Darragh Duffy

Darragh Duffy

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Darragh Duffy

Publications by authors named "Darragh Duffy"

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Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles.

Arthritis Res Ther 2019 Jun 14;21(1):147. Epub 2019 Jun 14.

Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1186/s13075-019-1929-4DOI Listing
June 2019

A Call for Blood-In Human Immunology.

Immunity 2019 Jun;50(6):1335-1336

Human Evolutionary Genetics Unit, CNRS UMR 2000, Institut Pasteur, Paris 75015, France.

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http://dx.doi.org/10.1016/j.immuni.2019.05.012DOI Listing
June 2019

Milieu intérieur: Defining the boundaries of a healthy immune response for improved vaccination strategies.

Authors:
Darragh Duffy

Hum Vaccin Immunother 2018 24;14(9):2217-2221. Epub 2018 Jul 24.

a Dendritic Cell Immunobiology Unit, Department of Immunology, Institut Pasteur , Paris , France.

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http://dx.doi.org/10.1080/21645515.2018.1466764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6183329PMC
May 2019

Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined.

Eur J Immunol 2019 May 7;49(5):790-800. Epub 2019 Mar 7.

Department of Biomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

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http://dx.doi.org/10.1002/eji.201847955DOI Listing
May 2019

Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS.

J Exp Med 2019 May 1;216(5):1199-1213. Epub 2019 Apr 1.

Immunity and Cancer Department, Institut Curie, Paris-Sciences-et-Lettres Research University, Institut National de la Santé et de la Recherche Medicale U932, Paris, France

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http://dx.doi.org/10.1084/jem.20181329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504208PMC
May 2019

Associations between usual diet and gut microbiota composition: results from the Milieu Intérieur cross-sectional study.

Am J Clin Nutr 2019 May;109(5):1472-1483

Sorbonne-Paris-Cité Research Center for Epidemiology and Statistics (CRESS), Nutritional Epidemiology Research Team (EREN) (INSERM U1153/INRA U1125/CNAM/Université Paris-XIII Nord), Bobigny, France.

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http://dx.doi.org/10.1093/ajcn/nqz029DOI Listing
May 2019

IP-10 contributes to the inhibition of mycobacterial growth in an ex vivo whole blood assay.

Int J Med Microbiol 2019 May 22. Epub 2019 May 22.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Università Cattolica del Sacro Cuore, Roma, Italy; Mater Olbia Hospital, Olbia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ijmm.2019.05.005DOI Listing
May 2019

Delineating the healthy human skin UV response and early induction of interferon pathway in cutaneous lupus erythematosus.

J Invest Dermatol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology and Allergology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jid.2019.02.035DOI Listing
April 2019

[Milieu Interieur: defining a healthy immune response for a better understanding of diseases].

Authors:
Darragh Duffy

Med Sci (Paris) 2019 Apr 30;35(4):327-331. Epub 2019 Apr 30.

Immunobiologie des cellules dendritiques, Institut Pasteur, 25, rue du Docteur Roux, 75015 Paris, France - Inserm U1223, 25, rue du Docteur Roux, 75015 Paris, France.

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http://dx.doi.org/10.1051/medsci/2019069DOI Listing
April 2019

Efficacy of JAK1/2 inhibition in the treatment of chilblain lupus due to TREX1 deficiency.

Ann Rheum Dis 2019 Mar 3;78(3):431-433. Epub 2018 Oct 3.

Department of Paediatric Haematology-Immunology and Rheumatology, Hôpital Necker-Enfants Malades, AP-HP, Paris, France

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2018-21403
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http://dx.doi.org/10.1136/annrheumdis-2018-214037DOI Listing
March 2019

First description of agonist and antagonist IP-10 in urine of patients with active TB.

Int J Infect Dis 2019 Jan 7;78:15-21. Epub 2018 Sep 7.

Translational Research Unit, Department of Epidemiology and Preclinical Research, "L. Spallanzani" National Institute for Infectious Diseases (INMI)-IRCCS, Rome, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S12019712183451
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http://dx.doi.org/10.1016/j.ijid.2018.09.001DOI Listing
January 2019

Standardized Immunomonitoring: Separating the Signals from the Noise.

Authors:
Darragh Duffy

Trends Biotechnol 2018 11 29;36(11):1107-1115. Epub 2018 Jun 29.

Dendritic Cell Immunobiology Unit, Institut Pasteur, Paris, France; INSERM U1223, Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01677799183016
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http://dx.doi.org/10.1016/j.tibtech.2018.06.002DOI Listing
November 2018

Potential utility of the Genedrive point-of-care test for HCV RNA detection.

Gut 2018 Sep 22. Epub 2018 Sep 22.

Immunobiology of Dendritic Cells, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1136/gutjnl-2018-317218DOI Listing
September 2018

Immune response biomarkers in human and veterinary research.

Comp Immunol Microbiol Infect Dis 2018 Aug 24;59:57-62. Epub 2018 Sep 24.

Immunobiology of Dendritic Cells, Institut Pasteur, Paris, France; INSERM U1223, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.cimid.2018.09.008DOI Listing
August 2018

JAK inhibitor improves type I interferon induced damage: proof of concept in dermatomyositis.

Brain 2018 Jun;141(6):1609-1621

Sorbonne Université, INSERM, Association Institut de Myologie, Center of Research in Myology, UMRS 974, AP-HP, Department of Internal Medicine and Clinical Immunology, DHU I2B, Pitié-Salpêtrière Hospital, F-75013, Paris, France.

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http://dx.doi.org/10.1093/brain/awy105DOI Listing
June 2018

T-cell biomarkers for diagnosis of tuberculosis: candidate evaluation by a simple whole blood assay for clinical translation.

Eur Respir J 2018 03 22;51(3). Epub 2018 Mar 22.

South African Tuberculosis Vaccine Initiative (SATVI), Institute of Infectious Disease and Molecular Medicine, and Division of Immunology, Dept of Pathology, University of Cape Town, Cape Town, South Africa.

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http://dx.doi.org/10.1183/13993003.00153-2018DOI Listing
March 2018

Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study.

Clin Immunol 2017 10 22;183:325-335. Epub 2017 Sep 22.

Center for Translational Research, Institut Pasteur, Paris, France; Immunobiology of Dendritic Cells, Institut Pasteur, Paris, France; INSERM U1223, Institut Pasteur, Paris, France; Department of Cancer Immunology, Genentech Inc., San Francisco, CA 94080, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15216616173019
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http://dx.doi.org/10.1016/j.clim.2017.09.019DOI Listing
October 2017

Brief Report: Blockade of TANK-Binding Kinase 1/IKKɛ Inhibits Mutant Stimulator of Interferon Genes (STING)-Mediated Inflammatory Responses in Human Peripheral Blood Mononuclear Cells.

Arthritis Rheumatol 2017 07 5;69(7):1495-1501. Epub 2017 Jun 5.

Paris Descartes University, Sorbonne-Paris-Cité, Institut Imagine and INSERM UMR 1163, Laboratory of Neurogenetics and Neuroinflammation, Paris, France.

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http://dx.doi.org/10.1002/art.40122DOI Listing
July 2017

Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children.

J Allergy Clin Immunol 2016 12 20;138(6):1752-1755. Epub 2016 Aug 20.

Pediatric Hematology-Immunology and Rheumatology Department, Hôpital Necker-Enfants Malades, Paris, France; Paris Descartes University, Sorbonne-Paris-Cité, Institut Imagine, Paris, France; INSERM UMR 1163, Laboratory of Immunogenetics of Pediatric Autoimmunity, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.07.015DOI Listing
December 2016

Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations.

Cell 2016 Oct;167(3):643-656.e17

Human Evolutionary Genetics Unit, Institut Pasteur, Paris 75015, France; CNRS, URA3012, Paris 75015, France; Center of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, Paris 75015, France. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075285PMC
October 2016

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses.

Cell Rep 2016 09 25;16(10):2777-2791. Epub 2016 Aug 25.

Laboratory of Dendritic Cell Immunobiology, Department of Immunology, Institut Pasteur, Paris 75015, France; INSERM U1223, Paris 75015, France; Center for Translational Research, Institut Pasteur, Paris 75015, France; Department of Cancer Immunology, Genentech Inc., San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.08.011DOI Listing
September 2016

Inhibition of DPP4 activity in humans establishes its in vivo role in CXCL10 post-translational modification: prospective placebo-controlled clinical studies.

EMBO Mol Med 2016 06 1;8(6):679-83. Epub 2016 Jun 1.

The Laboratory of Dendritic Cell Immunobiology, Institut Pasteur, Paris, France INSERM U818, Paris, France Center for Human Immunology, Institut Pasteur, Paris, France Department of Cancer Immunotherapy, Genentech, South San Francisco, CA, USA

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http://embomolmed.embopress.org/lookup/doi/10.15252/emmm.201
Publisher Site
http://dx.doi.org/10.15252/emmm.201506145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888857PMC
June 2016

Dynamic Changes of Post-Translationally Modified Forms of CXCL10 and Soluble DPP4 in HCV Subjects Receiving Interferon-Free Therapy.

PLoS One 2015 16;10(7):e0133236. Epub 2015 Jul 16.

The Laboratory of Dendritic Cell Immunobiology, Institut Pasteur, Paris, France; INSERM U818, Paris, France; Center for Human Immunology, Institut Pasteur, Paris, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133236PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504464PMC
April 2016

The Milieu Intérieur study - an integrative approach for study of human immunological variance.

Clin Immunol 2015 Apr 3;157(2):277-93. Epub 2015 Jan 3.

Center for Human Immunology, Institut Pasteur, Paris, France; Laboratory of Dendritic Cell Immunobiology, Department of Immunology, Institut Pasteur, Paris, France; INSERM U818, France; INSERM UMS20, France. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2014.12.004DOI Listing
April 2015

Semi-automated and standardized cytometric procedures for multi-panel and multi-parametric whole blood immunophenotyping.

Clin Immunol 2015 Apr 6;157(2):261-76. Epub 2015 Jan 6.

Center for Human Immunology, Institut Pasteur, Paris, France; Laboratory of Immunoregulation, Department of Immunology, Institut Pasteur, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2014.12.008DOI Listing
April 2015

Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli.

Immunity 2014 Mar;40(3):436-50

Center for Human Immunology, Institut Pasteur, 75015 Paris, France; INSERM U818, 75015 Paris, France; Laboratory of Dendritic Cell Immunobiology, Department of Immunology, Institut Pasteur, 75015 Paris, France; INSERM UMS20, 75015 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.03.002DOI Listing
March 2014

CXCL10 antagonism and plasma sDPPIV correlate with increasing liver disease in chronic HCV genotype 4 infected patients.

Cytokine 2013 Aug 7;63(2):105-12. Epub 2013 May 7.

Laboratory of Dendritic Cell Immunobiology, Institut Pasteur, Paris, France; Faculty of Medicine, Aim Shams University, Cairo, Egypt.

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http://dx.doi.org/10.1016/j.cyto.2013.04.016DOI Listing
August 2013

Intradermal immunization triggers epidermal Langerhans cell mobilization required for CD8 T-cell immune responses.

J Invest Dermatol 2012 Mar 15;132(3 Pt 1):615-25. Epub 2011 Dec 15.

Laboratory of Immunity and Infection, Institut National de la Santé et de la Recherche Médicale, INSERM UMR-S 945 and Université Pierre et Marie Curie, UPMC Univ Paris 06, Paris, France.

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http://dx.doi.org/10.1038/jid.2011.346DOI Listing
March 2012

Cutting edge: Protective effect of CX3CR1+ dendritic cells in a vaccinia virus pulmonary infection model.

J Immunol 2012 Feb 4;188(3):952-6. Epub 2012 Jan 4.

INSERM, Unité Mixte de Recherche-S 945, 75013 Paris, France.

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http://dx.doi.org/10.4049/jimmunol.1004164DOI Listing
February 2012

Targeting of HIV-p24 particle-based vaccine into differential skin layers induces distinct arms of the immune responses.

Vaccine 2011 Aug 7;29(37):6379-91. Epub 2011 May 7.

Institut National de la Santé et de la Recherche Médicale, INSERM UMR-S 945 and Université Pierre et Marie Curie (UPMC University Paris 06), Laboratory of Immunity and Infection, 83/91, Boulevard de l'Hôpital, 75013 Paris Cedex 13, France.

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X110063
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http://dx.doi.org/10.1016/j.vaccine.2011.04.080DOI Listing
August 2011

CD56brightCD16+ NK cells: a functional intermediate stage of NK cell differentiation.

J Immunol 2011 Jun 9;186(12):6753-61. Epub 2011 May 9.

INSERM Unité Mixte de Recherche-S 945, Hôpital Pitié-Salpêtrière, 75013 Paris, France.

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http://dx.doi.org/10.4049/jimmunol.1100330DOI Listing
June 2011

Nanoparticle-based targeting of vaccine compounds to skin antigen-presenting cells by hair follicles and their transport in mice.

J Invest Dermatol 2009 May 4;129(5):1156-64. Epub 2008 Dec 4.

Laboratoire d'Immunologie Cellulaire, INSERM U543, Université Pierre et Marie Curie-Paris6, Paris, France.

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http://dx.doi.org/10.1038/jid.2008.356DOI Listing
May 2009

Transgenic CD4 T cells (DO11.10) are destroyed in MHC-compatible hosts by NK cells and CD8 T cells.

J Immunol 2008 Jan;180(2):747-53

Immunology Section, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.180.2.747DOI Listing
January 2008

Naive T-cell receptor transgenic T cells help memory B cells produce antibody.

Immunology 2006 Nov;119(3):376-84

Division of Immunology, Faculty of Life Sciences, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/j.1365-2567.2006.02446.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819572PMC
November 2006