Darell D Bigner

Darell D Bigner

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Darell D Bigner

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Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations.

J Immunother Cancer 2019 May 29;7(1):142. Epub 2019 May 29.

Department of Neurosurgery and the Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Medical Sciences Research Building, Rm 181c, Box 3156, Durham, NC, 27710, USA.

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http://dx.doi.org/10.1186/s40425-019-0614-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542114PMC
May 2019

MGMT: Immunohistochemical Detection in High-Grade Astrocytomas.

J Neuropathol Exp Neurol 2019 Jan;78(1):57-64

The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1093/jnen/nly110DOI Listing
January 2019

Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models.

J Neurooncol 2018 Jul 21;138(3):489-498. Epub 2018 Mar 21.

Preston Robert Tisch Brain Tumor Center at Duke, Department of Neurosurgery, Duke University Medical Center, 3624 DUMC, Baker House, Durham, NC, 27710, USA.

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http://dx.doi.org/10.1007/s11060-018-2832-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999169PMC
July 2018

Recurrent Glioblastoma Treated with Recombinant Poliovirus.

N Engl J Med 2018 07 26;379(2):150-161. Epub 2018 Jun 26.

From the Departments of Neurosurgery (A.D., M.G., A.H.F., H.S.F., K.B.P., D.R., J.H.S., G.V., D.A., D.D.B.), Biostatistics (J.E.H., F.M.), Surgery (D.P.B., S.N.), and Pathology (W.T.H., R.E.M.) and the Preston Robert Tisch Brain Tumor Center (A.D., M.G., J.E.H., D.P.B., A.H.F., H.S.F., F.M., S.N., K.B.P., D.R., J.H.S., G.V., W.T.H., R.E.M., D.A., D.D.B.), Duke University Medical Center, and Istari Oncology (D.P.B.) - all in Durham, NC; Tempus Labs, Chicago (N.B.); and the School of Medicine, Deakin University, Geelong, VIC, Australia (A.M.M.).

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http://dx.doi.org/10.1056/NEJMoa1716435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065102PMC
July 2018

Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation.

Cancer Res 2017 11 22;77(22):6097-6108. Epub 2017 Sep 22.

Department of Pathology and the Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-1018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690824PMC
November 2017

The role of angiogenesis in Group 3 medulloblastoma pathogenesis and survival.

Neuro Oncol 2017 Sep;19(9):1217-1227

Department of Neurosurgery, Duke University, Durham, North Carolina; Preston Robert Tisch Brain Tumor Center, Duke University, Durham, North Carolina; Brain Imaging and Analysis Center, Duke University, Durham, North Carolina; Department of Radiology, Duke University, Durham, North Carolina; Department of Radiology, Stanford University, Palo Alto, California; Department of Medicine, Duke University, Durham, North Carolina; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany; and Department of Pediatric Neuro-Oncogenomics, German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany; Department of Pathology, Duke University, Durham, North Carolina; Division of Haematology/Oncology, the Arthur and Sonia Labatt Brain Tumour Research Centre, Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada; Division of Neurosurgery, the Arthur and Sonia Labatt Brain Tumour Research Centre, Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1093/neuonc/nox033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570262PMC
September 2017

Production and quality control assessment of a GLP-grade immunotoxin, D2C7-(scdsFv)-PE38KDEL, for a phase I/II clinical trial.

Appl Microbiol Biotechnol 2017 Apr 24;101(7):2747-2766. Epub 2016 Dec 24.

Preston Robert Tisch Brain Tumor Center at Duke and Department of Pathology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1007/s00253-016-8063-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354975PMC
April 2017

Development and validation of a cell-based fluorescent method for measuring antibody affinity.

J Immunol Methods 2017 03 24;442:49-53. Epub 2016 Dec 24.

Department of Pathology, Duke University Medical Center, Durham, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2016.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293658PMC
March 2017

Immunotoxin Therapy for Lung Cancer.

Chin Med J (Engl) 2017 Mar;130(5):607-612

Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.

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http://dx.doi.org/10.4103/0366-6999.200540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339936PMC
March 2017

Rapid Reprogramming of Primary Human Astrocytes into Potent Tumor-Initiating Cells with Defined Genetic Factors.

Cancer Res 2016 09 30;76(17):5143-50. Epub 2016 Jun 30.

Department of Dermatology, Duke University Medical Center, Durham, North Carolina. Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082736PMC
http://dx.doi.org/10.1158/0008-5472.CAN-16-0171DOI Listing
September 2016

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.

Authors:
Eric M Thompson Thomas Hielscher Eric Bouffet Marc Remke Betty Luu Sridharan Gururangan Roger E McLendon Darell D Bigner Eric S Lipp Sebastien Perreault Yoon-Jae Cho Gerald Grant Seung-Ki Kim Ji Yeoun Lee Amulya A Nageswara Rao Caterina Giannini Kay Ka Wai Li Ho-Keung Ng Yu Yao Toshihiro Kumabe Teiji Tominaga Wieslawa A Grajkowska Marta Perek-Polnik David C Y Low Wan Tew Seow Kenneth T E Chang Jaume Mora Ian F Pollack Ronald L Hamilton Sarah Leary Andrew S Moore Wendy J Ingram Andrew R Hallahan Anne Jouvet Michelle Fèvre-Montange Alexandre Vasiljevic Cecile Faure-Conter Tomoko Shofuda Naoki Kagawa Naoya Hashimoto Nada Jabado Alexander G Weil Tenzin Gayden Takafumi Wataya Tarek Shalaby Michael Grotzer Karel Zitterbart Jaroslav Sterba Leos Kren Tibor Hortobágyi Almos Klekner Bognár László Tímea Pócza Peter Hauser Ulrich Schüller Shin Jung Woo-Youl Jang Pim J French Johan M Kros Marie-Lise C van Veelen Luca Massimi Jeffrey R Leonard Joshua B Rubin Rajeev Vibhakar Lola B Chambless Michael K Cooper Reid C Thompson Claudia C Faria Alice Carvalho Sofia Nunes José Pimentel Xing Fan Karin M Muraszko Enrique López-Aguilar David Lyden Livia Garzia David J H Shih Noriyuki Kijima Christian Schneider Jennifer Adamski Paul A Northcott Marcel Kool David T W Jones Jennifer A Chan Ana Nikolic Maria Luisa Garre Erwin G Van Meir Satoru Osuka Jeffrey J Olson Arman Jahangiri Brandyn A Castro Nalin Gupta William A Weiss Iska Moxon-Emre Donald J Mabbott Alvaro Lassaletta Cynthia E Hawkins Uri Tabori James Drake Abhaya Kulkarni Peter Dirks James T Rutka Andrey Korshunov Stefan M Pfister Roger J Packer Vijay Ramaswamy Michael D Taylor

Lancet Oncol 2016 04 12;17(4):484-495. Epub 2016 Mar 12.

Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045150058
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http://dx.doi.org/10.1016/S1470-2045(15)00581-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907853PMC
April 2016

EGFR/EGFRvIII-targeted immunotoxin therapy for the treatment of glioblastomas via convection-enhanced delivery.

Receptors Clin Investig 2016 ;3(4)

Preston Robert Tisch Brain Tumor Center at Duke and Department of Pathology, Duke University Medical Center, Durham, NC, 27710, USA.

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http://dx.doi.org/10.14800/rci.1430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341612PMC
January 2016

Phosphorylation of Glutathione S-Transferase P1 (GSTP1) by Epidermal Growth Factor Receptor (EGFR) Promotes Formation of the GSTP1-c-Jun N-terminal kinase (JNK) Complex and Suppresses JNK Downstream Signaling and Apoptosis in Brain Tumor Cells.

J Biol Chem 2015 Dec 1;290(52):30866-78. Epub 2015 Oct 1.

From the Departments of Neurosurgery and the Preston Robert Tisch Brain Tumor Center, Duke Cancer Institute and Duke University School of Medicine, Durham, North Carolina 27710 Pathology and

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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.656140
Publisher Site
http://dx.doi.org/10.1074/jbc.M115.656140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692215PMC
December 2015

A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study.

Neuro Oncol 2015 Jun 13;17(6):854-61. Epub 2015 Jan 13.

Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania (J.S.); The Neurological Institute of Columbia University, New York, New York (R.K.L.); Stanford Cancer Center, Stanford, California (L.D.R.); Duke University Medical Center, Durham, North Carolina (D.A.R., G.E.A., D.D.B., J.H.S.); Evanston Northwestern Healthcare, Evanston, Illinois (N.A.P.); University of Texas M.D. Anderson Cancer Center, Houston, Texas (M.D.G.); University of Washington School of Medicine, Seattle, Washington (M.M.M.); Huntsman Cancer Institute at the University of Utah, Salt Lake City, Utah (R.J.); Yale University School of Medicine, New Haven, Connecticut (J.M.B); University Hospital-Case Medical Center & Case Comprehensive Cancer Center, Cleveland, Ohio (A.S.); Scott Cruickshank & Associates, Inc., Santa Barbara, C alifornia (S.C.); Celldex Therapeutics, Inc., Hampton, New Jersey (J.A.G., T.K., T.A.D.); University of Texas M.D. Anderson Cancer Center, Houston, Texas (A.B.H.).

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http://dx.doi.org/10.1093/neuonc/nou348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483122PMC
June 2015

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

Authors:
Daniel J Brat Roel G W Verhaak Kenneth D Aldape W K Alfred Yung Sofie R Salama Lee A D Cooper Esther Rheinbay C Ryan Miller Mark Vitucci Olena Morozova A Gordon Robertson Houtan Noushmehr Peter W Laird Andrew D Cherniack Rehan Akbani Jason T Huse Giovanni Ciriello Laila M Poisson Jill S Barnholtz-Sloan Mitchel S Berger Cameron Brennan Rivka R Colen Howard Colman Adam E Flanders Caterina Giannini Mia Grifford Antonio Iavarone Rajan Jain Isaac Joseph Jaegil Kim Katayoon Kasaian Tom Mikkelsen Bradley A Murray Brian Patrick O'Neill Lior Pachter Donald W Parsons Carrie Sougnez Erik P Sulman Scott R Vandenberg Erwin G Van Meir Andreas von Deimling Hailei Zhang Daniel Crain Kevin Lau David Mallery Scott Morris Joseph Paulauskis Robert Penny Troy Shelton Mark Sherman Peggy Yena Aaron Black Jay Bowen Katie Dicostanzo Julie Gastier-Foster Kristen M Leraas Tara M Lichtenberg Christopher R Pierson Nilsa C Ramirez Cynthia Taylor Stephanie Weaver Lisa Wise Erik Zmuda Tanja Davidsen John A Demchok Greg Eley Martin L Ferguson Carolyn M Hutter Kenna R Mills Shaw Bradley A Ozenberger Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean Claude Zenklusen Brenda Ayala Julien Baboud Sudha Chudamani Mark A Jensen Jia Liu Todd Pihl Rohini Raman Yunhu Wan Ye Wu Adrian Ally J Todd Auman Miruna Balasundaram Saianand Balu Stephen B Baylin Rameen Beroukhim Moiz S Bootwalla Reanne Bowlby Christopher A Bristow Denise Brooks Yaron Butterfield Rebecca Carlsen Scott Carter Lynda Chin Andy Chu Eric Chuah Kristian Cibulskis Amanda Clarke Simon G Coetzee Noreen Dhalla Tim Fennell Sheila Fisher Stacey Gabriel Gad Getz Richard Gibbs Ranabir Guin Angela Hadjipanayis D Neil Hayes Toshinori Hinoue Katherine Hoadley Robert A Holt Alan P Hoyle Stuart R Jefferys Steven Jones Corbin D Jones Raju Kucherlapati Phillip H Lai Eric Lander Semin Lee Lee Lichtenstein Yussanne Ma Dennis T Maglinte Harshad S Mahadeshwar Marco A Marra Michael Mayo Shaowu Meng Matthew L Meyerson Piotr A Mieczkowski Richard A Moore Lisle E Mose Andrew J Mungall Angeliki Pantazi Michael Parfenov Peter J Park Joel S Parker Charles M Perou Alexei Protopopov Xiaojia Ren Jeffrey Roach Thaís S Sabedot Jacqueline Schein Steven E Schumacher Jonathan G Seidman Sahil Seth Hui Shen Janae V Simons Payal Sipahimalani Matthew G Soloway Xingzhi Song Huandong Sun Barbara Tabak Angela Tam Donghui Tan Jiabin Tang Nina Thiessen Timothy Triche David J Van Den Berg Umadevi Veluvolu Scot Waring Daniel J Weisenberger Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Andrew W Xu Lixing Yang Travis I Zack Jianhua Zhang B Arman Aksoy Harindra Arachchi Chris Benz Brady Bernard Daniel Carlin Juok Cho Daniel DiCara Scott Frazer Gregory N Fuller JianJiong Gao Nils Gehlenborg David Haussler David I Heiman Lisa Iype Anders Jacobsen Zhenlin Ju Sol Katzman Hoon Kim Theo Knijnenburg Richard Bailey Kreisberg Michael S Lawrence William Lee Kalle Leinonen Pei Lin Shiyun Ling Wenbin Liu Yingchun Liu Yuexin Liu Yiling Lu Gordon Mills Sam Ng Michael S Noble Evan Paull Arvind Rao Sheila Reynolds Gordon Saksena Zack Sanborn Chris Sander Nikolaus Schultz Yasin Senbabaoglu Ronglai Shen Ilya Shmulevich Rileen Sinha Josh Stuart S Onur Sumer Yichao Sun Natalie Tasman Barry S Taylor Doug Voet Nils Weinhold John N Weinstein Da Yang Kosuke Yoshihara Siyuan Zheng Wei Zhang Lihua Zou Ty Abel Sara Sadeghi Mark L Cohen Jenny Eschbacher Eyas M Hattab Aditya Raghunathan Matthew J Schniederjan Dina Aziz Gene Barnett Wendi Barrett Darell D Bigner Lori Boice Cathy Brewer Chiara Calatozzolo Benito Campos Carlos Gilberto Carlotti Timothy A Chan Lucia Cuppini Erin Curley Stefania Cuzzubbo Karen Devine Francesco DiMeco Rebecca Duell J Bradley Elder Ashley Fehrenbach Gaetano Finocchiaro William Friedman Jordonna Fulop Johanna Gardner Beth Hermes Christel Herold-Mende Christine Jungk Ady Kendler Norman L Lehman Eric Lipp Ouida Liu Randy Mandt Mary McGraw Roger Mclendon Christopher McPherson Luciano Neder Phuong Nguyen Ardene Noss Raffaele Nunziata Quinn T Ostrom Cheryl Palmer Alessandro Perin Bianca Pollo Alexander Potapov Olga Potapova W Kimryn Rathmell Daniil Rotin Lisa Scarpace Cathy Schilero Kelly Senecal Kristen Shimmel Vsevolod Shurkhay Suzanne Sifri Rosy Singh Andrew E Sloan Kathy Smolenski Susan M Staugaitis Ruth Steele Leigh Thorne Daniela P C Tirapelli Andreas Unterberg Mahitha Vallurupalli Yun Wang Ronald Warnick Felicia Williams Yingli Wolinsky Sue Bell Mara Rosenberg Chip Stewart Franklin Huang Jonna L Grimsby Amie J Radenbaugh Jianan Zhang
June 2015

Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients.

Nature 2015 Mar 11;519(7543):366-9. Epub 2015 Mar 11.

1] Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina 27710, USA [2] Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA [3] Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA [4] Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA [5] Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1038/nature14320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510871PMC
March 2015

Novel role of hematopoietic stem cells in immunologic rejection of malignant gliomas.

Oncoimmunology 2015 Mar 22;4(3):e994374. Epub 2015 Jan 22.

UF Brain Tumor Immunotherapy Program; Preston A. Wells, Jr. Center for Brain Tumor Therapy; Department of Neurosurgery; University of Florida ; Gainesville, FL, USA.

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http://dx.doi.org/10.4161/2162402X.2014.994374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404923PMC
March 2015

EGFRvIII-specific chimeric antigen receptor T cells migrate to and kill tumor deposits infiltrating the brain parenchyma in an invasive xenograft model of glioblastoma.

PLoS One 2014 10;9(4):e94281. Epub 2014 Apr 10.

Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America; Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094281PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983153PMC
January 2015

Oncolytic polio virotherapy of cancer.

Cancer 2014 Nov 17;120(21):3277-86. Epub 2014 Jun 17.

Department of Surgery, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina; Division of Neurosurgery Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina; Department of Molecular Genetics and Microbiology, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina.

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http://doi.wiley.com/10.1002/cncr.28862
Publisher Site
http://dx.doi.org/10.1002/cncr.28862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205207PMC
November 2014

Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase.

J Virol 2014 Nov 3;88(22):13135-48. Epub 2014 Sep 3.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA Department of Surgery, Division of Neurosurgery, Duke University Medical Center, Durham, North Carolina, USA

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http://dx.doi.org/10.1128/JVI.01883-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249076PMC
November 2014

Malignant brainstem gliomas in adults: clinicopathological characteristics and prognostic factors.

J Neurooncol 2014 Aug 17;119(1):177-85. Epub 2014 May 17.

Division of Neurosurgery, Department of Surgery, Duke University Medical Center, 2624, Durham, NC, 27710, USA.

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http://dx.doi.org/10.1007/s11060-014-1471-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510613PMC
August 2014

Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.

Nat Genet 2014 Jul 1;46(7):726-30. Epub 2014 Jun 1.

Department of Pathology, Duke University Medical Center, The Preston Robert Tisch Brain Tumor Center, The Pediatric Brain Tumor Foundation Institute, Durham, North Carolina, USA.

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http://dx.doi.org/10.1038/ng.2995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073211PMC
July 2014

Affinity-matured recombinant immunotoxin targeting gangliosides 3'-isoLM1 and 3',6'-isoLD1 on malignant gliomas.

MAbs 2013 Sep-Oct;5(5):748-62. Epub 2013 Jul 25.

Preston Robert Tisch Brain Tumor Center at Duke and Department of Pathology; Duke University Medical Center; Durham, NC USA.

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http://dx.doi.org/10.4161/mabs.25860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851227PMC
May 2014

The genetic landscape of anaplastic astrocytoma.

Oncotarget 2014 Mar;5(6):1452-7

Department of Pathology, Duke University Medical Center, The Preston Robert Tisch Brain Tumor Center at Duke, and Pediatric Brain Tumor Foundation Institute at Duke, Durham, NC.

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http://www.oncotarget.com/fulltext/1505
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039223PMC
http://dx.doi.org/10.18632/oncotarget.1505DOI Listing
March 2014

Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma.

J Clin Neurosci 2014 Jan 17;21(1):189-90. Epub 2013 Sep 17.

Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Box 3050, Durham, NC 27710, USA; Department of Pathology, Duke University Medical Center, Durham, NC, USA; The Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jocn.2013.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867597PMC
January 2014

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.

Acta Neuropathol 2013 Dec 31;126(6):917-29. Epub 2013 Oct 31.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00401-013-1198-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830749PMC
December 2013

Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody.

Oncoimmunology 2013 Dec 22;2(12):e26757. Epub 2013 Oct 22.

Duke Brain Tumor Immunotherapy Program; Division of Neurosurgery; Department of Surgery; Duke University Medical Center; Durham, NC USA ; The Preston Robert Tisch Brain Tumor Center at Duke; Duke University Medical Center; Durham, NC USA.

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http://dx.doi.org/10.4161/onci.26757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891636PMC
December 2013

A novel recombinant immunotoxin-based therapy targeting wild-type and mutant EGFR improves survival in murine models of glioblastoma.

Oncoimmunology 2013 Dec 22;2(12):e26852. Epub 2013 Oct 22.

Preston Robert Tisch Brain Tumor Center at Duke; Duke University Medical Center; Durham, NC USA ; Department of Pathology; Duke University Medical Center; Durham, NC USA.

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http://dx.doi.org/10.4161/onci.26852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912004PMC
December 2013

KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation.

Oncotarget 2013 Nov;4(11):2144-53

The Preston Robert Tisch Brain Tumor Center at Duke and Pediatric Brain Tumor Foundation Institute, Duke University, Durham, NC.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875776PMC
http://dx.doi.org/10.18632/oncotarget.1555DOI Listing
November 2013

The somatic genomic landscape of glioblastoma.

Cell 2013 Oct;155(2):462-77

Human Oncology and Pathogenesis Program, Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, Department of Neurological Surgery, Weill Cornell Medical Center, New York, NY 10065, USA. Electronic address:

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https://www.genome.gov/Multimedia/Slides/TCGA2/27_Verhaak.pd
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http://linkinghub.elsevier.com/retrieve/pii/S009286741301208
Publisher Site
http://dx.doi.org/10.1016/j.cell.2013.09.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910500PMC
October 2013

Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.

PLoS One 2013 18;8(3):e59082. Epub 2013 Mar 18.

Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059082PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601076PMC
September 2013

Rational design and generation of recombinant control reagents for bispecific antibodies through CDR mutagenesis.

J Immunol Methods 2013 Sep 24;395(1-2):14-20. Epub 2013 Jun 24.

Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, United States.

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http://dx.doi.org/10.1016/j.jim.2013.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746479PMC
September 2013

Human regulatory T cells kill tumor cells through granzyme-dependent cytotoxicity upon retargeting with a bispecific antibody.

Cancer Immunol Res 2013 Sep;1(3):163

Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710 ; Department of Pathology, Duke University Medical Center, Durham, NC 27710 ; The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, NC 27710.

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http://dx.doi.org/10.1158/2326-6066.CIR-13-0049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932050PMC
September 2013

Antibody, T-cell and dendritic cell immunotherapy for malignant brain tumors.

Future Oncol 2013 Jul;9(7):977-90

Duke University Medical Center, Department of Pathology, Durham, NC 27710, USA.

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http://dx.doi.org/10.2217/fon.13.47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904373PMC
July 2013

An EGFRvIII-targeted bispecific T-cell engager overcomes limitations of the standard of care for glioblastoma.

Expert Rev Clin Pharmacol 2013 Jul;6(4):375-86

Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1586/17512433.2013.811806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034273PMC
July 2013

Isocitrate dehydrogenase 1: what it means to the neurosurgeon: a review.

J Neurosurg 2013 Jun 12;118(6):1176-80. Epub 2013 Apr 12.

Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672384PMC
June 2013

BLyS levels correlate with vaccine-induced antibody titers in patients with glioblastoma lymphodepleted by therapeutic temozolomide.

Cancer Immunol Immunother 2013 Jun 17;62(6):983-7. Epub 2013 Apr 17.

Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1007/s00262-013-1405-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665719PMC
June 2013

Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors.

Int J Cancer 2013 May 23;132(10):2339-48. Epub 2012 Nov 23.

Preston Robert Tisch Brain Tumor Center at Duke and Department of Pathology, Duke University Medical Center, Durham, NC.

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http://dx.doi.org/10.1002/ijc.27919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809846PMC
May 2013

A novel bispecific antibody recruits T cells to eradicate tumors in the "immunologically privileged" central nervous system.

Oncoimmunology 2013 Apr;2(4):e23639

Duke Brain Tumor Immunotherapy Program; Division of Neurosurgery; Department of Surgery; Duke University Medical Center; Durham, NC USA ; Department of Pathology; Duke University Medical Center; Durham, NC USA ; The Preston Robert Tisch Brain Tumor Center at Duke; Duke University Medical Center; Durham, NC USA.

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http://dx.doi.org/10.4161/onci.23639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654588PMC
April 2013

Toxin-based targeted therapy for malignant brain tumors.

Clin Dev Immunol 2012 9;2012:480429. Epub 2012 Feb 9.

Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287048PMC
March 2013

Reversing the Warburg effect as a treatment for glioblastoma.

J Biol Chem 2013 Mar 13;288(13):9153-64. Epub 2013 Feb 13.

Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

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http://dx.doi.org/10.1074/jbc.M112.440354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610988PMC
March 2013

Rindopepimut: anti-EGFRvIII peptide vaccine, oncolytic.

Drugs Future 2013 Mar;38(3):147-155

Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA. ; The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1358/dof.2013.038.03.1933992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317793PMC
March 2013

Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.

Cancer Res 2013 Jan 30;73(2):496-501. Epub 2012 Nov 30.

The Preston Robert Tisch Brain Tumor Center, The Pediatric Brain Tumor Foundation Institute, and The Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-2852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548957PMC
January 2013

Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma.

Proc Natl Acad Sci U S A 2013 Jan 17;110(1):270-5. Epub 2012 Dec 17.

Duke Brain Tumor Immunotherapy Program, Division of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1219817110
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http://dx.doi.org/10.1073/pnas.1219817110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538214PMC
January 2013

Convection enhanced delivery of macromolecules for brain tumors.

Curr Drug Discov Technol 2012 Dec;9(4):305-10

Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.2174/157016312803305951DOI Listing
December 2012

A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.

Genome Res 2012 Dec 16;22(12):2339-55. Epub 2012 Aug 16.

The Preston Robert Tisch Brain Tumor Center, The Pediatric Brain Tumor Foundation Institute, The Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1101/gr.132738.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514664PMC
December 2012

Mechanism of anti-glioma activity and in vivo efficacy of the cannabinoid ligand KM-233.

J Neurooncol 2012 Nov 9;110(2):163-77. Epub 2012 Aug 9.

Department of Pharmaceutical Sciences, The University of Tennessee Health Science Center, Memphis, TN, USA.

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http://dx.doi.org/10.1007/s11060-012-0958-5DOI Listing
November 2012

Enzyme redesign guided by cancer-derived IDH1 mutations.

Nat Chem Biol 2012 Nov 23;8(11):887-9. Epub 2012 Sep 23.

Department of Pathology, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1038/nchembio.1065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487689PMC
November 2012

Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways.

Proc Natl Acad Sci U S A 2012 Oct 8;109(43):17603-8. Epub 2012 Oct 8.

The Preston Robert Tisch Brain Tumor Center at Duke, Pediatric Brain Tumor Foundation Institute, cDepartment of Pathology, Duke University, Durham, NC 27710, USA.

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http://dx.doi.org/10.1073/pnas.1208807109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491484PMC
October 2012

Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells.

PLoS One 2012 27;7(4):e36211. Epub 2012 Apr 27.

Department of Pathology, The Pediatric Brain Tumor Foundation Institute, and The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center, Durham, North Carolina, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338642PMC
September 2012

Subgroup-specific structural variation across 1,000 medulloblastoma genomes.

Authors:
Paul A Northcott David J H Shih John Peacock Livia Garzia A Sorana Morrissy Thomas Zichner Adrian M Stütz Andrey Korshunov Jüri Reimand Steven E Schumacher Rameen Beroukhim David W Ellison Christian R Marshall Anath C Lionel Stephen Mack Adrian Dubuc Yuan Yao Vijay Ramaswamy Betty Luu Adi Rolider Florence M G Cavalli Xin Wang Marc Remke Xiaochong Wu Readman Y B Chiu Andy Chu Eric Chuah Richard D Corbett Gemma R Hoad Shaun D Jackman Yisu Li Allan Lo Karen L Mungall Ka Ming Nip Jenny Q Qian Anthony G J Raymond Nina T Thiessen Richard J Varhol Inanc Birol Richard A Moore Andrew J Mungall Robert Holt Daisuke Kawauchi Martine F Roussel Marcel Kool David T W Jones Hendrick Witt Africa Fernandez-L Anna M Kenney Robert J Wechsler-Reya Peter Dirks Tzvi Aviv Wieslawa A Grajkowska Marta Perek-Polnik Christine C Haberler Olivier Delattre Stéphanie S Reynaud François F Doz Sarah S Pernet-Fattet Byung-Kyu Cho Seung-Ki Kim Kyu-Chang Wang Wolfram Scheurlen Charles G Eberhart Michelle Fèvre-Montange Anne Jouvet Ian F Pollack Xing Fan Karin M Muraszko G Yancey Gillespie Concezio Di Rocco Luca Massimi Erna M C Michiels Nanne K Kloosterhof Pim J French Johan M Kros James M Olson Richard G Ellenbogen Karel Zitterbart Leos Kren Reid C Thompson Michael K Cooper Boleslaw Lach Roger E McLendon Darell D Bigner Adam Fontebasso Steffen Albrecht Nada Jabado Janet C Lindsey Simon Bailey Nalin Gupta William A Weiss László Bognár Almos Klekner Timothy E Van Meter Toshihiro Kumabe Teiji Tominaga Samer K Elbabaa Jeffrey R Leonard Joshua B Rubin Linda M Liau Erwin G Van Meir Maryam Fouladi Hideo Nakamura Giuseppe Cinalli Miklós Garami Peter Hauser Ali G Saad Achille Iolascon Shin Jung Carlos G Carlotti Rajeev Vibhakar Young Shin Ra Shenandoah Robinson Massimo Zollo Claudia C Faria Jennifer A Chan Michael L Levy Poul H B Sorensen Matthew Meyerson Scott L Pomeroy Yoon-Jae Cho Gary D Bader Uri Tabori Cynthia E Hawkins Eric Bouffet Stephen W Scherer James T Rutka David Malkin Steven C Clifford Steven J M Jones Jan O Korbel Stefan M Pfister Marco A Marra Michael D Taylor

Nature 2012 Aug;488(7409):49-56

Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683624PMC
August 2012

Mutant IDH1 is required for IDH1 mutated tumor cell growth.

Oncotarget 2012 Aug;3(8):774-82

The Preston Robert Tisch Brain Tumor Center, The Pediatric Brain Tumor Foundation Institute, and The Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478455PMC
http://dx.doi.org/10.18632/oncotarget.577DOI Listing
August 2012

Central nervous system.

Cancer Biomark 2010 ;9(1-6):193-210

Departments of Surgery (neurosurgery) and Neurobiology, Duke University, Neurosurgery Section, Durham VA Medical Center, US.

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http://dx.doi.org/10.3233/CBM-2011-0177DOI Listing
July 2012

Immunotherapy of brain tumors.

Handb Clin Neurol 2012 ;104:309-30

North Carolina State University, Raleigh, NC, USA.

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http://dx.doi.org/10.1016/B978-0-444-52138-5.00020-7DOI Listing
April 2012

Bispecific antibodies engage T cells for antitumor immunotherapy.

Expert Opin Biol Ther 2011 Jul 30;11(7):843-53. Epub 2011 Mar 30.

Duke Brain Tumor Immunotherapy Program, Duke University Medical Center, Division of Neurosurgery, Department of Surgery, Durham, North Carolina 27710 , USA.

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http://dx.doi.org/10.1517/14712598.2011.572874DOI Listing
July 2011

Medical diagnostic radiation exposures and risk of gliomas.

Radiat Res 2011 Jun 5;175(6):790-6. Epub 2011 Apr 5.

Department of Epidemiology, School of Public Health, University of Illinois at Chicago, Chicago, Illinois 60612, USA.

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http://www.bioone.org/doi/10.1667/RR2186.1
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http://dx.doi.org/10.1667/RR2186.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151669PMC
June 2011

Monitoring radiographic brain tumor progression.

Toxins (Basel) 2011 03 15;3(3):191-200. Epub 2011 Mar 15.

Division of Neurosurgery, Duke University Medical Center, Box 3807, Durham, NC 27710, USA.

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http://dx.doi.org/10.3390/toxins3030191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202817PMC
March 2011

Imaging of convection enhanced delivery of toxins in humans.

Toxins (Basel) 2011 03 15;3(3):201-6. Epub 2011 Mar 15.

Division of Neurosurgery, Duke University Medical Center, Box 3807, Durham, NC 27710, USA.

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http://dx.doi.org/10.3390/toxins3030201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202819PMC
March 2011

Assessment of type of allergy and antihistamine use in the development of glioma.

Cancer Epidemiol Biomarkers Prev 2011 Feb;20(2):370-8

Department of Epidemiology/Biostatistics, School of Public Health, University of Illinois at Chicago, 1603 W. Taylor St. (M/C 923), Chicago, IL 60612, USA.

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http://cebp.aacrjournals.org/cgi/doi/10.1158/1055-9965.EPI-1
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http://dx.doi.org/10.1158/1055-9965.EPI-10-0948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077928PMC
February 2011

2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations.

PLoS One 2011 Feb 4;6(2):e16812. Epub 2011 Feb 4.

The Preston Robert Tisch Brain Tumor Center at Duke, Pediatric Brain Tumor Foundation Institute, and Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016812PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033901PMC
February 2011