Publications by authors named "Daret K St Clair"

100Publications

UVB-induced inactivation of manganese-containing superoxide dismutase promotes mitophagy via ROS-mediated mTORC2 pathway activation.

J Biol Chem 2019 04 11;294(17):6831-6842. Epub 2019 Mar 11.

From the Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky 40536 and

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http://dx.doi.org/10.1074/jbc.RA118.006595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497943PMC
April 2019

Plausible biochemical mechanisms of chemotherapy-induced cognitive impairment ("chemobrain"), a condition that significantly impairs the quality of life of many cancer survivors.

Biochim Biophys Acta Mol Basis Dis 2019 06 10;1865(6):1088-1097. Epub 2019 Feb 10.

Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA; Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2019.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502692PMC
June 2019

Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects.

Cell Chem Biol 2019 03 17;26(3):366-377.e12. Epub 2019 Jan 17.

Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY 40536, USA; Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557261PMC
March 2019

The triangle of death of neurons: Oxidative damage, mitochondrial dysfunction, and loss of choline-containing biomolecules in brains of mice treated with doxorubicin. Advanced insights into mechanisms of chemotherapy induced cognitive impairment ("chemobrain") involving TNF-α.

Free Radic Biol Med 2019 04 26;134:1-8. Epub 2018 Dec 26.

Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA; Markey Cancer Center, University of Kentucky, Lexington, KY 40536 USA, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.12.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588453PMC
April 2019

Profiles of Radioresistance Mechanisms in Prostate Cancer.

Crit Rev Oncog 2018 ;23(1-2):39-67

Department of Toxicology and Cancer Biology, Department of Urology, Department of Biochemistry, University of Kentucky, Lexington, Kentucky.

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http://dx.doi.org/10.1615/CritRevOncog.2018025946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231577PMC
June 2019

Extracellular redox state shift: A novel approach to target prostate cancer invasion.

Free Radic Biol Med 2018 03 2;117:99-109. Epub 2018 Feb 2.

Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.01.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845758PMC
March 2018

Redox Paradox: A Novel Approach to Therapeutics-Resistant Cancer.

Antioxid Redox Signal 2018 11 21;29(13):1237-1272. Epub 2018 Feb 21.

1 Department of Toxicology and Cancer Biology, University of Kentucky-Lexington , Lexington, Kentucky.

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https://www.liebertpub.com/doi/10.1089/ars.2017.7485
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http://dx.doi.org/10.1089/ars.2017.7485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157438PMC
November 2018

Hematopoietic Stem Cells: Normal Versus Malignant.

Antioxid Redox Signal 2018 12 20;29(16):1612-1632. Epub 2017 Dec 20.

Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky , Lexington, Kentucky.

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http://dx.doi.org/10.1089/ars.2017.7326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207150PMC
December 2018

Chemotherapy-Induced Tissue Injury: An Insight into the Role of Extracellular Vesicles-Mediated Oxidative Stress Responses.

Antioxidants (Basel) 2017 Sep 28;6(4). Epub 2017 Sep 28.

Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA.

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http://www.mdpi.com/2076-3921/6/4/75
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http://dx.doi.org/10.3390/antiox6040075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745485PMC
September 2017

Acute treatment with doxorubicin affects glutamate neurotransmission in the mouse frontal cortex and hippocampus.

Brain Res 2017 Oct 11;1672:10-17. Epub 2017 Jul 11.

Spinal Cord & Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Departments of Neuroscience, Neurology, Neurosurgery, Psychiatry and Electrical Engineering, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Center for Microelectrode Technology, University of Kentucky College of Medicine, Lexington, KY 40536, USA; Brain Research Center, University of Kentucky College of Medicine, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1016/j.brainres.2017.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576558PMC
October 2017

Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function.

Handb Exp Pharmacol 2017 ;240:439-456

Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, 890-8544, Japan.

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http://dx.doi.org/10.1007/164_2016_117DOI Listing
December 2017

RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells.

Cancer Res 2017 03 20;77(6):1345-1356. Epub 2017 Jan 20.

Department of Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354963PMC
March 2017

Radiation Induced Apoptosis of Murine Bone Marrow Cells Is Independent of Early Growth Response 1 (EGR1).

PLoS One 2017 12;12(1):e0169767. Epub 2017 Jan 12.

Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, Kentucky, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169767PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5230770PMC
August 2017

Dysregulation of cytokine mediated chemotherapy induced cognitive impairment.

Pharmacol Res 2017 03 4;117:267-273. Epub 2017 Jan 4.

Department of Chemistry, University of Kentucky, Lexington, KY, 40506-0055, USA; Markey Cancer Center, University of Keutucky College of Medicine, Lexington, KY, 40536, USA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2017.01.001DOI Listing
March 2017

Increased ROS production in non-polarized mammary epithelial cells induces monocyte infiltration in 3D culture.

J Cell Sci 2017 01 21;130(1):190-202. Epub 2016 Sep 21.

Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA

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http://dx.doi.org/10.1242/jcs.186031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518217PMC
January 2017

Chasing great paths of Helmut Sies "Oxidative Stress".

Arch Biochem Biophys 2016 Apr;595:54-60

Department of Toxicology and Cancer Biology, University of Kentucky College of Medicine, Lexington, KY 40506, USA.

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http://dx.doi.org/10.1016/j.abb.2015.10.023DOI Listing
April 2016

Arjunolic acid ameliorates reactive oxygen species via inhibition of p47(phox)-serine phosphorylation and mitochondrial dysfunction.

Int J Biochem Cell Biol 2015 Nov 28;68:70-7. Epub 2015 Aug 28.

Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center, Shreveport, USA; Internal Medicine, University of Kentucky, Lexington, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2015.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630159PMC
November 2015

Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin, and enhances rat gastric tumor cell invasion.

J Clin Biochem Nutr 2015 Jul 22;57(1):13-20. Epub 2015 May 22.

Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan ; Department of Space Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan.

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http://dx.doi.org/10.3164/jcbn.14-146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512892PMC
July 2015

Superoxide induces protein oxidation in plasma and TNF-α elevation in macrophage culture: Insights into mechanisms of neurotoxicity following doxorubicin chemotherapy.

Cancer Lett 2015 Oct 28;367(2):157-61. Epub 2015 Jul 28.

Department of Chemistry, University of Kentucky, Lexington, KY 40506-0055, USA; Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506-0055, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835150047
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http://dx.doi.org/10.1016/j.canlet.2015.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543408PMC
October 2015

A mitochondrial superoxide theory for oxidative stress diseases and aging.

J Clin Biochem Nutr 2015 Jan 23;56(1):1-7. Epub 2014 Dec 23.

Department of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan ; Department of Space Environmental Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1, Sakuragaoka, Kagoshima 890-8544, Japan.

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http://dx.doi.org/10.3164/jcbn.14-42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306659PMC
January 2015

Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo.

Nat Med 2014 May 20;20(5):555-60. Epub 2014 Apr 20.

1] Institute for Neuronal Cell Biology, Technical University Munich, Munich, Germany. [2] Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. [3] German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. [4] Center for Integrated Protein Sciences (CIPS), Munich, Germany. [5].

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http://dx.doi.org/10.1038/nm.3520DOI Listing
May 2014

Nuclear interaction between ADR-induced p65 and p53 mediates cardiac injury in iNOS (-/-) mice.

PLoS One 2014 25;9(2):e89251. Epub 2014 Feb 25.

Graduate Centers for Toxicology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089251PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934890PMC
December 2014

Metabolic effects of acute thiamine depletion are reversed by rapamycin in breast and leukemia cells.

PLoS One 2014 15;9(1):e85702. Epub 2014 Jan 15.

Department of Pediatrics, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085702PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893258PMC
September 2014

Redox-modulated phenomena and radiation therapy: the central role of superoxide dismutases.

Antioxid Redox Signal 2014 Apr 14;20(10):1567-89. Epub 2014 Feb 14.

1 Graduate Center for Toxicology, University of Kentucky , Lexington, Kentucky.

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http://dx.doi.org/10.1089/ars.2012.5000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942704PMC
April 2014

Redox-mediated and ionizing-radiation-induced inflammatory mediators in prostate cancer development and treatment.

Antioxid Redox Signal 2014 Mar 22;20(9):1481-500. Epub 2014 Jan 22.

1 Graduate Center for Toxicology, University of Kentucky , Lexington, Kentucky.

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http://www.liebertpub.com/doi/10.1089/ars.2013.5637
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http://dx.doi.org/10.1089/ars.2013.5637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936609PMC
March 2014

FUsed in sarcoma is a novel regulator of manganese superoxide dismutase gene transcription.

Antioxid Redox Signal 2014 Apr 20;20(10):1550-66. Epub 2013 Sep 20.

1 Graduate Center for Toxicology, University of Kentucky , Lexington, Kentucky.

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http://dx.doi.org/10.1089/ars.2012.4984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942683PMC
April 2014

Mitochondrial superoxide mediates labile iron level: evidence from Mn-SOD-transgenic mice and heterozygous knockout mice and isolated rat liver mitochondria.

Free Radic Biol Med 2013 Dec 20;65:143-149. Epub 2013 Jun 20.

Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40506, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2013.06.026DOI Listing
December 2013

Curbing cancer's sweet tooth: is there a role for MnSOD in regulation of the Warburg effect?

Mitochondrion 2013 May 20;13(3):170-88. Epub 2012 Jul 20.

Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1016/j.mito.2012.07.104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604438PMC
May 2013

Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease.

Exp Neurol 2012 Aug 22;236(2):249-58. Epub 2012 May 22.

Dept. of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1016/j.expneurol.2012.05.011DOI Listing
August 2012

Manganese superoxide dismutase regulation and cancer.

Free Radic Biol Med 2012 Jun 1-15;52(11-12):2209-22. Epub 2012 Apr 25.

Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2012.03.009DOI Listing
October 2012

Pharmacologic properties of polyethylene glycol-modified Bacillus thiaminolyticus thiaminase I enzyme.

J Pharmacol Exp Ther 2012 Jun 19;341(3):775-83. Epub 2012 Mar 19.

Department of Pediatrics, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.112.19181
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http://dx.doi.org/10.1124/jpet.112.191817DOI Listing
June 2012

Inverse relationship between PSA and IL-8 in prostate cancer: an insight into a NF-κB-mediated mechanism.

PLoS One 2012 5;7(3):e32905. Epub 2012 Mar 5.

Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032905PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293904PMC
July 2012

p53 regulation of energy metabolism and mitochondria regulation of p53 in cancer cells: an insight into the role of manganese superoxide dismutase.

Curr Pharm Biotechnol 2013 ;14(3):261-73

Graduate Center for Toxicology, 454 HSRB, University of Kentucky, Lexington, KY 40536, USA.

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http://dx.doi.org/10.2174/1389201011314030003DOI Listing
October 2013

Global effects of adriamycin treatment on mouse splenic protein levels.

J Proteome Res 2012 Feb 4;11(2):1054-64. Epub 2012 Jan 4.

Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.

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http://dx.doi.org/10.1021/pr200798gDOI Listing
February 2012

Manganese superoxide dismutase: guardian of the powerhouse.

Int J Mol Sci 2011 21;12(10):7114-62. Epub 2011 Oct 21.

Graduate Center for Toxicology, University of Kentucky, 454 HSRB, 1095 VA Drive, Lexington, KY 40536, USA; E-Mails: (A.K.H.); (V.B.); (J.M.V.-R.).

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http://dx.doi.org/10.3390/ijms12107114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3211030PMC
November 2014

Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages.

Cancer Res 2011 Nov 18;71(21):6684-95. Epub 2011 Oct 18.

Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-1233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206134PMC
November 2011

Chemotherapy-induced weakness and fatigue in skeletal muscle: the role of oxidative stress.

Antioxid Redox Signal 2011 Nov 15;15(9):2543-63. Epub 2011 Jun 15.

Department of Physiology, University of Kentucky, Lexington, USA.

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http://dx.doi.org/10.1089/ars.2011.3965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176345PMC
November 2011

Mitochondrial superoxide dismutase--signals of distinction.

Anticancer Agents Med Chem 2011 Feb;11(2):181-90

Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427752PMC
http://dx.doi.org/10.2174/187152011795255920DOI Listing
February 2011

miR-17* suppresses tumorigenicity of prostate cancer by inhibiting mitochondrial antioxidant enzymes.

PLoS One 2010 Dec 22;5(12):e14356. Epub 2010 Dec 22.

Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014356PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008681PMC
December 2010

p53 Protects lung cancer cells against metabolic stress.

Int J Oncol 2010 Dec;37(6):1575-81

Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086553PMC
http://dx.doi.org/10.3892/ijo_00000811DOI Listing
December 2010

Doxorubicin-induced thymus senescence.

J Proteome Res 2010 Dec 9;9(12):6232-41. Epub 2010 Nov 9.

Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, United States.

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http://pubs.acs.org/doi/abs/10.1021/pr100465m
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http://dx.doi.org/10.1021/pr100465mDOI Listing
December 2010

RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells.

Ann N Y Acad Sci 2010 Jul;1201:129-36

Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2010.05613.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107504PMC
July 2010

Manganese superoxide dismutase versus p53: the mitochondrial center.

Ann N Y Acad Sci 2010 Jul;1201:72-8

Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2010.05612.xDOI Listing
July 2010

Manganese superoxide dismutase vs. p53: regulation of mitochondrial ROS.

Mitochondrion 2010 Nov 1;10(6):649-61. Epub 2010 Jul 1.

Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, United States.

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http://dx.doi.org/10.1016/j.mito.2010.06.003DOI Listing
November 2010

Manganese superoxide dismutase: beyond life and death.

Amino Acids 2012 Jan 8;42(1):139-58. Epub 2010 May 8.

University of Kentucky, Lexington, USA.

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http://dx.doi.org/10.1007/s00726-010-0600-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975048PMC
January 2012

RelB-dependent differential radiosensitization effect of STI571 on prostate cancer cells.

Mol Cancer Ther 2010 Apr 6;9(4):803-12. Epub 2010 Apr 6.

Department of Radiation Medicine, University of Kentucky, College of Medicine, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-09-1001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2852498PMC
April 2010

Nuclear factor kappaB- and specificity protein 1-dependent p53-mediated bi-directional regulation of the human manganese superoxide dismutase gene.

J Biol Chem 2010 Mar 8;285(13):9835-46. Epub 2010 Jan 8.

Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA.

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http://dx.doi.org/10.1074/jbc.M109.060715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843232PMC
March 2010

Preventing Dr. Jekyll from becoming Mr. Hyde: is manganese superoxide dismutase the key to prevent radiation-induced neoplastic transformation?

Cancer Biol Ther 2009 Oct 27;8(20):1972-3. Epub 2009 Oct 27.

Graduate Center for Toxicology, University of Kentucky, Lexington, KY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864549PMC
http://dx.doi.org/10.4161/cbt.8.20.9941DOI Listing
October 2009

Doxorubicin acts through tumor necrosis factor receptor subtype 1 to cause dysfunction of murine skeletal muscle.

J Appl Physiol (1985) 2009 Dec 24;107(6):1935-42. Epub 2009 Sep 24.

Department of Physiology, 3Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536-0298, USA.

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http://dx.doi.org/10.1152/japplphysiol.00776.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793196PMC
December 2009

Regulation of superoxide dismutase genes: implications in disease.

Free Radic Biol Med 2009 Aug 25;47(4):344-56. Epub 2009 May 25.

Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S08915849090029
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http://dx.doi.org/10.1016/j.freeradbiomed.2009.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731574PMC
August 2009

Nucleophosmin blocks mitochondrial localization of p53 and apoptosis.

J Biol Chem 2009 Jun 14;284(24):16409-18. Epub 2009 Apr 14.

Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA.

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http://dx.doi.org/10.1074/jbc.M109.005736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713525PMC
June 2009

Watching the watcher: regulation of p53 by mitochondria.

Future Oncol 2009 Feb;5(1):117-30

Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA.

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http://dx.doi.org/10.2217/14796694.5.1.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710969PMC
February 2009

Mrp1 localization and function in cardiac mitochondria after doxorubicin.

Mol Pharmacol 2009 May 20;75(5):1117-26. Epub 2009 Feb 20.

Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536-0305, USA.

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http://dx.doi.org/10.1124/mol.108.052209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672805PMC
May 2009

Oxidative damage in brain from human mutant APP/PS-1 double knock-in mice as a function of age.

Free Radic Biol Med 2008 Nov 16;45(10):1420-5. Epub 2008 Aug 16.

Department of Chemistry, Center for Membrane Sciences, University of Kentucky, Lexington, KY 40506-0055, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2008.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597707PMC
November 2008

The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism.

Mol Pharmacol 2008 Oct 15;74(4):1000-7. Epub 2008 Jul 15.

Department of Molecular and Biomedical Pharmacology, The University of Kentucky College of Medicine, 800 Rose St., UKMC MS 305, Lexington, KY 40536-0084, USA.

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http://molpharm.aspetjournals.org/content/early/2008/07/15/m
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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.108.04
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http://dx.doi.org/10.1124/mol.108.047993DOI Listing
October 2008

Blocking mitochondrial permeability transition prevents p53 mitochondrial translocation during skin tumor promotion.

FEBS Lett 2008 Apr 20;582(9):1319-24. Epub 2008 Mar 20.

Department of Pharmacology, Toxicology and Neuroscience, LSU Health Sciences Center, Shreveport, LA 71130, USA.

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http://dx.doi.org/10.1016/j.febslet.2008.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2367455PMC
April 2008

ROS and p53: a versatile partnership.

Free Radic Biol Med 2008 Apr 26;44(8):1529-35. Epub 2008 Jan 26.

Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40506, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2008.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359898PMC
April 2008

Chronic exposure to 12-O-tetradecanoylphorbol-13-acetate represses sod2 induction in vivo: the negative role of p50.

Carcinogenesis 2007 Dec 25;28(12):2605-13. Epub 2007 Jul 25.

Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgm163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656647PMC
December 2007

Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice.

Neurobiol Dis 2007 Sep 12;27(3):301-11. Epub 2007 Jun 12.

Department of Molecular and Cellular Biochemistry, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536-0230, USA.

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http://dx.doi.org/10.1016/j.nbd.2007.06.002DOI Listing
September 2007

Collateral damage in cancer chemotherapy: oxidative stress in nontargeted tissues.

Mol Interv 2007 Jun;7(3):147-56

Graduate Center for Toxicology and Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA.

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http://dx.doi.org/10.1124/mi.7.3.6DOI Listing
June 2007

Mitochondrial and nuclear p53 localization in cardiomyocytes: redox modulation by doxorubicin (Adriamycin)?

Antioxid Redox Signal 2007 Jul;9(7):1001-8

Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.

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http://www.liebertpub.com/doi/10.1089/ars.2007.1632
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http://dx.doi.org/10.1089/ars.2007.1632DOI Listing
July 2007

The role of a single-stranded nucleotide loop in transcriptional regulation of the human sod2 gene.

J Biol Chem 2007 Jun 9;282(22):15981-94. Epub 2007 Apr 9.

Graduate Center for Toxicology, Department of Radiation Medicine, University of Kentucky, Lexington 40536-0305, USA.

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http://dx.doi.org/10.1074/jbc.M608979200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654256PMC
June 2007

Evidence for p53 as guardian of the cardiomyocyte mitochondrial genome following acute adriamycin treatment.

J Histochem Cytochem 2007 Jun 20;55(6):629-39. Epub 2007 Feb 20.

Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, USA.

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http://dx.doi.org/10.1369/jhc.6A7146.2007DOI Listing
June 2007

Increase in Mrp1 expression and 4-hydroxy-2-nonenal adduction in heart tissue of Adriamycin-treated C57BL/6 mice.

Mol Cancer Ther 2006 Nov;5(11):2851-60

Graduate Center for Toxicology, University of Kentucky, 306 Health Sciences Research Building, Lexington, KY 40536, USA.

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http://mct.aacrjournals.org/lookup/doi/10.1158/1535-7163.MCT
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http://dx.doi.org/10.1158/1535-7163.MCT-06-0297DOI Listing
November 2006

Redox proteomic identification of oxidized cardiac proteins in adriamycin-treated mice.

Free Radic Biol Med 2006 Nov 11;41(9):1470-7. Epub 2006 Aug 11.

Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40506, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2006.08.006DOI Listing
November 2006