Publications by authors named "Darren R Carpizo"

41Publications

Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants.

Elife 2020 Dec 2;9. Epub 2020 Dec 2.

Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, United States.

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http://dx.doi.org/10.7554/eLife.61487DOI Listing
December 2020

Does Major Pancreatic Surgery Have Utility in Nonagenarians with Pancreas Cancer?

Ann Surg Oncol 2020 Nov 3. Epub 2020 Nov 3.

Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, GA, Georgia.

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http://dx.doi.org/10.1245/s10434-020-09279-8DOI Listing
November 2020

Conditional survival analysis of hepatocellular carcinoma.

J Surg Oncol 2020 Jun 10. Epub 2020 Jun 10.

Division of Surgical Oncology, Wilmot Cancer Institute, University of Rochester, Rochester, New York.

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http://dx.doi.org/10.1002/jso.26049DOI Listing
June 2020

IGF2 drives formation of ileal neuroendocrine tumors in patients and mice.

Endocr Relat Cancer 2020 03;27(3):175-186

Raymond and Beverly Sackler Foundation, New Brunswick, New Jersey, USA.

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http://dx.doi.org/10.1530/ERC-19-0505DOI Listing
March 2020

Modernizing the clinical risk score to more accurately predict survival following resection of colorectal liver metastases.

Transl Gastroenterol Hepatol 2019 26;4:49. Epub 2019 Jun 26.

Department of Surgery, Saint Barnabas Medical Center, RWJBarnabas Health, Livingston, NJ, USA.

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http://dx.doi.org/10.21037/tgh.2019.06.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624353PMC
June 2019

Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding.

Mol Cancer Ther 2019 08 13;18(8):1355-1365. Epub 2019 Jun 13.

Program of Surgical Oncology, Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, New Jersey.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-1080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677634PMC
August 2019

Flipping the "switch" on mutant p53 by zinc metallochaperones: how a brief pulse of zinc can reactivate mutant p53 to kill cancer.

Oncotarget 2019 Jan 29;10(9):918-919. Epub 2019 Jan 29.

Darren R. Carpizo: Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA; Department of Pharmacology, Rutgers University, Piscataway, NJ, USA; Z53 Therapeutics Inc.

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http://dx.doi.org/10.18632/oncotarget.26561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398179PMC
January 2019

Adjuvant therapeutic strategies for resectable pancreatic adenocarcinoma.

Ann Pancreat Cancer 2018 Aug 6;1. Epub 2018 Aug 6.

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.

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http://dx.doi.org/10.21037/apc.2018.07.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345263PMC
August 2018

Zinc Metallochaperones as Mutant p53 Reactivators: A New Paradigm in Cancer Therapeutics.

Cancers (Basel) 2018 May 29;10(6). Epub 2018 May 29.

Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.

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http://dx.doi.org/10.3390/cancers10060166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025018PMC
May 2018

Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle Arrest in Glioblastoma-Patient-Derived Cells.

Cell Chem Biol 2018 05 22;25(5):585-594.e7. Epub 2018 Mar 22.

Department of Biological Sciences, Columbia University, New York, NY 10027, USA; Department of Chemistry, Columbia University, New York, NY 10027, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959763PMC
May 2018

A novel combined interventional radiologic and hepatobiliary surgical approach to a complex traumatic hilar biliary stricture.

Int J Surg Case Rep 2018 3;44:185-190. Epub 2018 Mar 3.

Department of Surgery, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA; Division of Surgical Oncology, Department of Surgery, Rutgers Cancer Institute of New Jersey, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1016/j.ijscr.2018.02.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928284PMC
March 2018

U1 Adaptors Suppress the Oncogenic Axis in Human Pancreatic Cancer Xenografts.

Mol Cancer Ther 2017 08 4;16(8):1445-1455. Epub 2017 Apr 4.

Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.

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http://dx.doi.org/10.1158/1535-7163.MCT-16-0867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544574PMC
August 2017

Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53.

Mol Pharmacol 2017 06 20;91(6):567-575. Epub 2017 Mar 20.

Rutgers Cancer Institute of New Jersey (X.Y., A.T.T., S.Z., Y.L., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., A.T.T, Y.L., D.R.C.), Rutgers Translational Sciences, Department of Chemistry and Chemical Biology (S.D.K.), Department of Medicinal Chemistry, Rutgers Ernest Mario School of Pharmacy (J.G., A.F.B., S.D.K.), Rutgers University, New Brunswick, New Jersey; Department of Biochemistry and Molecular Biology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York (A.B., S.N.L.); and Mount Sinai St. Luke's Roosevelt General Surgery Residency Program, New York, New York (A.T.T.)

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http://dx.doi.org/10.1124/mol.116.107409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438133PMC
June 2017

Corrigendum to "Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer" [Drug Discov. Today 20 (11) (2015) 1391-1397].

Drug Discov Today 2016 10 29;21(10):1728. Epub 2016 Jul 29.

Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA; Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2016.07.012DOI Listing
October 2016

Fluid administration and morbidity in transhiatal esophagectomy.

J Surg Res 2016 Jan 16;200(1):91-7. Epub 2015 Jul 16.

Department of Surgery, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, 08903; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, 08903. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2015.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914131PMC
January 2016

Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer.

Drug Discov Today 2015 11 20;20(11):1391-7. Epub 2015 Jul 20.

Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA; Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2015.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922747PMC
November 2015

Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing.

Genes Dev 2015 Jul 15;29(14):1576-85. Epub 2015 Jul 15.

Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA; Cancer Biology Program, Stanford University School of Medicine, Stanford, California 94305, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1101/gad.264861.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526740PMC
July 2015

A sensitive liquid chromatography-mass spectrometry bioanalytical assay for a novel anticancer candidate--ZMC1.

Biomed Chromatogr 2015 Nov 5;29(11):1708-14. Epub 2015 May 5.

Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ, 08901, USA.

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http://dx.doi.org/10.1002/bmc.3483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481844PMC
November 2015

Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore.

Mol Pharmacol 2015 May 20;87(5):825-31. Epub 2015 Feb 20.

Department of Biochemistry and Molecular Biology (A.R.B.,S.N.L.) and Department of Neuroscience and Physiology (R.S.O., E.C.O.), State University of New York Upstate Medical University, Syracuse, New York; Rutgers Cancer Institute of New Jersey (X.Y., D.R.C.), Department of Surgery, Rutgers Robert Wood Johnson Medical School (X.Y., D.R.C.), Office of Translational Sciences (J.A.G., D.J.A., S.D.K.), and Department of Chemistry and Chemical Biology (T.J.E.), Rutgers University, New Brunswick, New Jersey; and Department of Physics, Syracuse University, Syracuse, New York (A.J.W., L.M.)

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http://dx.doi.org/10.1124/mol.114.097550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407733PMC
May 2015

The relationship of perioperative fluid administration to outcomes in colorectal and pancreatic surgery: a review of the literature.

J Surg Oncol 2015 Mar 2;111(4):472-7. Epub 2015 Feb 2.

Department of Surgery, Division of Surgical Oncology, Rutgers Cancer Institute of New Jersey, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey.

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http://dx.doi.org/10.1002/jso.23857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499324PMC
March 2015

Outcomes of microwave ablation for colorectal cancer liver metastases: a single center experience.

J Surg Oncol 2015 Mar 29;111(4):410-3. Epub 2014 Dec 29.

Department of Surgery, Division of Surgical Oncology, Rutgers-Robert Wood Johnson Medical School/Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.

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http://dx.doi.org/10.1002/jso.23849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499323PMC
March 2015

Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism.

Oncotarget 2014 Oct;5(19):8879-92

Rutgers Cancer Institute of New Jersey, New Jersey. Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253404PMC
http://dx.doi.org/10.18632/oncotarget.2432DOI Listing
October 2014

Small molecule compounds targeting the p53 pathway: are we finally making progress?

Apoptosis 2014 Jul;19(7):1055-68

Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers-The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ, 08903, USA.

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http://dx.doi.org/10.1007/s10495-014-0990-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039992PMC
July 2014

Pilot study of angiogenic response to yttrium-90 radioembolization with resin microspheres.

J Vasc Interv Radiol 2014 Feb 20;25(2):297-306.e1. Epub 2013 Dec 20.

Department of Radiology, Rutgers Robert Wood Johnson Medical School, One Robert Wood Johnson Place MEB 404, PO Box 19, New Brunswick, NJ 08903-0019. Electronic address:

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http://dx.doi.org/10.1016/j.jvir.2013.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496007PMC
February 2014

Intraoperative fluid administration is associated with perioperative outcomes in pancreaticoduodenectomy: a single center retrospective analysis.

J Surg Oncol 2013 Sep 1;108(4):242-7. Epub 2013 Aug 1.

Division of Surgical Oncology, Department of Surgery, Rutgers-Robert Wood Johnson Medical School/Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.

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http://dx.doi.org/10.1002/jso.23393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481842PMC
September 2013

Safety and efficacy of LigaSure usage in pancreaticoduodenectomy.

HPB (Oxford) 2013 Oct 19;15(10):747-52. Epub 2013 Jun 19.

Department of Surgery, The Cancer Institute of New Jersey, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ.

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http://dx.doi.org/10.1111/hpb.12116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791113PMC
October 2013

Evaluation of hepatic tumor response to yttrium-90 radioembolization therapy using texture signatures generated from contrast-enhanced CT images.

Acad Radiol 2012 Oct 26;19(10):1201-7. Epub 2012 Jul 26.

Center for Biomedical Imaging & Informatics, The Cancer Institute of New Jersey, 195 Little Albany St, Room 3521, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1016/j.acra.2012.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438382PMC
October 2012

Allele-specific p53 mutant reactivation.

Cancer Cell 2012 May;21(5):614-25

The Cancer Institute of New Jersey, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.03.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366694PMC
May 2012

Liver resection for metastatic colorectal cancer in the presence of extrahepatic disease.

Lancet Oncol 2009 Aug;10(8):801-9

Division of Surgical Oncology, The Cancer Institute of New Jersey, Robert Wood-Johnson University Medical School, New Brunswick, NJ, USA.

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http://dx.doi.org/10.1016/S1470-2045(09)70081-6DOI Listing
August 2009

Liver resection for metastatic colorectal cancer in the presence of extrahepatic disease.

Ann Surg Oncol 2009 Sep 25;16(9):2411-21. Epub 2009 Jun 25.

Division of Surgical Oncology, The Cancer Institute of New Jersey, Robert Wood-Johnson University Medical School, New Brunswick, NJ, USA.

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http://dx.doi.org/10.1245/s10434-009-0493-6DOI Listing
September 2009

Liver resection for metastatic colorectal cancer in patients with concurrent extrahepatic disease: results in 127 patients treated at a single center.

Ann Surg Oncol 2009 Aug 3;16(8):2138-46. Epub 2009 Jun 3.

Division of Surgical Oncology, The Cancer Institute of New Jersey, Robert Wood-Johnson University Medical School, New Brunswick, NJ, USA.

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http://www.springerlink.com/index/10.1245/s10434-009-0521-6
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http://dx.doi.org/10.1245/s10434-009-0521-6DOI Listing
August 2009

Management and extent of resection for intrahepatic cholangiocarcinoma.

Surg Oncol Clin N Am 2009 Apr;18(2):289-305, viii-ix

Division of Surgery, UMDNJ-Robert Wood Johnson Medical School, The Cancer Institute of New Jersey, 195 Little Albany Street, Room 3040, New Brunswick, NJ 08901, USA.

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http://dx.doi.org/10.1016/j.soc.2008.12.010DOI Listing
April 2009

ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165.

J Biol Chem 2003 Jun 25;278(26):23656-65. Epub 2003 Apr 25.

Department of Molecular, University of California, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1074/jbc.M212964200DOI Listing
June 2003