Darrell R Borger

Darrell R Borger

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Darrell R Borger

Publications by authors named "Darrell R Borger"

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A Phase I, Open-Label, Multicenter, Dose-escalation Study of the Oral Selective FGFR Inhibitor Debio 1347 in Patients with Advanced Solid Tumors Harboring Gene Alterations.

Authors:
Martin H Voss Cinta Hierro Rebecca S Heist James M Cleary Funda Meric-Bernstam Josep Tabernero Filip Janku Leena Gandhi A John Iafrate Darrell R Borger Nobuya Ishii Youyou Hu Yulia Kirpicheva Valerie Nicolas-Metral Anna Pokorska-Bocci Anne Vaslin Chessex Claudio Zanna Keith T Flaherty Jose Baselga

Clin Cancer Res 2019 05 11;25(9):2699-2707. Epub 2019 Feb 11.

Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1959DOI Listing
May 2019

PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma.

Authors:
Shota Tanaka Tracy T Batchelor A John Iafrate Dora Dias-Santagata Darrell R Borger Leif W Ellisen Daniel Yang David N Louis Daniel P Cahill Andrew S Chi

Acta Neuropathol Commun 2019 04 29;7(1):66. Epub 2019 Apr 29.

Perlmutter Cancer Center, New York University Langone Health and School of Medicine, New York, USA.

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http://dx.doi.org/10.1186/s40478-019-0720-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487518PMC
April 2019

Enrichment of Amplification in Brain Metastases from Primary Gastrointestinal Malignancies.

Authors:
Devarati Mitra Jeffrey W Clark Helen A Shih Kevin S Oh Priscilla K Brastianos Jennifer Y Wo Matthew R Strickland William T Curry Aparna R Parikh Ryan B Corcoran David P Ryan A John Iafrate Darrell R Borger Jochen K Lennerz Theodore S Hong

Oncologist 2019 02 29;24(2):193-201. Epub 2018 Oct 29.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA

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http://theoncologist.alphamedpress.org/lookup/doi/10.1634/th
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http://dx.doi.org/10.1634/theoncologist.2018-0152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369954PMC
February 2019

Isocitrate dehydrogenase 1 and 2 mutations, 2-hydroxyglutarate levels, and response to standard chemotherapy for patients with newly diagnosed acute myeloid leukemia.

Authors:
Andrew M Brunner Donna S Neuberg Seth A Wander Hossein Sadrzadeh Karen K Ballen Philip C Amrein Eyal Attar Gabriela S Hobbs Yi-Bin Chen Ashley Perry Christine Connolly Christelle Joseph Meghan Burke Aura Ramos Ilene Galinsky Katharine Yen Hua Yang Kimberly Straley Sam Agresta Sophia Adamia Darrell R Borger Anthony Iafrate Timothy A Graubert Richard M Stone Amir T Fathi

Cancer 2019 02 13;125(4):541-549. Epub 2018 Nov 13.

Massachusetts General Hospital, Boston, Massachusetts.

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http://doi.wiley.com/10.1002/cncr.31729
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http://dx.doi.org/10.1002/cncr.31729DOI Listing
February 2019

L265P mutation and loss are early mutational events in primary central nervous system diffuse large B-cell lymphomas.

Authors:
Naema Nayyar Michael D White Corey M Gill Matthew Lastrapes Mia Bertalan Alexander Kaplan Megan R D'Andrea Ivanna Bihun Andrew Kaneb Jorg Dietrich Judith A Ferry Maria Martinez-Lage Anita Giobbie-Hurder Darrell R Borger Fausto J Rodriguez Matthew P Frosch Emily Batchelor Kaitlin Hoang Benjamin Kuter Sarah Fortin Matthias Holdhoff Daniel P Cahill Scott Carter Priscilla K Brastianos Tracy T Batchelor

Blood Adv 2019 02;3(3):375-383

Division of Hematology/Oncology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

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http://www.bloodadvances.org/lookup/doi/10.1182/bloodadvance
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http://dx.doi.org/10.1182/bloodadvances.2018027672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373750PMC
February 2019

Primary tumor sidedness is an independent prognostic marker for survival in metastatic colorectal cancer: Results from a large retrospective cohort with mutational analysis.

Authors:
Sophia C Kamran Jeffrey W Clark Hui Zheng Darrell R Borger Lawrence S Blaszkowsky Jill N Allen Eunice L Kwak Jennifer Y Wo Aparna R Parikh Ryan D Nipp Janet E Murphy Lipika Goyal Andrew X Zhu A John Iafrate Ryan B Corcoran David P Ryan Theodore S Hong

Cancer Med 2018 May 17. Epub 2018 May 17.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1002/cam4.1558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051212PMC
May 2018

Phase II Study of Proton-Based Stereotactic Body Radiation Therapy for Liver Metastases: Importance of Tumor Genotype.

Authors:
Theodore S Hong Jennifer Y Wo Darrell R Borger Beow Y Yeap Erin I McDonnell Henning Willers Lawrence S Blaszkowsky Eunice L Kwak Jill N Allen Jeffrey W Clark Shyam Tanguturi Lipika Goyal Janet E Murphy John A Wolfgang Lorraine C Drapek Ronald S Arellano Harvey J Mamon John T Mullen Kenneth K Tanabe Cristina R Ferrone David P Ryan A John Iafrate Thomas F DeLaney Andrew X Zhu

J Natl Cancer Inst 2017 09;109(9)

Department of Radiation Oncology, Department of Pathology, Division of Biostatistics, Department of Medicine, Division of Medical Oncology, Department of Medicine, Department of Radiology, and Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA; Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA; Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1093/jnci/djx031DOI Listing
September 2017

Targeted sequencing of SMO and AKT1 in anterior skull base meningiomas.

Authors:
Matthew R Strickland Corey M Gill Naema Nayyar Megan R D'Andrea Christian Thiede Tareq A Juratli Gabriele Schackert Darrell R Borger Sandro Santagata Matthew P Frosch Daniel P Cahill Priscilla K Brastianos Fred G Barker

J Neurosurg 2017 08 25;127(2):438-444. Epub 2016 Nov 25.

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.3171/2016.8.JNS161076DOI Listing
August 2017

A phase 2 and biomarker study of cabozantinib in patients with advanced cholangiocarcinoma.

Authors:
Lipika Goyal Hui Zheng Matthew B Yurgelun Thomas A Abrams Jill N Allen James M Cleary Michelle Knowles Eileen Regan Amanda Reardon Anna Khachatryan Rakesh K Jain Valentina Nardi Darrell R Borger Dan G Duda Andrew X Zhu

Cancer 2017 06 13;123(11):1979-1988. Epub 2017 Feb 13.

Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.30571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444988PMC
June 2017

Biliary Adenofibroma of Liver: Morphology, Tumor Genetics, and Outcomes in 6 Cases.

Authors:
Thomas Arnason Darrell R Borger Christopher Corless Catherine Hagen A John Iafrate Hala Makhlouf Joseph Misdraji Heidi Sapp Wilson M Tsui Ian R Wanless Tania Zuluaga Toro Gregory Y Lauwers

Am J Surg Pathol 2017 Apr;41(4):499-505

*Queen Elizabeth II Health Sciences Centre, Halifax, NS, Canada †Massachusetts General Hospital, Boston, MA ‡Oregon Health & Science University, Portland, OR §National Institute of Health/National Cancer Institute, Rockville, MD ∥Caritas Medical Center, Kowloon, Hong Kong ¶University of Florida, Gainesville, FL #University of California San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1097/PAS.0000000000000773DOI Listing
April 2017

Colorectal cancer in Crohn's colitis is comparable to sporadic colorectal cancer.

Authors:
Jochen K Lennerz Kimberley W J van der Sloot Long Phi Le Julie M Batten Jae Young Han Kenneth C Fan Corey A Siegel Amitabh Srivastava Do Youn Park Jey-Hsin Chen Bruce E Sands Joshua R Korzenik Robert D Odze Dora Dias-Santagata Darrell R Borger Hamed Khalili A John Iafrate Gregory Y Lauwers

Int J Colorectal Dis 2016 05 30;31(5):973-982. Epub 2016 Mar 30.

Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, 02116, USA.

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http://dx.doi.org/10.1007/s00384-016-2574-xDOI Listing
May 2016

Elevation of Urinary 2-Hydroxyglutarate in IDH-Mutant Glioma.

Authors:
Amir T Fathi Brian V Nahed Seth A Wander A John Iafrate Darrell R Borger Ranliang Hu Ashraf Thabet Daniel P Cahill Ashley M Perry Christelle P Joseph Alona Muzikansky Andrew S Chi

Oncologist 2016 Feb 1;21(2):214-9. Epub 2016 Feb 1.

Division of Neuro-Oncology, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA Division of Hematology/Oncology, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1634/theoncologist.2015-0342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746092PMC
February 2016

Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET-Amplified Esophagogastric Cancer.

Authors:
Eunice L Kwak Leanne G Ahronian Giulia Siravegna Benedetta Mussolin Darrell R Borger Jason T Godfrey Nicholas A Jessop Jeffrey W Clark Lawrence S Blaszkowsky David P Ryan Jochen K Lennerz A John Iafrate Alberto Bardelli Theodore S Hong Ryan B Corcoran

Cancer Discov 2015 12 2;5(12):1271-81. Epub 2015 Oct 2.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts. Department of Medicine, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670804PMC
December 2015

Detection of Dual IDH1 and IDH2 Mutations by Targeted Next-Generation Sequencing in Acute Myeloid Leukemia and Myelodysplastic Syndromes.

Authors:
Mia Y Platt Amir T Fathi Darrell R Borger Andrew M Brunner Robert P Hasserjian Leonora Balaj Amy Lum Stephen Yip Dora Dias-Santagata Zongli Zheng Long P Le Timothy A Graubert A John Iafrate Valentina Nardi

J Mol Diagn 2015 Nov 30;17(6):661-8. Epub 2015 Aug 30.

Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15251578150014
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http://dx.doi.org/10.1016/j.jmoldx.2015.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630164PMC
November 2015

Prognosis and Clinicopathologic Features of Patients With Advanced Stage Isocitrate Dehydrogenase (IDH) Mutant and IDH Wild-Type Intrahepatic Cholangiocarcinoma.

Authors:
Lipika Goyal Aparna Govindan Rahul A Sheth Valentina Nardi Lawrence S Blaszkowsky Jason E Faris Jeffrey W Clark David P Ryan Eunice L Kwak Jill N Allen Janet E Murphy Supriya K Saha Theodore S Hong Jennifer Y Wo Cristina R Ferrone Kenneth K Tanabe Dawn Q Chong Vikram Deshpande Darrell R Borger A John Iafrate Nabeel Bardeesy Hui Zheng Andrew X Zhu

Oncologist 2015 Sep 5;20(9):1019-27. Epub 2015 Aug 5.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA

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http://dx.doi.org/10.1634/theoncologist.2015-0210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571807PMC
September 2015

Squamous Cell Carcinoma of the Vulva: A Subclassification of 97 Cases by Clinicopathologic, Immunohistochemical, and Molecular Features (p16, p53, and EGFR).

Authors:
Fei Dong Sakiko Kojiro Darrell R Borger Whitfield B Growdon Esther Oliva

Am J Surg Pathol 2015 Aug;39(8):1045-53

Departments of *Pathology †Obstetrics and Gynecology, Massachusetts General Hospital, Boston.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/PAS.0000000000000454DOI Listing
August 2015

HER2 over-expressing high grade endometrial cancer expresses high levels of p95HER2 variant.

Authors:
Whitfield B Growdon Jolijn Groeneweg Virginia Byron Celeste DiGloria Darrell R Borger Rosemary Tambouret Rosemary Foster Ahmed Chenna Jeff Sperinde John Winslow Bo R Rueda

Gynecol Oncol 2015 Apr 17;137(1):160-6. Epub 2015 Jan 17.

Vincent Center for Reproductive Biology, Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, United States; Gynecologic Oncology Division, Vincent Department of Obstetrics & Gynecology, Massachusetts General Hospital, Boston, MA 02114, United States; Harvard Medical School, Boston, MA 02115, United States.

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http://dx.doi.org/10.1016/j.ygyno.2015.01.533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380649PMC
April 2015

Microsatellite instability in gallbladder carcinoma.

Authors:
Andrea P Moy Mohammad Shahid Cristina R Ferrone Darrell R Borger Andrew X Zhu David Ting Vikram Deshpande

Virchows Arch 2015 Apr 14;466(4):393-402. Epub 2015 Feb 14.

Pathology Service, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Warren 256, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s00428-015-1720-0DOI Listing
April 2015

RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer.

Authors:
Matthew J Niederst Lecia V Sequist John T Poirier Craig H Mermel Elizabeth L Lockerman Angel R Garcia Ryohei Katayama Carlotta Costa Kenneth N Ross Teresa Moran Emily Howe Linnea E Fulton Hillary E Mulvey Lindsay A Bernardo Farhiya Mohamoud Norikatsu Miyoshi Paul A VanderLaan Daniel B Costa Pasi A Jänne Darrell R Borger Sridhar Ramaswamy Toshi Shioda Anthony J Iafrate Gad Getz Charles M Rudin Mari Mino-Kenudson Jeffrey A Engelman

Nat Commun 2015 Mar 11;6:6377. Epub 2015 Mar 11.

1] Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA [2] Department of Medicine, Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncomms7377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357281PMC
March 2015

Dual HER2 targeting impedes growth of HER2 gene-amplified uterine serous carcinoma xenografts.

Authors:
Jolijn W Groeneweg Silvia F Hernandez Virginia F Byron Celeste M DiGloria Hector Lopez Vanessa Scialabba Minji Kim Ling Zhang Darrell R Borger Rosemary Tambouret Rosemary Foster Bo R Rueda Whitfield B Growdon

Clin Cancer Res 2014 Dec 7;20(24):6517-6528. Epub 2014 Oct 7.

Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, United States.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268047PMC
December 2014

Synergistic effects of targeted PI3K signaling inhibition and chemotherapy in liposarcoma.

Authors:
Shang Guo Hector Lopez-Marquez Kenneth C Fan Edwin Choy Gregory Cote David Harmon G Petur Nielsen Cao Yang Changqing Zhang Henry Mankin Francis J Hornicek Darrell R Borger Zhenfeng Duan

PLoS One 2014 2;9(4):e93996. Epub 2014 Apr 2.

Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093996PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973642PMC
November 2014

Genomic profiling of intrahepatic cholangiocarcinoma: refining prognosis and identifying therapeutic targets.

Authors:
Andrew X Zhu Darrell R Borger Yuhree Kim David Cosgrove Aslam Ejaz Sorin Alexandrescu Ryan Thomas Groeschl Vikram Deshpande James M Lindberg Cristina Ferrone Christine Sempoux Thomas Yau Ronnie Poon Irinel Popescu Todd W Bauer T Clark Gamblin Jean Francois Gigot Robert A Anders Timothy M Pawlik

Ann Surg Oncol 2014 Nov 3;21(12):3827-34. Epub 2014 Jun 3.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1245/s10434-014-3828-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324507PMC
November 2014

A phase 1/2 and biomarker study of preoperative short course chemoradiation with proton beam therapy and capecitabine followed by early surgery for resectable pancreatic ductal adenocarcinoma.

Authors:
Theodore S Hong David P Ryan Darrell R Borger Lawrence S Blaszkowsky Beow Y Yeap Marek Ancukiewicz Vikram Deshpande Shweta Shinagare Jennifer Y Wo Yves Boucher Raymond C Wadlow Eunice L Kwak Jill N Allen Jeffrey W Clark Andrew X Zhu Cristina R Ferrone Harvey J Mamon Judith Adams Barbara Winrich Tarin Grillo Rakesh K Jain Thomas F DeLaney Carlos Fernandez-del Castillo Dan G Duda

Int J Radiat Oncol Biol Phys 2014 Jul 24;89(4):830-8. Epub 2014 May 24.

Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

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http://bacbuc.hd.free.fr/WebDAV/data/CEDIT/Protonth%C3%A9rap
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http://linkinghub.elsevier.com/retrieve/pii/S036030161400391
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http://dx.doi.org/10.1016/j.ijrobp.2014.03.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791180PMC
July 2014

Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas.

Authors:
Hiroaki Wakimoto Shota Tanaka William T Curry Franziska Loebel Dan Zhao Kensuke Tateishi Juxiang Chen Lindsay K Klofas Nina Lelic James C Kim Dora Dias-Santagata Leif W Ellisen Darrell R Borger Sarah-Maria Fendt Matthew G Vander Heiden Tracy T Batchelor A John Iafrate Daniel P Cahill Andrew S Chi

Clin Cancer Res 2014 Jun 8;20(11):2898-909. Epub 2014 Apr 8.

Authors' Affiliations: Department of Neurosurgery; Division of Hematology/Oncology, Department of Neurology, Stephen E. and Catherine Pappas Center for Neuro-Oncology, Translational Research Laboratory; Department of Pathology; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge; Translational Neuro-Oncology Laboratory; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts; Vesalius Research Center, VIB and Department of Oncology, KU Leuven, Leuven, BelgiumAuthors' Affiliations: Department of Neurosurgery; Division of Hematology/Oncology, Department of Neurology, Stephen E. and Catherine Pappas Center for Neuro-Oncology, Translational Research Laboratory; Department of Pathology; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge; Translational Neuro-Oncology Laboratory; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts; Vesalius Research Center, VIB and Department of Oncology, KU Leuven, Leuven, BelgiumAuthors' Affiliations: Department of Neurosurgery; Division of Hematology/Oncology, Department of Neurology, Stephen E. and Catherine Pappas Center for Neuro-Oncology, Translational Research Laboratory; Department of Pathology; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge; Translational Neuro-Oncology Laboratory; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts; Vesalius Research Center, VIB and Department of Oncology, KU Leuven, Leuven, Belgium

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http://dx.doi.org/10.1158/1078-0432.CCR-13-3052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070445PMC
June 2014

Isocitrate dehydrogenase 1 (IDH1) mutation in breast adenocarcinoma is associated with elevated levels of serum and urine 2-hydroxyglutarate.

Authors:
Amir T Fathi Hossein Sadrzadeh Amy H Comander Michaela J Higgins Aditya Bardia Ashley Perry Meghan Burke Regina Silver Christina R Matulis Kimberly S Straley Katharine E Yen Sam Agresta Hyeryun Kim David P Schenkein Darrell R Borger

Oncologist 2014 Jun 23;19(6):602-7. Epub 2014 Apr 23.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA; Agios Pharmaceuticals, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1634/theoncologist.2013-0417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041671PMC
June 2014

Mutational analysis and clinical correlation of metastatic colorectal cancer.

Authors:
Andrea L Russo Darrell R Borger Jackie Szymonifka David P Ryan Jennifer Y Wo Lawrence S Blaszkowsky Eunice L Kwak Jill N Allen Raymond C Wadlow Andrew X Zhu Janet E Murphy Jason E Faris Dora Dias-Santagata Kevin M Haigis Leif W Ellisen Anthony J Iafrate Theodore S Hong

Cancer 2014 May 5;120(10):1482-90. Epub 2014 Feb 5.

Harvard Radiation Oncology Program, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.28599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327902PMC
May 2014

BRAF mutation in 'sarcomas': a possible method to detect de-differentiated melanomas.

Authors:
Nicole A Cipriani Igor Letovanec Francis J Hornicek John T Mullen Zhenfeng Duan Darrell R Borger Gunnlaugur Petur Nielsen

Histopathology 2014 Apr 7;64(5):639-46. Epub 2013 Dec 7.

Department of Pathology, The University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1111/his.12305DOI Listing
April 2014

Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma.

Authors:
Darrell R Borger Lipika Goyal Thomas Yau Ronnie T Poon Marek Ancukiewicz Vikram Deshpande David C Christiani Hannah M Liebman Hua Yang Hyeryun Kim Katharine Yen Jason E Faris A John Iafrate Eunice L Kwak Jeffrey W Clark Jill N Allen Lawrence S Blaszkowsky Janet E Murphy Supriya K Saha Theodore S Hong Jennifer Y Wo Cristina R Ferrone Kenneth K Tanabe Nabeel Bardeesy Kimberly S Straley Sam Agresta David P Schenkein Leif W Ellisen David P Ryan Andrew X Zhu

Clin Cancer Res 2014 Apr 29;20(7):1884-90. Epub 2014 Jan 29.

Authors' Affiliations: Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston; Agios Pharmaceuticals, Cambridge, Massachusetts; and Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107454PMC
April 2014

Mutational and clinical predictors of pathologic complete response in the treatment of locally advanced rectal cancer.

Authors:
Andrea L Russo David P Ryan Darrell R Borger Jennifer Y Wo Jackie Szymonifka Wen-Yih Liang Eunice L Kwak Lawrence S Blaszkowsky Jeffrey W Clark Jill N Allen Andrew X Zhu David L Berger James C Cusack Harvey J Mamon Kevin M Haigis Theodore S Hong

J Gastrointest Cancer 2014 Mar;45(1):34-9

Harvard Radiation Oncology Program, Boston, MA, USA.

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http://dx.doi.org/10.1007/s12029-013-9546-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361942PMC
March 2014

Inactivation of the tumor suppressor WTX in a subset of pediatric tumors.

Authors:
Sara Akhavanfard Sara O Vargas Moonjoo Han Mai Nitta Clarice B Chang Long P Le Ladan Fazlollahi Quan Nguyen Yunqing Ma Arjola Cosper Dora Dias-Santagata Jae Y Han Kristin Bergethon Darrell R Borger Leif W Ellisen Scott L Pomeroy Daniel A Haber A John Iafrate Miguel N Rivera

Genes Chromosomes Cancer 2014 Jan 5;53(1):67-77. Epub 2013 Nov 5.

Department of Pathology, Massachusetts General Hospital, Boston, MA; Cancer Center, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1002/gcc.22118DOI Listing
January 2014

BRAF V600E mutation identifies a subset of low-grade diffusely infiltrating gliomas in adults.

Authors:
Andrew S Chi Tracy T Batchelor Daniel Yang Dora Dias-Santagata Darrell R Borger Leif W Ellisen A John Iafrate David N Louis

J Clin Oncol 2013 May 1;31(14):e233-6. Epub 2013 Apr 1.

Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA.

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http://dx.doi.org/10.1200/JCO.2012.46.0220DOI Listing
May 2013

Case records of the Massachusetts General Hospital. Case 14-2013. A 70-year-old woman with vaginal bleeding.

Authors:
Richard T Penson Annekathryn Goodman Whitfield B Growdon Darrell R Borger Susanna I Lee Esther Oliva

N Engl J Med 2013 May;368(19):1827-35

Division of Hematology and Oncology, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1056/NEJMcpc1209276DOI Listing
May 2013

Detection of novel actionable genetic changes in salivary duct carcinoma helps direct patient treatment.

Authors:
Valentina Nardi Peter M Sadow Dejan Juric Dave Zhao Arjola K Cosper Kristin Bergethon Vanessa L Scialabba Julie M Batten Darrell R Borger Anthony John Iafrate Rebecca S Heist Donald P Lawrence Keith T Flaherty Johanna C Bendell Daniel Deschler Yi Li Lori J Wirth Dora Dias-Santagata

Clin Cancer Res 2013 Jan 27;19(2):480-90. Epub 2012 Nov 27.

Departments of Pathology and Medicine, Massachusetts General Hospital; Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-1842DOI Listing
January 2013

Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response.

Authors:
Amir T Fathi Hossein Sadrzadeh Darrell R Borger Karen K Ballen Philip C Amrein Eyal C Attar Julia Foster Meghan Burke Hector U Lopez Christina R Matulis Katherine M Edmonds A John Iafrate Kimberly S Straley Katharine E Yen Samuel Agresta David P Schenkein Cedric Hill Ashkan Emadi Donna S Neuberg Richard M Stone Yi-Bin Chen

Blood 2012 Nov 16;120(23):4649-52. Epub 2012 Oct 16.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1182/blood-2012-06-438267DOI Listing
November 2012

Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping.

Authors:
Darrell R Borger Kenneth K Tanabe Kenneth C Fan Hector U Lopez Valeria R Fantin Kimberly S Straley David P Schenkein Aram F Hezel Marek Ancukiewicz Hannah M Liebman Eunice L Kwak Jeffrey W Clark David P Ryan Vikram Deshpande Dora Dias-Santagata Leif W Ellisen Andrew X Zhu A John Iafrate

Oncologist 2012 16;17(1):72-9. Epub 2011 Dec 16.

Division of Hematology-Oncology, Massachusetts General Hospital, Boston 02114-2698, USA

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http://dx.doi.org/10.1634/theoncologist.2011-0386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267826PMC
June 2012

IDH mutations: new genetic signatures in cholangiocarcinoma and therapeutic implications.

Authors:
Darrell R Borger Andrew X Zhu

Expert Rev Anticancer Ther 2012 May;12(5):543-6

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http://dx.doi.org/10.1586/era.12.32DOI Listing
May 2012

Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model.

Authors:
Christopher K McCann Whitfield B Growdon Kashmira Kulkarni-Datar Michael D Curley Anne M Friel Jennifer L Proctor Hana Sheikh Igor Deyneko Jeanne A Ferguson Vinod Vathipadiekal Michael J Birrer Darrell R Borger Gayatry Mohapatra Lawrence R Zukerberg Rosemary Foster John R Macdougall Bo R Rueda

PLoS One 2011 29;6(11):e28077. Epub 2011 Nov 29.

Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028077PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226669PMC
April 2012

Activation of PI3K signaling in Merkel cell carcinoma.

Authors:
Valentina Nardi Youngchul Song Juan A Santamaria-Barria Arjola K Cosper Quynh Lam Anthony C Faber Genevieve M Boland Beow Y Yeap Kristin Bergethon Vanessa L Scialabba Hensin Tsao Jeffrey Settleman David P Ryan Darrell R Borger Atul K Bhan Mai P Hoang Anthony J Iafrate James C Cusack Jeffrey A Engelman Dora Dias-Santagata

Clin Cancer Res 2012 Mar 18;18(5):1227-36. Epub 2012 Jan 18.

Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02214, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-2308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912509PMC
March 2012

Phase 1/2 study of everolimus in advanced hepatocellular carcinoma.

Authors:
Andrew X Zhu Thomas A Abrams Rebecca Miksad Lawrence S Blaszkowsky Jeffrey A Meyerhardt Hui Zheng Alona Muzikansky Jeffrey W Clark Eunice L Kwak Deborah Schrag Kathryn R Jors Charles S Fuchs A John Iafrate Darrell R Borger David P Ryan

Cancer 2011 Nov 27;117(22):5094-102. Epub 2011 Apr 27.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/cncr.26165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417818PMC
November 2011

Tissue-specific signatures of activating PIK3CA and RAS mutations in carcinosarcomas of gynecologic origin.

Authors:
Whitfield B Growdon Breton N Roussel Vanessa L Scialabba Rosemary Foster Dora Dias-Santagata A John Iafrate Leif W Ellisen Rosemary H Tambouret Bo R Rueda Darrell R Borger

Gynecol Oncol 2011 Apr 17;121(1):212-7. Epub 2010 Dec 17.

Vincent Center for Reproductive Biology, MGH/Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009082581000867
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http://dx.doi.org/10.1016/j.ygyno.2010.11.039DOI Listing
April 2011

BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications.

Authors:
Dora Dias-Santagata Quynh Lam Kathy Vernovsky Natalie Vena Jochen K Lennerz Darrell R Borger Tracy T Batchelor Keith L Ligon A John Iafrate Azra H Ligon David N Louis Sandro Santagata

PLoS One 2011 Mar 29;6(3):e17948. Epub 2011 Mar 29.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017948PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066220PMC
March 2011

A platform for rapid detection of multiple oncogenic mutations with relevance to targeted therapy in non-small-cell lung cancer.

Authors:
Zengliu Su Dora Dias-Santagata Markeesa Duke Katherine Hutchinson Ya-Lun Lin Darrell R Borger Christine H Chung Pierre P Massion Cindy L Vnencak-Jones A John Iafrate William Pao

J Mol Diagn 2011 Jan 23;13(1):74-84. Epub 2010 Dec 23.

Vanderbilt-Ingram Cancer Center, the Department of Medicine/Division of Hematology-Oncology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1016/j.jmoldx.2010.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070558PMC
January 2011

Epigenetic regulation of CD133 and tumorigenicity of CD133 positive and negative endometrial cancer cells.

Authors:
Anne M Friel Ling Zhang Michael D Curley Vanessa A Therrien Petra A Sergent Sarah E Belden Darrell R Borger Gayatry Mohapatra Lawrence R Zukerberg Rosemary Foster Bo R Rueda

Reprod Biol Endocrinol 2010 Dec 1;8:147. Epub 2010 Dec 1.

Vincent Center for Reproductive Biology, Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1186/1477-7827-8-147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027593PMC
December 2010

Activity of IPI-504, a novel heat-shock protein 90 inhibitor, in patients with molecularly defined non-small-cell lung cancer.

Authors:
Lecia V Sequist Scott Gettinger Neil N Senzer Renato G Martins Pasi A Jänne Rogerio Lilenbaum Jhanelle E Gray A John Iafrate Ryohei Katayama Nafeeza Hafeez Jennifer Sweeney John R Walker Christian Fritz Robert W Ross David Grayzel Jeffrey A Engelman Darrell R Borger Guillermo Paez Ronald Natale

J Clin Oncol 2010 Nov 12;28(33):4953-60. Epub 2010 Oct 12.

Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.

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http://dx.doi.org/10.1200/JCO.2010.30.8338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676802PMC
November 2010

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine.

Authors:
Dora Dias-Santagata Sara Akhavanfard Serena S David Kathy Vernovsky Georgiana Kuhlmann Susan L Boisvert Hannah Stubbs Ultan McDermott Jeffrey Settleman Eunice L Kwak Jeffrey W Clark Steven J Isakoff Lecia V Sequist Jeffrey A Engelman Thomas J Lynch Daniel A Haber David N Louis Leif W Ellisen Darrell R Borger A John Iafrate

EMBO Mol Med 2010 May;2(5):146-58

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1002/emmm.201000070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377316PMC
May 2010

Decreased survival in EGFR gene amplified vulvar carcinoma.

Authors:
Whitfield B Growdon Susan L Boisvert Sara Akhavanfard Esther Oliva Dora C Dias-Santagata Sakiko Kojiro Neil S Horowitz A John Iafrate Darrell R Borger Bo R Rueda

Gynecol Oncol 2008 Nov 3;111(2):289-97. Epub 2008 Sep 3.

Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, THR 901A, 55 Fruit Street, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1016/j.ygyno.2008.07.038DOI Listing
November 2008

AMP-activated protein kinase is essential for survival in chronic hypoxia.

Authors:
Darrell R Borger L Cristina Gavrilescu Maria C Bucur Mircea Ivan James A Decaprio

Biochem Biophys Res Commun 2008 May 24;370(2):230-4. Epub 2008 Mar 24.

Dana-Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, Mayer Building 440, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.bbrc.2008.03.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2387098PMC
May 2008

Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53.

Authors:
Darrell R Borger James A DeCaprio

J Virol 2006 May;80(9):4292-303

Dana-Farber Cancer Institute, Department of Medical Oncology, Harvard Medical School, Mayer Building 457, 44 Binney Street, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1128/JVI.80.9.4292-4303.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1472010PMC
May 2006