Microbe 2015 Sep;18(3):371-81

Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA; Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. Electronic address:

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http://www.cell.com/cell-host-microbe/pdf/S1931-3128(15)0033
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http://linkinghub.elsevier.com/retrieve/pii/S193131281500331
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http://dx.doi.org/10.1016/j.chom.2015.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567697PMC
September 2015

The Mu subunit of Plasmodium falciparum clathrin-associated adaptor protein 2 modulates in vitro parasite response to artemisinin and quinine.

Antimicrob Agents Chemother 2015 May 17;59(5):2540-7. Epub 2015 Feb 17.

Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom Department of Clinical Parasitology, Hospital for Tropical Diseases, University College London Hospital, London, United Kingdom

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http://dx.doi.org/10.1128/AAC.04067-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394773PMC
May 2015

Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum.

Antimicrob Agents Chemother 2015 Apr 20;59(4):1977-82. Epub 2015 Jan 20.

Departments of Physiology and Pharmacology, Molecular Microbiology, and Immunology, Oregon Health & Science University, Portland, Oregon, USA VA Medical Center, Portland, Oregon, USA

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http://dx.doi.org/10.1128/AAC.04149-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356778PMC
April 2015

Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance.

PLoS Biol 2015 Apr 22;13(4):e1002132. Epub 2015 Apr 22.

Department of Biochemistry and Molecular Biology and ARC Centre of Excellence for Coherent X-ray Science, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia.

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http://mathmodelling.sph.unimelb.edu.au/publications/Dogovsk
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http://dx.plos.org/10.1371/journal.pbio.1002132
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http://dx.doi.org/10.1371/journal.pbio.1002132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406523PMC
April 2015

Editing the Plasmodium vivax genome, using zinc-finger nucleases.

J Infect Dis 2015 Jan 31;211(1):125-9. Epub 2014 Jul 31.

Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1093/infdis/jiu423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334824PMC
January 2015

Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates.

Science 2015 Jan 11;347(6220):428-31. Epub 2014 Dec 11.

Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY, USA. Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.

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http://dx.doi.org/10.1126/science.1260867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349400PMC
January 2015

CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites.

Genome Med 2014 26;6(8):63. Epub 2014 Aug 26.

Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, NY 10032 USA ; Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032 USA.

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http://dx.doi.org/10.1186/s13073-014-0063-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254425PMC
December 2014

Transfusion of stored blood impairs host defenses against Gram-negative pathogens in mice.

Transfusion 2014 Nov 19;54(11):2842-51. Epub 2014 May 19.

Institute of Comparative Medicine, Columbia University Medical Center-New York Presbyterian Hospital, New York, New York; Department of Pathology and Cell Biology, Columbia University Medical Center-New York Presbyterian Hospital, New York, New York.

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http://dx.doi.org/10.1111/trf.12712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229414PMC
November 2014

DNA repair mechanisms and their biological roles in the malaria parasite Plasmodium falciparum.

Microbiol Mol Biol Rev 2014 Sep;78(3):469-86

Department of Microbiology and Immunology, Columbia University, New York, New York, USA Division of Infectious Diseases, Department of Medicine, Columbia University, New York, New York, USA

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http://mmbr.asm.org/cgi/doi/10.1128/MMBR.00059-13
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http://dx.doi.org/10.1128/MMBR.00059-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187680PMC
September 2014

Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate.

Cell 2014 Aug;158(4):916-928

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Computational and Integrative Biomedical Research Center, Baylor College of Medicine, Houston, TX 77030, USA; Verna and Marrs McLean Department of Biochemistry and Alkek Center for Molecular Discovery, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167585PMC
August 2014

Origin of robustness in generating drug-resistant malaria parasites.

Mol Biol Evol 2014 Jul 16;31(7):1649-60. Epub 2014 Apr 16.

Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, ThailandCenter of Excellence in Malaria, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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http://dx.doi.org/10.1093/molbev/msu140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069624PMC
July 2014

Characterization of the ATG8-conjugation system in 2 Plasmodium species with special focus on the liver stage: possible linkage between the apicoplastic and autophagic systems?

Autophagy 2014 Feb 12;10(2):269-84. Epub 2013 Dec 12.

Department of Molecular Microbiology and Immunology; Malaria Research Institute; Johns Hopkins University Bloomberg School of Public Health; Baltimore, MD USA.

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http://dx.doi.org/10.4161/auto.27166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5396099PMC
February 2014

Modeling within-host effects of drugs on Plasmodium falciparum transmission and prospects for malaria elimination.

PLoS Comput Biol 2014 Jan 23;10(1):e1003434. Epub 2014 Jan 23.

Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York, United States of America ; Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1003434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900379PMC
January 2014

Identification of MMV malaria box inhibitors of plasmodium falciparum early-stage gametocytes using a luciferase-based high-throughput assay.

Antimicrob Agents Chemother 2013 Dec 23;57(12):6050-62. Epub 2013 Sep 23.

Discovery Biology, Eskitis Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia.

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http://dx.doi.org/10.1128/AAC.00870-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837862PMC
December 2013

Using genetic methods to define the targets of compounds with antimalarial activity.

J Med Chem 2013 Oct 6;56(20):7761-71. Epub 2013 Sep 6.

Department of Pediatrics, University of California, San Diego, School of Medicine , 9500 Gilman Drive 0741, La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/jm400325jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880619PMC
October 2013

An integrated strategy for efficient vector construction and multi-gene expression in Plasmodium falciparum.

Malar J 2013 Oct 26;12:373. Epub 2013 Oct 26.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1186/1475-2875-12-373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842810PMC
October 2013

Spatial and temporal mapping of the PfEMP1 export pathway in Plasmodium falciparum.

Cell Microbiol 2013 Aug 14;15(8):1401-18. Epub 2013 Mar 14.

Department of Biochemistry and Molecular Biology, The University of Melbourne, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/cmi.12125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711974PMC
August 2013

Microbiology. Eliminating malaria.

Authors:
David A Fidock

Science 2013 Jun;340(6140):1531-3

Department of Microbiology and Immunology and Division of Infectious Diseases, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1126/science.1240539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361224PMC
June 2013

Malaria's missing number: calculating the human component of R0 by a within-host mechanistic model of Plasmodium falciparum infection and transmission.

PLoS Comput Biol 2013 Apr 18;9(4):e1003025. Epub 2013 Apr 18.

Department of Microbiology and Immunology, Columbia University College of Physicians and Surgeons, New York, New York, USA.

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http://dx.doi.org/10.1371/journal.pcbi.1003025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630126PMC
April 2013

Novel diaryl ureas with efficacy in a mouse model of malaria.

Bioorg Med Chem Lett 2013 Feb 20;23(4):1022-5. Epub 2012 Dec 20.

Department of Medicinal Chemistry, Jacobus Pharmaceutical Company, 37 Cleveland Lane, Princeton, NJ 08540, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746744PMC
February 2013

Degrees of chloroquine resistance in Plasmodium - is the redox system involved?

Int J Parasitol Drugs Drug Resist 2012 Dec;2:47-57

Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.ijpddr.2011.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388501PMC
December 2012

PfCRT and its role in antimalarial drug resistance.

Trends Parasitol 2012 Nov 25;28(11):504-14. Epub 2012 Sep 25.

Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.pt.2012.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478492PMC
November 2012

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases.

Nat Methods 2012 Oct 26;9(10):993-8. Epub 2012 Aug 26.

Department of Microbiology & Immunology, Columbia University College of Physicians and Surgeons, New York, New York, USA.

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http://dx.doi.org/10.1038/nmeth.2143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697006PMC
October 2012

Tricks in Plasmodium's molecular repertoire--escaping 3'UTR excision-based conditional silencing of the chloroquine resistance transporter gene.

Int J Parasitol 2012 Oct 27;42(11):969-74. Epub 2012 Sep 27.

Department of Microbiology and Immunology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.ijpara.2012.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517811PMC
October 2012