Prof. Daryoush Shahbazi-Gahrouei, PhD - Isfahan University of Medical Sciences - Professor

Prof. Daryoush Shahbazi-Gahrouei

PhD

Isfahan University of Medical Sciences

Professor

Isfahan, Isfahan | Iran (Islamic Republic of)

Main Specialties: Biotechnology, Nuclear Medicine, Nuclear Radiology

Additional Specialties: Medical Physics

ORCID logohttps://orcid.org/0000-0002-8538-1898


Top Author

Prof. Daryoush Shahbazi-Gahrouei, PhD - Isfahan University of Medical Sciences - Professor

Prof. Daryoush Shahbazi-Gahrouei

PhD

Introduction

Date of Birth: 26th March 1964
- PhD. Medical Physics (1997-2000), University of Western Sydney, Sydney, Australia. - MSc. Medical Physics (1987-1991), University of Tarbiat Modarres, Tehran, Iran.
- BSc. Physics (1983-1987), University of Isfahan, Isfahan, Iran
- High School, Mathematics and Physics (1980-1983), Shahid Beheshti High School, Shahrekord, Iran
Ph.D. Thesis: “Development and Application of New Cancer-Specific Contrast Agents for Tumour Detection by Magnetic Resonance Imaging”.

Address: Dept. of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IRAN
Telephone: +98-31-37929095
E-mail: shahbazi24@yahoo.com or shahbazi@med.mui.ac.ir

Primary Affiliation: Isfahan University of Medical Sciences - Isfahan, Isfahan , Iran (Islamic Republic of)

Specialties:

Additional Specialties:

Research Interests:


View Prof. Daryoush Shahbazi-Gahrouei’s Resume / CV

Education

Dec 2018
University of Western Sydney
PhD

Experience

Oct 2018
Professor in Medical Physics
Lecturere and Researcher

Publications

48Publications

1021Reads

127Profile Views

107PubMed Central Citations

Synthesis and characterisation of LiBO nanophosphor as a TL dosimeter.

IET Nanobiotechnol 2020 Jun;14(4):300-307

Department of Physics, Urmia University, Urmia, Iran.

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http://dx.doi.org/10.1049/iet-nbt.2019.0381DOI Listing
June 2020
1.500 Impact Factor

Assessment of Ploy Dopamine Coated Fe3O4 Nanoparticles for Melanoma (B16-F10 and A-375) Cells Detection.

Anticancer Agents Med Chem 2020 May 12. Epub 2020 May 12.

Department of Radiology, Askarieh Hospital, Isfahan. Iran.

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http://dx.doi.org/10.2174/1871520620666200513084616DOI Listing
May 2020
2.469 Impact Factor

The Radioprotective Effect of Ascorbic Acid and Kefir against Genotoxicity Induced by Exposure in Mice Blood Lymphocytes.

Nutr Cancer 2020 Apr 30:1-7. Epub 2020 Apr 30.

Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://dx.doi.org/10.1080/01635581.2020.1758169DOI Listing
April 2020
2.322 Impact Factor

Synthesis and characterisation of iron oxide nanoparticles conjugated with epidermal growth factor receptor (EGFR) monoclonal antibody as MRI contrast agent for cancer detection.

IET Nanobiotechnol 2019 Jun;13(4):400-406

Department of Anatomical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

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http://dx.doi.org/10.1049/iet-nbt.2018.5285DOI Listing
June 2019
2 Reads
1.500 Impact Factor

Evaluation of the Radiosensitizing Potency of Bromelain for Radiation Therapy of 4T1 Breast Cancer Cells.

J Med Signals Sens 2019 Jan-Mar;9(1):68-74

Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

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http://dx.doi.org/10.4103/jmss.JMSS_25_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419564PMC
April 2019
3 Reads

Medical imaging modalities using nanoprobes for cancer diagnosis: A literature review on recent findings.

J Res Med Sci 2019 26;24:38. Epub 2019 Apr 26.

School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://dx.doi.org/10.4103/jrms.JRMS_437_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521609PMC
April 2019
2 Reads
0.608 Impact Factor

Essential considerations for accurate evaluation of photoneutron contamination in Radiotherapy.

Appl Radiat Isot 2019 Mar 5;145:24-31. Epub 2018 Dec 5.

Department of Nuclear Engineering, Faculty of Advanced Sciences and Technologies, University of Isfahan, Isfahan, Iran.

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https://linkinghub.elsevier.com/retrieve/pii/S09698043183076
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http://dx.doi.org/10.1016/j.apradiso.2018.12.007DOI Listing
March 2019
38 Reads
1.056 Impact Factor

Effect of livergol on the improvement of fatty liver in patients with cancer undergoing irinotecan- and oxaliplatin-based chemotherapy regimen.

J Res Med Sci 2018 28;23:111. Epub 2018 Dec 28.

Department of Radiation Oncology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://dx.doi.org/10.4103/jrms.JRMS_793_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327848PMC
December 2018
1 Read
0.608 Impact Factor

The effect of gel homogeneity on dose response in a low-density polymer gel dosimeter for radiation therapy.

J Cancer Res Ther 2018 Apr-Jun;14(3):563-566

Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://dx.doi.org/10.4103/0973-1482.183204DOI Listing
October 2018
9 Reads

AS1411 aptamer-targeted gold nanoclusters effect on the enhancement of radiation therapy efficacy in breast tumor-bearing mice.

Nanomedicine (Lond) 2018 10 18;13(20):2563-2578. Epub 2018 Oct 18.

Department of Physiology, Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan 81746-73461, Iran.

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https://www.futuremedicine.com/doi/10.2217/nnm-2018-0180
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http://dx.doi.org/10.2217/nnm-2018-0180DOI Listing
October 2018
25 Reads
5.413 Impact Factor

Evaluation of Targeted Image-Guided Radiation Therapy Treatment Planning System by Use of American Association of Physicists in Medicine Task Group-119 Test Cases.

J Med Signals Sens 2018 Apr-Jun;8(2):95-100

Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992903PMC
June 2018
14 Reads

Gold nanoparticles in combination with megavoltage radiation energy increased radiosensitization and apoptosis in colon cancer HT-29 cells.

Int J Radiat Biol 2017 03 2;93(3):315-323. Epub 2016 Nov 2.

d Stem Cell Research Center , Golestan University of Medical Science , Gorgan , Iran.

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https://www.tandfonline.com/doi/full/10.1080/09553002.2017.1
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http://dx.doi.org/10.1080/09553002.2017.1242816DOI Listing
March 2017
18 Reads
1 Citation
1.840 Impact Factor

Aptamer-conjugated Magnetic Nanoparticles as Targeted Magnetic Resonance Imaging Contrast Agent for Breast Cancer.

J Med Signals Sens 2016 Oct-Dec;6(4):243-247

Department of Clinical Biochemistry, School of Pharmacy and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157001PMC
December 2016
82 Reads
4 Citations

Multiple MTS Assay as the Alternative Method to Determine Survival Fraction of the Irradiated HT-29 Colon Cancer Cells.

J Med Signals Sens 2016 Apr-Jun;6(2):112-6

Department of Cell Sciences Research Center Medical Science, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855884PMC
May 2016
17 Reads
1 Citation

Comparison of Accuracy in Calculation of Absorbed Dose to Patients Following Bone Scan with (99m)Tc-Marked Diphosphonates by Two Different Background Correction Methods.

J Med Signals Sens 2016 Jan-Mar;6(1):33-8

Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786961PMC
March 2016
11 Reads

The effect of continuous ELF-MFs on the level of 5-HIAA in the raphe nucleus of the rat.

J Radiat Res 2016 Mar 24;57(2):127-32. Epub 2016 Jan 24.

Department of Physiology, Pasteur Institute, Tehran, Iran.

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http://dx.doi.org/10.1093/jrr/rrv093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795953PMC
March 2016
5 Reads
3 Citations
1.691 Impact Factor

Non Invasive XRF Analysis of Human Hair for Health State Determination of Breast Tissue.

Iran J Cancer Prev 2015 Dec 23;8(6):e3983. Epub 2015 Dec 23.

Department of Radiology and Radiotherapy, School of Allied Medicine, Tehran University of Medical Sciences, Tehran, IR Iran.

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http://dx.doi.org/10.17795/ijcp-3983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736071PMC
December 2015
10 Reads

Cobalt Zinc Ferrite Nanoparticles as a Potential Magnetic Resonance Imaging Agent: An In vitro Study.

Avicenna J Med Biotechnol 2015 Apr-Jun;7(2):64-8

Department of Physics, Nano-center, Maleke-ashtar University of Technology, Shahin-shahr, Isfahan, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483316PMC
July 2015
10 Reads
5 Citations

Does nitrogen gas bubbled through a low density polymer gel dosimeter solution affect the polymerization process?

Adv Biomed Res 2015 11;4:88. Epub 2015 May 11.

Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://dx.doi.org/10.4103/2277-9175.156651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434445PMC
May 2015
21 Reads

Determination of Organ Doses in Radioiodine Therapy using Monte Carlo Simulation.

World J Nucl Med 2015 Jan-Apr;14(1):16-8

Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.

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http://dx.doi.org/10.4103/1450-1147.150517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337001PMC
February 2015
11 Reads
2 Citations

Health effects of living near mobile phone base transceiver station (BTS) antennae: a report from Isfahan, Iran.

Electromagn Biol Med 2014 Sep 19;33(3):206-10. Epub 2013 Jun 19.

Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences , Isfahan , Iran.

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http://dx.doi.org/10.3109/15368378.2013.801352DOI Listing
September 2014
15 Reads
8 Citations

Detection of MUC1-expressing ovarian cancer by C595 monoclonal antibody-conjugated SPIONs using MR imaging.

ScientificWorldJournal 2013 30;2013:609151. Epub 2013 Sep 30.

Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://dx.doi.org/10.1155/2013/609151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806490PMC
June 2014
28 Reads
8 Citations
1.220 Impact Factor

Extremely low-frequency electromagnetic field influences the survival and proliferation effect of human adipose derived stem cells.

Adv Biomed Res 2014 9;3:25. Epub 2014 Jan 9.

Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://dx.doi.org/10.4103/2277-9175.124668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928843PMC
March 2014
62 Reads
7 Citations

Assessment of entrance surface dose and health risk from common radiology examinations in Iran.

Radiat Prot Dosimetry 2013 13;154(3):308-13. Epub 2012 Sep 13.

Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Iran.

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http://dx.doi.org/10.1093/rpd/ncs244DOI Listing
October 2013
9 Reads
3 Citations
0.913 Impact Factor

Superparamagnetic iron oxide-C595: Potential MR imaging contrast agents for ovarian cancer detection.

J Med Phys 2013 Oct;38(4):198-204

Department of Medical Physics and Radiation Technology, School of Paramedical Sciences, Bushehr University of Medical Sciences, Bushehr, Iran.

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http://dx.doi.org/10.4103/0971-6203.121198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959000PMC
October 2013
11 Reads
9 Citations

Photoneutron contamination from an 18 MV Saturne medical linear accelerator in the treatment room.

Radiat Prot Dosimetry 2013 Sep 28;156(3):356-63. Epub 2013 Mar 28.

Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://dx.doi.org/10.1093/rpd/nct078DOI Listing
September 2013
12 Reads
1 Citation
0.913 Impact Factor

Functionalized magnetic nanoparticles for the detection and quantitative analysis of cell surface antigen.

Biomed Res Int 2013 31;2013:349408. Epub 2012 Dec 31.

Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Hezar Jerib Street, Isfahan, Iran.

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http://dx.doi.org/10.1155/2013/349408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591120PMC
September 2013
26 Reads
9 Citations

A review on natural background radiation.

Adv Biomed Res 2013 Jul 30;2:65. Epub 2013 Jul 30.

Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://dx.doi.org/10.4103/2277-9175.115821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814895PMC
July 2013
175 Reads
3 Citations

Synthesis and in vitro evaluation of MR molecular imaging probes using J591 mAb-conjugated SPIONs for specific detection of prostate cancer.

Contrast Media Mol Imaging 2013 Mar-Apr;8(2):175-84

Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://dx.doi.org/10.1002/cmmi.1514DOI Listing
July 2013
46 Reads
16 Citations
2.923 Impact Factor

The correlation between high background radiation and blood level of the trace elements (copper, zinc, iron and magnesium) in workers of Mahallat's hot springs.

Adv Biomed Res 2012 28;1:64. Epub 2012 Aug 28.

Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://dx.doi.org/10.4103/2277-9175.100190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544083PMC
January 2013
13 Reads
1 Citation

Investigation of patient dose from common radiology examinations in Isfahan, Iran.

Adv Biomed Res 2012 11;1:11. Epub 2012 May 11.

Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://dx.doi.org/10.4103/2277-9175.96064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507008PMC
December 2012
9 Reads

A Monte Carlo and experimental investigation of the dosimetric behavior of low- and medium-perturbation diodes used for entrance in vivo dosimetry in megavoltage photon beams.

J Appl Clin Med Phys 2012 Nov 8;13(6):3917. Epub 2012 Nov 8.

Physics Unit, Department of Radiotherapy and Oncology and Centre for Research in Medical Physics and Biomedical Engineering, Shiraz University of Medical Sciences, Shiraz, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718541PMC
http://dx.doi.org/10.1120/jacmp.v13i6.3917DOI Listing
November 2012
122 Reads
3 Citations
1.110 Impact Factor

Estimation of Organ Absorbed Doses in Patients from (99m)Tc-diphosphonate Using the Data of MIRDose Software.

J Med Signals Sens 2012 Oct;2(4):231-4

Department of Medical Physics and Biomedical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662107PMC
October 2012
10 Reads
2 Citations

Comparison of three methods of calculation, experimental and monte carlo simulation in investigation of organ doses (thyroid, sternum, cervical vertebra) in radioiodine therapy.

J Med Signals Sens 2012 Jul;2(3):149-52

Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660710PMC
July 2012
132 Reads
2 Citations

Mobile phone radiation interferes laboratory immunoenzymometric assays: Example chorionic gonadotropin assays.

Pathophysiology 2012 Feb 9;19(1):43-7. Epub 2012 Feb 9.

Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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http://dx.doi.org/10.1016/j.pathophys.2012.01.002DOI Listing
February 2012
18 Reads
10 Citations

Novel MR imaging contrast agents for cancer detection.

J Res Med Sci 2009 May;14(3):141-7

Department of Medical Physics and Medical Engineering, Isfahan University of Medical Sciences, Isfahan, Iran. E-mail:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129053PMC
May 2009
10 Reads
6 Citations
0.610 Impact Factor

Quantitative analysis of left ventricular performance from sequences of cardiac magnetic resonance imaging using active mesh model.

Comput Med Imaging Graph. 2009 Apr;33(3):222-34.

Comput Med Imaging Graph.

In this study, the local and global left ventricular function are estimated by fitting three-dimensional active mesh model (3D-AMM) to the initial sparse displacement which is measured from an establishing point correspondence procedure. To evaluate the performance of the algorithm, eight image sequences were used and the results were compared with those reported by other researchers. The findings were consistent with previously published values and the clinical evidence as well. The results demonstrated the superiority of the novel strategy with respect to formerly presented algorithm reported by author et al. Furthermore, the results are comparable to the current state-of-the-art methods.

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April 2009
16 Reads

natural background radiation dosimetry in the highest altitude region of Iran.

J Radiat Res 2003 Sep;44(3):285-7

Department of Medical Physics, Shahrekord University of Medical Sciences, Iran.

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http://dx.doi.org/10.1269/jrr.44.285DOI Listing
September 2003
10 Reads
2 Citations
1.691 Impact Factor

natural background radiation dosimetry in the highest altitude region of Iran.

J Radiat Res. 2003 Sep;44(3):285-7.

J Radiat Res.

The natural background radiation has been measured in one of the highest altitude regions (Zagros Mountains), Chaharmahal and Bakhtiari province, in the south west of Iran. The outdoors-environmental monitoring exposure rate of radiation was measured in 200 randomly chosen regions using portable Geiger-Muller and scintillation detectors. Eight measurements were made in each region and an average value was used to calculate the exposure rate from natural background radiation. The average exposure rate was found to be 0.246 microGy/h and the annual average effective dose equivalent was found to be 0.49 mSv. An overall population-weighted mean outdoor dose rate was calculated to be 49 nGy/h, which is higher than the world-wide mean value of 44 nGy/h, as reported by UNSCEAR in 1998, and is comparable to the annual effective dose equivalent of 0.38 mSv. A good correlation between the altitude and the exposure rate was observed, as the higher altitude regions have higher natural background radiation levels.

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September 2003
16 Reads

In vitro studies of gadolinium-DTPA conjugated with monoclonal antibodies as cancer-specific magnetic resonance imaging contrast agents.

Australas Phys Eng Sci Med. 2002 Mar;25(1):31-8.

Australas Phys Eng Sci Med

The monoclonal antibodies, 9.2.27 against human melanoma cell lines and WM53 against leukemia cell lines, were conjugated with cyclic anhydride gadolinium-diethylenetriaminepenta-acetic acid (Gd-cDTPAa) and used as tumor-specific contrast agents in magnetic resonance imaging (MRI). The data indicate that Gd-DTPA-9.2.27 in solution decreased the T1 relaxation of water protons at 7.0 Tesla (300 MHz) in direct proportion to the gadolinium concentration, and this effect was greater than in Gd-DTPA solutions. These conjugates show high specificity for melanoma and leukemia cell lines. T1 relaxation time at 7.0 Tesla, measured for the melanoma cell line (MM-138) and leukemia cell line (HL-60) after incubation at 37 degrees C for 4 hr, were significantly decreased (approximately 25%) relative to controls. The gadolinium concentration in cells and washing solutions was measured by inductively coupled plasma atomic emission spectroscopy (ICP-AES). A linear relationship was observed between T1 relaxation rates and gadolinium concentrations obtained by ICP-AES. The ICP-AES results showed no gadolinium uptake in the non-targeted HT-29 colorectal cancer cells

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March 2002
18 Reads

In vitro study of relationship between signal intensity and Gd-DTPA concentration at high magnetic field strength.

Australas Radiol. 2001 Aug;45(3):298-304

Australasian Radilology

Although gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) has been used as a contrast material in MRI, it is known that the contrast enhancement effect is not uniform for high concentrations of Gd-DTPA. In order to evaluate the proper pulse sequences for dynamic MRI in aqueous solutions of Gd-DTPA, blood samples and melanoma cells, the signal intensity for several concentrations of Gd-DTPA were measured under inversion recovery (T1-weighted) at high magnetic field strength (7.0 Tesla). For aqueous solutions of Gd-DTPA, signal intensity correlated linearly with the concentration of Gd-DTPA between 0 mmol/L and 4 mmol/L. Using blood and melanoma cells, signal intensity correlated non-linearly with the concentration of Gd-DTPA between 0 mmol/L and 1.5 mmol/L. For concentrations of more than 4 mmol/L in aqueous solutions of Gd-DTPA, 1 mmol/L in blood and 1.5 mmol/L in melanoma, signal intensity decreased with increased Gd-DTPA concentration

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August 2001
16 Reads

In vivo studies of Gd-DTPA-monoclonal antibody and Gd-porphyrins: potential MR imaging contrast agents for cancer.

J Magn Reson Imaging. 2001 Aug;14(2):169-74.

Journal of Magnetic Resonance Imagin

New tumour-specific contrast agents for clinical imaging and therapy for cancer are required. To this end Gd-H (Gd-hematoporphyrin), Gd-TCP (Gd-tetra-carboranylmethoxyphenyl-porphyrin), Gd DTPA-WM53, and Gd-DTPA-9.2.27 are synthesised and applied to nude mice with human melanoma (MM-138) xenografts in nude mice. The biodistribution, T1 relaxation times and MR image signal enhancement of the contrast agents are presented and compared. A specific and significant (20%) modification in T1 relaxation times of water in human melanoma tumour xenografts was revealed 24-hr after injection of Gd-DTPA-9.2.27. The percent of injected antibody or gadolinium that localised to the tumour was measured by ICP-AES to be approximately 35%. A higher concentration of gadolinium was achieved compared with non-specific compounds indicating selective delivery of Gd-DTPA-9.2.27 to the melanoma xenografts. Porphyrin based contrast agents (Gd H and Gd-TCP) also showed significant uptake in melanomas. The uptake of Gd TCP by the tumour was sufficient to deliver boron atoms into the tumour, making possible it’s the dual use for both MR imaging and boron neutron capture therapy (BNCT). The linear relationship between the paramagnetic contribution to the relaxation rates and contrast agent concentration making possible quantitative studies of paramagnetic contrast agent uptake.

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January 2001
15 Reads

In vivo studies of Gd-DTPA-monoclonal antibody and Gd-porphyrins: potential MR imaging contrast agents for cancer

Pubmed, ISI

J. Magn. Reson. Imaging

New tumour-specific contrast agents for clinical imaging and therapy for cancer are required. To this end Gd-H (Gd-hematoporphyrin), Gd-TCP (Gd-tetra-carboranylmethoxyphenyl-porphyrin), Gd DTPA-WM53, and Gd-DTPA-9.2.27 are synthesised and applied to nude mice with human melanoma (MM-138) xenografts in nude mice. The biodistribution, T1 relaxation times and MR image signal enhancement of the contrast agents are presented and compared. A specific and significant (20%) modification in T1 relaxation times of water in human melanoma tumour xenografts was revealed 24-hr after injection of Gd-DTPA-9.2.27. The percent of injected antibody or gadolinium that localised to the tumour was measured by ICP-AES to be approximately 35%. A higher concentration of gadolinium was achieved compared with non-specific compounds indicating selective delivery of Gd-DTPA-9.2.27 to the melanoma xenografts. Porphyrin based contrast agents (Gd H and Gd-TCP) also showed significant uptake in melanomas. The uptake of Gd TCP by the tumour was sufficient to deliver boron atoms into the tumour, making possible it’s the dual use for both MR imaging and boron neutron capture therapy (BNCT). The linear relationship between the paramagnetic contribution to the relaxation rates and contrast agent concentration making possible quantitative studies of paramagnetic contrast agent uptake.

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January 2001
15 Reads

Top co-authors

Mohammad Abdolahi
Mohammad Abdolahi

Isfahan University of Medical Sciences

5
Milad Baradaran-Ghahfarokhi
Milad Baradaran-Ghahfarokhi

School of Medicine

5
Mehrdad Gholami
Mehrdad Gholami

Isfahan University of Medical Sciences

3
Corine Sermeus
Corine Sermeus

Isfahan University of Medical Sciences

2
Behzad Baradaran
Behzad Baradaran

Immunology Research Center

2
Masoud A Mehrgardi
Masoud A Mehrgardi

University of Isfahan

2
Saba Ayat
Saba Ayat

Islamic Azad University

2
Mohammad Bagher Tavakoli
Mohammad Bagher Tavakoli

Isfahan University of Medical Sciences

2