David A Bennett

David A Bennett

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David A Bennett

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Alzheimer's disease frequency peaks in the tenth decade and is lower afterwards.

Acta Neuropathol Commun 2019 Jul 3;7(1):104. Epub 2019 Jul 3.

Rush Alzheimer's Disease Center, Rush University Medical Center, 1750 W. Harrison, Suite 1000, Chicago, IL, 60612, USA.

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http://dx.doi.org/10.1186/s40478-019-0752-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609405PMC
July 2019

Associations of health and financial literacy with mortality in advanced age.

Aging Clin Exp Res 2019 Jul 4. Epub 2019 Jul 4.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1007/s40520-019-01259-7DOI Listing
July 2019

Association of Lifespan Cognitive Reserve Indicator With Dementia Risk in the Presence of Brain Pathologies.

JAMA Neurol 2019 Jul 14. Epub 2019 Jul 14.

Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.

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http://dx.doi.org/10.1001/jamaneurol.2019.2455DOI Listing
July 2019

Association of TDP-43 Pathology With Domain-specific Literacy in Older Persons.

Alzheimer Dis Assoc Disord 2019 Jul 10. Epub 2019 Jul 10.

Rush Alzheimer's Disease Center.

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http://dx.doi.org/10.1097/WAD.0000000000000334DOI Listing
July 2019

Religious Orders Study and Rush Memory and Aging Project.

J Alzheimers Dis 2018 ;64(s1):S161-S189

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.3233/JAD-179939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380522PMC
June 2019

Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline.

Neurobiol Aging 2019 06 20;78:142-154. Epub 2019 Feb 20.

Institute for Memory Impairments and Neurological Disorders, University of California-Irvine, Irvine, CA, USA; Department of Neurology, University of California-Irvine, Irvine, CA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.02.012DOI Listing
June 2019

Single-cell transcriptomic analysis of Alzheimer's disease.

Nature 2019 Jun 1;570(7761):332-337. Epub 2019 May 1.

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41586-019-1195-2DOI Listing
June 2019

Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer's Disease Patients.

Cell Stem Cell 2019 Jun 23;24(6):974-982.e3. Epub 2019 May 23.

Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608595PMC
June 2019

Rate of brain aging and are synergistic risk factors for Alzheimer's disease.

Life Sci Alliance 2019 Jun 27;2(3). Epub 2019 May 27.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA

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http://dx.doi.org/10.26508/lsa.201900303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537750PMC
June 2019

Motoric cognitive risk syndrome and predictors of transition to dementia: A multicenter study.

Alzheimers Dement 2019 Jun 1. Epub 2019 Jun 1.

Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.

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http://dx.doi.org/10.1016/j.jalz.2019.03.011DOI Listing
June 2019

Financial and health literacy discrepancies with cognition in older adults.

Neuropsychology 2019 Jun 17. Epub 2019 Jun 17.

Rush Alzheimer's Disease Center.

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http://dx.doi.org/10.1037/neu0000565DOI Listing
June 2019

TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits.

Am J Hum Genet 2019 Jun 10. Epub 2019 Jun 10.

Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.05.018DOI Listing
June 2019

Different combinations of mobility metrics derived from a wearable sensor are associated with distinct health outcomes in older adults.

J Gerontol A Biol Sci Med Sci 2019 Jun 27. Epub 2019 Jun 27.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1093/gerona/glz160DOI Listing
June 2019

Quantitative mobility metrics from a wearable sensor predict incident parkinsonism in older adults.

Parkinsonism Relat Disord 2019 Jun 22. Epub 2019 Jun 22.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.parkreldis.2019.06.012DOI Listing
June 2019

Associations of amygdala volume and shape with transactive response DNA-binding protein 43 (TDP-43) pathology in a community cohort of older adults.

Neurobiol Aging 2019 05 31;77:104-111. Epub 2019 Jan 31.

Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Diagnostic Radiology, Rush University Medical Center, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486844PMC
May 2019

Brain IGFBP-5 modifies the relation of depressive symptoms to decline in cognition in older persons.

J Affect Disord 2019 05 8;250:313-318. Epub 2019 Mar 8.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183240
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http://dx.doi.org/10.1016/j.jad.2019.03.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530787PMC
May 2019

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

Authors:
Gail Davies Max Lam Sarah E Harris Joey W Trampush Michelle Luciano W David Hill Saskia P Hagenaars Stuart J Ritchie Riccardo E Marioni Chloe Fawns-Ritchie David C M Liewald Judith A Okely Ari V Ahola-Olli Catriona L K Barnes Lars Bertram Joshua C Bis Katherine E Burdick Andrea Christoforou Pamela DeRosse Srdjan Djurovic Thomas Espeseth Stella Giakoumaki Sudheer Giddaluru Daniel E Gustavson Caroline Hayward Edith Hofer M Arfan Ikram Robert Karlsson Emma Knowles Jari Lahti Markus Leber Shuo Li Karen A Mather Ingrid Melle Derek Morris Christopher Oldmeadow Teemu Palviainen Antony Payton Raha Pazoki Katja Petrovic Chandra A Reynolds Muralidharan Sargurupremraj Markus Scholz Jennifer A Smith Albert V Smith Natalie Terzikhan Anbupalam Thalamuthu Stella Trompet Sven J van der Lee Erin B Ware B Gwen Windham Margaret J Wright Jingyun Yang Jin Yu David Ames Najaf Amin Philippe Amouyel Ole A Andreassen Nicola J Armstrong Amelia A Assareh John R Attia Deborah Attix Dimitrios Avramopoulos David A Bennett Anne C Böhmer Patricia A Boyle Henry Brodaty Harry Campbell Tyrone D Cannon Elizabeth T Cirulli Eliza Congdon Emily Drabant Conley Janie Corley Simon R Cox Anders M Dale Abbas Dehghan Danielle Dick Dwight Dickinson Johan G Eriksson Evangelos Evangelou Jessica D Faul Ian Ford Nelson A Freimer He Gao Ina Giegling Nathan A Gillespie Scott D Gordon Rebecca F Gottesman Michael E Griswold Vilmundur Gudnason Tamara B Harris Annette M Hartmann Alex Hatzimanolis Gerardo Heiss Elizabeth G Holliday Peter K Joshi Mika Kähönen Sharon L R Kardia Ida Karlsson Luca Kleineidam David S Knopman Nicole A Kochan Bettina Konte John B Kwok Stephanie Le Hellard Teresa Lee Terho Lehtimäki Shu-Chen Li Christina M Lill Tian Liu Marisa Koini Edythe London Will T Longstreth Oscar L Lopez Anu Loukola Tobias Luck Astri J Lundervold Anders Lundquist Leo-Pekka Lyytikäinen Nicholas G Martin Grant W Montgomery Alison D Murray Anna C Need Raymond Noordam Lars Nyberg William Ollier Goran Papenberg Alison Pattie Ozren Polasek Russell A Poldrack Bruce M Psaty Simone Reppermund Steffi G Riedel-Heller Richard J Rose Jerome I Rotter Panos Roussos Suvi P Rovio Yasaman Saba Fred W Sabb Perminder S Sachdev Claudia L Satizabal Matthias Schmid Rodney J Scott Matthew A Scult Jeannette Simino P Eline Slagboom Nikolaos Smyrnis Aïcha Soumaré Nikos C Stefanis David J Stott Richard E Straub Kjetil Sundet Adele M Taylor Kent D Taylor Ioanna Tzoulaki Christophe Tzourio André Uitterlinden Veronique Vitart Aristotle N Voineskos Jaakko Kaprio Michael Wagner Holger Wagner Leonie Weinhold K Hoyan Wen Elisabeth Widen Qiong Yang Wei Zhao Hieab H H Adams Dan E Arking Robert M Bilder Panos Bitsios Eric Boerwinkle Ornit Chiba-Falek Aiden Corvin Philip L De Jager Stéphanie Debette Gary Donohoe Paul Elliott Annette L Fitzpatrick Michael Gill David C Glahn Sara Hägg Narelle K Hansell Ahmad R Hariri M Kamran Ikram J Wouter Jukema Eero Vuoksimaa Matthew C Keller William S Kremen Lenore Launer Ulman Lindenberger Aarno Palotie Nancy L Pedersen Neil Pendleton David J Porteous Katri Räikkönen Olli T Raitakari Alfredo Ramirez Ivar Reinvang Igor Rudan Dan Rujescu Reinhold Schmidt Helena Schmidt Peter W Schofield Peter R Schofield John M Starr Vidar M Steen Julian N Trollor Steven T Turner Cornelia M Van Duijn Arno Villringer Daniel R Weinberger David R Weir James F Wilson Anil Malhotra Andrew M McIntosh Catharine R Gale Sudha Seshadri Thomas H Mosley Jan Bressler Todd Lencz Ian J Deary

Nat Commun 2019 May 1;10(1):2068. Epub 2019 May 1.

Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.

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http://dx.doi.org/10.1038/s41467-019-10160-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494826PMC
May 2019

Total daily physical activity and the risk of parkinsonism in community-dwelling older adults.

J Gerontol A Biol Sci Med Sci 2019 May 2. Epub 2019 May 2.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1093/gerona/glz111DOI Listing
May 2019

Association of Variants in PINX1 and TREM2 With Late-Onset Alzheimer Disease.

JAMA Neurol 2019 May 6. Epub 2019 May 6.

Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York.

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http://dx.doi.org/10.1001/jamaneurol.2019.1066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503572PMC
May 2019

Antiphospholipid Antibodies: Cognitive and Motor Decline, Neuroimaging and Neuropathology.

Neuroepidemiology 2019 May 8:1-8. Epub 2019 May 8.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.

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http://dx.doi.org/10.1159/000500157DOI Listing
May 2019

Causes and Patterns of Dementia: An Update in the Era of Redefining Alzheimer's Disease.

Annu Rev Public Health 2019 Apr 14;40:65-84. Epub 2019 Jan 14.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA; email:

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http://dx.doi.org/10.1146/annurev-publhealth-040218-043758DOI Listing
April 2019

DNA methylation variability in Alzheimer's disease.

Neurobiol Aging 2019 04 21;76:35-44. Epub 2018 Dec 21.

Department of Epidemiology, University of Florida, Gainesville, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436841PMC
April 2019

Progressive parkinsonism in older adults is related to the burden of mixed brain pathologies.

Neurology 2019 Apr 20;92(16):e1821-e1830. Epub 2019 Mar 20.

From the Rush Alzheimer's Disease Center (A.S.B., L.Y., R.S.W., S.E.L., S.N., L.L.B., J.A.S., D.A.B.), and Departments of Neurological Sciences (A.S.B., L.Y., R.S.W., S.E.L., J.A.S., D.A.B.), Behavioral Sciences (R.S.W., L.L.B.), and Pathology (Neuropathology) (S.N., J.A.S.), Rush University Medical Center, Chicago, IL; Departments of Neurology, Molecular and Human Genetics, Neuroscience, and Program in Developmental Biology (J.M.S.), Baylor College of Medicine, Houston, TX; and Jan and Dan Duncan Neurological Research Institute (J.M.S.), Texas Children's Hospital, Houston.

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http://dx.doi.org/10.1212/WNL.0000000000007315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6550497PMC
April 2019

Incident Mobility Disability, Mild Cognitive Impairment, and Mortality in Community-Dwelling Older Adults.

Neuroepidemiology 2019 Apr 15:1-8. Epub 2019 Apr 15.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.

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http://dx.doi.org/10.1159/000499334DOI Listing
April 2019

Scam Awareness Related to Incident Alzheimer Dementia and Mild Cognitive Impairment: A Prospective Cohort Study.

Ann Intern Med 2019 Apr 16. Epub 2019 Apr 16.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois (P.A.B., L.Y., J.A.S., R.S.W., D.A.B.).

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http://dx.doi.org/10.7326/M18-2711DOI Listing
April 2019

Associations of literacy with diabetes indicators in older adults.

J Epidemiol Community Health 2019 Mar 7;73(3):250-255. Epub 2018 Dec 7.

Rush Alzheimer's Disease Center, Chicago, Illinois, USA.

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http://dx.doi.org/10.1136/jech-2018-210977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417101PMC
March 2019

Education and cognitive reserve in old age.

Neurology 2019 Mar 6;92(10):e1041-e1050. Epub 2019 Feb 6.

From the Departments of Neurological Sciences (R.S.W., L.Y., J.A.S., D.A.B.), Behavioral Sciences (R.S.W., M.L., P.A.B.), and Pathology (J.A.S.), Rush University Medical Center, Rush Alzheimer's Disease Center, Chicago, IL.

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http://dx.doi.org/10.1212/WNL.0000000000007036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442015PMC
March 2019

Healthcare and Financial Decision Making and Incident Adverse Cognitive Outcomes among Older Adults.

J Am Geriatr Soc 2019 Mar 18. Epub 2019 Mar 18.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.

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http://dx.doi.org/10.1111/jgs.15880DOI Listing
March 2019

White matter correlates of scam susceptibility in community-dwelling older adults.

Brain Imaging Behav 2019 Mar 20. Epub 2019 Mar 20.

Rush Alzheimer's Disease Center, Rush University Medical Center, 1750 W Harrison Street, Suite 1000, Chicago, IL, 60612, USA.

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http://dx.doi.org/10.1007/s11682-019-00079-7DOI Listing
March 2019

APOE genotypes as a risk factor for age-dependent accumulation of cerebrovascular disease in older adults.

Alzheimers Dement 2019 Feb 12;15(2):258-266. Epub 2018 Oct 12.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA; Department of Pathology, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.jalz.2018.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368888PMC
February 2019

In vivo hippocampal subfield shape related to TDP-43, amyloid beta, and tau pathologies.

Neurobiol Aging 2019 02 25;74:171-181. Epub 2018 Oct 25.

Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580183037
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http://dx.doi.org/10.1016/j.neurobiolaging.2018.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331233PMC
February 2019

Cognitive decline after elective and nonelective hospitalizations in older adults.

Neurology 2019 Feb 11;92(7):e690-e699. Epub 2019 Jan 11.

From the Rush Alzheimer's Disease Center (B.D.J., R.S.W., A.W.C., P.A.B., R.C.S., M.L., D.A.B., J.A.S.), Departments of Internal Medicine (B.D.J.), Neurological Sciences (R.S.W., A.W.C., M.L., D.A.B., J.A.S.), Behavioral Sciences (R.S.W., P.A.B.), Family Medicine (R.C.S.), and Pathology (J.A.S.), Rush University Medical Center, Chicago, IL; Center for Quality of Aging (E.W.E.), Vanderbilt Medical School, Nashville; Division of Allergy, Pulmonary, and Critical Care Medicine (E.W.E.), Vanderbilt University, Nashville; and Veterans Affairs Tennessee Valley Geriatric Research, Education, and Clinical Center (GRECC) (E.W.E.), Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN.

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http://dx.doi.org/10.1212/WNL.0000000000006918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382369PMC
February 2019

Impaired olfaction is associated with cognitive decline and neurodegeneration in the brain.

Neurology 2019 Feb 16;92(7):e700-e709. Epub 2019 Jan 16.

From the Aging Research Center (C.S.D., A.M., D.R., R.W., J.S., W.X.), Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University; Department of Clinical Neuroscience (J.S.), Psychology Division, Karolinska Institutet, Stockholm, Sweden; Department of Biomedical Engineering (K.A.), Illinois Institute of Technology, Chicago; Rush Alzheimer's Disease Center (K.A., D.A.B.), and Department of Neurological Sciences (D.A.B.), Rush University Medical Center, Chicago, IL; and Department of Epidemiology and Biostatistics (W.X.), School of Public Health, Tianjin Medical University, China.

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http://dx.doi.org/10.1212/WNL.0000000000006919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382360PMC
February 2019

Physical activity, common brain pathologies, and cognition in community-dwelling older adults.

Neurology 2019 Feb 16;92(8):e811-e822. Epub 2019 Jan 16.

From the Rush Alzheimer's Disease Center (A.S.B., L.Y., R.S.W., R.J.D., C.G., S.E.L., J.A.S., D.A.B.), and Departments of Neurological Sciences (A.S.B., L.Y., R.S.W., C.G., S.E.L., J.A.S., D.A.B.), Radiology (R.J.D.), Psychology (R.S.W.), and Pathology (Neuropathology) (J.A.S.), Rush University Medical Center, Chicago, IL; and Department of Neurology (A.L.), University of Toronto, Canada.

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http://dx.doi.org/10.1212/WNL.0000000000006954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396972PMC
February 2019

Investigation of frailty as a moderator of the relationship between neuropathology and dementia in Alzheimer's disease: a cross-sectional analysis of data from the Rush Memory and Aging Project.

Lancet Neurol 2019 Feb;18(2):177-184

Geriatric Medicine Research, Centre for Health Care of the Elderly, Nova Scotia Health Authority, Halifax, NS, Canada; Department of Medicine, Dalhousie University, Halifax, NS, Canada. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(18)30371-5DOI Listing
February 2019

Postmortem neurodegenerative markers and trajectories of decline in cognitive systems.

Neurology 2019 Feb 23;92(8):e831-e840. Epub 2019 Jan 23.

From the Departments of Neurological Sciences (R.S.W., J.Y., L.Y., S.E.L., A.W.C., J.A.S., D.A.B.), Behavioral Sciences (R.S.W., P.A.B.), and Pathology (J.A.S.), Rush University Medical Center, Rush Alzheimer's Disease Center, Chicago, IL.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000006949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396970PMC
February 2019

Disentangling the genetics of lean mass.

Authors:
David Karasik M Carola Zillikens Yi-Hsiang Hsu Ali Aghdassi Kristina Akesson Najaf Amin Inês Barroso David A Bennett Lars Bertram Murielle Bochud Ingrid B Borecki Linda Broer Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos-Obando Jane A Cauley Peggy M Cawthon John C Chambers Zhao Chen Nam H Cho Hyung Jin Choi Wen-Chi Chou Steven R Cummings Lisette C P G M de Groot Phillip L De Jager Ilja Demuth Luda Diatchenko Michael J Econs Gudny Eiriksdottir Anke W Enneman Joel Eriksson Johan G Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Christian Gieger Harald Grallert Vilmundur Gudnason Launer J Lenore Caroline Hayward Albert Hofman Georg Homuth Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Toby Johnson Reiner Biffar Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Daniel L Koller Jaspal S Kooner William E Kraus Stephen Kritchevsky Zoltán Kutalik Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Markus M Lerch Joshua R Lewis Christina Lill Lars Lind Cecilia Lindgren Yongmei Liu Gregory Livshits Östen Ljunggren Ruth J F Loos Mattias Lorentzon Jian'an Luan Robert N Luben Ida Malkin Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Maria Nethander Anne B Newman Jeffery R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Munro Peacock Markus Perola Annette Peters Richard L Prince Bruce M Psaty Katri Räikkönen Stuart H Ralston Samuli Ripatti Fernando Rivadeneira John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Sabine Schipf Chan Soo Shin Albert V Smith Shad B Smith Nicole Soranzo Timothy D Spector Alena Stancáková Kari Stefansson Elisabeth Steinhagen-Thiessen Lisette Stolk Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Patricia Thompson Cynthia A Thomson Gudmar Thorleifsson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah André G Uitterlinden Cornelia M van Duijn Natasja M van Schoor Liesbeth Vandenput Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Nicholas J Wareham Dawn Waterworth Michael N Weedon H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Laura M Yerges-Armstrong Lei Yu Weihua Zhang Jing Hua Zhao Yanhua Zhou Carrie M Nielson Tamara B Harris Serkalem Demissie Douglas P Kiel Claes Ohlsson

Am J Clin Nutr 2019 Feb;109(2):276-287

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1093/ajcn/nqy272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500901PMC
February 2019

Risk Aversion and Alzheimer Disease in Old Age.

Am J Geriatr Psychiatry 2019 Feb 21. Epub 2019 Feb 21.

Behavioral Sciences (RSW, PAB).

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http://dx.doi.org/10.1016/j.jagp.2019.02.011DOI Listing
February 2019

The transition between turning and sitting in patients with Parkinson's disease: A wearable device detects an unexpected sequence of events.

Gait Posture 2019 01 21;67:224-229. Epub 2018 Oct 21.

Center for the study of Movement, Cognition, and Mobility, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Physical Therapy, Sackler Faculty of Medicine, Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.gaitpost.2018.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287952PMC
January 2019

Attributable risk of Alzheimer's dementia attributed to age-related neuropathologies.

Ann Neurol 2019 Jan 19;85(1):114-124. Epub 2018 Dec 19.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.

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http://dx.doi.org/10.1002/ana.25380DOI Listing
January 2019

Spinal motor neurons and motor function in older adults.

J Neurol 2019 Jan 16;266(1):174-182. Epub 2018 Nov 16.

Rush Alzheimer's Disease Center, Rush University Medical Center, Jelke Building, Suite #1000; 1750 West Harrison Street, Chicago, IL, 60612, USA.

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http://link.springer.com/10.1007/s00415-018-9118-y
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http://dx.doi.org/10.1007/s00415-018-9118-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344292PMC
January 2019

Neuropathological correlates and genetic architecture of microglial activation in elderly human brain.

Nat Commun 2019 01 24;10(1):409. Epub 2019 Jan 24.

Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, 630 West 168th Street, New York, NY, 10032, USA.

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http://dx.doi.org/10.1038/s41467-018-08279-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345810PMC
January 2019

Sex differences in Alzheimer's disease and common neuropathologies of aging.

Acta Neuropathol 2018 12 17;136(6):887-900. Epub 2018 Oct 17.

Rush Alzheimer's Disease Center, Rush University Medical Center, 1750 W Harrison, Suite 1000, Chicago, IL, USA.

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http://dx.doi.org/10.1007/s00401-018-1920-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279593PMC
December 2018

White matter correlates of temporal discounting in older adults.

Brain Struct Funct 2018 Nov 10;223(8):3653-3663. Epub 2018 Jul 10.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, 60612, USA.

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http://dx.doi.org/10.1007/s00429-018-1712-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379138PMC
November 2018

Sexual dimorphism in predisposition to Alzheimer's disease.

Neurobiol Aging 2018 10 17;70:308-324. Epub 2018 Apr 17.

Departments of Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368179PMC
October 2018

Watershed microinfarct pathology and cognition in older persons.

Neurobiol Aging 2018 10 30;70:10-17. Epub 2018 May 30.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378107PMC
October 2018

An MRI biomarker of mixed pathology.

Authors:
David A Bennett

Neurology 2018 Oct 14;91(15):682-683. Epub 2018 Sep 14.

From Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.

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http://dx.doi.org/10.1212/WNL.0000000000006305DOI Listing
October 2018

Deconstructing and targeting the genomic architecture of human neurodegeneration.

Nat Neurosci 2018 10 26;21(10):1310-1317. Epub 2018 Sep 26.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1038/s41593-018-0240-zDOI Listing
October 2018

The Molecular and Neuropathological Consequences of Genetic Risk for Alzheimer's Dementia.

Front Neurosci 2018 8;12:699. Epub 2018 Oct 8.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States.

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http://dx.doi.org/10.3389/fnins.2018.00699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187226PMC
October 2018

Fractal regulation and incident Alzheimer's disease in elderly individuals.

Alzheimers Dement 2018 09 4;14(9):1114-1125. Epub 2018 May 4.

Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201319PMC
September 2018

Postmortem brain MRI is related to cognitive decline, independent of cerebral vessel disease in older adults.

Neurobiol Aging 2018 09 23;69:177-184. Epub 2018 May 23.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424332PMC
September 2018

Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study.

Lancet Neurol 2018 09 6;17(9):773-781. Epub 2018 Aug 6.

The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(18)30251-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154505PMC
September 2018

Dietary Patterns and Self-reported Incident Disability in Elderly.

J Gerontol A Biol Sci Med Sci 2018 Sep 21. Epub 2018 Sep 21.

Rush University Medical Center, Department of Internal Medicine.

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http://dx.doi.org/10.1093/gerona/gly211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625581PMC
September 2018

Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.

Nat Commun 2018 09 26;9(1):3945. Epub 2018 Sep 26.

The University of Texas Health Science Center at Houston Institute of Molecular Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/s41467-018-06234-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158214PMC
September 2018

Late-life blood pressure association with cerebrovascular and Alzheimer disease pathology.

Neurology 2018 Aug 11;91(6):e517-e525. Epub 2018 Jul 11.

From the Rush Alzheimer's Disease Center (Z.A., A.W.C., M.L., R.C.S., L.L.B., D.A.B., J.A.S.), and Departments of Neurological Sciences (Z.A., A.W.C., M.L., L.L.B., D.A.B., J.A.S.), Family Medicine (R.C.S.), Behavioral Sciences (L.L.B.), and Pathology (J.A.S.), Rush University Medical Center, Chicago, IL.

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http://dx.doi.org/10.1212/WNL.0000000000005951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105052PMC
August 2018

Differences in the Associations between Memory Complaints and Depressive Symptoms among Black and White Older Adults.

J Gerontol B Psychol Sci Soc Sci 2018 Aug 9. Epub 2018 Aug 9.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.

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http://dx.doi.org/10.1093/geronb/gby091DOI Listing
August 2018

Bivariate Causal Discovery and Its Applications to Gene Expression and Imaging Data Analysis.

Front Genet 2018 31;9:347. Epub 2018 Aug 31.

Department of Biostatistics and Data Science, The University of Texas School of Public Health, Houston, TX, United States.

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https://www.frontiersin.org/article/10.3389/fgene.2018.00347
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http://dx.doi.org/10.3389/fgene.2018.00347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127271PMC
August 2018

Neopterin is associated with hippocampal subfield volumes and cognition in HIV.

Neurol Neuroimmunol Neuroinflamm 2018 Jul 11;5(4):e467. Epub 2018 Jun 11.

Rush Alzheimer's Disease Center (D.A.F., K.A., S.L., M.L., D.A.B., L.L.B.), Rush University Medical Center; the Department of Neurological Sciences (D.A.F., S.L., M.L., D.A.B., L.L.B.), the Department of Behavioral Sciences (D.A.F., M.L., L.L.B.), the Department of Preventive Medicine (S.L.), the Department of Diagnostic Radiology and Nuclear Medicine (K.A.), Rush University Medical Center; Ruth M. Rothstein CORE Center (O.M.A.); the Biomedical Engineering (K.A.), Illinois Institute of Technology, Chicago; the Blood Systems Research Institute (S.M.K.), San Francisco, CA; and the University of California at San Francisco (S.M.K.), Laboratory Medicine.

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http://dx.doi.org/10.1212/NXI.0000000000000467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999345PMC
July 2018

Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation.

Proc Natl Acad Sci U S A 2018 07 2;115(29):7611-7616. Epub 2018 Jul 2.

Key Laboratory of Computational Biology, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, Collaborative Innovation Center for Genetics and Developmental Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031 Shanghai, China;

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http://dx.doi.org/10.1073/pnas.1800656115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055154PMC
July 2018

Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain.

Mol Neurodegener 2018 07 24;13(1):38. Epub 2018 Jul 24.

Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, 630 West 168th Street, PH 19 - 302, New York, NY, 10032, USA.

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http://dx.doi.org/10.1186/s13024-018-0272-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057096PMC
July 2018

ε2ε4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults.

Neurology 2018 Jun 11;90(24):e2127-e2134. Epub 2018 May 11.

From Rush Alzheimer's Disease Center (S.O., A.S.B., L.Y., J.F., C.G., J.A.S., D.A.B.) and Departments of Neurological Sciences (A.S.B., L.Y., J.A.S., D.A.B.) and Pathology (J.F., J.A.S.), Rush University Medical Center, Chicago, IL; Shariati Hospital (S.O.), Tehran University of Medical Sciences, Iran; Department of Geriatrics (J.F.), University of Sao Paulo Medical School, Brazil; University Hospital (V.H.), University of Western Ontario, London, Canada; Broad Institute (P.L.D.J.), Cambridge, MA; Center for Translational & Systems Neuroimmunology (P.L.D.J.), Department of Neurology, Columbia University Medical Center, New York, NY.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000005677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996834PMC
June 2018

Tau Activates Transposable Elements in Alzheimer's Disease.

Cell Rep 2018 Jun;23(10):2874-2880

Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurologic Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181645PMC
June 2018

Variability and Coupling of Olfactory Identification and Episodic Memory in Older Adults.

J Gerontol B Psychol Sci Soc Sci 2018 May 14. Epub 2018 May 14.

University of Victoria, Victoria, BC, Canada.

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http://dx.doi.org/10.1093/geronb/gby058DOI Listing
May 2018

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

Authors:
Gail Davies Max Lam Sarah E Harris Joey W Trampush Michelle Luciano W David Hill Saskia P Hagenaars Stuart J Ritchie Riccardo E Marioni Chloe Fawns-Ritchie David C M Liewald Judith A Okely Ari V Ahola-Olli Catriona L K Barnes Lars Bertram Joshua C Bis Katherine E Burdick Andrea Christoforou Pamela DeRosse Srdjan Djurovic Thomas Espeseth Stella Giakoumaki Sudheer Giddaluru Daniel E Gustavson Caroline Hayward Edith Hofer M Arfan Ikram Robert Karlsson Emma Knowles Jari Lahti Markus Leber Shuo Li Karen A Mather Ingrid Melle Derek Morris Christopher Oldmeadow Teemu Palviainen Antony Payton Raha Pazoki Katja Petrovic Chandra A Reynolds Muralidharan Sargurupremraj Markus Scholz Jennifer A Smith Albert V Smith Natalie Terzikhan Anbupalam Thalamuthu Stella Trompet Sven J van der Lee Erin B Ware B Gwen Windham Margaret J Wright Jingyun Yang Jin Yu David Ames Najaf Amin Philippe Amouyel Ole A Andreassen Nicola J Armstrong Amelia A Assareh John R Attia Deborah Attix Dimitrios Avramopoulos David A Bennett Anne C Böhmer Patricia A Boyle Henry Brodaty Harry Campbell Tyrone D Cannon Elizabeth T Cirulli Eliza Congdon Emily Drabant Conley Janie Corley Simon R Cox Anders M Dale Abbas Dehghan Danielle Dick Dwight Dickinson Johan G Eriksson Evangelos Evangelou Jessica D Faul Ian Ford Nelson A Freimer He Gao Ina Giegling Nathan A Gillespie Scott D Gordon Rebecca F Gottesman Michael E Griswold Vilmundur Gudnason Tamara B Harris Annette M Hartmann Alex Hatzimanolis Gerardo Heiss Elizabeth G Holliday Peter K Joshi Mika Kähönen Sharon L R Kardia Ida Karlsson Luca Kleineidam David S Knopman Nicole A Kochan Bettina Konte John B Kwok Stephanie Le Hellard Teresa Lee Terho Lehtimäki Shu-Chen Li Christina M Lill Tian Liu Marisa Koini Edythe London Will T Longstreth Oscar L Lopez Anu Loukola Tobias Luck Astri J Lundervold Anders Lundquist Leo-Pekka Lyytikäinen Nicholas G Martin Grant W Montgomery Alison D Murray Anna C Need Raymond Noordam Lars Nyberg William Ollier Goran Papenberg Alison Pattie Ozren Polasek Russell A Poldrack Bruce M Psaty Simone Reppermund Steffi G Riedel-Heller Richard J Rose Jerome I Rotter Panos Roussos Suvi P Rovio Yasaman Saba Fred W Sabb Perminder S Sachdev Claudia L Satizabal Matthias Schmid Rodney J Scott Matthew A Scult Jeannette Simino P Eline Slagboom Nikolaos Smyrnis Aïcha Soumaré Nikos C Stefanis David J Stott Richard E Straub Kjetil Sundet Adele M Taylor Kent D Taylor Ioanna Tzoulaki Christophe Tzourio André Uitterlinden Veronique Vitart Aristotle N Voineskos Jaakko Kaprio Michael Wagner Holger Wagner Leonie Weinhold K Hoyan Wen Elisabeth Widen Qiong Yang Wei Zhao Hieab H H Adams Dan E Arking Robert M Bilder Panos Bitsios Eric Boerwinkle Ornit Chiba-Falek Aiden Corvin Philip L De Jager Stéphanie Debette Gary Donohoe Paul Elliott Annette L Fitzpatrick Michael Gill David C Glahn Sara Hägg Narelle K Hansell Ahmad R Hariri M Kamran Ikram J Wouter Jukema Eero Vuoksimaa Matthew C Keller William S Kremen Lenore Launer Ulman Lindenberger Aarno Palotie Nancy L Pedersen Neil Pendleton David J Porteous Katri Räikkönen Olli T Raitakari Alfredo Ramirez Ivar Reinvang Igor Rudan Dan Rujescu Reinhold Schmidt Helena Schmidt Peter W Schofield Peter R Schofield John M Starr Vidar M Steen Julian N Trollor Steven T Turner Cornelia M Van Duijn Arno Villringer Daniel R Weinberger David R Weir James F Wilson Anil Malhotra Andrew M McIntosh Catharine R Gale Sudha Seshadri Thomas H Mosley Jan Bressler Todd Lencz Ian J Deary

Nat Commun 2018 05 29;9(1):2098. Epub 2018 May 29.

Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, School of Philosophy, Psychology and Language Sciences, The University of Edinburgh, Edinburgh, EH8 9JZ, UK.

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http://dx.doi.org/10.1038/s41467-018-04362-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974083PMC
May 2018

Class-Specific Incidence of All-Cause Dementia and Alzheimer's Disease: A Latent Class Approach.

J Alzheimers Dis 2018 ;66(1):347-357

Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.

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http://dx.doi.org/10.3233/JAD-180604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329008PMC
January 2018