Darryle D Schoepp

Darryle D Schoepp

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Darryle D Schoepp

Darryle D Schoepp

Publications by authors named "Darryle D Schoepp"

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Metabotropic glutamate receptors, 5 years on.

Neuropharmacology 2017 03 29;115:1-3. Epub 2016 Nov 29.

Merck Research Laboratories, Merck and Company, Inc., West Point, PA, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2016.09.029DOI Listing
March 2017

Alzheimer's disease research and development: a call for a new research roadmap.

Ann N Y Acad Sci 2014 Apr;1313:1-16

Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1111/nyas.12424DOI Listing
April 2014

CNS distribution of metabotropic glutamate 2 and 3 receptors: transgenic mice and [³H]LY459477 autoradiography.

Neuropharmacology 2013 Mar 31;66:89-98. Epub 2012 Jan 31.

Neuroscience Discovery Research, Eli Lilly and Company, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2012.01.019DOI Listing
March 2013

Where will new neuroscience therapies come from?

Nat Rev Drug Discov 2011 09 30;10(10):715-6. Epub 2011 Sep 30.

Neuroscience and Ophthalmology Research at Merck 351 Sumneytown Pike, North Wales, Pennsylvania 19454, USA.

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http://dx.doi.org/10.1038/nrd3559DOI Listing
September 2011

Evidence for the role of metabotropic glutamate (mGlu)2 not mGlu3 receptors in the preclinical antipsychotic pharmacology of the mGlu2/3 receptor agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY404039).

J Pharmacol Exp Ther 2008 Jul 18;326(1):209-17. Epub 2008 Apr 18.

Neuroscience Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, DC0510, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1124/jpet.108.136861DOI Listing
July 2008

Efficacy and tolerability of an mGlu2/3 agonist in the treatment of generalized anxiety disorder.

Neuropsychopharmacology 2008 Jun 22;33(7):1603-10. Epub 2007 Aug 22.

Orexigen Therapeutics, San Diego, CA 92130, USA.

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http://dx.doi.org/10.1038/sj.npp.1301531DOI Listing
June 2008

Schizophrenia: moving beyond monoamine antagonists.

Mol Interv 2008 Apr;8(2):99-107

Vanderbilt University, Department of Pharmacology, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1124/mi.8.2.7DOI Listing
April 2008

In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders.

Psychopharmacology (Berl) 2007 Jul 24;193(1):121-36. Epub 2007 Mar 24.

Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, DC0510, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1007/s00213-007-0758-3DOI Listing
July 2007

Metabotropic glutamate receptors in the control of mood disorders.

CNS Neurol Disord Drug Targets 2007 Apr;6(2):87-100

Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.

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April 2007

The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats.

Behav Brain Res 2006 Aug 6;171(2):207-15. Epub 2006 May 6.

Department of Psychiatry, Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, 46202-4887, USA.

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http://dx.doi.org/10.1016/j.bbr.2006.03.032DOI Listing
August 2006

Effects of mGlu2 or mGlu3 receptor deletions on mGlu2/3 receptor agonist (LY354740)-induced brain c-Fos expression: specific roles for mGlu2 in the amygdala and subcortical nuclei, and mGlu3 in the hippocampus.

Neuropharmacology 2006 Aug 2;51(2):213-28. Epub 2006 Jun 2.

Neuroscience Discovery, Lilly Research Laboratories, Central Nervous System Research, Eli Lilly and Company, Lilly Corporate Center, drop code 0510, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2006.03.014DOI Listing
August 2006

5-Hydroxytryptamine2A (5-HT2A) receptor regulation in rat prefrontal cortex: interaction of a phenethylamine hallucinogen and the metabotropic glutamate2/3 receptor agonist LY354740.

Neurosci Lett 2006 Aug 6;403(3):256-60. Epub 2006 Jun 6.

Yale School of Medicine, Department of Psychiatry, New Haven, CT 06508, USA.

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http://dx.doi.org/10.1016/j.neulet.2006.05.021DOI Listing
August 2006

Improved bioavailability of the mGlu2/3 receptor agonist LY354740 using a prodrug strategy: in vivo pharmacology of LY544344.

J Pharmacol Exp Ther 2006 Feb 13;316(2):905-13. Epub 2005 Oct 13.

Neuroscience Discovery Research Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1124/jpet.105.091926DOI Listing
February 2006

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

Neuron 2005 Dec;48(6):913-22

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1016/j.neuron.2005.10.028DOI Listing
December 2005

Metabotropic glutamate receptors as novel targets for anxiety and stress disorders.

Nat Rev Drug Discov 2005 Feb;4(2):131-44

Eli Lilly and Company, Neuroscience Division, Lilly Corporate Center DC 0510, Indianapolis, Indiana 46285, USA.

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http://dx.doi.org/10.1038/nrd1630DOI Listing
February 2005

The mGlu2/3 receptor agonist, LY354740, blocks immobilization-induced increases in noradrenaline and dopamine release in the rat medial prefrontal cortex.

J Neurochem 2004 Jan;88(1):194-202

Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.

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http://dx.doi.org/10.1046/j.1471-4159.2003.02125.xDOI Listing
January 2004

A role for noradrenergic transmission in the actions of phencyclidine and the antipsychotic and antistress effects of mGlu2/3 receptor agonists.

Ann N Y Acad Sci 2003 Nov;1003:309-17

Neuroscience Research, Eli Lilly and Company, Indianapolis, Indiana 46285, USA.

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http://dx.doi.org/10.1196/annals.1300.019DOI Listing
November 2003

Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice.

Neuropharmacology 2003 Sep;45(4):473-83

Eli Lilly and Company, Lilly Corporate Center, drop code 0150, Lilly Research Laboratories, Indianapolis, IN 42685, USA.

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http://dx.doi.org/10.1016/s0028-3908(03)00200-4DOI Listing
September 2003

LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress.

Stress 2003 Sep;6(3):189-97

Neuroscience Research, Lilly Research Laboratories, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1080/1025389031000146773DOI Listing
September 2003

Evaluation of [3H]LY341495 for labeling group II metabotropic glutamate receptors in vivo.

Nucl Med Biol 2003 Feb;30(2):187-90

Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/s0969-8051(02)00423-7DOI Listing
February 2003

The group II metabotropic glutamate receptor agonist (-)-2-oxa-4-aminobicyclo[3.1.0.]hexane-4,6-dicarboxylate (LY379268) and clozapine reverse phencyclidine-induced behaviors in monoamine-depleted rats.

J Pharmacol Exp Ther 2002 Dec;303(3):919-27

Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, Indiana 46285, USA.

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http://dx.doi.org/10.1124/jpet.102.038422DOI Listing
December 2002

Metabotropic glutamate receptors.

Pharmacol Biochem Behav 2002 Sep;73(2):285-6

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http://dx.doi.org/10.1016/s0091-3057(02)00824-9DOI Listing
September 2002

Effects of the mGlu2/3 receptor agonist LY379268 on motor activity in phencyclidine-sensitized rats.

Pharmacol Biochem Behav 2002 Sep;73(2):339-46

Neuroscience Research Division, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Mail Drop 0510, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1016/s0091-3057(02)00848-1DOI Listing
September 2002

The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam.

Pharmacol Biochem Behav 2002 Sep;73(2):367-74

Neuroscience Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop 0510, Indianapolis, IN 46285, USA.

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http://dx.doi.org/10.1016/s0091-3057(02)00850-xDOI Listing
September 2002