Darryl C Zeldin

Darryl C Zeldin

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Darryl C Zeldin

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Synergistic Association of House Endotoxin Exposure and Ambient Air Pollution with Asthma Outcomes.

Am J Respir Crit Care Med 2019 Sep;200(6):712-720

Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa.

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http://dx.doi.org/10.1164/rccm.201809-1733OCDOI Listing
September 2019

Author Correction: Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment.

Nature 2019 Sep;573(7772):E1

Stem Cell Program and Division of Haematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41586-019-1489-4DOI Listing
September 2019

Cockroach, dust mite, and shrimp sensitization correlations in the National Health and Nutrition Examination Survey.

Ann Allergy Asthma Immunol 2019 May 23;122(5):536-538.e1. Epub 2019 Feb 23.

Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.anai.2019.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500746PMC
May 2019

Primary care clinician adherence with asthma guidelines: the National Asthma Survey of Physicians.

J Asthma 2019 Mar 1:1-13. Epub 2019 Mar 1.

c Division of Intramural Research , National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park , NC , USA.

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http://dx.doi.org/10.1080/02770903.2019.1579831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717679PMC
March 2019

An improved protocol for the treatment of fulminant myocarditis.

Sci China Life Sci 2019 Mar 1;62(3):433-434. Epub 2019 Mar 1.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.1007/s11427-019-9507-xDOI Listing
March 2019

Prediagnostic Serum Levels of Fatty Acid Metabolites and Risk of Ovarian Cancer in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.

Cancer Epidemiol Biomarkers Prev 2019 Jan 27;28(1):189-197. Epub 2018 Sep 27.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://cebp.aacrjournals.org/lookup/doi/10.1158/1055-9965.EP
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http://dx.doi.org/10.1158/1055-9965.EPI-18-0392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325018PMC
January 2019

Ablation of soluble epoxide hydrolase reprogram white fat to beige-like fat through an increase in mitochondrial integrity, HO-1-adiponectin in vitro and in vivo.

Prostaglandins Other Lipid Mediat 2018 09 21;138:1-8. Epub 2018 Jul 21.

Department of Pharmacology, New York Medical College, Valhalla, NY, 10595, USA; Joan Edward School of Medicine, Marshall University, Huntington, WV, 25701, USA. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2018.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314013PMC
September 2018

NIEHS: Making a Mark on Translational Research Science.

Environ Health Perspect 2018 08 2;126(8):081001. Epub 2018 Aug 2.

Office of the Director, National Institute of Environmental Health Sciences, Durham, North Carolina, USA.

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http://dx.doi.org/10.1289/EHP4075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108839PMC
August 2018

Bedroom Allergen Exposure Beyond House Dust Mites.

Curr Allergy Asthma Rep 2018 08 20;18(10):52. Epub 2018 Aug 20.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Research Triangle Park, North Carolina, 27709, USA.

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http://dx.doi.org/10.1007/s11882-018-0805-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222253PMC
August 2018

Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2.

Int J Mol Sci 2018 Jul 16;19(7). Epub 2018 Jul 16.

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS UMR8601, Université Paris Descartes, 75270 Paris CEDEX 06, France.

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http://www.mdpi.com/1422-0067/19/7/2066
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http://dx.doi.org/10.3390/ijms19072066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073854PMC
July 2018

Bedroom allergen exposures in US households.

J Allergy Clin Immunol 2018 05 30;141(5):1870-1879.e14. Epub 2017 Nov 30.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.08.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938098PMC
May 2018

Exposure and Sensitization to Pets Modify Endotoxin Association with Asthma and Wheeze.

J Allergy Clin Immunol Pract 2018 Nov - Dec;6(6):2006-2013.e4. Epub 2018 Apr 21.

Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2018.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524530PMC
April 2018

Endotoxin predictors and associated respiratory outcomes differ with climate regions in the U.S.

Environ Int 2018 03 23;112:218-226. Epub 2017 Dec 23.

Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.envint.2017.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899028PMC
March 2018

Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia.

J Biol Chem 2018 03 3;293(9):3281-3292. Epub 2018 Jan 3.

From the Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, 27709 and

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http://dx.doi.org/10.1074/jbc.RA117.000298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836130PMC
March 2018

House Dust Endotoxin Association with Chronic Bronchitis and Emphysema.

Environ Health Perspect 2018 03 23;126(3):037007. Epub 2018 Mar 23.

Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa, USA

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http://dx.doi.org/10.1289/EHP2452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071737PMC
March 2018

Commercial scale production of RvD4 opens the resolving door to new research.

J Leukoc Biol 2018 Mar 30. Epub 2018 Mar 30.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, USA.

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http://dx.doi.org/10.1002/JLB.3CE0118-032RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165702PMC
March 2018

Conditional ablation of the RFX4 isoform 1 transcription factor: Allele dosage effects on brain phenotype.

PLoS One 2018 3;13(1):e0190561. Epub 2018 Jan 3.

Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, Unites States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190561PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752003PMC
February 2018

Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A Proves Renal Origins of Urinary PGI-M and TX-M.

Circ Res 2018 02 3;122(4):555-559. Epub 2018 Jan 3.

From the National Heart and Lung Institute, Imperial College London, United Kingdom (J.A.M., N.S.K., D.M.R.); Blizard Institute, Queen Mary University of London, United Kingdom (R.B.K., W.E.W., M.V.C., M.M.Y., T.D.W.); National Institute for Environmental Health Sciences, Research Triangle, NC (M.L.E., D.C.Z.); Department of Nephrology (W.E.W., M.M.Y.) and Immunology Department (H.L.), Barts Health NHS Trust, London, United Kingdom; and Departments of Pharmacology and Medicine, Vanderbilt University, Nashville, TN (G.L.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.312144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816977PMC
February 2018

Clinician Agreement, Self-Efficacy, and Adherence with the Guidelines for the Diagnosis and Management of Asthma.

J Allergy Clin Immunol Pract 2018 May - Jun;6(3):886-894.e4. Epub 2018 Feb 3.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.

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http://dx.doi.org/10.1016/j.jaip.2018.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948143PMC
February 2018

Mite-impermeable bedding casings and severe asthma exacerbations.

J Pediatr 2018 01;192:266-269

National Institute of Health Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1016/j.jpeds.2017.10.058DOI Listing
January 2018

A Slippery Cause of a Slimy Problem: Mucin Induction by an Esterified Lipid.

Am J Respir Cell Mol Biol 2017 12;57(6):633-634

3 National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1165/rcmb.2017-0275EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800897PMC
December 2017

Role of Müller cell cytochrome P450 2c44 in murine retinal angiogenesis.

Prostaglandins Other Lipid Mediat 2017 Nov 23;133:93-102. Epub 2017 Apr 23.

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, D-60596, Germany; German Center of Cardiovascular Research (DZHK) Partner site Rhein-Main, Frankfurt am Main, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10988823173001
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http://dx.doi.org/10.1016/j.prostaglandins.2017.04.002DOI Listing
November 2017

Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia.

Biochim Biophys Acta Gen Subj 2017 Nov 27;1861(11 Pt A):2758-2765. Epub 2017 Jul 27.

Department of Nutrition, University of California Davis, One Shields Ave, Davis, CA 95616, United States; Comprehensive Cancer Center, University of California Davis, Sacramento, CA 95817, United States; Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, University of California Davis, Sacramento, CA 95817, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2017.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873293PMC
November 2017

Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock.

J Immunol 2017 11 16;199(10):3634-3643. Epub 2017 Oct 16.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;

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http://dx.doi.org/10.4049/jimmunol.1700820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685187PMC
November 2017

Changes in Food-Specific IgE Over Time in the National Health and Nutrition Examination Survey (NHANES).

J Allergy Clin Immunol Pract 2016 Jul-Aug;4(4):713-20. Epub 2016 Apr 25.

Division of Pediatric Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, Md. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2016.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939113PMC
October 2017

It All Begins In Utero: Cord Blood Bacterial DNA and T Cell Immunity.

Am J Respir Cell Mol Biol 2017 10;57(4):379-380

2 Division of Intramural Research National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1165/rcmb.2017-0185EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650091PMC
October 2017

Generation and characterization of epoxide hydrolase 3 (EPHX3)-deficient mice.

PLoS One 2017 6;12(4):e0175348. Epub 2017 Apr 6.

Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0175348PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383309PMC
September 2017

WEC 2016 special issue editorial.

Prostaglandins Other Lipid Mediat 2017 09 18;132:1-2. Epub 2017 Sep 18.

Division of Intramural Research, National Institutes of Health/National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States.

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http://dx.doi.org/10.1016/j.prostaglandins.2017.09.006DOI Listing
September 2017

Effect of Soluble Epoxide Hydrolase on the Modulation of Coronary Reactive Hyperemia: Role of Oxylipins and PPARγ.

PLoS One 2016 1;11(9):e0162147. Epub 2016 Sep 1.

Basic Pharmaceutical Sciences, School of Pharmacy, Center for Basic and Translational Stroke Research, West Virginia University, Morgantown, WV, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0162147PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008628PMC
August 2017

Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and ω-Hydroxylases.

PLoS One 2017 5;12(1):e0169584. Epub 2017 Jan 5.

Basic Pharmaceutical Sciences, School of Pharmacy, Center for Basic and Translational Stroke Research. West Virginia University, Morgantown, West Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169584PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215949PMC
August 2017

Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice.

PLoS One 2017 22;12(3):e0174137. Epub 2017 Mar 22.

Basic Pharmaceutical Sciences, School of Pharmacy, Center for Basic and Translational Stroke Research. West Virginia University, Morgantown, West Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174137PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362206PMC
August 2017

Characterization of the Tissue Distribution of the Mouse Subfamily by Quantitative PCR Analysis.

Drug Metab Dispos 2017 07 27;45(7):807-816. Epub 2017 Apr 27.

Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina

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http://dx.doi.org/10.1124/dmd.117.075697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478903PMC
July 2017

Sensitization and Exposure to Pets: The Effect on Asthma Morbidity in the US Population.

J Allergy Clin Immunol Pract 2018 Jan - Feb;6(1):101-107.e2. Epub 2017 Jul 8.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC.

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http://dx.doi.org/10.1016/j.jaip.2017.05.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756688PMC
July 2017

Reduced coronary reactive hyperemia in mice was reversed by the soluble epoxide hydrolase inhibitor (t-AUCB): Role of adenosine A receptor and plasma oxylipins.

Prostaglandins Other Lipid Mediat 2017 07 7;131:83-95. Epub 2017 Sep 7.

Basic Pharmaceutical Sciences, School of Pharmacy, Center for Basic and Translational Stroke Research, West Virginia University, Morgantown, WV, United States. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2017.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635996PMC
July 2017

20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (G) to Affect Vascular Function and Trigger Hypertension.

Circ Res 2017 May 21;120(11):1776-1788. Epub 2017 Mar 21.

From the Department of Pharmacology, New York Medical College School of Medicine, Valhalla (V.G., A.G., B.S., V.P., F.F.Z., M.L.S.); Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas (R.D., S.K.G., N.R.R., J.R.F.); Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC (J.P.G., A.G., D.C.Z.); and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (J.H.C.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.310525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5446268PMC
May 2017

Vagal innervation is required for pulmonary function phenotype in mice.

Am J Physiol Lung Cell Mol Physiol 2017 Apr 27;312(4):L520-L530. Epub 2017 Jan 27.

Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina;

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http://www.physiology.org/doi/10.1152/ajplung.00495.2016
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http://dx.doi.org/10.1152/ajplung.00495.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407097PMC
April 2017

Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1.

FASEB J 2016 12 15;30(12):4256-4266. Epub 2016 Sep 15.

The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom;

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http://dx.doi.org/10.1096/fj.201600530RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102123PMC
December 2016

Vascular endothelial over-expression of soluble epoxide hydrolase (Tie2-sEH) enhances adenosine A receptor-dependent contraction in mouse mesenteric arteries: role of ATP-sensitive K channels.

Mol Cell Biochem 2016 Nov 15;422(1-2):197-206. Epub 2016 Sep 15.

Department of Pharmaceutical Sciences, Center for Basic and Translational Stroke Research, Health Science Center-North, School of Pharmacy, West Virginia University, Biomedical Research Building, 2nd floor, Room # 220, 1 Medical Center Drive, PO Box 9530, Morgantown, WV, 26506-9530, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056159PMC
http://dx.doi.org/10.1007/s11010-016-2821-zDOI Listing
November 2016

Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis.

EBioMedicine 2016 Nov 30;13:201-211. Epub 2016 Sep 30.

Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 01248, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264653PMC
November 2016

Racial/ethnic and socioeconomic differences in self-reported food allergy among food-sensitized children in National Health and Nutrition Examination Survey III.

Ann Allergy Asthma Immunol 2016 11 24;117(5):570-572.e3. Epub 2016 Oct 24.

Division of Pediatric Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2016.08.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517088PMC
November 2016

The Role of Cytochrome P450 Epoxygenases, Soluble Epoxide Hydrolase, and Epoxyeicosatrienoic Acids in Metabolic Diseases.

Adv Nutr 2016 11 15;7(6):1122-1128. Epub 2016 Nov 15.

Department of Internal Medicine and the Institute of Hypertension, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China; and

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http://dx.doi.org/10.3945/an.116.012245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105036PMC
November 2016

Deletion of soluble epoxide hydrolase enhances coronary reactive hyperemia in isolated mouse heart: role of oxylipins and PPARγ.

Am J Physiol Regul Integr Comp Physiol 2016 10 3;311(4):R676-R688. Epub 2016 Aug 3.

Basic Pharmaceutical Sciences, School of Pharmacy, Center for Basic and Translational Stroke Research, West Virginia University, Morgantown, West Virginia;

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http://dx.doi.org/10.1152/ajpregu.00237.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142160PMC
October 2016

Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis.

Prostaglandins Other Lipid Mediat 2016 09 9;125:19-29. Epub 2016 Jul 9.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2016.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035202PMC
September 2016

Cytochrome P450 Oxidase 2C Inhibition Adds to ω-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization.

Arterioscler Thromb Vasc Biol 2016 09 14;36(9):1919-27. Epub 2016 Jul 14.

From the Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, MA (Y.G., Z.F., C.-H.L., Z.W., Z.S., T.W.F., N.J.S., P.C.M., S.B.B., S.S.M., E.P.M., L.E.H.S.); Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC (M.L.E., F.B.L., D.C.Z.); Department of Entomology and Comprehensive Cancer Center, University of California, Davis (K.S.S.L., B.D.H.); Section on Nutritional Neurosciences in the Laboratory of Membrane Biophysics and Biochemistry, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD (J.P.S.G.); and Department of Ophthalmology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (A.H.).

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.116.307558
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http://dx.doi.org/10.1161/ATVBAHA.116.307558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010176PMC
September 2016

Efficacy of an in-home test kit in reducing dust mite allergen levels: results of a randomized controlled pilot study.

J Asthma 2016 24;53(2):133-8. Epub 2015 Aug 24.

a Division of Intramural Research , National Institute of Environmental Health Sciences, National Institutes of Health , Research Triangle Park , NC , USA .

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http://dx.doi.org/10.3109/02770903.2015.1072721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769118PMC
July 2016

Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation.

Mol Metab 2016 Jul 23;5(7):506-526. Epub 2016 Apr 23.

Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Nutrition, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Nutrition Obesity Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2016.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921943PMC
July 2016

CYP450-derived oxylipins mediate inflammatory resolution.

Proc Natl Acad Sci U S A 2016 Jun 25;113(23):E3240-9. Epub 2016 May 25.

Comparative Biomedical Sciences, Royal Veterinary College, London NW1 0TU, United Kingdom

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http://dx.doi.org/10.1073/pnas.1521453113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988604PMC
June 2016

Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium.

Exp Neurol 2016 May 20;279:75-85. Epub 2016 Feb 20.

Department of Anesthesiology & Perioperative Medicine, The Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2016.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834246PMC
May 2016

Contribution of alveolar type II cell-derived cyclooxygenase-2 to basal airway function, lung inflammation, and lung fibrosis.

FASEB J 2016 Jan 22;30(1):160-73. Epub 2015 Sep 22.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684524PMC
January 2016

Cytochrome P450-derived epoxyeicosatrienoic acids and coronary artery disease in humans: a targeted metabolomics study.

J Lipid Res 2016 Jan 10;57(1):109-19. Epub 2015 Nov 10.

Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, University of North Carolina at Chapel Hill School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC Center for Pharmacogenomics and Individualized Therapy, University of North Carolina at Chapel Hill School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC McAllister Heart Institute, University of North Carolina at Chapel Hill School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC

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http://dx.doi.org/10.1194/jlr.M061697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689337PMC
January 2016

Indoor determinants of dustborne allergens in Mexican homes.

Allergy Asthma Proc 2015 Mar-Apr;36(2):130-7

Instituto Nacional de Salud Pública, Av. Universidad No. 655, Col. Santa María Ahuacatitlán, Cuernavaca, Morelos, Mexico.

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http://dx.doi.org/10.2500/aap.2015.36.3801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338857PMC
December 2015

Endotoxin Exposure: Predictors and Prevalence of Associated Asthma Outcomes in the United States.

Am J Respir Crit Care Med 2015 Dec;192(11):1287-97

2 Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina; and.

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http://dx.doi.org/10.1164/rccm.201502-0251OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731700PMC
December 2015

Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.

FASEB J 2015 Nov 16;29(11):4568-78. Epub 2015 Jul 16.

*National Heart and Lung Institute, Imperial College London, London, United Kingdom; William Harvey Research Institute, Queen Mary University of London, London, United Kingdom; National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA; Department of Comparative Biomedical Sciences, Royal Veterinary College, London, United Kingdom; Department of Pharmacology and Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA; and Immunology Department, Barts Health and the London National Health Service Trust, London, United Kingdom

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http://www.fasebj.org/content/early/2015/07/16/fj.15-275065.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608906PMC
November 2015

Epoxyeicosatrienoic acids regulate macrophage polarization and prevent LPS-induced cardiac dysfunction.

J Cell Physiol 2015 Sep;230(9):2108-19

Departments of Internal Medicine and Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.1002/jcp.24939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467528PMC
September 2015

Quantitative Polymerase Chain Reaction Analysis of the Mouse Cyp2j Subfamily: Tissue Distribution and Regulation.

Drug Metab Dispos 2015 Aug 20;43(8):1169-80. Epub 2015 May 20.

Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina

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http://dx.doi.org/10.1124/dmd.115.064139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518061PMC
August 2015

Intimal smooth muscle cells are a source but not a sensor of anti-inflammatory CYP450 derived oxylipins.

Biochem Biophys Res Commun 2015 Aug 15;463(4):774-80. Epub 2015 Jun 15.

Comparative Biomedical Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533761PMC
August 2015

Vascular actions of 20-HETE.

Prostaglandins Other Lipid Mediat 2015 Jul 23;120:9-16. Epub 2015 Mar 23.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2015.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575602PMC
July 2015

Soluble epoxide hydrolase null mice exhibit female and male differences in regulation of vascular homeostasis.

Prostaglandins Other Lipid Mediat 2015 Jul 20;120:139-47. Epub 2015 Apr 20.

Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA; Department of Internal Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA. Electronic address:

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http://dx.doi.org/10.1016/j.prostaglandins.2015.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575626PMC
July 2015

CYP2J2 overexpression ameliorates hyperlipidemia via increased fatty acid oxidation mediated by the AMPK pathway.

Obesity (Silver Spring) 2015 Jul 5;23(7):1401-13. Epub 2015 Jun 5.

Department of Internal Medicine, Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

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http://dx.doi.org/10.1002/oby.21115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565055PMC
July 2015

Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment.

Nature 2015 Jul;523(7561):468-71

1] Stem Cell Program and Division of Haematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachuestts 02115, USA [2] Chemical Biology Program, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nature14569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754787PMC
July 2015

Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli.

J Leukoc Biol 2015 Apr 5;97(4):723-36. Epub 2015 Feb 5.

*Laboratories of Signal Transduction and Respiratory Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA; and Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina, USA

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http://dx.doi.org/10.1189/jlb.3A0214-106RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370050PMC
April 2015

Cardiomyocyte-specific expression of CYP2J2 prevents development of cardiac remodelling induced by angiotensin II.

Cardiovasc Res 2015 Mar 24;105(3):304-17. Epub 2015 Jan 24.

Department of Internal Medicine and Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Jiefang Avenue, Wuhan 430030, P. R. China

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http://dx.doi.org/10.1093/cvr/cvv018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351370PMC
March 2015

Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine.

Xenobiotica 2015 Feb 20;45(2):124-30. Epub 2014 Aug 20.

Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd. , Kainan, Wakayama , Japan .

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http://dx.doi.org/10.3109/00498254.2014.952800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294552PMC
February 2015

CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPARγ.

Am J Physiol Endocrinol Metab 2015 Feb 11;308(4):E270-82. Epub 2014 Nov 11.

Departments of Internal Medicine and Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; and

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http://dx.doi.org/10.1152/ajpendo.00118.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329496PMC
February 2015

Genetic variation in HTR4 and lung function: GWAS follow-up in mouse.

FASEB J 2015 Jan 23;29(1):323-35. Epub 2014 Oct 23.

*Division of Intramural Research, National Institute of Environmental Health Sciences, U.S. National Institutes of Health, Research Triangle Park, North Carolina, USA; and Division of the National Toxicology Program, U.S. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA

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http://dx.doi.org/10.1096/fj.14-253898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285547PMC
January 2015

CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice.

Am J Physiol Endocrinol Metab 2015 Jan 11;308(2):E97-E110. Epub 2014 Nov 11.

Department of Internal Medicine and Gene Therapy Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China;

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http://dx.doi.org/10.1152/ajpendo.00366.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297779PMC
January 2015

CYP2J2 targeting to endothelial cells attenuates adiposity and vascular dysfunction in mice fed a high-fat diet by reprogramming adipocyte phenotype.

Hypertension 2014 Dec 22;64(6):1352-61. Epub 2014 Sep 22.

From the Departments of Medicine and Pharmacology, New York Medical College, Valhalla (N.G.A., M.L.S.); Departments of Medicine and Obstetrics and Gynecology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV (K.S., A.M.S.); Biochemistry Section and Medicinal Chemistry Section, Department of Drug Sciences, University of Catania, Catania, Italy (L.V.); Department of Clinical and Experimental Sciences, Division of Anatomy and Physiopathology, University of Brescia, Brescia, Italy (G.F., R.R.); Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC (C.L., D.C.Z.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.03884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230994PMC
December 2014

Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006.

J Allergy Clin Immunol 2014 Aug 9;134(2):350-9. Epub 2014 Feb 9.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.12.1071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119838PMC
August 2014

Cyp2c44 epoxygenase in the collecting duct is essential for the high K+ intake-induced antihypertensive effect.

Am J Physiol Renal Physiol 2014 Aug 25;307(4):F453-60. Epub 2014 Jun 25.

Department of Medicine, Vanderbilt University, Nashville, Tennessee.

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http://dx.doi.org/10.1152/ajprenal.00123.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137132PMC
August 2014

Vascular characterization of mice with endothelial expression of cytochrome P450 4F2.

FASEB J 2014 Jul 25;28(7):2915-31. Epub 2014 Mar 25.

Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA;

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http://dx.doi.org/10.1096/fj.13-241927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062824PMC
July 2014

Respiratory disease in United States farmers.

Occup Environ Med 2014 Jul;71(7):484-91

Epidemiology Branch, National Institute of Environmental Health Sciences, NIH/DHHS, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1136/oemed-2013-101983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542002PMC
July 2014

High salt diet exacerbates vascular contraction in the absence of adenosine A₂A receptor.

J Cardiovasc Pharmacol 2014 May;63(5):385-94

*Department of Physiology and Pharmacology/Department of Basic Pharmaceutical Sciences, Center for Cardiovascular and Respiratory Sciences, School of Medicine/School of Pharmacy, West Virginia University, Morgantown, WV; †Division of Intramural Research, Pulmonary Department, NIEHS/NIH, Research Triangle Park, NC; ‡IRIBHN, Universite Libre de Bruxelles, Bruxelles, Belgium; and §Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX.

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http://dx.doi.org/10.1097/FJC.0000000000000058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013230PMC
May 2014

Basal and inducible anti-inflammatory epoxygenase activity in endothelial cells.

Biochem Biophys Res Commun 2014 Apr 13;446(2):633-7. Epub 2014 Mar 13.

Comparative Biomedical Sciences, Royal Veterinary College, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991391PMC
April 2014

Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report.

Arterioscler Thromb Vasc Biol 2014 Mar 23;34(3):581-6. Epub 2014 Jan 23.

From the Department of Ophthalmology, Boston Children's Hospital (Z.S., Z.F., J.-S.J., C. Hatton, A.J., C. Hurst, L.E., Z.C., D.P., Y.G., D.X., K.T., H.B., J.C., L.E.H.S.) and Department of Pathology, Beth Israel Deaconess Medical Center (D.P.), Harvard Medical School, Boston, MA; University Eye Hospital Freiburg, Freiburg, Germany (A.S.); Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, NC (M.L.E., F.L., D.C.Z.); Department of Ophthalmology, Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, Quebec, Canada (P.S.); and Department of Ophthalmology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden (A.H.).

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http://dx.doi.org/10.1161/ATVBAHA.113.302927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005334PMC
March 2014

CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure.

Mol Pharmacol 2014 Jan 21;85(1):105-15. Epub 2013 Oct 21.

Department of Internal Medicine, Institute of Hypertension, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China (X.W., L.N., L.Y., Q.D., C.C., D.W.W.); and the Division of Intramural Research, National Institutes of Health National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina (M.L.E., D.C.Z.).

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http://dx.doi.org/10.1124/mol.113.087122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868901PMC
January 2014

Relationship between serum cholesterol and indices of erythrocytes and platelets in the US population.

J Lipid Res 2013 Nov 2;54(11):3177-88. Epub 2013 Sep 2.

Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709.

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http://www.jlr.org/lookup/doi/10.1194/jlr.P037614
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http://dx.doi.org/10.1194/jlr.P037614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793622PMC
November 2013

Nitrogen dioxide and allergic sensitization in the 2005-2006 National Health and Nutrition Examination Survey.

Respir Med 2013 Nov 28;107(11):1763-72. Epub 2013 Aug 28.

Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1016/j.rmed.2013.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071349PMC
November 2013

Role of caveolae in shear stress-mediated endothelium-dependent dilation in coronary arteries.

Cardiovasc Res 2013 Oct 19;100(1):151-9. Epub 2013 Jun 19.

Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1093/cvr/cvt157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778958PMC
October 2013

Phthalate exposure and allergy in the U.S. population: results from NHANES 2005-2006.

Environ Health Perspect 2013 Oct 25;121(10):1129-34. Epub 2013 Jun 25.

Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Heath and Human Services (DHHS), Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/ehp.1206211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801456PMC
October 2013