Darren Plant

Darren Plant

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Differential DNA methylation correlates with response to methotrexate in rheumatoid arthritis.

Rheumatology (Oxford) 2019 Oct 10. Epub 2019 Oct 10.

University College Dublin School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1093/rheumatology/kez411DOI Listing
October 2019

A Dashboard for Latent Class Trajectory Modeling: Application in Rheumatoid Arthritis.

Stud Health Technol Inform 2019 Aug;264:911-915

Centre for Health Informatics, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.3233/SHTI190356DOI Listing
August 2019

Adding value to real-world data: the role of biomarkers.

Rheumatology (Oxford) 2019 Apr 16. Epub 2019 Apr 16.

Manchester Academic Health Science Centre, The University of Manchester, Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester, UK.

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http://dx.doi.org/10.1093/rheumatology/kez113DOI Listing
April 2019

Assessing the Role of DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio in Rheumatoid Arthritis.

J Immunol Res 2018 14;2018:2624981. Epub 2018 Aug 14.

MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.

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http://dx.doi.org/10.1155/2018/2624981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112073PMC
November 2018

Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis.

Pharmacogenomics J 2018 09 31;18(5):657-664. Epub 2018 Aug 31.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/s41397-018-0040-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150911PMC
September 2018

Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins.

Genome Med 2018 09 4;10(1):64. Epub 2018 Sep 4.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s13073-018-0575-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122744PMC
September 2018

HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome-wide association study.

Ann Rheum Dis 2017 12 12;76(12):e51. Epub 2017 May 12.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2017-211512DOI Listing
December 2017

The predictive value of serum S100A9 and response to etanercept is not confirmed in a large UK rheumatoid arthritis cohort.

Rheumatology (Oxford) 2017 06;56(6):1019-1024

Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, The University of Manchester.

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http://dx.doi.org/10.1093/rheumatology/kew387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5445600PMC
June 2017

High frequency of antidrug antibodies and association of random drug levels with efficacy in certolizumab pegol-treated patients with rheumatoid arthritis: results from the BRAGGSS cohort.

Ann Rheum Dis 2017 Jan 31;76(1):208-213. Epub 2016 May 31.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2015-208849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264213PMC
January 2017

Detection of anti-drug antibodies using a bridging ELISA compared with radioimmunoassay in adalimumab-treated rheumatoid arthritis patients with random drug levels.

Rheumatology (Oxford) 2016 Nov 25;55(11):2050-2055. Epub 2016 Aug 25.

NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK

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http://dx.doi.org/10.1093/rheumatology/kew299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088626PMC
November 2016

Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23.

Genome Biol 2016 11 1;17(1):212. Epub 2016 Nov 1.

Arthritis Research UK Centre for Genetics and Genomics, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1186/s13059-016-1078-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088679PMC
November 2016

Differential Methylation as a Biomarker of Response to Etanercept in Patients With Rheumatoid Arthritis.

Arthritis Rheumatol 2016 06 21;68(6):1353-60. Epub 2016 Apr 21.

NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, and Central Manchester NHS Trust, and Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1002/art.39590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914881PMC
June 2016

Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort.

Pharmacogenomics 2016 05 16;17(7):715-20. Epub 2016 May 16.

Arthritis Research UK, Centre for Genetics & Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.2217/pgs.16.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996314PMC
May 2016

Major histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis.

Sci Rep 2016 04 25;6:25014. Epub 2016 Apr 25.

Arthritis Research UK Centre for Genetics and Genomics, Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, Manchester Academic Health Science Centre, University of Manchester, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1038/srep25014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842957PMC
April 2016

Genetic and genomic markers of anti-TNF treatment response in rheumatoid arthritis.

Biomark Med 2015 ;9(6):499-512

Arthritis Research UK Centre for Genetics & Genomics, Centre for Musculoskeletal Research, Institute of Inflammation & Repair, University Of Manchester, Manchester, M13 9PL, UK.

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http://dx.doi.org/10.2217/bmm.15.18DOI Listing
March 2016

Investigating CD11c expression as a potential genomic biomarker of response to TNF inhibitor biologics in whole blood rheumatoid arthritis samples.

Arthritis Res Ther 2015 Dec 14;17:359. Epub 2015 Dec 14.

Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, the University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s13075-015-0868-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704535PMC
December 2015

Association of chemokine CXC ligand 12 gene polymorphism (rs1746048) with cardiovascular mortality in patients with rheumatoid arthritis: results from the Norfolk Arthritis Register.

Ann Rheum Dis 2015 Nov 31;74(11):2099-102. Epub 2015 Aug 31.

Arthritis Research UK Centre for Epidemiology, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

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http://ard.bmj.com/content/74/11/2099.full.pdf
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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2015-20785
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http://dx.doi.org/10.1136/annrheumdis-2015-207851DOI Listing
November 2015

Clinical utility of random anti-tumor necrosis factor drug-level testing and measurement of antidrug antibodies on the long-term treatment response in rheumatoid arthritis.

Arthritis Rheumatol 2015 May;67(8):2011-9

Darren Plant, PhD, Anne Barton, MBChB, PhD, FRCP: Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, and NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, UK.

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http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(
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http://doi.wiley.com/10.1002/art.39169
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http://dx.doi.org/10.1002/art.39169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843946PMC
May 2015

Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.

JAMA 2015 Apr;313(16):1645-56

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, England2NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manches.

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http://dx.doi.org/10.1001/jama.2015.3435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928097PMC
April 2015

Impact of inadequate adherence on response to subcutaneously administered anti-tumour necrosis factor drugs: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort.

Rheumatology (Oxford) 2015 Mar 10;54(3):494-9. Epub 2014 Sep 10.

Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, National Institute of Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science, Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, National Institute of Health Research Leeds Musculoskeletal Biomedical Research Unit, Leeds, Academic Unit of Rheumatology, Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and National Institute of Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne and Institute for Inflammation and Repair, University of Manchester, Manchester, UK. Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, National Institute of Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science, Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, National Institute of Health Research Leeds Musculoskeletal Biomedical Research Unit, Leeds, Academic Unit of Rheumatology, Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University and National Institute of Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne and Institute for Inflammation and Repair, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1093/rheumatology/keu358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334684PMC
March 2015

Clinical utility of random anti-tumour necrosis factor drug testing and measurement of anti-drug antibodies on long-term treatment response in rheumatoid arthritis.

Lancet 2015 Feb;385 Suppl 1:S48

Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, UK.

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http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(
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http://linkinghub.elsevier.com/retrieve/pii/S014067361560363
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http://dx.doi.org/10.1016/S0140-6736(15)60363-4DOI Listing
February 2015

Genetic and epigenetic predictors of responsiveness to treatment in RA.

Nat Rev Rheumatol 2014 Jun 18;10(6):329-37. Epub 2014 Feb 18.

Arthritis Research UK Centre of Excellence for Musculoskeletal Genetics, Manchester Academy of Health Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1038/nrrheum.2014.16DOI Listing
June 2014

Testing the role of vitamin D in response to antitumour necrosis factor α therapy in a UK cohort: a Mendelian randomisation approach.

Ann Rheum Dis 2014 May 9;73(5):938-40. Epub 2013 Dec 9.

Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, , Manchester, UK.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2013-20444
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http://dx.doi.org/10.1136/annrheumdis-2013-204443DOI Listing
May 2014

Investigation of an interleukin-6 receptor gene polymorphism (rs2228145) as a predictor of cardiovascular mortality in inflammatory polyarthritis: results from the Norfolk Arthritis Register.

Ann Rheum Dis 2014 Apr 27;73(4):787-8. Epub 2013 Nov 27.

Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, , Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2013-204330DOI Listing
April 2014

The potential use of expression profiling: implications for predicting treatment response in rheumatoid arthritis.

Ann Rheum Dis 2013 Jul 13;72(7):1118-24. Epub 2013 Mar 13.

Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, School of Translational Medicine, University of Manchester, Manchester, UK.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2012-20274
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http://dx.doi.org/10.1136/annrheumdis-2012-202743DOI Listing
July 2013

Genetics and epigenetics of rheumatoid arthritis.

Nat Rev Rheumatol 2013 Mar 5;9(3):141-53. Epub 2013 Feb 5.

Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

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http://www.nature.com/articles/nrrheum.2012.237
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http://dx.doi.org/10.1038/nrrheum.2012.237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694322PMC
March 2013

Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients.

Ann Rheum Dis 2012 Dec 1;71(12):1984-90. Epub 2012 Jun 1.

Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2011-201225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595982PMC
December 2012

Heterogeneity of anticitrullinated peptide antibodies and response to anti-tumor necrosis factor agents in rheumatoid arthritis.

J Rheumatol 2012 May 1;39(5):929-32. Epub 2012 Apr 1.

Kennedy Institute of Rheumatology, Imperial College London, London, UK.

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http://dx.doi.org/10.3899/jrheum.111315DOI Listing
May 2012

Long-term stability of anti-cyclic citrullinated peptide antibody status in patients with early inflammatory polyarthritis.

Arthritis Res Ther 2012 May 9;14(3):R109. Epub 2012 May 9.

Arthritis Research UK Epidemiology Unit, Manchester Academy of Health Sciences, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

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http://arthritis-research.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/ar3834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446486PMC
May 2012

Genetic and genomic predictors of anti-TNF response.

Pharmacogenomics 2011 Nov;12(11):1571-85

Arthritis Research UK Epidemiology Unit, Manchester Academy of Health Sciences, University of Manchester, Manchester, UK.

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https://www.futuremedicine.com/doi/10.2217/pgs.11.114
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http://dx.doi.org/10.2217/pgs.11.114DOI Listing
November 2011

The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register.

Rheumatology (Oxford) 2011 Jan 10;50(1):78-84. Epub 2010 Mar 10.

ARC Epidemiology Unit, Manchester Academic Health Sciences Centre, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1093/rheumatology/keq032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999953PMC
January 2011

Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development.

Proc Natl Acad Sci U S A 2007 Dec 6;104(50):19966-70. Epub 2007 Dec 6.

Departments of Immunohematology and Blood Transfusion and Rheumatology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.

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http://dx.doi.org/10.1073/pnas.0710260104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2148406PMC
December 2007

The CX3CL1-CX3CR1 system and psoriasis.

Exp Dermatol 2006 Nov;15(11):900-3

Arc Epidemiology Unit, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/j.1600-0625.2006.00486.xDOI Listing
November 2006

Macrophage migration inhibitory factor gene polymorphism is associated with psoriasis.

J Invest Dermatol 2004 Sep;123(3):484-7

Arthritis Research Campaign Epidemiology Unit, Stopford Building, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/j.0022-202X.2004.23314.xDOI Listing
September 2004