Publications by authors named "Daria Mochly-Rosen"

100Publications

Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy.

J Neuroinflammation 2020 Jan 27;17(1):36. Epub 2020 Jan 27.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.

View Article and Find Full Text PDF
January 2020

Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer's disease related pathology.

Acta Neuropathol Commun 2019 12 12;7(1):190. Epub 2019 Dec 12.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.

View Article and Find Full Text PDF
December 2019

Alcohol consumption and vascular disease: other points to consider.

Lancet 2019 11;394(10209):1617-1618

Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address:

View Article and Find Full Text PDF
November 2019

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration.

Nat Neurosci 2019 10 23;22(10):1635-1648. Epub 2019 Sep 23.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.

View Article and Find Full Text PDF
October 2019

ALDH2 and Cardiovascular Disease.

Adv Exp Med Biol 2019 ;1193:53-67

Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, CA, USA.

View Article and Find Full Text PDF
September 2019

Small-Molecule Activators of Glucose-6-phosphate Dehydrogenase (G6PD) Bridging the Dimer Interface.

ChemMedChem 2019 07 27;14(14):1321-1324. Epub 2019 Jun 27.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

View Article and Find Full Text PDF
July 2019

Proteasome-Dependent Regulation of Distinct Metabolic States During Long-Term Culture of Human iPSC-Derived Cardiomyocytes.

Circ Res 2019 06 20;125(1):90-103. Epub 2019 May 20.

From the Stanford Cardiovascular Institute (A.E., Y.D., S.S., H.C., Y.L., P.G., J.C.W.), Stanford University School of Medicine, CA.

View Article and Find Full Text PDF
June 2019

Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy.

J Mol Cell Cardiol 2019 05 11;130:160-169. Epub 2019 Apr 11.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

View Article and Find Full Text PDF
May 2019

ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH Melanoma-Initiating Cells.

Cell Chem Biol 2018 12 4;25(12):1456-1469.e6. Epub 2018 Oct 4.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK. Electronic address:

View Article and Find Full Text PDF
December 2018

Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator.

Nat Commun 2018 10 2;9(1):4045. Epub 2018 Oct 2.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

View Article and Find Full Text PDF
October 2018

Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo.

Sci Rep 2018 09 19;8(1):14034. Epub 2018 Sep 19.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

View Article and Find Full Text PDF
September 2018

Targeting mitochondrial dysfunction and oxidative stress in heart failure: Challenges and opportunities.

Free Radic Biol Med 2018 12 15;129:155-168. Epub 2018 Sep 15.

Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, Brazil. Electronic address:

View Article and Find Full Text PDF
December 2018

Surviving in the Valley of Death: Opportunities and Challenges in Translating Academic Drug Discoveries.

Annu Rev Pharmacol Toxicol 2019 01 12;59:405-421. Epub 2018 Sep 12.

SPARK Translational Research Program, Stanford University School of Medicine, Stanford, California 94305, USA; email:

View Article and Find Full Text PDF
January 2019

Structural analysis of clinically relevant pathogenic G6PD variants reveals the importance of tetramerization for G6PD activity.

Matters (Zur) 2017 Sep;2017

Department of Chemical and Systems Biology, Stanford University School of Medicine.

View Article and Find Full Text PDF
September 2017

Mortal engines: Mitochondrial bioenergetics and dysfunction in neurodegenerative diseases.

Pharmacol Res 2018 12 23;138:2-15. Epub 2018 Aug 23.

Department of Chemical and Systems Biology, School of Medicine, Stanford University, CA, 94305-5174, USA. Electronic address:

View Article and Find Full Text PDF
December 2018

Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease.

Oncotarget 2018 Jan 22;9(5):6128-6143. Epub 2017 Dec 22.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

View Article and Find Full Text PDF
January 2018

Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis.

EMBO Mol Med 2018 03;10(3)

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA

View Article and Find Full Text PDF
March 2018

Human Chitotriosidase Does Not Catabolize Hyaluronan.

Int J Biol Macromol 2018 Apr 13;109:629-633. Epub 2017 Dec 13.

Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

View Article and Find Full Text PDF
April 2018

Thiophene bridged aldehydes (TBAs) image ALDH activity in cells modulation of intramolecular charge transfer.

Chem Sci 2017 Oct 24;8(10):7143-7151. Epub 2017 Aug 24.

Department of Bioengineering , University of California , 140 Hearst Memorial Mining Building , Berkeley , CA 94720 , USA . Email:

View Article and Find Full Text PDF
October 2017

Aldehyde dehydrogenase 2*2 knock-in mice show increased reactive oxygen species production in response to cisplatin treatment.

J Biomed Sci 2017 May 22;24(1):33. Epub 2017 May 22.

Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, CA, 94305, USA.

View Article and Find Full Text PDF
May 2017

The Role of Mitochondrial Aldehyde Dehydrogenase 2 (ALDH2) in Neuropathology and Neurodegeneration.

Acta Neurol Taiwan 2016 Dec;25(4):111-123

Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford CA 94305-5174 USA.

View Article and Find Full Text PDF
December 2016

Coupling between Protein Stability and Catalytic Activity Determines Pathogenicity of G6PD Variants.

Cell Rep 2017 03;18(11):2592-2599

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

View Article and Find Full Text PDF
March 2017

Peptides and peptidomimetics as regulators of protein-protein interactions.

Curr Opin Struct Biol 2017 06 4;44:59-66. Epub 2017 Jan 4.

Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, CA 94305-5174, USA. Electronic address:

View Article and Find Full Text PDF
June 2017

Aldehyde dehydrogenase 2 activation and coevolution of its εPKC-mediated phosphorylation sites.

J Biomed Sci 2017 Jan 5;24(1). Epub 2017 Jan 5.

Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, CA, 94305-5174, USA.

View Article and Find Full Text PDF
January 2017

Disruption of mitochondrial quality control in peripheral artery disease: New therapeutic opportunities.

Pharmacol Res 2017 01 19;115:96-106. Epub 2016 Nov 19.

Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, Brazil. Electronic address:

View Article and Find Full Text PDF
January 2017

Engineered Substrate-Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics.

Angew Chem Int Ed Engl 2016 12 17;55(50):15672-15679. Epub 2016 Nov 17.

Department of Chemical and Systems Biology, School of Medicine Stanford, Stanford University, CA, 94305-5174, USA.

View Article and Find Full Text PDF
December 2016

Peptidomimetic therapeutics: scientific approaches and opportunities.

Drug Discov Today 2017 02 14;22(2):454-462. Epub 2016 Nov 14.

Stanford University, Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford, CA 94305, USA.

View Article and Find Full Text PDF
February 2017

Potential biomarkers to follow the progression and treatment response of Huntington's disease.

J Exp Med 2016 11 7;213(12):2655-2669. Epub 2016 Nov 7.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305

View Article and Find Full Text PDF
November 2016

Correcting mitochondrial fusion by manipulating mitofusin conformations.

Nature 2016 12 24;540(7631):74-79. Epub 2016 Oct 24.

Center for Pharmacogenomics, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

View Article and Find Full Text PDF
December 2016

Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial Membrane Potential and Myocardial Reperfusion Injury.

J Am Heart Assoc 2016 09 26;5(9). Epub 2016 Sep 26.

Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, CA

View Article and Find Full Text PDF
September 2016

Aldehyde dehydrogenase 2 in aplastic anemia, Fanconi anemia and hematopoietic stem cells.

Mol Genet Metab 2016 09 15;119(1-2):28-36. Epub 2016 Jul 15.

Division of Stem Cell Biology and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.

View Article and Find Full Text PDF
September 2016

PKC-ALDH2 Pathway Plays a Novel Role in Adipocyte Differentiation.

PLoS One 2016 30;11(8):e0161993. Epub 2016 Aug 30.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

View Article and Find Full Text PDF
August 2017

VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.

Nat Commun 2016 08 26;7:12646. Epub 2016 Aug 26.

Department of Physiology &Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.

View Article and Find Full Text PDF
August 2016

Glucose-6-Phosphate Dehydrogenase Deficiency and the Need for a Novel Treatment to Prevent Kernicterus.

Clin Perinatol 2016 Jun 28;43(2):341-54. Epub 2016 Feb 28.

Department of Chemical and Systems Biology, Stanford University, 269 Campus Drive, Stanford, CA 94305, USA. Electronic address:

View Article and Find Full Text PDF
June 2016

Selective Phosphorylation Inhibitor of Delta Protein Kinase C-Pyruvate Dehydrogenase Kinase Protein-Protein Interactions: Application for Myocardial Injury in Vivo.

J Am Chem Soc 2016 06 8;138(24):7626-35. Epub 2016 Jun 8.

Department of Chemical and Systems Biology, School of Medicine, Stanford University , Stanford, California 94305-5174, United States.

View Article and Find Full Text PDF
June 2016

The entangled ER-mitochondrial axis as a potential therapeutic strategy in neurodegeneration: A tangled duo unchained.

Cell Calcium 2016 09 7;60(3):218-34. Epub 2016 May 7.

Department of Chemical & Systems Biology, School of Medicine, Stanford University, CA, USA. Electronic address:

View Article and Find Full Text PDF
September 2016

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Protein-Protein Interaction Inhibitor Reveals a Non-catalytic Role for GAPDH Oligomerization in Cell Death.

J Biol Chem 2016 Jun 27;291(26):13608-21. Epub 2016 Apr 27.

From the Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305-5174 and

View Article and Find Full Text PDF
June 2016

Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease.

EMBO Mol Med 2015 Oct;7(10):1307-26

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA

View Article and Find Full Text PDF
October 2015

Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo.

Proc Natl Acad Sci U S A 2015 Mar 23;112(10):3074-9. Epub 2015 Feb 23.

Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, CA 94305-5174

View Article and Find Full Text PDF
March 2015

New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases.

J Mol Med (Berl) 2015 Mar 5;93(3):279-87. Epub 2015 Feb 5.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

View Article and Find Full Text PDF
March 2015

The many hats of protein kinase Cδ: one enzyme with many functions.

Biochem Soc Trans 2014 Dec;42(6):1529-33

*Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, CA 94305-5174, U.S.A.

View Article and Find Full Text PDF
December 2014

A personalized medicine approach for Asian Americans with the aldehyde dehydrogenase 2*2 variant.

Annu Rev Pharmacol Toxicol 2015 29;55:107-27. Epub 2014 Sep 29.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, School of Medicine, Stanford, California 94305.

View Article and Find Full Text PDF
September 2015

Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism.

Exp Neurol 2015 Jan 28;263:244-53. Epub 2014 Sep 28.

Neuroscience Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan; Section of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan; Healthy Aging Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

View Article and Find Full Text PDF
January 2015

Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system.

Sci Transl Med 2014 Sep;6(255):255ra130

Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

View Article and Find Full Text PDF
September 2014

Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain.

Sci Transl Med 2014 Aug;6(251):251ra118

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

View Article and Find Full Text PDF
August 2014

The challenge in translating basic research discoveries to treatment of Huntington disease.

Rare Dis 2014 31;2:e28637. Epub 2014 Mar 31.

Department of Physiology & Biophysics; Center of Mitochondrial Disease; Case Western Reserve University School of Medicine; Cleveland, OH USA.

View Article and Find Full Text PDF
July 2014

Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling.

Cardiovasc Res 2014 Sep 9;103(4):498-508. Epub 2014 May 9.

Department of Anatomy, Institute of Biomedical Sciences, Paulo, Brazil Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA

View Article and Find Full Text PDF
September 2014

Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones.

J Med Chem 2014 Feb 31;57(3):714-22. Epub 2014 Jan 31.

Department of Biochemistry & Molecular Biology, Indiana University School of Medicine , MS4053, 635 Barnhill Drive, Indianapolis, Indiana 46202, United States.

View Article and Find Full Text PDF
February 2014

Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction.

J Am Heart Assoc 2013 Oct 8;2(5):e000461. Epub 2013 Oct 8.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, 94305, CA.

View Article and Find Full Text PDF
October 2013

Nociceptive-induced myocardial remote conditioning is mediated by neuronal gamma protein kinase C.

Basic Res Cardiol 2013 Sep 28;108(5):381. Epub 2013 Aug 28.

Department of Anesthesiology, School of Medicine, Stanford University, Stanford, CA 94305, USA.

View Article and Find Full Text PDF
September 2013

PKCε activation promotes FGF-2 exocytosis and induces endothelial cell proliferation and sprouting.

J Mol Cell Cardiol 2013 Oct 20;63:107-17. Epub 2013 Jul 20.

Department of Life Sciences, University of Siena, 53100 Siena, Italy.

View Article and Find Full Text PDF
October 2013

Translational medicine: mitigating risks for investigators.

Nat Rev Drug Discov 2013 May;12(5):327-8

Center for Cardiovascular Research, Division of Cardiology and at the Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8086, St Louis, Missouri 63110, USA.

View Article and Find Full Text PDF
May 2013

Selective activation of protein kinase C∊ in mitochondria is neuroprotective in vitro and reduces focal ischemic brain injury in mice.

J Neurosci Res 2013 Jun 21;91(6):799-807. Epub 2013 Feb 21.

Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA.

View Article and Find Full Text PDF
June 2013

A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.

J Cell Sci 2013 Feb 13;126(Pt 3):789-802. Epub 2012 Dec 13.

Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Case Western Reserve University School of Medicine Cleveland, OH 44106 Cleveland, OH 44106 USA.

View Article and Find Full Text PDF
February 2013

Protein kinase C, an elusive therapeutic target?

Nat Rev Drug Discov 2012 Dec;11(12):937-57

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305-5174, USA.

View Article and Find Full Text PDF
December 2012

Activation of εPKC reduces reperfusion arrhythmias and improves recovery from ischemia: optical mapping of activation patterns in the isolated guinea-pig heart.

Biochem Biophys Res Commun 2012 Sep 22;426(2):237-41. Epub 2012 Aug 22.

Cardiovascular Research Program, VA New York Harbor Health Care System, Brooklyn, NY 11209, USA.

View Article and Find Full Text PDF
September 2012

Protein quality control disruption by PKCβII in heart failure; rescue by the selective PKCβII inhibitor, βIIV5-3.

PLoS One 2012 30;7(3):e33175. Epub 2012 Mar 30.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, United States of America.

View Article and Find Full Text PDF
August 2012

Identification of εPKC targets during cardiac ischemic injury.

Circ J 2012 27;76(6):1476-85. Epub 2012 Mar 27.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.

View Article and Find Full Text PDF
October 2012

Mitigation of radiation-induced dermatitis by activation of aldehyde dehydrogenase 2 using topical alda-1 in mice.

Radiat Res 2012 Jul 9;178(1):69-74. Epub 2012 Mar 9.

Department of Radiation Oncology, Stanford University Medical Center, Stanford, California 94305, USA.

View Article and Find Full Text PDF
July 2012

Regulation of cardiac excitability by protein kinase C isozymes.

Front Biosci (Schol Ed) 2012 Jan 1;4:532-46. Epub 2012 Jan 1.

Stanford University, School of Medicine, Stanford, CA, USA.

View Article and Find Full Text PDF
January 2012

ALDH2 activator inhibits increased myocardial infarction injury by nitroglycerin tolerance.

Sci Transl Med 2011 Nov;3(107):107ra111

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA.

View Article and Find Full Text PDF
November 2011

Nitroglycerin use in myocardial infarction patients.

Circ J 2012 1;76(1):15-21. Epub 2011 Nov 1.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA.

View Article and Find Full Text PDF
July 2012

Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases.

J Biol Chem 2011 Dec 21;286(50):43486-94. Epub 2011 Oct 21.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

View Article and Find Full Text PDF
December 2011

Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy.

J Mol Cell Cardiol 2011 Dec 2;51(6):980-7. Epub 2011 Sep 2.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174, USA.

View Article and Find Full Text PDF
December 2011

β2-adrenergic receptors mediate cardioprotection through crosstalk with mitochondrial cell death pathways.

J Mol Cell Cardiol 2011 Nov 2;51(5):781-9. Epub 2011 Jul 2.

Department of Pediatrics (Cardiology), Stanford University, Stanford, CA, USA.

View Article and Find Full Text PDF
November 2011

PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC-3 prostate cancer cells.

Prostate 2011 Jun 23;71(9):946-54. Epub 2010 Nov 23.

Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, California 94305-5174, USA.

View Article and Find Full Text PDF
June 2011

Regulation of mitochondrial processes: a target for heart failure.

Drug Discov Today Dis Mech 2010 ;7(2):e95-e102

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305-5174.

View Article and Find Full Text PDF
January 2010

Matrix metalloproteinases modulated by protein kinase Cε mediate resistin-induced migration of human coronary artery smooth muscle cells.

J Vasc Surg 2011 Apr 31;53(4):1044-51. Epub 2011 Jan 31.

Division of Vascular and Endovascular Surgery, Department of Surgery, Stanford University, Stanford, CA 94304, USA.

View Article and Find Full Text PDF
April 2011

Therapeutic potential for protein kinase C inhibitor in vascular restenosis.

J Cardiovasc Pharmacol Ther 2011 Jun 23;16(2):160-7. Epub 2010 Dec 23.

Division of Vascular and Endovascular Surgery, Department of Surgery, Stanford University, Stanford, CA 94350, USA.

View Article and Find Full Text PDF
June 2011