Daron I Freedberg

Daron I Freedberg

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Daron I Freedberg

Daron I Freedberg

Publications by authors named "Daron I Freedberg"

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Chemical structure and genetic organization of the E. coli O6:K15 capsular polysaccharide.

Sci Rep 2020 Jul 28;10(1):12608. Epub 2020 Jul 28.

Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, 20993, USA.

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http://dx.doi.org/10.1038/s41598-020-69476-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387560PMC
July 2020

Dispersing the crowd: Adopting C direct detection for glycans.

J Magn Reson 2020 Jul 21;318:106792. Epub 2020 Jul 21.

Laboratory of Bacterial Polysaccharides, Food and Drug Administration (FDA), Silver Spring, MD 20993, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jmr.2020.106792DOI Listing
July 2020

A combined NMR, MD and DFT conformational analysis of 9-O-acetyl sialic acid-containing GM3 ganglioside glycan and its 9-N-acetyl mimic.

Glycobiology 2020 Apr 29. Epub 2020 Apr 29.

Laboratory of Bacterial Polysaccharides, Food and Drug Administration (FDA), Silver Spring, MD 20993.

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http://dx.doi.org/10.1093/glycob/cwaa040DOI Listing
April 2020

Editorial.

J Biomol NMR 2019 Sep;73(8-9):399

The University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1007/s10858-019-00269-xDOI Listing
September 2019

Iron and Zinc Regulate Expression of a Putative ABC Metal Transporter in Corynebacterium diphtheriae.

J Bacteriol 2018 05 24;200(10). Epub 2018 Apr 24.

Laboratory of Respiratory and Special Pathogens, Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA

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http://jb.asm.org/lookup/doi/10.1128/JB.00051-18
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http://dx.doi.org/10.1128/JB.00051-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915790PMC
May 2018

Improving Analytical Characterization of Glycoconjugate Vaccines through Combined High-Resolution MS and NMR: Application to Neisseria meningitidis Serogroup B Oligosaccharide-Peptide Glycoconjugates.

Anal Chem 2018 04 3;90(8):5040-5047. Epub 2018 Apr 3.

Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research , Food and Drug Administration (FDA) , Silver Spring , Maryland 20993 , United States.

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http://dx.doi.org/10.1021/acs.analchem.7b04748DOI Listing
April 2018

The β-reducing end in α(2-8)-polysialic acid constitutes a unique structural motif.

Glycobiology 2017 09;27(9):900-911

Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20903, USA.

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http://dx.doi.org/10.1093/glycob/cwx025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283323PMC
September 2017

Application of 2D-NMR with room temperature NMR probes for the assessment of the higher order structure of filgrastim.

J Pharm Biomed Anal 2017 Jul 4;141:229-233. Epub 2017 Apr 4.

Institute for Bioscience and Biotechnology Research, National Institute of Standards and Technology and the University of Maryland, 9600 Gudelsky Drive, Rockville, MD 20850, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2017.03.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057790PMC
July 2017

Single synonymous mutation in factor IX alters protein properties and underlies haemophilia B.

J Med Genet 2017 05 22;54(5):338-345. Epub 2016 Dec 22.

Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.

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http://dx.doi.org/10.1136/jmedgenet-2016-104072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192418PMC
May 2017

Glycan OH Exchange Rate Determination in Aqueous Solution: Seeking Evidence for Transient Hydrogen Bonds.

J Phys Chem B 2017 02 25;121(4):683-695. Epub 2017 Jan 25.

Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Food and Drug Administration , 10903 New Hampshire Avenue, Silver Spring, Maryland 20903, United States.

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http://pubs.acs.org/doi/10.1021/acs.jpcb.6b10594
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http://dx.doi.org/10.1021/acs.jpcb.6b10594DOI Listing
February 2017

Uncovering Nonconventional and Conventional Hydrogen Bonds in Oligosaccharides through NMR Experiments and Molecular Modeling: Application to Sialyl Lewis-X.

J Am Chem Soc 2015 Oct 15;137(42):13444-7. Epub 2015 Oct 15.

Laboratory of Bacterial Polysaccharides, Food and Drug Administration ,10903 New Hampshire Avenue, Silver Spring, Maryland 20903, United States.

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http://pubs.acs.org/doi/10.1021/jacs.5b03824
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http://dx.doi.org/10.1021/jacs.5b03824DOI Listing
October 2015

NMR profiling of biomolecules at natural abundance using 2D 1H-15N and 1H-13C multiplicity-separated (MS) HSQC spectra.

J Magn Reson 2015 Feb 4;251:65-70. Epub 2014 Dec 4.

Division of Pharmaceutical Analysis, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, United States.

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http://dx.doi.org/10.1016/j.jmr.2014.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057795PMC
February 2015

Live cell NMR.

Annu Rev Biophys 2014 ;43:171-92

Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland 20852-1448; email:

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http://www.annualreviews.org/doi/10.1146/annurev-biophys-051
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http://dx.doi.org/10.1146/annurev-biophys-051013-023136DOI Listing
August 2014

Sialo-CEST: chemical exchange saturation transfer NMR of oligo- and poly-sialic acids and the assignment of their hydroxyl groups using selective- and HSQC-TOCSY.

Carbohydr Res 2014 May 18;389:165-73. Epub 2014 Feb 18.

School of Chemistry, Tel Aviv University, Levanon Street, Ramat Aviv, Tel Aviv 69978, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.carres.2014.02.008DOI Listing
May 2014

NMR of glycans: shedding new light on old problems.

Prog Nucl Magn Reson Spectrosc 2014 May 14;79:48-68. Epub 2014 Feb 14.

Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, United States. Electronic address:

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http://dx.doi.org/10.1016/j.pnmrs.2014.01.001DOI Listing
May 2014

Direct evidence for hydrogen bonding in glycans: a combined NMR and molecular dynamics study.

J Phys Chem B 2013 May 12;117(17):4860-9. Epub 2013 Apr 12.

Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, Maryland 20852-1448, United States.

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http://dx.doi.org/10.1021/jp400402bDOI Listing
May 2013

Constant time INEPT CT-HSQC (CTi-CT-HSQC) - A new NMR method to measure accurate one-bond J and RDCs with strong 1H-1H couplings in natural abundance.

J Magn Reson 2013 Mar 3;228:159-65. Epub 2012 Dec 3.

Laboratory of Bacterial Polysaccharides, CBER/FDA, Bethesda, MD 20892, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S10907807120034
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http://dx.doi.org/10.1016/j.jmr.2012.11.007DOI Listing
March 2013

Accurate determinations of one-bond 13C-13C couplings in 13C-labeled carbohydrates.

J Magn Reson 2013 Mar 11;228:130-5. Epub 2013 Jan 11.

Laboratory of Bacterial Polysaccharides, Structural Biology Section, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, Rockville, MD 20852-1448, United States.

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http://dx.doi.org/10.1016/j.jmr.2013.01.001DOI Listing
March 2013

Evidence for helical structure in a tetramer of α2-8 sialic acid: unveiling a structural antigen.

J Am Chem Soc 2012 Jul 22;134(26):10717-20. Epub 2012 Jun 22.

Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, Maryland 20852-1448, USA.

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http://dx.doi.org/10.1021/ja300624jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3441056PMC
July 2012

Transient hydrogen bonding in uniformly ¹³C,¹⁵N-labeled carbohydrates in water.

Biopolymers 2012 Mar 19;97(3):145-54. Epub 2011 Aug 19.

Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, FDA, Rockville, MD 20852-1448, USA.

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http://dx.doi.org/10.1002/bip.21710DOI Listing
March 2012

More accurate 1J(CH) coupling measurement in the presence of 3J(HH) strong coupling in natural abundance.

J Magn Reson 2012 Feb 22;215:10-22. Epub 2011 Sep 22.

Laboratory of Bacterial Polysaccharides, CBER/FDA, Bethesda, MD 20892, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S109078071100364
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http://dx.doi.org/10.1016/j.jmr.2011.09.037DOI Listing
February 2012

NMR detection and characterization of sialylated glycoproteins and cell surface polysaccharides.

J Biomol NMR 2011 Sep 27;51(1-2):163-71. Epub 2011 Sep 27.

Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA.

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http://link.springer.com/10.1007/s10858-011-9550-0
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http://dx.doi.org/10.1007/s10858-011-9550-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199143PMC
September 2011

Release of DNA oligonucleotides and their conjugates from controlled-pore glass under thermolytic conditions.

Curr Protoc Nucleic Acid Chem 2008 Dec;Chapter 3:Unit 3.17

Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/0471142700.nc0317s35DOI Listing
December 2008

NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B.

Nat Struct Mol Biol 2008 Aug 20;15(8):868-9. Epub 2008 Jul 20.

Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nsmb.1465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574748PMC
August 2008

Thermolytic release of covalently linked DNA oligonucleotides and their conjugates from controlled-pore glass at near neutral pH.

Bioconjug Chem 2008 Aug 23;19(8):1696-706. Epub 2008 Jul 23.

Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1021/bc800189eDOI Listing
August 2008

Extracellular structure of polysialic acid explored by on cell solution NMR.

Proc Natl Acad Sci U S A 2007 Jul 3;104(28):11557-61. Epub 2007 Jul 3.

Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852-1448, USA.

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http://dx.doi.org/10.1073/pnas.0704404104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906721PMC
July 2007

Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions.

Anal Chem 2005 Jun;77(11):3466-78

Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1021/ac050064yDOI Listing
June 2005

The utility of residual dipolar couplings in detecting motion in carbohydrates: application to sucrose.

Carbohydr Res 2005 Apr;340(5):863-74

Laboratory of Biophysics, Center for Biologics Evaluation and Research, FDA, 1401 Rockville Pike, HFM-419, MD 20852, USA.

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http://dx.doi.org/10.1016/j.carres.2005.01.025DOI Listing
April 2005

Escherichia coli K1 polysialic acid O-acetyltransferase gene, neuO, and the mechanism of capsule form variation involving a mobile contingency locus.

Proc Natl Acad Sci U S A 2005 Apr 4;102(15):5564-9. Epub 2005 Apr 4.

Laboratory of Sialobiology, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0407428102
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http://dx.doi.org/10.1073/pnas.0407428102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC555961PMC
April 2005

Discriminating the helical forms of peptides by NMR and molecular dynamics simulation.

J Am Chem Soc 2004 Aug;126(33):10478-84

Contribution from the Laboratory of Biophysics, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Rockville, MD 20852, USA.

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http://dx.doi.org/10.1021/ja0484146DOI Listing
August 2004

An alternative method for pucker determination in carbohydrates from residual dipolar couplings: a solution NMR study of the fructofuranosyl ring of sucrose.

J Am Chem Soc 2002 Mar;124(10):2358-62

Laboratory of Biophysics, CBER/FDA, 29 Lincoln Drive, Building 29 HFM-419, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1021/ja010981vDOI Listing
March 2002

Rapid structural fluctuations of the free HIV protease flaps in solution: relationship to crystal structures and comparison with predictions of dynamics calculations.

Protein Sci 2002 Feb;11(2):221-32

Molecular Structural Biology Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373438PMC
http://dx.doi.org/10.1110/ps.33202DOI Listing
February 2002

Direct assignment of the absolute configuration of a distinct class of deoxyribonucleoside cyclic N-acylphosphoramidites at phosphorus by M-GOESY nuclear magnetic resonance spectroscopy.

J Am Chem Soc 2002 Feb;124(7):1180-1

Division of Therapeutic Proteins, Center for Biologics Evaluation and Research, Food and Drug Administration, 8800 Rockville Pike, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1021/ja017190dDOI Listing
February 2002