Dario Greco

Dario Greco

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Dario Greco

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An integrated quantitative structure and mechanism of action-activity relationship model of human serum albumin binding.

J Cheminform 2019 Jun 6;11(1):38. Epub 2019 Jun 6.

Faculty of Medicine and Health Technology, Tampere University, Arvo Ylpön katu 34, Tampere, Finland.

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http://dx.doi.org/10.1186/s13321-019-0359-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551915PMC
June 2019

Molecular Signature of Asthma-Enhanced Sensitivity to CuO Nanoparticle Aerosols from 3D Cell Model.

ACS Nano 2019 Jun 17;13(6):6932-6946. Epub 2019 Jun 17.

Human Microbiome Research, Faculty of Medicine , University of Helsinki , P.O. Box 21, Helsinki 00290 , Finland.

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http://dx.doi.org/10.1021/acsnano.9b01823DOI Listing
June 2019

Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy.

J Allergy Clin Immunol 2019 Jun 13. Epub 2019 Jun 13.

Adult Immunodeficiency Unit, Infectious Diseases, Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Rare Diseases Center and Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.06.003DOI Listing
June 2019

MaNGA: a novel multi-objective multi-niche genetic algorithm for QSAR modelling.

Bioinformatics 2019 Jun 24. Epub 2019 Jun 24.

Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

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http://dx.doi.org/10.1093/bioinformatics/btz521DOI Listing
June 2019

Tape-stripping alters the microbe-host correlations in mouse skin.

Allergy 2019 Mar 22;74(3):617-621. Epub 2018 Nov 22.

Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.

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http://doi.wiley.com/10.1111/all.13653
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http://dx.doi.org/10.1111/all.13653DOI Listing
March 2019

Peanut oral immunotherapy increases IgG4 to Ara h 1, 2, and 6 but does not affect IgG4 to other allergens.

Pediatr Allergy Immunol 2019 03 31;30(2):248-252. Epub 2019 Jan 31.

Department of Allergology, the Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1111/pai.13012DOI Listing
March 2019

FunMappOne: a tool to hierarchically organize and visually navigate functional gene annotations in multiple experiments.

BMC Bioinformatics 2019 Feb 15;20(1):79. Epub 2019 Feb 15.

Faculty of Medicine and Life Sciences, University of Tampere, Arvo Ylpön katu 34 - Arvo building, Tampere, FI-33014, Finland.

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http://dx.doi.org/10.1186/s12859-019-2639-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376640PMC
February 2019

eUTOPIA: solUTion for Omics data PreprocessIng and Analysis.

Source Code Biol Med 2019 29;14. Epub 2019 Jan 29.

1Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland.

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http://dx.doi.org/10.1186/s13029-019-0071-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352382PMC
January 2019

INfORM: Inference of NetwOrk Response Modules.

Bioinformatics 2018 06;34(12):2136-2138

Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1093/bioinformatics/bty063DOI Listing
June 2018

DNA methylation in childhood asthma: an epigenome-wide meta-analysis.

Lancet Respir Med 2018 05 26;6(5):379-388. Epub 2018 Feb 26.

GRIAC research institute Groningen, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pediatric Pulmonology and Pediatric Allergy, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30052-3DOI Listing
May 2018

IntEREst: intron-exon retention estimator.

BMC Bioinformatics 2018 04 11;19(1):130. Epub 2018 Apr 11.

Institute of Biotechnology, University of Helsinki, P.O. Box 56 (Viikinkaari 5), FI-00014, Helsinki, Finland.

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http://dx.doi.org/10.1186/s12859-018-2122-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896110PMC
April 2018

Gene Expression Profiling of Gliadin Effects on Intestinal Epithelial Cells Suggests Novel Non-Enzymatic Functions of Pepsin and Trypsin.

PLoS One 2013 18;8(6):e66307. Epub 2013 Jun 18.

Research Programs Unit, Immunobiology, and Haartman Institute, Department of Medical Genetics, University of Helsinki, Helsinki, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066307PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688875PMC
October 2017

Genetic modifiers of CHEK2*1100delC-associated breast cancer risk.

Genet Med 2017 05 6;19(5):599-603. Epub 2016 Oct 6.

Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/gim.2016.147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382131PMC
May 2017

Peanut oral immunotherapy decreases IgE to Ara h 2 and Ara h 6 but does not enhance sensitization to cross-reactive allergens.

J Allergy Clin Immunol 2017 04 1;139(4):1393-1396.e6. Epub 2016 Dec 1.

Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.jaci.2016.09.054DOI Listing
April 2017

Network Analysis Reveals Similar Transcriptomic Responses to Intrinsic Properties of Carbon Nanomaterials in Vitro and in Vivo.

ACS Nano 2017 04 11;11(4):3786-3796. Epub 2017 Apr 11.

Institute of Environmental Medicine (IMM), Karolinska Institutet , 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1021/acsnano.6b08650DOI Listing
April 2017

CONDOP: an R package for CONdition-Dependent Operon Predictions.

Bioinformatics 2016 10 13;32(20):3199-3200. Epub 2016 Jun 13.

Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1093/bioinformatics/btw330DOI Listing
October 2016

Expression of DAI by an oncolytic vaccinia virus boosts the immunogenicity of the virus and enhances antitumor immunity.

Mol Ther Oncolytics 2016 23;3:16002. Epub 2016 Mar 23.

Laboratory of ImmunoViroTherapy, Centre for Drug Research (CDR), Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki , Helsinki, Finland.

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http://dx.doi.org/10.1038/mto.2016.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008257PMC
September 2016

Divergent genes in potential inoculant Sinorhizobium strains are related to DNA replication, recombination, and repair.

J Basic Microbiol 2016 Jun 16;56(6):680-5. Epub 2016 Feb 16.

Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland.

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http://doi.wiley.com/10.1002/jobm.201500592
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http://dx.doi.org/10.1002/jobm.201500592DOI Listing
June 2016

A secretomics analysis reveals major differences in the macrophage responses towards different types of carbon nanotubes.

Nanotoxicology 2015 17;9(6):719-28. Epub 2014 Oct 17.

Nanosafety Research Centre, Finnish Institute of Occupational Health , Helsinki , Finland.

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http://dx.doi.org/10.3109/17435390.2014.969346DOI Listing
April 2016

MVDA: a multi-view genomic data integration methodology.

BMC Bioinformatics 2015 Aug 19;16:261. Epub 2015 Aug 19.

Unit of Systems Toxicology and Nanosafety Research Centre, Finnish Institute of Occupational Health, FIOH, Helsinki, Finland.

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http://dx.doi.org/10.1186/s12859-015-0680-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539887PMC
August 2015

MicroRNA related polymorphisms and breast cancer risk.

Authors:
Sofia Khan Dario Greco Kyriaki Michailidou Roger L Milne Taru A Muranen Tuomas Heikkinen Kirsimari Aaltonen Joe Dennis Manjeet K Bolla Jianjun Liu Per Hall Astrid Irwanto Keith Humphreys Jingmei Li Kamila Czene Jenny Chang-Claude Rebecca Hein Anja Rudolph Petra Seibold Dieter Flesch-Janys Olivia Fletcher Julian Peto Isabel dos Santos Silva Nichola Johnson Lorna Gibson Zoe Aitken John L Hopper Helen Tsimiklis Minh Bui Enes Makalic Daniel F Schmidt Melissa C Southey Carmel Apicella Jennifer Stone Quinten Waisfisz Hanne Meijers-Heijboer Muriel A Adank Rob B van der Luijt Alfons Meindl Rita K Schmutzler Bertram Müller-Myhsok Peter Lichtner Clare Turnbull Nazneen Rahman Stephen J Chanock David J Hunter Angela Cox Simon S Cross Malcolm W R Reed Marjanka K Schmidt Annegien Broeks Laura J Van't Veer Frans B Hogervorst Peter A Fasching Michael G Schrauder Arif B Ekici Matthias W Beckmann Stig E Bojesen Børge G Nordestgaard Sune F Nielsen Henrik Flyger Javier Benitez Pilar M Zamora Jose I A Perez Christopher A Haiman Brian E Henderson Fredrick Schumacher Loic Le Marchand Paul D P Pharoah Alison M Dunning Mitul Shah Robert Luben Judith Brown Fergus J Couch Xianshu Wang Celine Vachon Janet E Olson Diether Lambrechts Matthieu Moisse Robert Paridaens Marie-Rose Christiaens Pascal Guénel Thérèse Truong Pierre Laurent-Puig Claire Mulot Frederick Marme Barbara Burwinkel Andreas Schneeweiss Christof Sohn Elinor J Sawyer Ian Tomlinson Michael J Kerin Nicola Miller Irene L Andrulis Julia A Knight Sandrine Tchatchou Anna Marie Mulligan Thilo Dörk Natalia V Bogdanova Natalia N Antonenkova Hoda Anton-Culver Hatef Darabi Mikael Eriksson Montserrat Garcia-Closas Jonine Figueroa Jolanta Lissowska Louise Brinton Peter Devilee Robert A E M Tollenaar Caroline Seynaeve Christi J van Asperen Vessela N Kristensen Susan Slager Amanda E Toland Christine B Ambrosone Drakoulis Yannoukakos Annika Lindblom Sara Margolin Paolo Radice Paolo Peterlongo Monica Barile Paolo Mariani Maartje J Hooning John W M Martens J Margriet Collée Agnes Jager Anna Jakubowska Jan Lubinski Katarzyna Jaworska-Bieniek Katarzyna Durda Graham G Giles Catriona McLean Hiltrud Brauch Thomas Brüning Yon-Dschun Ko Hermann Brenner Aida Karina Dieffenbach Volker Arndt Christa Stegmaier Anthony Swerdlow Alan Ashworth Nick Orr Michael Jones Jacques Simard Mark S Goldberg France Labrèche Martine Dumont Robert Winqvist Katri Pylkäs Arja Jukkola-Vuorinen Mervi Grip Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen Arto Mannermaa Ute Hamann Georgia Chenevix-Trench Carl Blomqvist Kristiina Aittomäki Douglas F Easton Heli Nevanlinna

PLoS One 2014 12;9(11):e109973. Epub 2014 Nov 12.

Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

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http://pubman.mpdl.mpg.de/pubman/item/escidoc:2147492/compon
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http://dx.plos.org/10.1371/journal.pone.0109973
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109973PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229095PMC
July 2015

A robust and accurate method for feature selection and prioritization from multi-class OMICs data.

PLoS One 2014 23;9(9):e107801. Epub 2014 Sep 23.

Unit of Systems Toxicology, Finnish Institute of Occupational Health (FIOH), Helsinki, Finland; Nanosafety Centre, Finnish Institute of Occupational Health (FIOH), Helsinki, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107801PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172658PMC
June 2015

A multi-view genomic data simulator.

BMC Bioinformatics 2015 May 12;16:151. Epub 2015 May 12.

Unit of Systems Toxicology and Nanosafety Research Centre, Finnish Institute of Occupational Health, FIOH, Helsinki, Finland.

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http://dx.doi.org/10.1186/s12859-015-0577-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448275PMC
May 2015

Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes.

Clin Epigenetics 2015 26;7:34. Epub 2015 Mar 26.

Department of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska Institutet, Stockholm, Sweden ; Folkhälsan Institute of Genetics, Helsinki, and Research Programs Unit, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1186/s13148-015-0064-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396570PMC
April 2015

Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus.

Hum Mol Genet 2015 Feb 25;24(3):875-90. Epub 2014 Sep 25.

Department of Biosciences and Nutrition, and Center for Innovative Medicine (CIMED), Karolinska Institutet, Stockholm 141 83, Sweden Centre of Allergy Research, Karolinska Institutet, Stockholm 171 77, Sweden

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddu479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291244PMC
February 2015

BACA: bubble chArt to compare annotations.

BMC Bioinformatics 2015 Feb 5;16:37. Epub 2015 Feb 5.

Unit of Systems Toxicology, Finnish Institute of Occupational Health (FIOH), Topeliuksenkatu 41b, 00250, Helsinki, Finland.

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http://dx.doi.org/10.1186/s12859-015-0477-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377007PMC
February 2015

Global analysis of the nuclear processing of transcripts with unspliced U12-type introns by the exosome.

Nucleic Acids Res 2014 Jun 21;42(11):7358-69. Epub 2014 May 21.

Institute of Biotechnology, P.O. Box 56, FI-00014 University of Helsinki, Finland

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http://dx.doi.org/10.1093/nar/gku391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066798PMC
June 2014

Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer.

Authors:
Kristen S Purrington Susan Slager Diana Eccles Drakoulis Yannoukakos Peter A Fasching Penelope Miron Jane Carpenter Jenny Chang-Claude Nicholas G Martin Grant W Montgomery Vessela Kristensen Hoda Anton-Culver Paul Goodfellow William J Tapper Sajjad Rafiq Susan M Gerty Lorraine Durcan Irene Konstantopoulou Florentia Fostira Athanassios Vratimos Paraskevi Apostolou Irene Konstanta Vassiliki Kotoula Sotiris Lakis Meletios A Dimopoulos Dimosthenis Skarlos Dimitrios Pectasides George Fountzilas Matthias W Beckmann Alexander Hein Matthias Ruebner Arif B Ekici Arndt Hartmann Ruediger Schulz-Wendtland Stefan P Renner Wolfgang Janni Brigitte Rack Christoph Scholz Julia Neugebauer Ulrich Andergassen Michael P Lux Lothar Haeberle Christine Clarke Nirmala Pathmanathan Anja Rudolph Dieter Flesch-Janys Stefan Nickels Janet E Olson James N Ingle Curtis Olswold Seth Slettedahl Jeanette E Eckel-Passow S Keith Anderson Daniel W Visscher Victoria L Cafourek Hugues Sicotte Naresh Prodduturi Elisabete Weiderpass Leslie Bernstein Argyrios Ziogas Jennifer Ivanovich Graham G Giles Laura Baglietto Melissa Southey Veli-Matti Kosma Hans-Peter Fischer Malcom W R Reed Simon S Cross Sandra Deming-Halverson Martha Shrubsole Qiuyin Cai Xiao-Ou Shu Mary Daly Joellen Weaver Eric Ross Jennifer Klemp Priyanka Sharma Diana Torres Thomas Rüdiger Heidrun Wölfing Hans-Ulrich Ulmer Asta Försti Thaer Khoury Shicha Kumar Robert Pilarski Charles L Shapiro Dario Greco Päivi Heikkilä Kristiina Aittomäki Carl Blomqvist Astrid Irwanto Jianjun Liu Vernon Shane Pankratz Xianshu Wang Gianluca Severi Arto Mannermaa Douglas Easton Per Hall Hiltrud Brauch Angela Cox Wei Zheng Andrew K Godwin Ute Hamann Christine Ambrosone Amanda Ewart Toland Heli Nevanlinna Celine M Vachon Fergus J Couch

Carcinogenesis 2014 May 9;35(5):1012-9. Epub 2013 Dec 9.

Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1093/carcin/bgt404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004200PMC
May 2014

Transcriptome dynamics-based operon prediction in prokaryotes.

BMC Bioinformatics 2014 May 16;15:145. Epub 2014 May 16.

Department of Computer Science (DI), NeuRoNe Lab, University of Salerno, via ponte don Melillo 84084, Fisciano, (SA), Italy.

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http://dx.doi.org/10.1186/1471-2105-15-145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235196PMC
May 2014

Differentially methylated regions in maternal and paternal uniparental disomy for chromosome 7.

Epigenetics 2014 Mar 18;9(3):351-65. Epub 2013 Nov 18.

Department of Medical Genetics; Haartman Institute; Molecular Neurology Program; Research Program's Unit; Folkhälsan Institute of Genetics; University of Helsinki; Helsinki, Finland; Department of Biosciences and Nutrition; Center for Biosciences; Karolinska Institutet; Stockholm, Sweden; Science for Life Laboratory; Karolinska Institutet; Solna, Sweden.

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http://dx.doi.org/10.4161/epi.27160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053454PMC
March 2014

Drug repositioning: a machine-learning approach through data integration.

J Cheminform 2013 Jun 22;5(1):30. Epub 2013 Jun 22.

Research Unit of Molecular Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1186/1758-2946-5-30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704944PMC
June 2013

Genome-wide association studies identify four ER negative-specific breast cancer risk loci.

Authors:
Montserrat Garcia-Closas Fergus J Couch Sara Lindstrom Kyriaki Michailidou Marjanka K Schmidt Mark N Brook Nick Orr Suhn Kyong Rhie Elio Riboli Heather S Feigelson Loic Le Marchand Julie E Buring Diana Eccles Penelope Miron Peter A Fasching Hiltrud Brauch Jenny Chang-Claude Jane Carpenter Andrew K Godwin Heli Nevanlinna Graham G Giles Angela Cox John L Hopper Manjeet K Bolla Qin Wang Joe Dennis Ed Dicks Will J Howat Nils Schoof Stig E Bojesen Diether Lambrechts Annegien Broeks Irene L Andrulis Pascal Guénel Barbara Burwinkel Elinor J Sawyer Antoinette Hollestelle Olivia Fletcher Robert Winqvist Hermann Brenner Arto Mannermaa Ute Hamann Alfons Meindl Annika Lindblom Wei Zheng Peter Devillee Mark S Goldberg Jan Lubinski Vessela Kristensen Anthony Swerdlow Hoda Anton-Culver Thilo Dörk Kenneth Muir Keitaro Matsuo Anna H Wu Paolo Radice Soo Hwang Teo Xiao-Ou Shu William Blot Daehee Kang Mikael Hartman Suleeporn Sangrajrang Chen-Yang Shen Melissa C Southey Daniel J Park Fleur Hammet Jennifer Stone Laura J Van't Veer Emiel J Rutgers Artitaya Lophatananon Sarah Stewart-Brown Pornthep Siriwanarangsan Julian Peto Michael G Schrauder Arif B Ekici Matthias W Beckmann Isabel Dos Santos Silva Nichola Johnson Helen Warren Ian Tomlinson Michael J Kerin Nicola Miller Federick Marme Andreas Schneeweiss Christof Sohn Therese Truong Pierre Laurent-Puig Pierre Kerbrat Børge G Nordestgaard Sune F Nielsen Henrik Flyger Roger L Milne Jose Ignacio Arias Perez Primitiva Menéndez Heiko Müller Volker Arndt Christa Stegmaier Peter Lichtner Magdalena Lochmann Christina Justenhoven Yon-Dschun Ko Taru A Muranen Kristiina Aittomäki Carl Blomqvist Dario Greco Tuomas Heikkinen Hidemi Ito Hiroji Iwata Yasushi Yatabe Natalia N Antonenkova Sara Margolin Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen Rosemary Balleine Chiu-Chen Tseng David Van Den Berg Daniel O Stram Patrick Neven Anne-Sophie Dieudonné Karin Leunen Anja Rudolph Stefan Nickels Dieter Flesch-Janys Paolo Peterlongo Bernard Peissel Loris Bernard Janet E Olson Xianshu Wang Kristen Stevens Gianluca Severi Laura Baglietto Catriona McLean Gerhard A Coetzee Ye Feng Brian E Henderson Fredrick Schumacher Natalia V Bogdanova France Labrèche Martine Dumont Cheng Har Yip Nur Aishah Mohd Taib Ching-Yu Cheng Martha Shrubsole Jirong Long Katri Pylkäs Arja Jukkola-Vuorinen Saila Kauppila Julia A Knight Gord Glendon Anna Marie Mulligan Robertus A E M Tollenaar Caroline M Seynaeve Mieke Kriege Maartje J Hooning Ans M W van den Ouweland Carolien H M van Deurzen Wei Lu Yu-Tang Gao Hui Cai Sabapathy P Balasubramanian Simon S Cross Malcolm W R Reed Lisa Signorello Qiuyin Cai Mitul Shah Hui Miao Ching Wan Chan Kee Seng Chia Anna Jakubowska Katarzyna Jaworska Katarzyna Durda Chia-Ni Hsiung Pei-Ei Wu Jyh-Cherng Yu Alan Ashworth Michael Jones Daniel C Tessier Anna González-Neira Guillermo Pita M Rosario Alonso Daniel Vincent Francois Bacot Christine B Ambrosone Elisa V Bandera Esther M John Gary K Chen Jennifer J Hu Jorge L Rodriguez-Gil Leslie Bernstein Michael F Press Regina G Ziegler Robert M Millikan Sandra L Deming-Halverson Sarah Nyante Sue A Ingles Quinten Waisfisz Helen Tsimiklis Enes Makalic Daniel Schmidt Minh Bui Lorna Gibson Bertram Müller-Myhsok Rita K Schmutzler Rebecca Hein Norbert Dahmen Lars Beckmann Kirsimari Aaltonen Kamila Czene Astrid Irwanto Jianjun Liu Clare Turnbull Nazneen Rahman Hanne Meijers-Heijboer Andre G Uitterlinden Fernando Rivadeneira Curtis Olswold Susan Slager Robert Pilarski Foluso Ademuyiwa Irene Konstantopoulou Nicholas G Martin Grant W Montgomery Dennis J Slamon Claudia Rauh Michael P Lux Sebastian M Jud Thomas Bruning Joellen Weaver Priyanka Sharma Harsh Pathak Will Tapper Sue Gerty Lorraine Durcan Dimitrios Trichopoulos Rosario Tumino Petra H Peeters Rudolf Kaaks Daniele Campa Federico Canzian Elisabete Weiderpass Mattias Johansson Kay-Tee Khaw Ruth Travis Françoise Clavel-Chapelon Laurence N Kolonel Constance Chen Andy Beck Susan E Hankinson Christine D Berg Robert N Hoover Jolanta Lissowska Jonine D Figueroa Daniel I Chasman Mia M Gaudet W Ryan Diver Walter C Willett David J Hunter Jacques Simard Javier Benitez Alison M Dunning Mark E Sherman Georgia Chenevix-Trench Stephen J Chanock Per Hall Paul D P Pharoah Celine Vachon Douglas F Easton Christopher A Haiman Peter Kraft

Nat Genet 2013 Apr;45(4):392-8, 398e1-2

1] Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK. [2] Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK. [3].

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http://dx.doi.org/10.1038/ng.2561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771695PMC
April 2013

What dictates the accumulation of desmosterol in the developing brain?

FASEB J 2013 Mar 10;27(3):865-70. Epub 2012 Dec 10.

Institute of Biomedicine, Anatomy, University of Helsinki, Helsinki, Finland.

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http://www.fasebj.org/content/early/2012/12/07/fj.12-211235.
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http://www.fasebj.org/cgi/doi/10.1096/fj.12-211235
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http://dx.doi.org/10.1096/fj.12-211235DOI Listing
March 2013

A mitochondrial ribosomal and RNA decay pathway blocks cell proliferation.

Curr Biol 2013 Mar 28;23(6):535-41. Epub 2013 Feb 28.

Research Programs Unit - Molecular Neurology and Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.cub.2013.02.019DOI Listing
March 2013

Re-analysis of bipolar disorder and schizophrenia gene expression complements the Kraepelinian dichotomy.

Adv Exp Med Biol 2012 ;736:563-77

Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1007/978-1-4419-7210-1_33DOI Listing
January 2013

A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11.

Authors:
Afshan Siddiq Fergus J Couch Gary K Chen Sara Lindström Diana Eccles Robert C Millikan Kyriaki Michailidou Daniel O Stram Lars Beckmann Suhn Kyong Rhie Christine B Ambrosone Kristiina Aittomäki Pilar Amiano Carmel Apicella Laura Baglietto Elisa V Bandera Matthias W Beckmann Christine D Berg Leslie Bernstein Carl Blomqvist Hiltrud Brauch Louise Brinton Quang M Bui Julie E Buring Saundra S Buys Daniele Campa Jane E Carpenter Daniel I Chasman Jenny Chang-Claude Constance Chen Françoise Clavel-Chapelon Angela Cox Simon S Cross Kamila Czene Sandra L Deming Robert B Diasio W Ryan Diver Alison M Dunning Lorraine Durcan Arif B Ekici Peter A Fasching Heather Spencer Feigelson Laura Fejerman Jonine D Figueroa Olivia Fletcher Dieter Flesch-Janys Mia M Gaudet Susan M Gerty Jorge L Rodriguez-Gil Graham G Giles Carla H van Gils Andrew K Godwin Nikki Graham Dario Greco Per Hall Susan E Hankinson Arndt Hartmann Rebecca Hein Judith Heinz Robert N Hoover John L Hopper Jennifer J Hu Scott Huntsman Sue A Ingles Astrid Irwanto Claudine Isaacs Kevin B Jacobs Esther M John Christina Justenhoven Rudolf Kaaks Laurence N Kolonel Gerhard A Coetzee Mark Lathrop Loic Le Marchand Adam M Lee I-Min Lee Timothy Lesnick Peter Lichtner Jianjun Liu Eiliv Lund Enes Makalic Nicholas G Martin Catriona A McLean Hanne Meijers-Heijboer Alfons Meindl Penelope Miron Kristine R Monroe Grant W Montgomery Bertram Müller-Myhsok Stefan Nickels Sarah J Nyante Curtis Olswold Kim Overvad Domenico Palli Daniel J Park Julie R Palmer Harsh Pathak Julian Peto Paul Pharoah Nazneen Rahman Fernando Rivadeneira Daniel F Schmidt Rita K Schmutzler Susan Slager Melissa C Southey Kristen N Stevens Hans-Peter Sinn Michael F Press Eric Ross Elio Riboli Paul M Ridker Fredrick R Schumacher Gianluca Severi Isabel Dos Santos Silva Jennifer Stone Malin Sund William J Tapper Michael J Thun Ruth C Travis Clare Turnbull Andre G Uitterlinden Quinten Waisfisz Xianshu Wang Zhaoming Wang Joellen Weaver Rüdiger Schulz-Wendtland Lynne R Wilkens David Van Den Berg Wei Zheng Regina G Ziegler Elad Ziv Heli Nevanlinna Douglas F Easton David J Hunter Brian E Henderson Stephen J Chanock Montserrat Garcia-Closas Peter Kraft Christopher A Haiman Celine M Vachon

Hum Mol Genet 2012 Dec 13;21(24):5373-84. Epub 2012 Sep 13.

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.

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December 2012

miRSeqNovel: an R based workflow for analyzing miRNA sequencing data.

Mol Cell Probes 2012 Oct 17;26(5):208-11. Epub 2012 May 17.

DNA Sequencing and Genomics Laboratory, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

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October 2012

Experience-dependent expression of NPAS4 regulates plasticity in adult visual cortex.

J Physiol 2012 Oct 6;590(19):4777-87. Epub 2012 Jun 6.

Scuola Normale Superiore, Neurobiology Laboratory, Piazza dei Cavalieri Pisa 56100 Italy.

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http://dx.doi.org/10.1113/jphysiol.2012.234237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487036PMC
October 2012

The role of genetic breast cancer susceptibility variants as prognostic factors.

Authors:
Peter A Fasching Paul D P Pharoah Angela Cox Heli Nevanlinna Stig E Bojesen Thomas Karn Annegien Broeks Flora E van Leeuwen Laura J van't Veer Renate Udo Alison M Dunning Dario Greco Kristiina Aittomäki Carl Blomqvist Mitul Shah Børge G Nordestgaard Henrik Flyger John L Hopper Melissa C Southey Carmel Apicella Montserrat Garcia-Closas Mark Sherman Jolanta Lissowska Caroline Seynaeve Petra E A Huijts Rob A E M Tollenaar Argyrios Ziogas Arif B Ekici Claudia Rauh Arto Mannermaa Vesa Kataja Veli-Matti Kosma Jaana M Hartikainen Irene L Andrulis Hilmi Ozcelik Anna-Marie Mulligan Gord Glendon Per Hall Kamila Czene Jianjun Liu Jenny Chang-Claude Shan Wang-Gohrke Ursula Eilber Stefan Nickels Thilo Dörk Maria Schiekel Michael Bremer Tjoung-Won Park-Simon Graham G Giles Gianluca Severi Laura Baglietto Maartje J Hooning John W M Martens Agnes Jager Mieke Kriege Annika Lindblom Sara Margolin Fergus J Couch Kristen N Stevens Janet E Olson Matthew Kosel Simon S Cross Sabapathy P Balasubramanian Malcolm W R Reed Alexander Miron Esther M John Robert Winqvist Katri Pylkäs Arja Jukkola-Vuorinen Saila Kauppila Barbara Burwinkel Frederik Marme Andreas Schneeweiss Christof Sohn Georgia Chenevix-Trench Diether Lambrechts Anne-Sophie Dieudonne Sigrid Hatse Erik van Limbergen Javier Benitez Roger L Milne M Pilar Zamora José Ignacio Arias Pérez Bernardo Bonanni Bernard Peissel Bernard Loris Paolo Peterlongo Preetha Rajaraman Sara J Schonfeld Hoda Anton-Culver Peter Devilee Matthias W Beckmann Dennis J Slamon Kelly-Anne Phillips Jonine D Figueroa Manjeet K Humphreys Douglas F Easton Marjanka K Schmidt

Hum Mol Genet 2012 Sep 24;21(17):3926-39. Epub 2012 Apr 24.

University Breast Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Comprehensive Cancer Center Erlangen Nuremberg, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.

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September 2012

Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses.

J Immunol 2012 Sep 17;189(6):2941-53. Epub 2012 Aug 17.

Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli 80131, Italy.

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September 2012

Variants on the promoter region of PTEN affect breast cancer progression and patient survival.

Breast Cancer Res 2011 15;13(6):R130. Epub 2011 Dec 15.

Department of Obstetrics and Gynecology, Helsinki University Central Hospital, 00029 HUS, Helsinki, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326572PMC
June 2012

NQO1 expression correlates inversely with NFκB activation in human breast cancer.

Breast Cancer Res Treat 2012 Apr 25;132(3):955-68. Epub 2011 Jun 25.

Department of Obstetrics and Gynecology, Biomedicum Helsinki, Helsinki University Central Hospital, PO Box 700, 00029 Helsinki, Finland.

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April 2012

19p13.1 is a triple-negative-specific breast cancer susceptibility locus.

Authors:
Kristen N Stevens Zachary Fredericksen Celine M Vachon Xianshu Wang Sara Margolin Annika Lindblom Heli Nevanlinna Dario Greco Kristiina Aittomäki Carl Blomqvist Jenny Chang-Claude Alina Vrieling Dieter Flesch-Janys Hans-Peter Sinn Shan Wang-Gohrke Stefan Nickels Hiltrud Brauch Yon-Dschun Ko Hans-Peter Fischer Rita K Schmutzler Alfons Meindl Claus R Bartram Sarah Schott Christoph Engel Andrew K Godwin Joellen Weaver Harsh B Pathak Priyanka Sharma Hermann Brenner Heiko Müller Volker Arndt Christa Stegmaier Penelope Miron Drakoulis Yannoukakos Alexandra Stavropoulou George Fountzilas Helen J Gogas Ruth Swann Miriam Dwek Annie Perkins Roger L Milne Javier Benítez María Pilar Zamora José Ignacio Arias Pérez Stig E Bojesen Sune F Nielsen Børge G Nordestgaard Henrik Flyger Pascal Guénel Thérèse Truong Florence Menegaux Emilie Cordina-Duverger Barbara Burwinkel Frederick Marmé Andreas Schneeweiss Christof Sohn Elinor Sawyer Ian Tomlinson Michael J Kerin Julian Peto Nichola Johnson Olivia Fletcher Isabel Dos Santos Silva Peter A Fasching Matthias W Beckmann Arndt Hartmann Arif B Ekici Artitaya Lophatananon Kenneth Muir Puttisak Puttawibul Surapon Wiangnon Marjanka K Schmidt Annegien Broeks Linde M Braaf Efraim H Rosenberg John L Hopper Carmel Apicella Daniel J Park Melissa C Southey Anthony J Swerdlow Alan Ashworth Nicholas Orr Minouk J Schoemaker Hoda Anton-Culver Argyrios Ziogas Leslie Bernstein Christina Clarke Dur Chen-Yang Shen Jyh-Cherng Yu Huan-Ming Hsu Chia-Ni Hsiung Ute Hamann Thomas Dünnebier Thomas Rüdiger Hans Ulrich Ulmer Paul P Pharoah Alison M Dunning Manjeet K Humphreys Qin Wang Angela Cox Simon S Cross Malcom W Reed Per Hall Kamila Czene Christine B Ambrosone Foluso Ademuyiwa Helena Hwang Diana M Eccles Montserrat Garcia-Closas Jonine D Figueroa Mark E Sherman Jolanta Lissowska Peter Devilee Caroline Seynaeve Rob A E M Tollenaar Maartje J Hooning Irene L Andrulis Julia A Knight Gord Glendon Anna Marie Mulligan Robert Winqvist Katri Pylkäs Arja Jukkola-Vuorinen Mervi Grip Esther M John Alexander Miron Grethe Grenaker Alnæs Vessela Kristensen Anne-Lise Børresen-Dale Graham G Giles Laura Baglietto Catriona A McLean Gianluca Severi Matthew L Kosel V S Pankratz Susan Slager Janet E Olson Paolo Radice Paolo Peterlongo Siranoush Manoukian Monica Barile Diether Lambrechts Sigrid Hatse Anne-Sophie Dieudonne Marie-Rose Christiaens Georgia Chenevix-Trench Jonathan Beesley Xiaoqing Chen Arto Mannermaa Veli-Matti Kosma Jaana M Hartikainen Ylermi Soini Douglas F Easton Fergus J Couch

Cancer Res 2012 Apr 13;72(7):1795-803. Epub 2012 Feb 13.

Departments of Health Sciences Research and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.

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April 2012

Human papillomavirus 16 E5 modulates the expression of host microRNAs.

PLoS One 2011 1;6(7):e21646. Epub 2011 Jul 1.

DNA Sequencing and Genomics Laboratory, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128596PMC
November 2011

Common breast cancer susceptibility loci are associated with triple-negative breast cancer.

Cancer Res 2011 Oct 15;71(19):6240-9. Epub 2011 Aug 15.

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327299PMC
October 2011

A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer.

Authors:
Christopher A Haiman Gary K Chen Celine M Vachon Federico Canzian Alison Dunning Robert C Millikan Xianshu Wang Foluso Ademuyiwa Shahana Ahmed Christine B Ambrosone Laura Baglietto Rosemary Balleine Elisa V Bandera Matthias W Beckmann Christine D Berg Leslie Bernstein Carl Blomqvist William J Blot Hiltrud Brauch Julie E Buring Lisa A Carey Jane E Carpenter Jenny Chang-Claude Stephen J Chanock Daniel I Chasman Christine L Clarke Angela Cox Simon S Cross Sandra L Deming Robert B Diasio Athanasios M Dimopoulos W Ryan Driver Thomas Dünnebier Lorraine Durcan Diana Eccles Christopher K Edlund Arif B Ekici Peter A Fasching Heather S Feigelson Dieter Flesch-Janys Florentia Fostira Asta Försti George Fountzilas Susan M Gerty Graham G Giles Andrew K Godwin Paul Goodfellow Nikki Graham Dario Greco Ute Hamann Susan E Hankinson Arndt Hartmann Rebecca Hein Judith Heinz Andrea Holbrook Robert N Hoover Jennifer J Hu David J Hunter Sue A Ingles Astrid Irwanto Jennifer Ivanovich Esther M John Nicola Johnson Arja Jukkola-Vuorinen Rudolf Kaaks Yon-Dschun Ko Laurence N Kolonel Irene Konstantopoulou Veli-Matti Kosma Swati Kulkarni Diether Lambrechts Adam M Lee Loïc Le Marchand Timothy Lesnick Jianjun Liu Sara Lindstrom Arto Mannermaa Sara Margolin Nicholas G Martin Penelope Miron Grant W Montgomery Heli Nevanlinna Stephan Nickels Sarah Nyante Curtis Olswold Julie Palmer Harsh Pathak Dimitrios Pectasides Charles M Perou Julian Peto Paul D P Pharoah Loreall C Pooler Michael F Press Katri Pylkäs Timothy R Rebbeck Jorge L Rodriguez-Gil Lynn Rosenberg Eric Ross Thomas Rüdiger Isabel dos Santos Silva Elinor Sawyer Marjanka K Schmidt Rüdiger Schulz-Wendtland Fredrick Schumacher Gianluca Severi Xin Sheng Lisa B Signorello Hans-Peter Sinn Kristen N Stevens Melissa C Southey William J Tapper Ian Tomlinson Frans B L Hogervorst Els Wauters JoEllen Weaver Hans Wildiers Robert Winqvist David Van Den Berg Peggy Wan Lucy Y Xia Drakoulis Yannoukakos Wei Zheng Regina G Ziegler Afshan Siddiq Susan L Slager Daniel O Stram Douglas Easton Peter Kraft Brian E Henderson Fergus J Couch

Nat Genet 2011 Oct 30;43(12):1210-4. Epub 2011 Oct 30.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, USA.

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http://dx.doi.org/10.1038/ng.985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279120PMC
October 2011

Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications.

Breast Cancer Res 2011 Sep 20;13(5):R90. Epub 2011 Sep 20.

Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu 8, Helsinki, FI-00029, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262202PMC
September 2011

Glycodelin expression associates with differential tumour phenotype and outcome in sporadic and familial non-BRCA1/2 breast cancer patients.

Breast Cancer Res Treat 2011 Jul 30;128(1):85-95. Epub 2010 Jul 30.

Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Biomedicum Helsinki, Helsinki, Finland.

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July 2011

Gene expression analysis in SV-40 immortalized human corneal epithelial cells cultured with an air-liquid interface.

Mol Vis 2010 Oct 15;16:2109-20. Epub 2010 Oct 15.

Institute of Biotechnology, Centre for Drug Research, Department of Ophthalmology, University of Helsinki, Helsinki, Finland.

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October 2010

An association analysis of circadian genes in anxiety disorders.

Biol Psychiatry 2010 Jun 1;67(12):1163-70. Epub 2010 Feb 1.

Research Program of Molecular Neurology, University of Helsinki, Helsinki, Finland.

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June 2010

Bayesian integrated modeling of expression data: a case study on RhoG.

BMC Bioinformatics 2010 Jun 1;11:295. Epub 2010 Jun 1.

Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894040PMC
June 2010

Gene expression in human NAFLD.

Am J Physiol Gastrointest Liver Physiol 2008 May 3;294(5):G1281-7. Epub 2008 Apr 3.

Institute of Biotechnology, University of Helsinki, Finland.

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May 2008

Pre-filtering improves reliability of Affymetrix GeneChips results when used to analyze gene expression in complex tissues.

Mol Cell Probes 2008 Apr 28;22(2):115-21. Epub 2007 Nov 28.

DNA-Microarray Laboratory, Institute of Biotechnology, University of Helsinki, Finland.

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April 2008

Microarray analysis of a Chlamydia pneumoniae-infected human epithelial cell line by use of gene ontology hierarchy.

J Infect Dis 2008 Jan;197(1):156-62

Drug Discovery and Technology Development Center, Faculty of Pharmacy, PO Box 56 (Viikinkaari 5 E), FIN-00014 University of Helsinki, Finland.

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January 2008

Bdnf gene is a downstream target of Nurr1 transcription factor in rat midbrain neurons in vitro.

J Neurochem 2007 Jul 15;102(2):441-53. Epub 2007 May 15.

Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Developmental Neurobiology, Naples, Italy.

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July 2007

GDNF signaling in embryonic midbrain neurons in vitro.

Brain Res 2007 Jul 5;1159:28-39. Epub 2007 May 5.

Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, via P. Castellino 111, 80131 Naples, Italy.

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July 2007

Methylphenidate administration to adolescent rats determines plastic changes on reward-related behavior and striatal gene expression.

Neuropsychopharmacology 2006 Sep 23;31(9):1946-56. Epub 2005 Nov 23.

Department of Cell Biology & Neurosciences, Behavioral Neuroscience Section, Istituto Superiore di Sanità, Roma, Italy.

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September 2006

Altered midbrain dopaminergic neurotransmission during development in an animal model of ADHD.

Neurosci Biobehav Rev 2003 Nov;27(7):661-9

Institute of Genetics and Biophysics 'A Buzzati Traverso', CNR, Via P. Castellino 111, Naples 80135, Italy.

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November 2003

The Cu,Zn superoxide dismutase in neuroblastoma SK-N-BE cells is exported by a microvesicles dependent pathway.

Brain Res Mol Brain Res 2003 Jan;110(1):45-51

Department of Neuroscience and Behavioral Sciences, Section of Physiology, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.

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January 2003

The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures.

Biol Chem 2002 Jan;383(1):167-76

Centro di Endocrinologia ed Oncologia Sperimentale, CNR, Dpt. Biologia e Patologia Cellulare e Molecolare, Napoli, Italy.

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January 2002