Dario Sangiolo

CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes.

Clin Cancer Res 2020 Dec 8;26(23):6321-6334. Epub 2020 Sep 8.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Turin, Italy.

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December 2020

Pazopanib and Trametinib as a Synergistic Strategy against Osteosarcoma: Preclinical Activity and Molecular Insights.

Cancers (Basel) 2020 Jun 10;12(6). Epub 2020 Jun 10.

Division of Medical Oncology, Candiolo Cancer Institute, FPO-IRCCS, Str. Prov. 142 km 3.95, 10060 Candiolo (TO), Italy.

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June 2020

Delving into PARP inhibition from bench to bedside and back.

Authors:

Giovanni Grignani Alessandra Merlini Dario Sangiolo Lorenzo D'Ambrosio Ymera Pignochino

Pharmacol Ther 2020 02 19;206:107446. Epub 2019 Nov 19.

Division of Medical Oncology, Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO), Italy,; Department of Oncology, University of Torino, Torino, Italy.

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February 2020

Significance of TIM3 expression in cancer: From biology to the clinic.

Authors:

Cinzia Solinas Pushpamali De Silva Dominique Bron Karen Willard-Gallo Dario Sangiolo

Semin Oncol 2019 Aug - Oct;46(4-5):372-379. Epub 2019 Nov 6.

Department of Oncology, University of Torino, Torino, Italy; Candiolo Cancer Institute FPO-IRCCS, Candiolo, Torino, Italy. Electronic address:

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January 2020

CAR-Based Strategies beyond T Lymphocytes: Integrative Opportunities for Cancer Adoptive Immunotherapy.

Authors:

Ramona Rotolo Valeria Leuci Chiara Donini Anna Cykowska Loretta Gammaitoni Giovanni Medico Giorgio Valabrega Massimo Aglietta Dario Sangiolo

Int J Mol Sci 2019 Jun 11;20(11). Epub 2019 Jun 11.

Department of Oncology, University of Torino, 10140 Torino, Italy.

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June 2019

Veliparib: a new therapeutic option in ovarian cancer?

Authors:

Eleonora Ghisoni Gaia Giannone Valentina Tuninetti Sofia Genta Giulia Scotto Massimo Aglietta Dario Sangiolo Gloria Mittica Giorgio Valabrega

Future Oncol 2019 Jun 10;15(17):1975-1987. Epub 2019 May 10.

Candiolo Cancer Institute FPO/IRCCS, Strada provinciale 142 km 3.95, 10060 Candiolo, Torino, Italy.

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June 2019

NK-mediated antibody-dependent cell-mediated cytotoxicity in solid tumors: biological evidence and clinical perspectives.

Authors:

Cristiana Lo Nigro Marco Macagno Dario Sangiolo Luca Bertolaccini Massimo Aglietta Marco Carlo Merlano

Ann Transl Med 2019 Mar;7(5):105

Department of Oncology, S. Croce & Carle Teaching Hospital, Cuneo, Italy.

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March 2019

Immunotherapy Associated Pulmonary Toxicity: Biology Behind Clinical and Radiological Features.

Authors:

Michele Porcu Pushpamali De Silva Cinzia Solinas Angelo Battaglia Marina Schena Mario Scartozzi Dominique Bron Jasjit S Suri Karen Willard-Gallo Dario Sangiolo Luca Saba

Cancers (Basel) 2019 Mar 5;11(3). Epub 2019 Mar 5.

Department of Radiology, University Hospital of Cagliari, 09042 Monserrato (Cagliari), Italy.

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March 2019

Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours.

Authors:

Valentina Martin Cristina Chiriaco Chiara Modica Anna Acquadro Marco Cortese Francesco Galimi Timothy Perera Loretta Gammaitoni Massimo Aglietta Paolo M Comoglio Elisa Vigna Dario Sangiolo

Br J Cancer 2019 03 6;120(5):527-536. Epub 2019 Feb 6.

Medical Oncology Division, Experimental Cell Therapy, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Torino, Italy.

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March 2019

Cytokine Induced Killer cells are effective against sarcoma cancer stem cells spared by chemotherapy and target therapy.

Authors:

Giulia Mesiano Giovanni Grignani Erika Fiorino Valeria Leuci Ramona Rotolo Lorenzo D'Ambrosio Chiara Salfi Loretta Gammaitoni Lidia Giraudo Alberto Pisacane Sara Butera Ymera Pignochino Marco Basiricó Federica Capozzi Anna Sapino Massimo Aglietta Dario Sangiolo

Oncoimmunology 2018;7(11):e1465161. Epub 2018 Aug 6.

Medical Oncology Division, Candiolo Cancer Institute, FPO-IRCCS. Str. Prov. 142, km 3.95, I-10060, Candiolo (To), Italy.

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August 2018

Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group.

Lancet Oncol 2018 10 11;19(10):1360-1371. Epub 2018 Sep 11.

Medical Oncology-Sarcoma Unit, Istituto di Candiolo-Fondazione del Piemonte per l'Oncologia, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Candiolo, Italy; Department of Oncology, University of Torino, Regione Gonzole, Orbassano, Italy.

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October 2018

Survivin-peptide vaccination elicits immune response after allogeneic nonmyeloablative transplantation: a safe strategy to enhance the graft versus tumor effect.

Authors:

Paola Circosta Katia Vitaggio Angela Rita Elia Maja Todorovic Dario Sangiolo Fabrizio Carnevale-Schianca Antonella Vallario Massimo Geuna Massimo Aglietta Alessandro Cignetti

Immunotherapy 2018 07;10(9):753-767

Molecular Biotechnology Center, University of Torino, 10126 Turin, Italy.

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July 2018

Next generation immune-checkpoints for cancer therapy.

Authors:

Chiara Donini Lorenzo D'Ambrosio Giovanni Grignani Massimo Aglietta Dario Sangiolo

J Thorac Dis 2018 May;10(Suppl 13):S1581-S1601

Department of Oncology, University of Torino, Torino, Italy.

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May 2018

BRAF and MEK Inhibitors Increase PD-1-Positive Melanoma Cells Leading to a Potential Lymphocyte-Independent Synergism with Anti-PD-1 Antibody.

Authors:

Martina Sanlorenzo Igor Vujic Arianna Floris Mauro Novelli Loretta Gammaitoni Lidia Giraudo Marco Macagno Valeria Leuci Ramona Rotolo Chiara Donini Marco Basiricò Pietro Quaglino Maria Teresa Fierro Silvia Giordano Maria Sibilia Fabrizio Carnevale-Schianca Massimo Aglietta Dario Sangiolo

Clin Cancer Res 2018 07 12;24(14):3377-3385. Epub 2018 Apr 12.

Department of Oncology, University of Turin, Turin, Italy.

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July 2018

Analytic and Dynamic Secretory Profile of Patient-Derived Cytokine-Induced Killer Cells.

Authors:

Giulia Mesiano Roberta Zini Giulia Montagner Nicoletta Bianchi Rossella Manfredini Antonella Chillemi Massimo Aglietta Giovanni Grignani Ilaria Lampronti Erika Fiorino Fabio Malavasi Dario Sangiolo Roberto Gambari Davide Ferrari

Mol Med 2017 10 9;23:235-246. Epub 2017 Aug 9.

Department of Life Science and Biotechnology, Sections of Microbiology and Applied Pathology; Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy.

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October 2017

Treating breast cancer with cell-based approaches: an overview.

Authors:

Susanna Gallo Dario Sangiolo Fabrizio Carnevale Schianca Massimo Aglietta Filippo Montemurro

Expert Opin Biol Ther 2017 10 20;17(10):1255-1264. Epub 2017 Jul 20.

c Investigative Clinical Oncology , Candiolo Cancer Institute-FPO (IRCCS) , Candiolo , Italy.

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October 2017

PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models.

Mol Cancer 2017 04 28;16(1):86. Epub 2017 Apr 28.

Sarcoma Unit, Medical Oncology, Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Torino, Italy.

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April 2017

Impact of a risk-based follow-up in patients affected by gastrointestinal stromal tumour.

Eur J Cancer 2017 06 24;78:122-132. Epub 2017 Apr 24.

Sarcoma Unit, Division of Medical Oncology Candiolo Cancer Institute - FPO, IRCCS, Strada Provinciale 142, Km 3.95, 10060 Candiolo, TO, Italy; University of Torino, Department of Oncology, Regione Gonzole, 10, 10043 Orbassano, TO, Italy. Electronic address:

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June 2017

Treatment of metastatic melanoma: a multidisciplinary approach.

Authors:

Paolo Fava Chiara Astrua Martina Sanlorenzo Simone Ribero Matteo Brizio Andrea R Filippi Elena Marra Franco Picciotto Dario Sangiolo Fabrizio Carnevale-Schianca Massimo Aglietta Sergio Sandrucci Umberto Ricardi Virginia Caliendo Pietro Quaglino Maria T Fierro

G Ital Dermatol Venereol 2017 Jun 14;152(3):241-261. Epub 2017 Mar 14.

Clinic of Dermatology, Department of Medical Sciences, School of Medicine, University of Turin, Turin, Italy.

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June 2017

Role of interferon in melanoma: old hopes and new perspectives.

Authors:

Martina Sanlorenzo Igor Vujic Fabrizio Carnevale-Schianca Pietro Quaglino Loretta Gammaitoni Maria Teresa Fierro Massimo Aglietta Dario Sangiolo

Expert Opin Biol Ther 2017 04 16;17(4):475-483. Epub 2017 Feb 16.

a Department of Oncology , University of Torino , Candiolo , Torino , Italy.

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April 2017

Post-Transplant Cyclophosphamide and Tacrolimus-Mycophenolate Mofetil Combination Prevents Graft-versus-Host Disease in Allogeneic Peripheral Blood Hematopoietic Cell Transplantation from HLA-Matched Donors.

Biol Blood Marrow Transplant 2017 Mar 27;23(3):459-466. Epub 2016 Dec 27.

Medical Oncology, Hematopoietic Stem Cells Unit, Turin Metropolitan Transplant Center, Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy; Department of Oncology, University of Torino, Turin, Italy; Department of Medical Oncology, Candiolo Cancer Institute-FPO, IRCCS, Candiolo, Italy.

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March 2017

VEGF blockade enhances the antitumor effect of BRAFV600E inhibition.

Authors:

Valentina Comunanza Davide Corà Francesca Orso Francesca Maria Consonni Emanuele Middonti Federica Di Nicolantonio Anton Buzdin Antonio Sica Enzo Medico Dario Sangiolo Daniela Taverna Federico Bussolino

EMBO Mol Med 2017 02;9(2):219-237

Department of Oncology, University of Torino, Candiolo, Italy

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February 2017

Cytokine-Induced Killer Cells Kill Chemo-surviving Melanoma Cancer Stem Cells.

Clin Cancer Res 2017 May 4;23(9):2277-2288. Epub 2016 Nov 4.

Division of Medical Oncology, Experimental Cell Therapy, Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Torino, Italy.

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May 2017

Adoptive immunotherapy against ovarian cancer.

Authors:

Gloria Mittica Sonia Capellero Sofia Genta Celeste Cagnazzo Massimo Aglietta Dario Sangiolo Giorgio Valabrega

J Ovarian Res 2016 May 17;9(1):30. Epub 2016 May 17.

Candiolo Cancer Institute-FPO- IRCCS, Candiolo, Turin, Italy.

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May 2016

Redirected T cells in cancer therapy.

Authors:

Dario Sangiolo

Expert Opin Biol Ther 2015 29;15(12):1667-70. Epub 2015 Oct 29.

a Department of Oncology , University of Turin , Turin , Italy.

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July 2016

Cytokine-induced killer cells as immunotherapy for solid tumors: current evidence and perspectives.

Authors:

Lidia Giraudo Loretta Gammaitoni Michela Cangemi Ramona Rotolo Massimo Aglietta Dario Sangiolo

Immunotherapy 2015 27;7(9):999-1010. Epub 2015 Aug 27.

Department of Oncology, University of Torino, Turin, Italy.

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August 2016

Synergy of molecular targeted approaches and immunotherapy in melanoma: preclinical basis and clinical perspectives.

Authors:

Martina Sanlorenzo Igor Vujic Adrian Moy Pietro Quaglino Maria Teresa Fierro Loretta Gammaitoni Fabrizio Carnevale-Schianca Massimo Aglietta Dario Sangiolo

Expert Opin Biol Ther 2015 24;15(10):1491-500. Epub 2015 Jul 24.

b 2 University of California San Francisco, Mt. Zion Cancer Research Center , 2340 Sutter Street N461, San Francisco, CA, USA.

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April 2016

The combination of sorafenib and everolimus shows antitumor activity in preclinical models of malignant pleural mesothelioma.

Authors:

Ymera Pignochino Carmine Dell'Aglio Simona Inghilleri Michele Zorzetto Marco Basiricò Federica Capozzi Marta Canta Davide Piloni Francesca Cemmi Dario Sangiolo Loretta Gammaitoni Marco Soster Serena Marchiò Ernesto Pozzi Patrizia Morbini Maurizio Luisetti Massimo Aglietta Giovanni Grignani Giulia M Stella

BMC Cancer 2015 May 8;15:374. Epub 2015 May 8.

Department of Molecular Medicine, - Section of Pneumology, Laboratory of Biochemistry & Genetics, University and Fondazione IRCCS Policlinico San Matteo, Pavia, 27100, Italy.

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May 2015