Dave S B Hoon

Dave S B Hoon

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Dave S B Hoon

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Detection of Minimal Residual Disease and Its Clinical Applications in Melanoma and Breast Cancer Patients.

Adv Exp Med Biol 2018;1100:83-95

Department of Translational Molecular Medicine, John Wayne Cancer Institute, Santa Monica, CA, USA.

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http://link.springer.com/10.1007/978-3-319-97746-1_5
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http://dx.doi.org/10.1007/978-3-319-97746-1_5DOI Listing
July 2019

B7H3 regulates differentiation and serves as a potential biomarker and theranostic target for human glioblastoma.

Lab Invest 2019 Jul 26;99(8):1117-1129. Epub 2019 Mar 26.

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

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http://dx.doi.org/10.1038/s41374-019-0238-5DOI Listing
July 2019

miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway.

Clin Epigenetics 2018 16;10:64. Epub 2018 May 16.

1The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing, China.

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http://dx.doi.org/10.1186/s13148-018-0495-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956756PMC
May 2019

Brain metastasis DNA methylomes, a novel resource for the identification of biological and clinical features.

Sci Data 2018 11 6;5:180245. Epub 2018 Nov 6.

Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA 90404, USA.

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http://www.nature.com/articles/sdata2018245
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http://dx.doi.org/10.1038/sdata.2018.245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219670PMC
November 2018

Epigenomic and Transcriptomic Characterization of Secondary Breast Cancers.

Ann Surg Oncol 2018 Oct 28;25(10):3082-3087. Epub 2018 Jun 28.

Center for Endocrine Tumors and Disorders, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA.

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http://dx.doi.org/10.1245/s10434-018-6582-7DOI Listing
October 2018

Predominance of triple wild-type and IGF2R mutations in mucosal melanomas.

BMC Cancer 2018 Oct 30;18(1):1054. Epub 2018 Oct 30.

Department of Translational Molecular Medicine, Division of Molecular Oncology, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, 90404, USA.

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-4977-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206730PMC
October 2018

Donald L. Morton, MD 1934-2014.

Authors:
Dave S B Hoon

Crit Rev Oncog 2016 ;21(1-2):1-2

Department of Molecular Oncology John Wayne Cancer Institute at Providence Saint John's Health Center Santa Monica, California.

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http://dx.doi.org/10.1615/CritRevOncog.2016017122DOI Listing
September 2018

Donald L. Morton, MD.... A Legendary Surgical Oncologist and Consummate Investigator.

Crit Rev Oncog 2016 ;21(1-2):3-5

Department of Molecular Oncology John Wayne Cancer Institute at Providence Saint John's Health Center Santa Monica, California.

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http://dx.doi.org/10.1615/CritRevOncog.2016016918DOI Listing
September 2018

Preface: The Living Legacy of Donald L. Morton.

Authors:
Dave S B Hoon

Crit Rev Oncog 2016 ;21(1-2):v-vi0

Department of Molecular Oncology John Wayne Cancer Institute at Providence Saint John's Health Center Santa Monica, California.

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http://dx.doi.org/10.1615/CritRevOncog.2016016917DOI Listing
September 2018

KDM6B Counteracts EZH2-Mediated Suppression of to Confer Resistance to PI3K/AKT Inhibitor Treatment in Breast Cancer.

Mol Cancer Ther 2018 09 20;17(9):1973-1983. Epub 2018 Jun 20.

Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology, and Research), Biopolis, Singapore.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0802DOI Listing
September 2018

The Epigenomic Landscape of Pituitary Adenomas Reveals Specific Alterations and Differentiates Among Acromegaly, Cushing's Disease and Endocrine-Inactive Subtypes.

Clin Cancer Res 2018 09 3;24(17):4126-4136. Epub 2018 Jul 3.

Department of Translational Molecular Medicine, John Wayne Cancer Institute at Saint John's Health Center, Providence Health System, Santa Monica, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2206DOI Listing
September 2018

Alternative splicing and cancer metastasis: prognostic and therapeutic applications.

Clin Exp Metastasis 2018 08 29;35(5-6):393-402. Epub 2018 May 29.

Department of Translational Molecular Medicine, John Wayne Cancer Institute, Santa Monica, CA, USA.

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http://dx.doi.org/10.1007/s10585-018-9905-yDOI Listing
August 2018

Liquid Biopsies for Assessing Metastatic Melanoma Progression.

Crit Rev Oncog 2016 ;21(1-2):141-54

Department of Molecular Oncology John Wayne Cancer Institute at Providence Saint John's Health Center Santa Monica, California.

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http://dx.doi.org/10.1615/CritRevOncog.2016016075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326707PMC
October 2017

P-REX1 amplification promotes progression of cutaneous melanoma via the PAK1/P38/MMP-2 pathway.

Cancer Lett 2017 10 10;407:66-75. Epub 2017 Aug 10.

Department of Translational Medicine, Division Molecular Oncology, John Wayne Cancer Institute (JWCI) at Providence Saint John's Health Center, Santa Monica, CA 90404, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.08.001DOI Listing
October 2017

MiR-200a Regulates CDK4/6 Inhibitor Effect by Targeting CDK6 in Metastatic Melanoma.

J Invest Dermatol 2017 09 16;137(9):1955-1964. Epub 2017 May 16.

Department of Translational Molecular Medicine, Division of Molecular Oncology, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California, USA; Sequencing Center, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.03.039DOI Listing
September 2017

ANGPTL4 promotes the progression of cutaneous melanoma to brain metastasis.

Oncotarget 2017 Sep 5;8(44):75778-75796. Epub 2017 Jul 5.

Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.18632/oncotarget.19018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652662PMC
September 2017

Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma.

Clin Cancer Res 2017 Aug 7;23(16):4831-4842. Epub 2017 Apr 7.

Division of Molecular Oncology, Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559338PMC
August 2017

Genome-wide chromatin accessibility, DNA methylation and gene expression analysis of histone deacetylase inhibition in triple-negative breast cancer.

Genom Data 2017 Jun 14;12:14-16. Epub 2017 Feb 14.

Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA 90404, USA.

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http://dx.doi.org/10.1016/j.gdata.2017.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318344PMC
June 2017

Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma.

N Engl J Med 2017 06;376(23):2211-2222

From the John Wayne Cancer Institute at Saint John's Health Center, Santa Monica (M.B.F., D.S.B.H.), and the Departments of Pathology (A.J.C.), Biomathematics (H.-J.W., D.A.E., R.M.E.), and Medicine (D.A.E.), University of California, Los Angeles - both in California; Melanoma Institute Australia and the University of Sydney, Sydney (J.F.T., O.E.N.), Peter MacCallum Cancer Centre, Melbourne, VIC (M.H.), Princess Alexandra Hospital, Brisbane, QLD (B.M.S.), and Newcastle Melanoma Unit, Waratah, NSW (P.H.) - all in Australia; Huntsman Cancer Institute, Salt Lake City (R.H.A., R.D.N.), and Intermountain Healthcare Cancer Services-Intermountain Medical Center, Murray (T.L.B.) - both in Utah; Istituto Nazionale dei Tumori Napoli, Naples (N.M.), Istituto Europeo di Oncologia, Milan (A.T.), and Istituto Oncologico Veneto-University of Padua, Padua (C.R.R.) - all in Italy; H. Lee Moffitt Cancer Center, Tampa, FL (J.S.Z.); Helsinki University Hospital, Helsinki (T.J.); Dallas Surgical Group, Dallas (P.D.B.); Universitair Medisch Centrum Groningen, Groningen (H.J.H.), and Netherlands Cancer Institute, Amsterdam (M.W.J.M.W.) - both in the Netherlands; Norfolk and Norwich University Hospital, Norwich (M. Moncrieff), and Guy's and St. Thomas' NHS Foundation Trust, London (A.M.-R.) - both in the United Kingdom; Swedish Melanoma Study Group-University Hospital Lund, Lund, Sweden (C.I.); University of Michigan, Ann Arbor (M.S.S.); Wake Forest University, Winston-Salem (E.A.L.), and Duke University, Durham (R.S.) - both in North Carolina; Ohio State University, Columbus (D.A.); University of Zurich, Zurich (R.D.), and Centre Hospitalier Universitaire Vaudois, Lausanne (M. Matter) - both in Switzerland; Penn State Hershey Cancer Institute, Hershey (R.I.N.), Thomas Jefferson University (A.C.B.) and Fox Chase Cancer Center (J.M.F.), Philadelphia, and St. Luke's University Health Network, Bethlehem (D.C.D.) - all in Pennsylvania; Greenville Health System Cancer Center, Greenville, SC (S.D.T.); Sunnybrook Research Institute, Toronto (F.W.), and Tom Baker Cancer Centre, Calgary, AB (G.M.) - both in Canada; University of Washington, Seattle (D.R.B.); Saint Louis University, St. Louis (E.H.); Vanderbilt University (D.B.J., M.C.K.), Nashville, and University of Tennessee, Knoxville (J.M.L.) - both in Tennessee; University Hospital Schleswig-Holstein-Campus Lübeck, Lübeck (P.T.), University Hospital of Würzburg, Würzburg (A.G.), and City Hospital of Nürnberg, Nuremberg (E.S.) - all in Germany; SUNY at Stony Brook Hospital Medical Center, Stony Brook (T.L.H.), Memorial Sloan Kettering Cancer Center, New York (C.E.A.), and Roswell Park Cancer Institute, Buffalo (J.M.K.) - all in New York; Northwestern University Feinberg School of Medicine (J.D.W.) and Rush University Medical Center (S.D.B.), Chicago; University of Wisconsin, Madison (H.B.N.); Tel Aviv Sourasky Medical Center, Tel Aviv, Israel (S.S.); M.D. Anderson Medical Center, Houston (J.E.G.); Johns Hopkins University School of Medicine, Baltimore (L.J.); University of Louisville, Louisville, KY (K.M.M.); Dartmouth-Hitchcock Medical Center, Lebanon, NH (R.J.B.); Hospital Clinic Barcelona, Barcelona (S.V.-S.); and Sentara CarePlex Hospital, Hampton, VA (R.A.H.).

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http://dx.doi.org/10.1056/NEJMoa1613210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548388PMC
June 2017

CCR4 is a determinant of melanoma brain metastasis.

Oncotarget 2017 May;8(19):31079-31091

Department of Cell Research and Immunology, George S. Wise, Faculty of Life Sciences, Tel-Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.18632/oncotarget.16076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458190PMC
May 2017

Emerging Utility of Urinary Cell-free Nucleic Acid Biomarkers for Prostate, Bladder, and Renal Cancers.

Eur Urol Focus 2017 04 31;3(2-3):265-272. Epub 2017 Mar 31.

Department of Translational Molecular Medicine, Division of Molecular Oncology, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.euf.2017.03.009DOI Listing
April 2017

Epigenomic landscape of melanoma progression to brain metastasis: unexplored therapeutic alternatives.

Epigenomics 2015 7;7(8):1303-11. Epub 2015 Dec 7.

Department of Molecular Oncology, John Wayne Cancer Institute at Providence Saint John's Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA.

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http://dx.doi.org/10.2217/epi.15.77DOI Listing
October 2016

Correction: Ono, S.; Lam, S.; Nagahara, M.; Hoon, D.S.B. Circulating microRNA Biomarkers as Liquid Biopsy for Cancer Patients: Pros and Cons of Current Assays. J. Clin. Med. 2015, 4, 1890-1907.

J Clin Med 2016 Sep 12;5(9). Epub 2016 Sep 12.

Department of Molecular Oncology, John Wayne Cancer Institute, Providence Saint John's Health Center, 2200 Santa Monica Blvd., Santa Monica, CA 90404, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039484PMC
http://dx.doi.org/10.3390/jcm5090081DOI Listing
September 2016

Circulating Tumor DNA as a Cancer Biomarker: Fact or Fiction?

Clin Chem 2016 08 3;62(8):1054-60. Epub 2016 Jun 3.

Associate Professor, University Medical Center of Montpellier, Hôpital Saint-Eloi - CHRU Montpellier, France.

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http://dx.doi.org/10.1373/clinchem.2016.260331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326709PMC
August 2016

Liquid biopsy utility for the surveillance of cutaneous malignant melanoma patients.

Mol Oncol 2016 Mar 17;10(3):450-63. Epub 2015 Dec 17.

Department of Molecular Oncology, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA 90404, United States. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307330PMC
March 2016

In Situ Sodium Bisulfite Modification of Genomic DNA from Microdissected Melanoma Paraffin-Embedded Archival Tissues.

Methods Mol Biol 2015 Dec 13. Epub 2015 Dec 13.

Department of Molecular Oncology, John Wayne Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, 90404, USA.

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http://dx.doi.org/10.1007/7651_2015_303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329140PMC
December 2015

The CASC15 Long Intergenic Noncoding RNA Locus Is Involved in Melanoma Progression and Phenotype Switching.

J Invest Dermatol 2015 Oct 27;135(10):2464-2474. Epub 2015 May 27.

Department of Molecular Oncology, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, California, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2015.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567947PMC
October 2015

RASSF8 regulates progression of cutaneous melanoma through nuclear factor-κb.

Oncotarget 2015 Oct;6(30):30165-77

Department of Molecular Oncology, John Wayne Cancer Institute (JWCI), Providence Saint John's Health Center, Santa Monica, CA, USA.

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http://dx.doi.org/10.18632/oncotarget.5030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745788PMC
October 2015

IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel.

Nat Commun 2015 Oct 27;6:8746. Epub 2015 Oct 27.

Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology and Research), 60 Biopolis Street, 02-01, Biopolis 138672, Singapore.

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http://dx.doi.org/10.1038/ncomms9746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640083PMC
October 2015

Circulating microRNA Biomarkers as Liquid Biopsy for Cancer Patients: Pros and Cons of Current Assays.

J Clin Med 2015 Oct 23;4(10):1890-907. Epub 2015 Oct 23.

Department of Molecular Oncology, John Wayne Cancer Institute, Providence Saint John's Health Center, 2200 Santa Monica Blvd., Santa Monica, CA 90404, USA.

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http://dx.doi.org/10.3390/jcm4101890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626661PMC
October 2015

Endosialin Expression in Metastatic Melanoma Tumor Microenvironment Vasculature: Potential Therapeutic Implications.

Cancer Microenviron 2015 Aug 18;8(2):111-8. Epub 2015 Jun 18.

Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA, USA.

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http://dx.doi.org/10.1007/s12307-015-0168-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542822PMC
August 2015

Vemurafenib resistance selects for highly malignant brain and lung-metastasizing melanoma cells.

Cancer Lett 2015 May 25;361(1):86-96. Epub 2015 Feb 25.

Department of Cell Research and Immunology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.02.041DOI Listing
May 2015

The metastatic microenvironment: Claudin-1 suppresses the malignant phenotype of melanoma brain metastasis.

Int J Cancer 2015 Mar 8;136(6):1296-307. Epub 2014 Sep 8.

Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1002/ijc.29090DOI Listing
March 2015

Genome-wide hypomethylation and specific tumor-related gene hypermethylation are associated with esophageal squamous cell carcinoma outcome.

J Thorac Oncol 2015 Mar;10(3):509-17

*Department of Molecular Oncology, John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, 2200 Santa Monica Blvd, Santa Monica, CA 90404; †Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan 160-8582; and ‡Biostatistics Division, John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, 2200 Santa Monica Blvd, Santa Monica, CA 90404.

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https://linkinghub.elsevier.com/retrieve/pii/S15560864153166
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http://dx.doi.org/10.1097/JTO.0000000000000441DOI Listing
March 2015

A direct plasma assay of circulating microRNA-210 of hypoxia can identify early systemic metastasis recurrence in melanoma patients.

Oncotarget 2015 Mar;6(9):7053-64

Department of Molecular Oncology, John Wayne Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466669PMC
http://dx.doi.org/10.18632/oncotarget.3142DOI Listing
March 2015

Epigenetic changes of EGFR have an important role in BRAF inhibitor-resistant cutaneous melanomas.

J Invest Dermatol 2015 Feb 22;135(2):532-541. Epub 2014 Sep 22.

Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California, USA; Sequencing Center, John Wayne Cancer Institute, Santa Monica, California, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2014.418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307785PMC
February 2015

MicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A.

Oncotarget 2015 Feb;6(5):3211-24

Department of Molecular Oncology, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413648PMC
http://dx.doi.org/10.18632/oncotarget.3085DOI Listing
February 2015

CD8+ T-cell immunosurveillance constrains lymphoid premetastatic myeloid cell accumulation.

Eur J Immunol 2015 Jan 10;45(1):71-81. Epub 2014 Nov 10.

Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA, USA.

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http://dx.doi.org/10.1002/eji.201444467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293284PMC
January 2015

Multi-platform Genome-wide Analysis of Melanoma Progression to Brain Metastasis.

Genom Data 2014 Dec;2:150-152

Department of Molecular Oncology, John Wayne Cancer Institute (JWCI), Providence Saint John's Health Center, Santa Monica, CA, 90404, USA.

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http://dx.doi.org/10.1016/j.gdata.2014.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311262PMC
December 2014

DNA methylation and gene deletion analysis of brain metastases in melanoma patients identifies mutually exclusive molecular alterations.

Neuro Oncol 2014 Nov 26;16(11):1499-509. Epub 2014 Jun 26.

Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California (D.M.M., J.L.H., D.S.B.H.); Department of Tissue Oncology and Diagnostic Pathology (R.A.S., M.E.B., J.F.T.) and Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital, Sydney, Australia (J.F.T.); Sydney Medical School, The University of Sydney, Sydney, Australia (R.A.S., J.S.W., M.E.B., J.F.T.); Melanoma Institute Australia, Sydney, Australia (R.A.S., J.S.W.); Cellular and Molecular Biology Laboratory, Institute of Histology and Embryology, Mendoza, Argentina (M.R.); Tumor Biology Laboratory, Institute of Medicine and Experimental Biology of Cuyo, Mendoza, Argentina (L.M.V.-R.); Department of Pathology (R.M.), Center for Molecular Oncology (R.M.), and Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York (R.M.); Division of Surgical Oncology, John Wayne Cancer Institute, Santa Monica, California (D.L.M.); Brain Tumor Center, Saint John's Health Center, Santa Monica, California (G.B., D.F.K.).

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http://dx.doi.org/10.1093/neuonc/nou107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201072PMC
November 2014

DNA methylation of apoptosis genes in rectal cancer predicts patient survival and tumor recurrence.

Apoptosis 2014 Nov;19(11):1581-93

Department of Surgery, K6-R, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s10495-014-1022-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362525PMC
November 2014

Donald Lee Morton: in memoriam (1934-2014).

Authors:
Dave S B Hoon

Cancer Res 2014 Aug;74(15):4009-10

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August 2014

Don Morton.

Authors:
Dave S B Hoon

Pigment Cell Melanoma Res 2014 Jul;27(4):681-2

John Wayne Cancer Institute.

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http://dx.doi.org/10.1111/pcmr.12263DOI Listing
July 2014

Circulating tumor cells as prognostic biomarkers in cutaneous melanoma patients.

Methods Mol Biol 2014 ;1102:513-22

Department of Molecular Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA.

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http://dx.doi.org/10.1007/978-1-62703-727-3_27DOI Listing
June 2014

Tumor necrosis factor-α and apoptosis induction in melanoma cells through histone modification by 3-deazaneplanocin A.

J Invest Dermatol 2014 May 13;134(5):1470-1473. Epub 2013 Nov 13.

Department of Molecular Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2013.489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300195PMC
May 2014

Epigenetic biomarkers in skin cancer.

Cancer Lett 2014 Jan 27;342(2):170-7. Epub 2012 Jan 27.

Department of Molecular Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA.

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http://dx.doi.org/10.1016/j.canlet.2012.01.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391356PMC
January 2014

B cells promote tumor progression via STAT3 regulated-angiogenesis.

PLoS One 2013 29;8(5):e64159. Epub 2013 May 29.

Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, California, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064159PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667024PMC
January 2014

Direct serum assay for microRNA in cancer patients.

Methods Mol Biol 2013 ;1024:147-55

Department of Molecular Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA.

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http://dx.doi.org/10.1007/978-1-62703-453-1_11DOI Listing
December 2013

Diagnostic and prognostic value of circulating tumor-related DNA in cancer patients.

Expert Rev Mol Diagn 2013 Nov 16;13(8):827-44. Epub 2013 Oct 16.

Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA, 90404, USA.

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http://dx.doi.org/10.1586/14737159.2013.845088DOI Listing
November 2013

Epigenetic regulation of REG1A and chemosensitivity of cutaneous melanoma.

Epigenetics 2013 Oct 31;8(10):1043-52. Epub 2013 Jul 31.

Department of Molecular Oncology; John Wayne Cancer Institute; Santa Monica, CA USA.

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http://dx.doi.org/10.4161/epi.25810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891685PMC
October 2013

B7-H3 associated with tumor progression and epigenetic regulatory activity in cutaneous melanoma.

J Invest Dermatol 2013 Aug 8;133(8):2050-8. Epub 2013 Mar 8.

Department of Molecular Oncology, John Wayne Cancer Institute (JWCI), Santa Monica, California 90404, USA.

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http://dx.doi.org/10.1038/jid.2013.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760237PMC
August 2013

Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis.

Proc Natl Acad Sci U S A 2013 Jul 19;110(27):11121-6. Epub 2013 Jun 19.

Cancer Biology and Pharmacology, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672.

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http://dx.doi.org/10.1073/pnas.1300873110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704014PMC
July 2013

The metastatic microenvironment: Brain-derived soluble factors alter the malignant phenotype of cutaneous and brain-metastasizing melanoma cells.

Int J Cancer 2012 Dec 12;131(11):2509-18. Epub 2012 Apr 12.

Department of Cell Research and Immunology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1002/ijc.27552DOI Listing
December 2012

DNA methylation index and methylation profile of invasive ductal breast tumors.

J Mol Diagn 2012 Nov 25;14(6):613-22. Epub 2012 Aug 25.

Laboratory of Cellular and Molecular Biology, Institute of Histology and Embryology (IHEM-CCT-CONICET), Mendoza, Argentina.

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http://dx.doi.org/10.1016/j.jmoldx.2012.07.001DOI Listing
November 2012

Heterogeneous epigenetic regulation of TIMP3 in prostate cancer.

Epigenetics 2012 Nov 28;7(11):1279-89. Epub 2012 Sep 28.

Department of Molecular Oncology, John Wayne Cancer Institute at St John's Health Center, Santa Monica, CA, USA.

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http://www.tandfonline.com/doi/abs/10.4161/epi.22333
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http://dx.doi.org/10.4161/epi.22333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499329PMC
November 2012

Epigenetics of regional lymph node metastasis in solid tumors.

Clin Exp Metastasis 2012 Oct 9;29(7):747-56. Epub 2012 Jun 9.

Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA.

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http://dx.doi.org/10.1007/s10585-012-9491-3DOI Listing
October 2012

Progression of cutaneous melanoma: implications for treatment.

Clin Exp Metastasis 2012 Oct 15;29(7):775-96. Epub 2012 Aug 15.

Center for Melanoma Research and Treatment and Department of Surgery, California Pacific Medical Center, San Francisco, CA, USA.

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http://dx.doi.org/10.1007/s10585-012-9521-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311146PMC
October 2012

The metastatic microenvironment: brain-residing melanoma metastasis and dormant micrometastasis.

Int J Cancer 2012 Sep 2;131(5):1071-82. Epub 2011 Dec 2.

Department of Cell Research and Immunology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1002/ijc.27324DOI Listing
September 2012

Hypomethylation of LINE-1 in primary tumor has poor prognosis in young breast cancer patients: a retrospective cohort study.

Breast Cancer Res Treat 2012 Aug 5;134(3):1103-14. Epub 2012 Apr 5.

Department of Molecular Oncology, John Wayne Cancer Institute (JWCI) at St. John's Health Center, 2200 Santa Monica Blvd., Santa Monica, CA 90404, USA.

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http://dx.doi.org/10.1007/s10549-012-2038-0DOI Listing
August 2012

Epigenetic regulation of cancer stem cell genes in triple-negative breast cancer.

Am J Pathol 2012 Jul 21;181(1):257-67. Epub 2012 May 21.

Department of Molecular Oncology, John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, CA 90404, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000294401200308
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http://dx.doi.org/10.1016/j.ajpath.2012.03.019DOI Listing
July 2012

AIM1 and LINE-1 epigenetic aberrations in tumor and serum relate to melanoma progression and disease outcome.

J Invest Dermatol 2012 Jun 8;132(6):1689-97. Epub 2012 Mar 8.

Department of Molecular Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California 90404, USA.

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http://dx.doi.org/10.1038/jid.2012.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352986PMC
June 2012

Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.

Proc Natl Acad Sci U S A 2012 May 30;109(20):7765-9. Epub 2012 Apr 30.

Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1073/pnas.1205132109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356652PMC
May 2012

Epigenetics of estrogen receptor-negative primary breast cancer.

Expert Rev Mol Diagn 2012 May;12(4):371-82

Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA.

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http://dx.doi.org/10.1586/erm.12.26DOI Listing
May 2012

S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites.

Cancer Cell 2012 May;21(5):642-54

Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute and City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.03.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360884PMC
May 2012

Primary tumor classification according to methylation pattern is prognostic in patients with early stage ER-negative breast cancer.

Breast Cancer Res Treat 2012 Feb 11;131(3):859-69. Epub 2011 Apr 11.

Department of Molecular Oncology, John Wayne Cancer Institute (JWCI) at St. John's Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA, 90404, USA.

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http://dx.doi.org/10.1007/s10549-011-1485-3DOI Listing
February 2012

Kinesin 18A expression: clinical relevance to colorectal cancer progression.

Int J Cancer 2011 Dec 9;129(11):2543-52. Epub 2011 Jun 9.

Department of Surgery and Molecular Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu, Oita, Japan.

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http://dx.doi.org/10.1002/ijc.25916DOI Listing
December 2011

Prognostic molecular biomarkers for cutaneous malignant melanoma.

J Surg Oncol 2011 Sep 9;104(4):438-46. Epub 2011 May 9.

Department of Molecular Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California, USA.

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http://doi.wiley.com/10.1002/jso.21969
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673884PMC
September 2011

Lymphovascular invasion of colorectal cancer is correlated to SPARC expression in the tumor stromal microenvironment.

Epigenetics 2011 Aug 1;6(8):1001-11. Epub 2011 Aug 1.

Department of Molecular Oncology, John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, CA USA.

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http://dx.doi.org/10.4161/epi.6.8.16063DOI Listing
August 2011

Cell-free nucleic acids as biomarkers in cancer patients.

Nat Rev Cancer 2011 Jun 12;11(6):426-37. Epub 2011 May 12.

Institute of Tumour Biology, Center of Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany.

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http://dx.doi.org/10.1038/nrc3066DOI Listing
June 2011

Molecular mechanisms of metastasis.

J Surg Oncol 2011 May;103(6):508-17

Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California 90404, USA.

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http://dx.doi.org/10.1002/jso.21690DOI Listing
May 2011

LINE-1 hypomethylation during primary colon cancer progression.

PLoS One 2011 Apr 14;6(4):e18884. Epub 2011 Apr 14.

Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018884PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077413PMC
April 2011

Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma.

Epigenetics 2011 Mar 1;6(3):388-94. Epub 2011 Mar 1.

Department of Molecular Oncology, John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063331PMC
http://dx.doi.org/10.4161/epi.6.3.14056DOI Listing
March 2011

Direct serum assay for microRNA-21 concentrations in early and advanced breast cancer.

Clin Chem 2011 Jan 29;57(1):84-91. Epub 2010 Oct 29.

Department of Molecular Oncology, John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA 90404, USA.

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http://www.clinchem.org/content/57/1/84.full.pdf
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http://www.clinchem.org/cgi/doi/10.1373/clinchem.2010.151845
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January 2011

B7-h3 ligand expression by primary breast cancer and associated with regional nodal metastasis.

Ann Surg 2010 Dec;252(6):1044-51

Department of Molecular Oncology, John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, CA, USA.

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http://dx.doi.org/10.1097/SLA.0b013e3181f1939dDOI Listing
December 2010