Publications by authors named "David A Brenner"

100Publications

Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice.

Arch Clin Biomed Res 2020 20;4(5):561-580. Epub 2020 Oct 20.

Department of Surgery, University of California, San Diego, La Jolla, CA, USA.

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October 2020

A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis.

Cell Metab 2020 Nov 30;32(5):878-888.e6. Epub 2020 Jun 30.

NAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Division of Epidemiology, Department of Family and Preventative Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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November 2020

Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder.

Front Physiol 2020 24;11:370. Epub 2020 Apr 24.

Department of Medicine, University of California, San Diego, San Diego, CA, United States.

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April 2020

Mechanisms of liver fibrosis and its role in liver cancer.

Exp Biol Med (Maywood) 2020 01 10;245(2):96-108. Epub 2020 Jan 10.

Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA.

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January 2020

The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease.

Cell Metab 2019 11;30(5):850-852

Department of Medicine, University of California, San Diego, San Diego, CA 92093, USA. Electronic address:

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November 2019

The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma.

Int J Mol Sci 2019 Apr 7;20(7). Epub 2019 Apr 7.

Department of Surgery, UC San Diego, La Jolla, CA 92093, USA.

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April 2019

Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis.

Hepatol Commun 2019 Feb 13;3(2):180-192. Epub 2018 Dec 13.

Department of Surgery University of California San Diego La Jolla CA.

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February 2019

Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians.

Clin Gastroenterol Hepatol 2019 01 18;17(2):218-230. Epub 2018 Sep 18.

Department of Pediatrics, University of California San Diego, La Jolla, California; Center for Microbiome Innovation, University of California San Diego, La Jolla, California; Department of Computer Science and Engineering, University of California San Diego, La Jolla, California; Department of Bioengineering, University of California San Diego, La Jolla, California. Electronic address:

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January 2019

Of Mice and Men and Nonalcoholic Steatohepatitis.

Authors:
David A Brenner

Hepatology 2018 12 13;68(6):2059-2061. Epub 2018 Nov 13.

School of Medicine, University of California San Diego, La Jolla, CA.

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December 2018

Publisher Correction: The gut-liver axis and the intersection with the microbiome.

Nat Rev Gastroenterol Hepatol 2018 12;15(12):785

Department of Pediatrics, University of California, San Diego, CA, USA.

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December 2018

The gut-liver axis and the intersection with the microbiome.

Nat Rev Gastroenterol Hepatol 2018 07;15(7):397-411

Department of Pediatrics, University of California, San Diego, CA, USA.

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July 2018

Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease.

Clin Gastroenterol Hepatol 2018 12 17;16(12):1974-1982.e7. Epub 2018 Jan 17.

NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, California; Division of Gastroenterology, Department of Medicine, University of California at San Diego, La Jolla, California; Division of Epidemiology, Department of Family and Preventive Medicine, University of California at San Diego, La Jolla, California. Electronic address:

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December 2018

Thomas E. Starzl: Transplantation pioneer.

Authors:
David A Brenner

Proc Natl Acad Sci U S A 2017 10 11;114(41):10808-10809. Epub 2017 Sep 11.

Department of Medicine, University of California, San Diego School of Medicine, La Jolla, CA 92093-0602

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October 2017

Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice.

Int J Mol Med 2017 Aug 14;40(2):454-464. Epub 2017 Jun 14.

Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, P.R. China.

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August 2017

Liver inflammation and fibrosis.

J Clin Invest 2017 01 3;127(1):55-64. Epub 2017 Jan 3.

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January 2017

Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice.

Age (Dordr) 2016 Aug 30;38(4):291-302. Epub 2016 Aug 30.

Department of Medicine, School of Medicine, University of California, 9500 Gilman Drive # 0702, La Jolla, San Diego, CA, 92093, USA.

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August 2016

New Developments on the Treatment of Liver Fibrosis.

Dig Dis 2016;34(5):589-96. Epub 2016 Jun 22.

School of Medicine, University of California, La Jolla, San Diego, Calif., USA.

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January 2017

Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial.

J Hepatol 2016 08 2;65(2):369-76. Epub 2016 May 2.

NAFLD Research Center, Department of Medicine, University of California at San Diego, La Jolla, CA, United States; Division of Epidemiology, Department of Family and Preventive Medicine, University of California at San Diego, La Jolla, CA, United States; Division of Gastroenterology, Department of Medicine, University of California at San Diego, La Jolla, CA, United States; San Diego Integrated NAFLD Research Consortium (SINC), United States. Electronic address:

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August 2016

Promising Therapy Candidates for Liver Fibrosis.

Front Physiol 2016 16;7:47. Epub 2016 Feb 16.

Department of Surgery, University of California San Diego, La Jolla, CA, USA.

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February 2016

Staging of fibrosis in experimental non-alcoholic steatohepatitis by quantitative molecular imaging in rat models.

Nucl Med Biol 2016 Feb 2;43(2):179-87. Epub 2015 Dec 2.

UCSD In Vivo Cancer & Molecular Imaging Program, University of California, San Diego, La Jolla, CA; Department of Radiology, University of California, San Diego, La Jolla, CA; Moores UCSD Cancer Center, University of California, San Diego, La Jolla, CA; Department of Surgery, University of California, San Diego, La Jolla, CA. Electronic address:

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February 2016

The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts.

Front Physiol 2016 2;7:17. Epub 2016 Feb 2.

Department of Medicine, University of California, San Diego La Jolla, CA, USA.

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February 2016

Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation.

Cell Host Microbe 2016 Feb;19(2):227-39

Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA; Department of Medicine, VA San Diego Healthcare System, San Diego, CA 92161, USA. Electronic address:

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February 2016

Liver: DNA methylation controls liver fibrogenesis.

Nat Rev Gastroenterol Hepatol 2016 Mar 10;13(3):126-8. Epub 2016 Feb 10.

Department of Medicine, University of California, La Jolla, California 92093, USA.

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March 2016

Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion.

J Clin Gastroenterol 2015 Nov-Dec;49 Suppl 1:S69-73

*Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT †Harvard Medical School ‡Mucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Boston ††Department of Transplantation, Lahey Hospital and Medical Center, Burlington, MA §Dairy & Food Culture Technologies, International Scientific Association of Probiotics and Prebiotics (ISAPP), Sacramento **Department of Medicine, University of California, San Diego, San Diego, CA ∥Departments of Internal Medicine, Academic Medical Center and VUmC, Amsterdam, The Netherlands ¶Wallenberg Laboratory, Gothenborg University, Gothenburg, Sweden #Minnesota Gastroenterology P.A., Minnesota, MN ‡‡Pediatric Liver & Liver Transplant, Gastroenterology/Transplantation, Phoenix Children's Hospital ∥∥Mayo Clinic, Phoenix §§Department of Pediatrics, University of Arizona, Tucson, AZ ¶¶Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, Naples ##Clinical Hepato-Gastroenterology Unit, Division of Gastroenterology & Digestive Endoscopy, S. Raffaele University Hospital, Milano, Italy ***Division of Gastroenterology, University of Alberta, Edmonton, AB, Canada †††Department of Gastroenterology, University of North Carolina School of Medicine, Chapel Hill, NC ‡‡‡The Lynda K. and David M. Underwood Center for Digestive Disorders, Houston Methodist Hospital, Houston, TX §§§Department of Medicine, Weill Cornell Medical College, New York ∥∥∥Department of Medicine and Surgery, Division of Gastroenterology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.

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July 2016

Role of Gut Microbiota in Liver Disease.

J Clin Gastroenterol 2015 Nov-Dec;49 Suppl 1:S25-7

*Department of Medicine, University of California San Diego, La Jolla, CA †Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine ‡Department of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, Korea.

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July 2016

Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation.

PLoS One 2015 29;10(7):e0129743. Epub 2015 Jul 29.

Department of Medicine, University of California San Diego, La Jolla, California, United States of America.

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April 2016

New therapies for hepatic fibrosis.

Clin Res Hepatol Gastroenterol 2015 Sep 20;39 Suppl 1:S75-9. Epub 2015 Jul 20.

School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, 92093 California, United States. Electronic address:

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September 2015

Recent advancement of molecular mechanisms of liver fibrosis.

J Hepatobiliary Pancreat Sci 2015 Jul 13;22(7):512-8. Epub 2015 Apr 13.

School of Medicine, University of California San Diego, La Jolla, CA, USA.

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July 2015

Aging and liver disease.

Curr Opin Gastroenterol 2015 May;31(3):184-91

aDepartment of Internal Medicine, Chonbuk National University Medical School, Jeonju, South Korea bDepartment of Internal Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA.

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May 2015

Contribution of bone marrow-derived fibrocytes to liver fibrosis.

Hepatobiliary Surg Nutr 2015 Feb;4(1):34-47

1 Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA ; 2 Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China ; 3 Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120752, Korea ; 4 Department of Medicine III, University Hospital Aachen, Aachen 52074, Germany ; 5 Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA.

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February 2015

Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial).

Hepatology 2015 Apr 27;61(4):1239-50. Epub 2015 Feb 27.

NAFLD Translational Research Unit, University of California at San Diego, La Jolla, CA; Division of Gastroenterology, Department of Medicine, University of California at San Diego, La Jolla, CA; Division of Epidemiology, Department of Family and Preventive Medicine, University of California at San Diego, La Jolla, CA.

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April 2015

Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice.

FASEB J 2015 Mar 2;29(3):1043-55. Epub 2014 Dec 2.

*Department of Medicine, University of California, San Diego, La Jolla, California, USA; Department of Medicine, VA San Diego Healthcare System, San Diego, California, USA; Genomics Institute of the Novartis Research Foundation, San Diego, California, USA; Systems and Translational Science, RTI International, Research Triangle Park, North Carolina, USA; and Department of Oral Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA

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March 2015

Reversibility of liver fibrosis.

Authors:
David A Brenner

Gastroenterol Hepatol (N Y) 2013 Nov;9(11):737-9

Vice Chancellor for Health Sciences Dean of the School of Medicine University of California, San Diego San Diego, California.

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November 2013

Transcriptional repression of the transforming growth factor β (TGF-β) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor κB (NF-κB) p50 enhances TGF-β signaling in hepatic stellate cells.

J Biol Chem 2014 Mar 21;289(10):7082-91. Epub 2014 Jan 21.

From the Division of Gastroenterology, Department of Medicine, University of California San Diego, School of Medicine, La Jolla, California 92093 and.

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March 2014

Interactions between the intestinal microbiome and liver diseases.

Gastroenterology 2014 May 15;146(6):1513-24. Epub 2014 Jan 15.

Department of Medicine, University of California San Diego, La Jolla, California.

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May 2014

Role of NADPH oxidases in liver fibrosis.

Antioxid Redox Signal 2014 Jun 24;20(17):2854-72. Epub 2014 Jan 24.

1 Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul, Korea.

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June 2014

M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway.

J Cell Biol 2013 Sep 9;202(6):951-66. Epub 2013 Sep 9.

Proteases and Tissue Remodeling Section and 2 Intracellular Membrane Trafficking Unit, Oral and Pharyngeal Cancer Branch, and 3 Matrix Metalloproteinase Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892.

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September 2013

Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts.

Curr Pathobiol Rep 2013 Sep;1(3):209-214

Dept. of Medicine, University of California, San Diego, CA, USA.

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September 2013

Fra, Fra away: the complex role of activator protein 1 in liver injury.

Authors:
David A Brenner

Hepatology 2014 Jan 20;59(1):19-20. Epub 2013 Nov 20.

University of California San Diego, La Jolla, CA.

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January 2014

Kenji Fujiwara, MD, PhD.

Gastroenterology 2013 Apr 26;144(4):661-3. Epub 2013 Feb 26.

Department of Gastroenterology, Jichi Medical University, Tochigi, Japan.

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April 2013

Origin of myofibroblasts in liver fibrosis.

Fibrogenesis Tissue Repair 2012 6;5(Suppl 1):S17. Epub 2012 Jun 6.

University of California, San Diego, School of Medicine, San Diego, CA, USA.

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May 2015

Next-generation academic medicine.

Authors:
David A Brenner

J Clin Invest 2012 Nov 1;122(11):4280-2. Epub 2012 Nov 1.

University of California, San Diego, 1318 Biomedical Sciences Building, 9500 Gilman Drive #0602, La Jolla, California 92093-0602, USA.

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November 2012

Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice.

Gastroenterology 2012 Nov 27;143(5):1330-1340.e1. Epub 2012 Jul 27.

Department of Medicine, University of California San Diego, La Jolla, California. Electronic address:

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November 2012

Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis.

Gut 2013 Mar 20;62(3):335-6. Epub 2012 Jun 20.

Department of Medicine, University of California San Diego, MC0702, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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March 2013

A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches.

Gastroenterology 2012 Aug 13;143(2):307-20. Epub 2012 Jun 13.

Department of Medicine, University of California, La Jolla, CA, USA.

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August 2012

Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist.

Proc Natl Acad Sci U S A 2012 May 25;109(21):E1369-76. Epub 2012 Apr 25.

Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.

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May 2012

What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis.

J Gastroenterol Hepatol 2012 Mar;27 Suppl 2:65-8

Department of Medicine, University of California, San Diego, La Jolla, California 92093-0602, USA.

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March 2012

NADPH oxidase mediated oxidative stress in hepatic fibrogenesis.

Korean J Hepatol 2011 Dec;17(4):251-7

Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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December 2011

Diagnosis and management of patients with α1-antitrypsin (A1AT) deficiency.

Clin Gastroenterol Hepatol 2012 Jun 23;10(6):575-80. Epub 2011 Dec 23.

Department of Medicine, University of Florida, Gainesville, Florida, USA.

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June 2012

The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis.

J Hepatol 2012 Apr 13;56(4):965-72. Epub 2011 Dec 13.

Dept. of Medicine, University of California, San Diego, CA, USA.

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April 2012