Darren J Perkins

Darren J Perkins

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Darren J Perkins

Darren J Perkins

Publications by authors named "Darren J Perkins"

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Quantitation of TLR4 Internalization in Response to LPS in Thioglycollate Elicited Peritoneal mouse Macrophages by Flow Cytometry.

Bio Protoc 2019 Sep;9(18)

Department of Microbiology and Immunology, University of Maryland Baltimore, Baltimore, USA.

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http://dx.doi.org/10.21769/BioProtoc.3369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812529PMC
September 2019

Influenza "Trains" the Host for Enhanced Susceptibility to Secondary Bacterial Infection.

mBio 2019 05 7;10(3). Epub 2019 May 7.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.1128/mBio.00810-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509193PMC
May 2019

Autocrine-paracrine prostaglandin E signaling restricts TLR4 internalization and TRIF signaling.

Nat Immunol 2018 12 5;19(12):1309-1318. Epub 2018 Nov 5.

Department of Microbiology and Immunology, University of Maryland, Baltimore, School of Medicine, Baltimore, MD, USA.

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http://www.nature.com/articles/s41590-018-0243-7
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http://dx.doi.org/10.1038/s41590-018-0243-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240378PMC
December 2018

AMP-activated Kinase (AMPK) Promotes Innate Immunity and Antiviral Defense through Modulation of Stimulator of Interferon Genes (STING) Signaling.

J Biol Chem 2017 Jan 22;292(1):292-304. Epub 2016 Nov 22.

From the Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, Maryland 21201

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http://dx.doi.org/10.1074/jbc.M116.763268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217687PMC
January 2017

Type I interferon licenses enhanced innate recognition and transcriptional responses to Franciscella tularensis live vaccine strain.

Innate Immun 2016 07 26;22(5):363-72. Epub 2016 May 26.

Department of Microbiology and Immunology, University of Maryland, Baltimore (UMB), School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1177/1753425916650027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955828PMC
July 2016

Epigenetic Mechanisms Governing Innate Inflammatory Responses.

J Interferon Cytokine Res 2016 07;36(7):454-61

1 Department of Microbiology and Immunology, University of Maryland , Baltimore (UMB), School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1089/jir.2016.0003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931723PMC
July 2016

Inflammation: Species-specific TLR signalling -- insight into human disease.

Nat Rev Rheumatol 2016 Apr;12(4):198-200

Department of Microbiology and Immunology, University of Maryland, School of Medicine, 685 W. Baltimore Street, Suite 380, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1038/nrrheum.2016.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955569PMC
April 2016

Salmonella Typhimurium Co-Opts the Host Type I IFN System To Restrict Macrophage Innate Immune Transcriptional Responses Selectively.

J Immunol 2015 Sep 22;195(5):2461-71. Epub 2015 Jul 22.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201; and.

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http://dx.doi.org/10.4049/jimmunol.1500105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546913PMC
September 2015

Space and time: New considerations about the relationship between Toll-like receptors (TLRs) and type I interferons (IFNs).

Cytokine 2015 Aug 25;74(2):171-4. Epub 2015 Mar 25.

Department of Microbiology and Immunology, University of Maryland, Baltimore (UMB), School of Medicine, Baltimore, MD 21201, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2015.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475459PMC
August 2015

CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance.

Proc Natl Acad Sci U S A 2015 Jul 23;112(27):8391-6. Epub 2015 Jun 23.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1424980112
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http://dx.doi.org/10.1073/pnas.1424980112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500272PMC
July 2015

Invasive Salmonella Typhimurium ST313 with naturally attenuated flagellin elicits reduced inflammation and replicates within macrophages.

PLoS Negl Trop Dis 2015 Jan 8;9(1):e3394. Epub 2015 Jan 8.

Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland, United States of America; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0003394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287482PMC
January 2015

Reprogramming of murine macrophages through TLR2 confers viral resistance via TRAF3-mediated, enhanced interferon production.

PLoS Pathog 2013 11;9(7):e1003479. Epub 2013 Jul 11.

Department of Microbiology and Immunology, University of Maryland, Baltimore (UMB), School of Medicine, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708851PMC
February 2014

Dissociation of endotoxin tolerance and differentiation of alternatively activated macrophages.

J Immunol 2013 May 29;190(9):4763-72. Epub 2013 Mar 29.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.4049/jimmunol.1202407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633613PMC
May 2013

Transcriptional regulation of murine IL-33 by TLR and non-TLR agonists.

J Immunol 2012 Jul 25;189(1):50-60. Epub 2012 May 25.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.4049/jimmunol.1003554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437667PMC
July 2012

A Toll-like receptor-responsive kinase, protein kinase R, is inactivated in endotoxin tolerance through differential K63/K48 ubiquitination.

mBio 2010 Oct 26;1(5). Epub 2010 Oct 26.

Department of Microbiology and Immunology, University of Maryland, Baltimore (UMB), School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1128/mBio.00239-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962435PMC
October 2010

TLR4/MyD88/PI3K interactions regulate TLR4 signaling.

J Leukoc Biol 2009 Jun 16;85(6):966-77. Epub 2009 Mar 16.

University of Maryland, Baltimore, 660 W. Redwood Street, Room 324, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1189/jlb.1208763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698589PMC
June 2009

Bordetella pertussis adenylate cyclase toxin (ACT) induces cyclooxygenase-2 (COX-2) in murine macrophages and is facilitated by ACT interaction with CD11b/CD18 (Mac-1).

Mol Microbiol 2007 Nov 10;66(4):1003-15. Epub 2007 Oct 10.

Department of Microbiology and Immunology, University of Maryland, Baltimore (UMB), School of Medicine, 660 W. Baltimore Street, Suite 324, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2007.05972.xDOI Listing
November 2007

Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts.

Mol Cell Biol 2004 Mar;24(5):2025-40

Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC350553PMC
http://dx.doi.org/10.1128/mcb.24.5.2025-2040.2004DOI Listing
March 2004