Publications by authors named "David A Bennett"

100Publications

Associations Between Personality Traits and Cognitive Resilience in Older Adults.

J Gerontol B Psychol Sci Soc Sci 2020 Sep 24. Epub 2020 Sep 24.

Department of Medical Social Sciences, Northwestern University, Chicago, Illinois.

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http://dx.doi.org/10.1093/geronb/gbaa135DOI Listing
September 2020

Bayesian Genome-wide TWAS Method to Leverage both cis- and trans-eQTL Information through Summary Statistics.

Am J Hum Genet 2020 Sep 10. Epub 2020 Sep 10.

Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2020.08.022DOI Listing
September 2020

Acculturation in context: The relationship between acculturation and socioenvironmental factors with level of and change in cognition in older Latinos.

J Gerontol B Psychol Sci Soc Sci 2020 Sep 12. Epub 2020 Sep 12.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1093/geronb/gbaa156DOI Listing
September 2020

Representation of Older Latinxs in Cohort Studies at the Rush Alzheimer's Disease Center.

Neuroepidemiology 2020 Sep 9:1-15. Epub 2020 Sep 9.

Rush Alzheimer's Disease Center, Chicago, Illinois, USA.

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http://dx.doi.org/10.1159/000509626DOI Listing
September 2020

Association of Cardiovascular Risk Burden With Risk and Progression of Disability: Mediating Role of Cardiovascular Disease and Cognitive Decline.

J Am Heart Assoc 2020 Sep 1;9(18):e017346. Epub 2020 Sep 1.

Department of Epidemiology and Biostatistics School of Public Health Tianjin Medical University Tianjin China.

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http://dx.doi.org/10.1161/JAHA.120.017346DOI Listing
September 2020

Extending AD biomarker studies into the Hispanic community.

Neurology 2020 Aug 26. Epub 2020 Aug 26.

Department of Neurology, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1212/WNL.0000000000010714DOI Listing
August 2020

Deconvolving the contributions of cell-type heterogeneity on cortical gene expression.

PLoS Comput Biol 2020 08 17;16(8):e1008120. Epub 2020 Aug 17.

Departments of Statistics and Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1371/journal.pcbi.1008120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7451979PMC
August 2020

Brain pathologies are associated with both the rate and variability of declining motor function in older adults.

Acta Neuropathol 2020 Oct 14;140(4):587-589. Epub 2020 Aug 14.

Rush Alzheimer's Disease Center, Rush University Medical Center, 1750 West Harrison Street, Jelke Building, Suite 100, Chicago, IL, 60612, USA.

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http://dx.doi.org/10.1007/s00401-020-02212-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501086PMC
October 2020

Limbic-predominant age-related TDP-43 encephalopathy in black and white decedents.

Neurology 2020 Aug 5. Epub 2020 Aug 5.

Rush Alzheimer Disease Center and Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1212/WNL.0000000000010602DOI Listing
August 2020

Limbic-Predominant Age-Related TDP-43 Encephalopathy (LATE), ADNC Pathology, and Cognitive Decline in Aging.

Neurology 2020 Aug 4. Epub 2020 Aug 4.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1212/WNL.0000000000010454DOI Listing
August 2020

BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology.

Mol Neurodegener 2020 07 29;15(1):44. Epub 2020 Jul 29.

Center for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, 630 West 168th st, PH19-311, New York, NY, 10032, USA.

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http://dx.doi.org/10.1186/s13024-020-00387-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389646PMC
July 2020

Person-specific contributions of brain pathologies to progressive parkinsonism in older adults.

J Gerontol A Biol Sci Med Sci 2020 Jul 28. Epub 2020 Jul 28.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1093/gerona/glaa176DOI Listing
July 2020

Self-reported experiences of discrimination in older black adults are associated with insula functional connectivity.

Brain Imaging Behav 2020 Jul 27. Epub 2020 Jul 27.

Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, 60612, USA.

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http://dx.doi.org/10.1007/s11682-020-00365-9DOI Listing
July 2020

What HIV in the Brain Can Teach Us About SARS-CoV-2 Neurological Complications?

AIDS Res Hum Retroviruses 2020 Aug 10. Epub 2020 Aug 10.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.

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http://dx.doi.org/10.1089/AID.2020.0161DOI Listing
August 2020

The Association of Late Life Cognitive Activity with Healthcare and Financial Decision-Making in Community-Dwelling, Nondemented Older Adults.

Am J Geriatr Psychiatry 2020 Jun 16. Epub 2020 Jun 16.

Rush Alzheimer's Disease Center, Rush University Medical Center (CMG, LY, RSW, DAB, PAB), Chicago, IL; Department of Psychiatry and Behavioral Sciences, Rush Medical College (CMG, RSW, PAB), Chicago, IL.

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http://dx.doi.org/10.1016/j.jagp.2020.06.010DOI Listing
June 2020

Synonymous variants associated with Alzheimer disease in multiplex families.

Neurol Genet 2020 Aug 8;6(4):e450. Epub 2020 Jun 8.

The Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.E.A., B.V., R.L., P.L.J., R.M., I.S.-M., C.R.); The Gertrude H. Sergievsky Center (M.T., D.R.-D., R.L., R.M., C.R.); Department of Neurology (P.L.J., R.M., C.R.); Department of Epidemiology (R.M., C.R.); Department of Psychiatry (R.M.), Columbia University, New York; Department of Pathology and Cell Biology (M.E.A., I.S.-M.), Columbia University, New York; Rush Alzheimer's Disease Center (D.A.B.); Department of Neurological Sciences (D.A.B.); Department of Pathology (D.A.B.), Rush University Medical Center, Chicago, IL; Center for Innovation in Brain Science , Departments of Pharmacology and Neurology , University of Arizona College of Medicine (M.T.), Tucson; Department of Medicine (R.L.), College of Physicians and Surgeons, Columbia University, New York, NY; School of Medicine (M.M.), Mother and Teacher Pontifical Catholic University, Santiago, Dominican Republic; and The Krembil Centre for Neuroinformatics (D.F.), Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1212/NXG.0000000000000450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323483PMC
August 2020

Association of Early-Life Cognitive Enrichment With Alzheimer Disease Pathological Changes and Cognitive Decline.

JAMA Neurol 2020 Jun 29. Epub 2020 Jun 29.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.

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http://dx.doi.org/10.1001/jamaneurol.2020.1941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325069PMC
June 2020

Fragmentation of Rest/Activity Patterns in Community-Based Elderly Individuals Predicts Incident Heart Failure.

Nat Sci Sleep 2020 27;12:299-307. Epub 2020 May 27.

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.2147/NSS.S253757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266944PMC
May 2020

Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function.

Ann Neurol 2020 Jun 18. Epub 2020 Jun 18.

Department of Neurology and Massachusetts Alzheimer's Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts.

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http://dx.doi.org/10.1002/ana.25826DOI Listing
June 2020

Healthy lifestyle and the risk of Alzheimer dementia: Findings from 2 longitudinal studies.

Neurology 2020 07 17;95(4):e374-e383. Epub 2020 Jun 17.

From the Rush Institute for Healthy Aging (K.D., D.A.E., M.C.M.) and Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; and Department of Public Health Sciences (K.B.R.), University of California at Davis.

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http://dx.doi.org/10.1212/WNL.0000000000009816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455318PMC
July 2020

Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology.

Neuron 2020 Aug 10;107(3):496-508.e6. Epub 2020 Jun 10.

The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2020.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416464PMC
August 2020

The human brain NGF metabolic pathway is impaired in the pre-clinical and clinical continuum of Alzheimers disease.

Mol Psychiatry 2020 Jun 2. Epub 2020 Jun 2.

Department of Neurology and Neurosurgery, McGill University, Montreal, Québec, Canada.

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http://dx.doi.org/10.1038/s41380-020-0797-2DOI Listing
June 2020

Fragile X Gray Zone Alleles Are Associated With Signs of Parkinsonism and Earlier Death.

Mov Disord 2020 Aug 28;35(8):1448-1456. Epub 2020 May 28.

Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.

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http://dx.doi.org/10.1002/mds.28086DOI Listing
August 2020

Genome-wide interaction analysis of pathological hallmarks in Alzheimer's disease.

Neurobiol Aging 2020 Sep 29;93:61-68. Epub 2020 Apr 29.

Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, Hubei, China. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2020.04.025DOI Listing
September 2020

Dietary antioxidants associated with slower progression of parkinsonian signs in older adults.

Nutr Neurosci 2020 May 22:1-8. Epub 2020 May 22.

Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1080/1028415X.2020.1769411DOI Listing
May 2020

Associations Between Cardiovascular Risk, Structural Brain Changes, and Cognitive Decline.

J Am Coll Cardiol 2020 May;75(20):2525-2534

Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China; Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2020.03.053DOI Listing
May 2020

Tissue Specific Fate of Nanomaterials by Advanced Analytical Imaging Techniques - A Review.

Chem Res Toxicol 2020 May 12;33(5):1145-1162. Epub 2020 May 12.

Department of Neurological Sciences, Rush University Medical Center, 1725 W. Harrison Street, Suite 1118, Chicago, Illinois 60612, United States.

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http://dx.doi.org/10.1021/acs.chemrestox.0c00072DOI Listing
May 2020

Total daily physical activity, brain pathologies, and parkinsonism in older adults.

PLoS One 2020 29;15(4):e0232404. Epub 2020 Apr 29.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232404PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190120PMC
July 2020

Association of lifespan cognitive reserve indicator with the risk of mild cognitive impairment and its progression to dementia.

Alzheimers Dement 2020 06 27;16(6):873-882. Epub 2020 Apr 27.

Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.

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http://dx.doi.org/10.1002/alz.12085DOI Listing
June 2020

Physicians and Alzheimer Dementia: Past, Present, and Future.

Ann Intern Med 2020 05 28;172(10):695-696. Epub 2020 Apr 28.

Rush Alzheimer's Disease Center, Rush University, Chicago, Illinois (R.C.S., D.A.B.).

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http://dx.doi.org/10.7326/M20-1500DOI Listing
May 2020

Bayesian integrative analysis of epigenomic and transcriptomic data identifies Alzheimer's disease candidate genes and networks.

PLoS Comput Biol 2020 04 7;16(4):e1007771. Epub 2020 Apr 7.

Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1007771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138305PMC
April 2020

Confidence in Financial and Health Literacy and Cognitive Health in Older Persons

J Alzheimers Dis 2020 ;75(4):1229-1240

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.3233/JAD-200001DOI Listing
January 2020

Normative Cognitive Decline in Old Age.

Ann Neurol 2020 Jun 14;87(6):816-829. Epub 2020 Mar 14.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.

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http://dx.doi.org/10.1002/ana.25711DOI Listing
June 2020

Shared Causal Paths underlying Alzheimer's dementia and Type 2 Diabetes.

Sci Rep 2020 03 5;10(1):4107. Epub 2020 Mar 5.

Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.

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http://dx.doi.org/10.1038/s41598-020-60682-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058072PMC
March 2020

Literacy Mediates Racial Differences in Financial and Healthcare Decision Making in Older Adults.

J Am Geriatr Soc 2020 Jun 24;68(6):1279-1285. Epub 2020 Feb 24.

Department of Behavioral Sciences and Psychiatry, Rush University Medical Center, Chicago, Illinois.

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http://dx.doi.org/10.1111/jgs.16381DOI Listing
June 2020

Dietary flavonols and risk of Alzheimer dementia.

Neurology 2020 04 29;94(16):e1749-e1756. Epub 2020 Jan 29.

From Rush Institute for Healthy Aging (T.M.H., P.A., Y.W., M.C.M.), Rush Alzheimer's Disease Center (S.E.L., D.A.B.), and Neurological Sciences (S.E.L., D.A.B.), Rush University Medical Center, Chicago, IL; and Jean Mayer USDA Human Nutrition Research Center on Aging (S.L.B.), Tufts University, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000008981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282875PMC
April 2020

Human Herpesvirus 6 Detection in Alzheimer's Disease Cases and Controls across Multiple Cohorts.

Neuron 2020 03 23;105(6):1027-1035.e2. Epub 2020 Jan 23.

Viral Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20814, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.12.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182308PMC
March 2020

miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients.

Front Neurosci 2019 26;13:1208. Epub 2019 Nov 26.

Laboratory for Neurodegenerative Disease Research, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.3389/fnins.2019.01208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902042PMC
November 2019

Association of Strawberries and Anthocyanidin Intake with Alzheimer's Dementia Risk.

Nutrients 2019 Dec 14;11(12). Epub 2019 Dec 14.

Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.

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http://dx.doi.org/10.3390/nu11123060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950087PMC
December 2019

Sleep fragmentation, microglial aging, and cognitive impairment in adults with and without Alzheimer's dementia.

Sci Adv 2019 12 11;5(12):eaax7331. Epub 2019 Dec 11.

Division of Neurology, Department of Medicine, Hurvitz Brain Sciences Program, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Toronto, Canada.

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http://dx.doi.org/10.1126/sciadv.aax7331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905859PMC
December 2019

Proportion of cognitive loss attributable to terminal decline.

Neurology 2020 01 2;94(1):e42-e50. Epub 2019 Dec 2.

From the Departments of Neurological Sciences (R.S.W., L.Y., S.E.L., D.A.B.) and Behavioral Sciences (R.S.W., P.A.B.), Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.

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http://dx.doi.org/10.1212/WNL.0000000000008671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011688PMC
January 2020

APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease.

Neurobiol Aging 2020 03 5;87:18-25. Epub 2019 Nov 5.

Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064375PMC
March 2020

Brain and blood metabolome for Alzheimer's dementia: findings from a targeted metabolomics analysis.

Neurobiol Aging 2020 02 5;86:123-133. Epub 2019 Nov 5.

Department of Epidemiology, University of Florida, Gainesville, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995427PMC
February 2020

Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons.

Neurology 2020 01 22;94(2):e142-e152. Epub 2019 Nov 22.

From the Rush Alzheimer's Disease Center (L.Y., P.A.B., R.J.D., D.A.B., K.A., J.A.S.), Department of Neurological Sciences (L.Y., D.A.B., J.A.S.), Department of Behavioral Sciences (P.A.B.), Department of Diagnostic Radiology and Nuclear Medicine (R.J.D., K.A.), and Department of Pathology (J.A.S.), Rush University Medical Center; and Department of Biomedical Engineering (K.A.), Illinois Institute of Technology, Chicago.

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http://dx.doi.org/10.1212/WNL.0000000000008679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988988PMC
January 2020

The synaptic pathology of cognitive life
.

Dialogues Clin Neurosci 2019 09;21(3):271-279

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, US.

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http://dx.doi.org/10.31887/DCNS.2019.21.3/whonerDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829169PMC
September 2019

What Is Dementia?

JAMA 2019 11;322(17):1728

Rush Alzheimer's Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois.

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http://dx.doi.org/10.1001/jama.2019.11653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455009PMC
November 2019

Associations of autozygosity with a broad range of human phenotypes.

Authors:
David W Clark Yukinori Okada Kristjan H S Moore Dan Mason Nicola Pirastu Ilaria Gandin Hannele Mattsson Catriona L K Barnes Kuang Lin Jing Hua Zhao Patrick Deelen Rebecca Rohde Claudia Schurmann Xiuqing Guo Franco Giulianini Weihua Zhang Carolina Medina-Gomez Robert Karlsson Yanchun Bao Traci M Bartz Clemens Baumbach Ginevra Biino Matthew J Bixley Marco Brumat Jin-Fang Chai Tanguy Corre Diana L Cousminer Annelot M Dekker David A Eccles Kristel R van Eijk Christian Fuchsberger He Gao Marine Germain Scott D Gordon Hugoline G de Haan Sarah E Harris Edith Hofer Alicia Huerta-Chagoya Catherine Igartua Iris E Jansen Yucheng Jia Tim Kacprowski Torgny Karlsson Marcus E Kleber Shengchao Alfred Li Ruifang Li-Gao Anubha Mahajan Koichi Matsuda Karina Meidtner Weihua Meng May E Montasser Peter J van der Most Matthias Munz Teresa Nutile Teemu Palviainen Gauri Prasad Rashmi B Prasad Tallapragada Divya Sri Priyanka Federica Rizzi Erika Salvi Bishwa R Sapkota Daniel Shriner Line Skotte Melissa C Smart Albert Vernon Smith Ashley van der Spek Cassandra N Spracklen Rona J Strawbridge Salman M Tajuddin Stella Trompet Constance Turman Niek Verweij Clara Viberti Lihua Wang Helen R Warren Robyn E Wootton Lisa R Yanek Jie Yao Noha A Yousri Wei Zhao Adebowale A Adeyemo Saima Afaq Carlos Alberto Aguilar-Salinas Masato Akiyama Matthew L Albert Matthew A Allison Maris Alver Tin Aung Fereidoun Azizi Amy R Bentley Heiner Boeing Eric Boerwinkle Judith B Borja Gert J de Borst Erwin P Bottinger Linda Broer Harry Campbell Stephen Chanock Miao-Li Chee Guanjie Chen Yii-Der I Chen Zhengming Chen Yen-Feng Chiu Massimiliano Cocca Francis S Collins Maria Pina Concas Janie Corley Giovanni Cugliari Rob M van Dam Anna Damulina Maryam S Daneshpour Felix R Day Graciela E Delgado Klodian Dhana Alexander S F Doney Marcus Dörr Ayo P Doumatey Nduna Dzimiri S Sunna Ebenesersdóttir Joshua Elliott Paul Elliott Ralf Ewert Janine F Felix Krista Fischer Barry I Freedman Giorgia Girotto Anuj Goel Martin Gögele Mark O Goodarzi Mariaelisa Graff Einat Granot-Hershkovitz Francine Grodstein Simonetta Guarrera Daniel F Gudbjartsson Kamran Guity Bjarni Gunnarsson Yu Guo Saskia P Hagenaars Christopher A Haiman Avner Halevy Tamara B Harris Mehdi Hedayati David A van Heel Makoto Hirata Imo Höfer Chao Agnes Hsiung Jinyan Huang Yi-Jen Hung M Arfan Ikram Anuradha Jagadeesan Pekka Jousilahti Yoichiro Kamatani Masahiro Kanai Nicola D Kerrison Thorsten Kessler Kay-Tee Khaw Chiea Chuen Khor Dominique P V de Kleijn Woon-Puay Koh Ivana Kolcic Peter Kraft Bernhard K Krämer Zoltán Kutalik Johanna Kuusisto Claudia Langenberg Lenore J Launer Deborah A Lawlor I-Te Lee Wen-Jane Lee Markus M Lerch Liming Li Jianjun Liu Marie Loh Stephanie J London Stephanie Loomis Yingchang Lu Jian'an Luan Reedik Mägi Ani W Manichaikul Paolo Manunta Gísli Másson Nana Matoba Xue W Mei Christa Meisinger Thomas Meitinger Massimo Mezzavilla Lili Milani Iona Y Millwood Yukihide Momozawa Amy Moore Pierre-Emmanuel Morange Hortensia Moreno-Macías Trevor A Mori Alanna C Morrison Taulant Muka Yoshinori Murakami Alison D Murray Renée de Mutsert Josyf C Mychaleckyj Mike A Nalls Matthias Nauck Matt J Neville Ilja M Nolte Ken K Ong Lorena Orozco Sandosh Padmanabhan Gunnar Pálsson James S Pankow Cristian Pattaro Alison Pattie Ozren Polasek Neil Poulter Peter P Pramstaller Lluis Quintana-Murci Katri Räikkönen Sarju Ralhan Dabeeru C Rao Wouter van Rheenen Stephen S Rich Paul M Ridker Cornelius A Rietveld Antonietta Robino Frank J A van Rooij Daniela Ruggiero Yasaman Saba Charumathi Sabanayagam Maria Sabater-Lleal Cinzia Felicita Sala Veikko Salomaa Kevin Sandow Helena Schmidt Laura J Scott William R Scott Bahareh Sedaghati-Khayat Bengt Sennblad Jessica van Setten Peter J Sever Wayne H-H Sheu Yuan Shi Smeeta Shrestha Sharvari Rahul Shukla Jon K Sigurdsson Timo Tonis Sikka Jai Rup Singh Blair H Smith Alena Stančáková Alice Stanton John M Starr Lilja Stefansdottir Leon Straker Patrick Sulem Gardar Sveinbjornsson Morris A Swertz Adele M Taylor Kent D Taylor Natalie Terzikhan Yih-Chung Tham Gudmar Thorleifsson Unnur Thorsteinsdottir Annika Tillander Russell P Tracy Teresa Tusié-Luna Ioanna Tzoulaki Simona Vaccargiu Jagadish Vangipurapu Jan H Veldink Veronique Vitart Uwe Völker Eero Vuoksimaa Salma M Wakil Melanie Waldenberger Gurpreet S Wander Ya Xing Wang Nicholas J Wareham Sarah Wild Chittaranjan S Yajnik Jian-Min Yuan Lingyao Zeng Liang Zhang Jie Zhou Najaf Amin Folkert W Asselbergs Stephan J L Bakker Diane M Becker Benjamin Lehne David A Bennett Leonard H van den Berg Sonja I Berndt Dwaipayan Bharadwaj Lawrence F Bielak Murielle Bochud Mike Boehnke Claude Bouchard Jonathan P Bradfield Jennifer A Brody Archie Campbell Shai Carmi Mark J Caulfield David Cesarini John C Chambers Giriraj Ratan Chandak Ching-Yu Cheng Marina Ciullo Marilyn Cornelis Daniele Cusi George Davey Smith Ian J Deary Rajkumar Dorajoo Cornelia M van Duijn David Ellinghaus Jeanette Erdmann Johan G Eriksson Evangelos Evangelou Michele K Evans Jessica D Faul Bjarke Feenstra Mary Feitosa Sylvain Foisy Andre Franke Yechiel Friedlander Paolo Gasparini Christian Gieger Clicerio Gonzalez Philippe Goyette Struan F A Grant Lyn R Griffiths Leif Groop Vilmundur Gudnason Ulf Gyllensten Hakon Hakonarson Anders Hamsten Pim van der Harst Chew-Kiat Heng Andrew A Hicks Hagit Hochner Heikki Huikuri Steven C Hunt Vincent W V Jaddoe Philip L De Jager Magnus Johannesson Åsa Johansson Jost B Jonas J Wouter Jukema Juhani Junttila Jaakko Kaprio Sharon L R Kardia Fredrik Karpe Meena Kumari Markku Laakso Sander W van der Laan Jari Lahti Matthias Laudes Rodney A Lea Wolfgang Lieb Thomas Lumley Nicholas G Martin Winfried März Giuseppe Matullo Mark I McCarthy Sarah E Medland Tony R Merriman Andres Metspalu Brian F Meyer Karen L Mohlke Grant W Montgomery Dennis Mook-Kanamori Patricia B Munroe Kari E North Dale R Nyholt Jeffery R O'connell Carole Ober Albertine J Oldehinkel Walter Palmas Colin Palmer Gerard G Pasterkamp Etienne Patin Craig E Pennell Louis Perusse Patricia A Peyser Mario Pirastu Tinca J C Polderman David J Porteous Danielle Posthuma Bruce M Psaty John D Rioux Fernando Rivadeneira Charles Rotimi Jerome I Rotter Igor Rudan Hester M Den Ruijter Dharambir K Sanghera Naveed Sattar Reinhold Schmidt Matthias B Schulze Heribert Schunkert Robert A Scott Alan R Shuldiner Xueling Sim Neil Small Jennifer A Smith Nona Sotoodehnia E-Shyong Tai Alexander Teumer Nicholas J Timpson Daniela Toniolo David-Alexandre Tregouet Tiinamaija Tuomi Peter Vollenweider Carol A Wang David R Weir John B Whitfield Cisca Wijmenga Tien-Yin Wong John Wright Jingyun Yang Lei Yu Babette S Zemel Alan B Zonderman Markus Perola Patrik K E Magnusson André G Uitterlinden Jaspal S Kooner Daniel I Chasman Ruth J F Loos Nora Franceschini Lude Franke Chris S Haley Caroline Hayward Robin G Walters John R B Perry Tōnu Esko Agnar Helgason Kari Stefansson Peter K Joshi Michiaki Kubo James F Wilson

Nat Commun 2019 10 31;10(1):4957. Epub 2019 Oct 31.

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland.

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http://dx.doi.org/10.1038/s41467-019-12283-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823371PMC
October 2019

More random motor activity fluctuations predict incident frailty, disability, and mortality.

Sci Transl Med 2019 10;11(516)

Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scitranslmed.aax1977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038816PMC
October 2019

Diagnosis and Management of Dementia: Review.

JAMA 2019 10;322(16):1589-1599

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.

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http://dx.doi.org/10.1001/jama.2019.4782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462122PMC
October 2019

Genetic architecture of subcortical brain structures in 38,851 individuals.

Authors:
Claudia L Satizabal Hieab H H Adams Derrek P Hibar Charles C White Maria J Knol Jason L Stein Markus Scholz Muralidharan Sargurupremraj Neda Jahanshad Gennady V Roshchupkin Albert V Smith Joshua C Bis Xueqiu Jian Michelle Luciano Edith Hofer Alexander Teumer Sven J van der Lee Jingyun Yang Lisa R Yanek Tom V Lee Shuo Li Yanhui Hu Jia Yu Koh John D Eicher Sylvane Desrivières Alejandro Arias-Vasquez Ganesh Chauhan Lavinia Athanasiu Miguel E Rentería Sungeun Kim David Hoehn Nicola J Armstrong Qiang Chen Avram J Holmes Anouk den Braber Iwona Kloszewska Micael Andersson Thomas Espeseth Oliver Grimm Lucija Abramovic Saud Alhusaini Yuri Milaneschi Martina Papmeyer Tomas Axelsson Stefan Ehrlich Roberto Roiz-Santiañez Bernd Kraemer Asta K Håberg Hannah J Jones G Bruce Pike Dan J Stein Allison Stevens Janita Bralten Meike W Vernooij Tamara B Harris Irina Filippi A Veronica Witte Tulio Guadalupe Katharina Wittfeld Thomas H Mosley James T Becker Nhat Trung Doan Saskia P Hagenaars Yasaman Saba Gabriel Cuellar-Partida Najaf Amin Saima Hilal Kwangsik Nho Nazanin Mirza-Schreiber Konstantinos Arfanakis Diane M Becker David Ames Aaron L Goldman Phil H Lee Dorret I Boomsma Simon Lovestone Sudheer Giddaluru Stephanie Le Hellard Manuel Mattheisen Marc M Bohlken Dalia Kasperaviciute Lianne Schmaal Stephen M Lawrie Ingrid Agartz Esther Walton Diana Tordesillas-Gutierrez Gareth E Davies Jean Shin Jonathan C Ipser Louis N Vinke Martine Hoogman Tianye Jia Ralph Burkhardt Marieke Klein Fabrice Crivello Deborah Janowitz Owen Carmichael Unn K Haukvik Benjamin S Aribisala Helena Schmidt Lachlan T Strike Ching-Yu Cheng Shannon L Risacher Benno Pütz Debra A Fleischman Amelia A Assareh Venkata S Mattay Randy L Buckner Patrizia Mecocci Anders M Dale Sven Cichon Marco P Boks Mar Matarin Brenda W J H Penninx Vince D Calhoun M Mallar Chakravarty Andre F Marquand Christine Macare Shahrzad Kharabian Masouleh Jaap Oosterlaan Philippe Amouyel Katrin Hegenscheid Jerome I Rotter Andrew J Schork David C M Liewald Greig I de Zubicaray Tien Yin Wong Li Shen Philipp G Sämann Henry Brodaty Joshua L Roffman Eco J C de Geus Magda Tsolaki Susanne Erk Kristel R van Eijk Gianpiero L Cavalleri Nic J A van der Wee Andrew M McIntosh Randy L Gollub Kazima B Bulayeva Manon Bernard Jennifer S Richards Jayandra J Himali Markus Loeffler Nanda Rommelse Wolfgang Hoffmann Lars T Westlye Maria C Valdés Hernández Narelle K Hansell Theo G M van Erp Christiane Wolf John B J Kwok Bruno Vellas Andreas Heinz Loes M Olde Loohuis Norman Delanty Beng-Choon Ho Christopher R K Ching Elena Shumskaya Baljeet Singh Albert Hofman Dennis van der Meer Georg Homuth Bruce M Psaty Mark E Bastin Grant W Montgomery Tatiana M Foroud Simone Reppermund Jouke-Jan Hottenga Andrew Simmons Andreas Meyer-Lindenberg Wiepke Cahn Christopher D Whelan Marjolein M J van Donkelaar Qiong Yang Norbert Hosten Robert C Green Anbupalam Thalamuthu Sebastian Mohnke Hilleke E Hulshoff Pol Honghuang Lin Clifford R Jack Peter R Schofield Thomas W Mühleisen Pauline Maillard Steven G Potkin Wei Wen Evan Fletcher Arthur W Toga Oliver Gruber Matthew Huentelman George Davey Smith Lenore J Launer Lars Nyberg Erik G Jönsson Benedicto Crespo-Facorro Nastassja Koen Douglas N Greve André G Uitterlinden Daniel R Weinberger Vidar M Steen Iryna O Fedko Nynke A Groenewold Wiro J Niessen Roberto Toro Christophe Tzourio William T Longstreth M Kamran Ikram Jordan W Smoller Marie-Jose van Tol Jessika E Sussmann Tomas Paus Hervé Lemaître Matthias L Schroeter Bernard Mazoyer Ole A Andreassen Florian Holsboer Chantal Depondt Dick J Veltman Jessica A Turner Zdenka Pausova Gunter Schumann Daan van Rooij Srdjan Djurovic Ian J Deary Katie L McMahon Bertram Müller-Myhsok Rachel M Brouwer Hilkka Soininen Massimo Pandolfo Thomas H Wassink Joshua W Cheung Thomas Wolfers Jean-Luc Martinot Marcel P Zwiers Matthias Nauck Ingrid Melle Nicholas G Martin Ryota Kanai Eric Westman René S Kahn Sanjay M Sisodiya Tonya White Arvin Saremi Hans van Bokhoven Han G Brunner Henry Völzke Margaret J Wright Dennis van 't Ent Markus M Nöthen Roel A Ophoff Jan K Buitelaar Guillén Fernández Perminder S Sachdev Marcella Rietschel Neeltje E M van Haren Simon E Fisher Alexa S Beiser Clyde Francks Andrew J Saykin Karen A Mather Nina Romanczuk-Seiferth Catharina A Hartman Anita L DeStefano Dirk J Heslenfeld Michael W Weiner Henrik Walter Pieter J Hoekstra Paul A Nyquist Barbara Franke David A Bennett Hans J Grabe Andrew D Johnson Christopher Chen Cornelia M van Duijn Oscar L Lopez Myriam Fornage Joanna M Wardlaw Reinhold Schmidt Charles DeCarli Philip L De Jager Arno Villringer Stéphanie Debette Vilmundur Gudnason Sarah E Medland Joshua M Shulman Paul M Thompson Sudha Seshadri M Arfan Ikram

Nat Genet 2019 11 21;51(11):1624-1636. Epub 2019 Oct 21.

Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1038/s41588-019-0511-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055269PMC
November 2019

Hospitalization, Alzheimer's Disease and Related Neuropathologies, and Cognitive Decline.

Ann Neurol 2019 12 23;86(6):844-852. Epub 2019 Oct 23.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.

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http://dx.doi.org/10.1002/ana.25621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973140PMC
December 2019

3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice.

Commun Biol 2019 4;2:360. Epub 2019 Oct 4.

1The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA USA.

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http://dx.doi.org/10.1038/s42003-019-0599-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778135PMC
May 2020

Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease.

Cell Rep 2019 10;29(2):301-316.e10

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919331PMC
October 2019

Interaction between the progression of Alzheimer's disease and fractal degradation.

Neurobiol Aging 2019 11 30;83:21-30. Epub 2019 Aug 30.

Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Department of Medicine, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858962PMC
November 2019

Common age-related neuropathologies and yearly variability in cognition.

Ann Clin Transl Neurol 2019 11 30;6(11):2140-2149. Epub 2019 Sep 30.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.

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http://dx.doi.org/10.1002/acn3.50857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856601PMC
November 2019

Insulin and adipokine signaling and their cross-regulation in postmortem human brain.

Neurobiol Aging 2019 12 20;84:119-130. Epub 2019 Aug 20.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960343PMC
December 2019

Neocortical Lewy bodies are associated with impaired odor identification in community-dwelling elders without clinical PD.

J Neurol 2019 Dec 18;266(12):3108-3118. Epub 2019 Sep 18.

Rush Alzheimer Disease Center, Suite 1000, Rush University Medical Center, 1750 W Harrison Street, Chicago, IL, 60612, USA.

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http://dx.doi.org/10.1007/s00415-019-09540-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851442PMC
December 2019

Microstructural changes in the brain mediate the association of AK4, IGFBP5, HSPB2, and ITPK1 with cognitive decline.

Neurobiol Aging 2019 12 26;84:17-25. Epub 2019 Jul 26.

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077920PMC
December 2019

Using Transcriptomic Hidden Variables to Infer Context-Specific Genotype Effects in the Brain.

Am J Hum Genet 2019 09 22;105(3):562-572. Epub 2019 Aug 22.

Department of Statistics and Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z4; Centre for Molecular Medicine and Therapeutics, Vancouver, BC V5Z 4H4, Canada; Canadian Institute for Advanced Research, Child and Brain Development Program, Toronto M5G 1M1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.07.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731371PMC
September 2019

Neuropsychological latent classes at enrollment and postmortem neuropathology.

Alzheimers Dement 2019 09 13;15(9):1195-1207. Epub 2019 Aug 13.

Albert Einstein College of Medicine, Bronx, NY, USA.

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http://dx.doi.org/10.1016/j.jalz.2019.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756968PMC
September 2019

cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis.

Cell Rep 2019 08;28(7):1799-1813.e5

Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA; Jan and Dan Duncan Neurologic Research Institute, Texas Children's Hospital, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.07.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703184PMC
August 2019

Integrating Gene and Protein Expression Reveals Perturbed Functional Networks in Alzheimer's Disease.

Cell Rep 2019 07;28(4):1103-1116.e4

Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.06.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7503200PMC
July 2019