Publications by authors named "Dante Rotili"

99Publications

Lysine Acetyltransferase Inhibitors From Natural Sources.

Front Pharmacol 2020 12;11:1243. Epub 2020 Aug 12.

Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.3389/fphar.2020.01243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434864PMC
August 2020

Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs).

Eur J Med Chem 2020 Dec 18;207:112750. Epub 2020 Aug 18.

Department of Chemistry and Technology of Drugs, "Sapienza" University of Rome, 00185, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2020.112750DOI Listing
December 2020

Targeting histone acetylation/deacetylation in parasites: an update (2017-2020).

Curr Opin Chem Biol 2020 08 29;57:65-74. Epub 2020 Jun 29.

Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cbpa.2020.05.008DOI Listing
August 2020

Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment.

Biochem Pharmacol 2020 08 29;178:114060. Epub 2020 May 29.

Department of Chemical Sciences and Technologies, University of Rome "Tor Vergata", Rome, Italy; The NAST Centre for Nanoscience and Nanotechnology and Innovative Instrumentation, University of Rome "Tor Vergata", Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2020.114060DOI Listing
August 2020

Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer.

Front Oncol 2020 15;10:474. Epub 2020 Apr 15.

Department of Chemistry and Technology of Drugs, "Sapienza" University of Rome, Rome, Italy.

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http://dx.doi.org/10.3389/fonc.2020.00474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177044PMC
April 2020

Sirtuin modulators: where are we now? A review of patents from 2015 to 2019.

Expert Opin Ther Pat 2020 Jun 13;30(6):389-407. Epub 2020 Apr 13.

Dipartimento di Chimica e Tecnologie del Farmaco, "Sapienza" Università di Roma, Rome, Italy.

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http://dx.doi.org/10.1080/13543776.2020.1749264DOI Listing
June 2020

Effects of Glutathione Transferase-Targeting Nitrobenzoxadiazole Compounds in Relation to PD-L1 Status in Human Melanoma Cells.

Chemotherapy 2019 22;64(3):138-145. Epub 2019 Oct 22.

Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy,

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http://dx.doi.org/10.1159/000503339DOI Listing
December 2019

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from (Sirt2).

J Med Chem 2019 10 20;62(19):8733-8759. Epub 2019 Sep 20.

Institute of Pharmaceutical Sciences , University of Freiburg , Albertstr. 25 , 79104 Freiburg , Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00638DOI Listing
October 2019

Epigenetic polypharmacology: A new frontier for epi-drug discovery.

Med Res Rev 2020 01 20;40(1):190-244. Epub 2019 Jun 20.

Department of Chemistry and Technologies of Drugs, "Sapienza" University of Rome, Rome, Italy.

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http://dx.doi.org/10.1002/med.21600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917854PMC
January 2020

α,γ-Diketocarboxylic Acids and Their Esters Act as Carbonic Anhydrase IX and XII Selective Inhibitors.

ACS Med Chem Lett 2019 Apr 19;10(4):661-665. Epub 2019 Feb 19.

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466837PMC
April 2019

Comparison of the effects of synthetic and plant-derived mTOR regulators on healthy human ovarian cells.

Eur J Pharmacol 2019 Jul 5;854:70-78. Epub 2019 Apr 5.

King Saud University, Department of Zoology, College of Science, Riyadh, 11451, Saudi Arabia.

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http://dx.doi.org/10.1016/j.ejphar.2019.03.048DOI Listing
July 2019

Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells.

Clin Epigenetics 2019 01 17;11(1):11. Epub 2019 Jan 17.

Laboratory of Molecular Neurobiology, Neurobiology Center, The Nencki Institute of Experimental Biology, 3 Pasteur Str, 02-093, Warsaw, Poland.

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http://dx.doi.org/10.1186/s13148-018-0598-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337817PMC
January 2019

Identification of novel quinazoline derivatives as potent antiplasmodial agents.

Eur J Med Chem 2019 Jan 17;161:277-291. Epub 2018 Oct 17.

CIIL U1019-CNRS UMR 8204, Université de Lille, Institut Pasteur de Lille, 1 rue du Professeur Calmette, 59019, Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.10.041DOI Listing
January 2019

Mass spectrometry characterization of DOTA-Nimotuzumab conjugate as precursor of an innovative β tracer suitable in radio-guided surgery.

J Pharm Biomed Anal 2018 Jul 12;156:8-15. Epub 2018 Mar 12.

Institute of Biochemistry and Clinical Biochemistry, Catholic University, Largo F. Vito 1, 00168, Rome, Italy; Institute of Chemistry of Molecular Recognition, CNR, Largo F. Vito 1, 00168, Rome, Italy.

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http://dx.doi.org/10.1016/j.jpba.2018.03.018DOI Listing
July 2018

Lysine acetyltransferase inhibitors: structure-activity relationships and potential therapeutic implications.

Future Med Chem 2018 05 20;10(9):1067-1091. Epub 2018 Apr 20.

Department of Drug Chemistry & Technologies, Sapienza University of Rome, P.le A Moro 5, 00185 Rome, Italy.

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http://dx.doi.org/10.4155/fmc-2017-0244DOI Listing
May 2018

Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches.

J Comput Aided Mol Des 2018 03 15;32(3):435-458. Epub 2018 Jan 15.

Rome Center for Molecular Design, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, P. le A. Moro 5, 00185, Roma, Italy.

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http://dx.doi.org/10.1007/s10822-018-0096-zDOI Listing
March 2018

The relevance of K calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor.

Eur J Med Chem 2017 Aug 5;136:480-486. Epub 2017 May 5.

University of Groningen, Groningen Research Institute of Pharmacy, Department of Chemical and Pharmaceutical Biology, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720340PMC
August 2017

Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives.

J Med Chem 2017 06 15;60(12):4780-4804. Epub 2017 Mar 15.

Dipartimento di Chimica e Tecnologie del Farmaco "Sapienza" Università di Roma , 00185 Rome, Italy.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01595DOI Listing
June 2017

Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.

Angew Chem Int Ed Engl 2017 01 19;56(4):1007-1011. Epub 2016 Dec 19.

Universität Bayreuth, Lehrstuhl Biochemie und Forschungszentrum für Biomakromoleküle, Universitätsstr. 30, 95447, Bayreuth, Germany.

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http://dx.doi.org/10.1002/anie.201610082DOI Listing
January 2017

Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity.

Bioorg Med Chem 2017 02 1;25(3):847-856. Epub 2016 Dec 1.

Department of Chemical and Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.11.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292237PMC
February 2017

At Long Last Potent and Selective KDM5 Inhibitors.

Cell Chem Biol 2016 07;23(7):749-751

Department of Biology and Biotechnology, University of Pavia, 27100 Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.07.003DOI Listing
July 2016

Sirtuin functions and modulation: from chemistry to the clinic.

Clin Epigenetics 2016 25;8:61. Epub 2016 May 25.

Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università degli Studi di Napoli, Vico L. De Crecchio 7, 80138 Napoli, Italy.

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http://dx.doi.org/10.1186/s13148-016-0224-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879741PMC
December 2016

Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells.

Am J Cancer Res 2016 15;6(4):859-75. Epub 2016 Mar 15.

Orthopaedic Pathophysiology and Regenerative Medicine Unit, Istituto Ortopedico RizzoliBologna, Italy; Department of Biomedical and Neuromotor Sciences, University of BolognaBologna, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859889PMC
May 2016

c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition.

J Transl Med 2016 Feb 4;14:37. Epub 2016 Feb 4.

Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier 1, 00133, Rome, Italy.

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http://dx.doi.org/10.1186/s12967-016-0796-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743117PMC
February 2016

The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases.

Biochem Pharmacol 2016 Feb 21;102:130-140. Epub 2015 Dec 21.

Pharmaceutical Gene Modulation, Groningen Research Institute of Pharmacy, University of Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871277PMC
February 2016

Enzyme kinetics and inhibition of histone acetyltransferase KAT8.

Eur J Med Chem 2015 Nov 22;105:289-96. Epub 2015 Oct 22.

Department of Pharmaceutical Gene Modulation, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871228PMC
November 2015

Targeting Lysine Deacetylases (KDACs) in Parasites.

PLoS Negl Trop Dis 2015 24;9(9):e0004026. Epub 2015 Sep 24.

The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America; Departments of Genetics and of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0004026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581690PMC
March 2016

Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells.

J Med Chem 2015 May 30;58(9):4073-9. Epub 2015 Apr 30.

§Department of Drug Chemistry and Technologies, Sapienza University of Roma, P.le A. Moro 5, 00185 Roma, Italy.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.5b00126
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http://dx.doi.org/10.1021/acs.jmedchem.5b00126DOI Listing
May 2015

A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib.

Biochem Pharmacol 2015 May 17;95(1):16-27. Epub 2015 Mar 17.

The NAST Centre for Nanoscience & Nanotechnology & Innovative Instrumentation, University of "Tor Vergata", Rome, Italy; Department of Experimental Medicine and Surgery, University of "Tor Vergata", Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.03.004DOI Listing
May 2015

Sirtuin modulators control reactive gliosis in an in vitro model of Alzheimer's disease.

Front Pharmacol 2014 13;5:89. Epub 2014 May 13.

Vittorio Erspamer School of Physiology and Pharmacology, SAPIENZA University of Rome Rome, Italy.

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http://dx.doi.org/10.3389/fphar.2014.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027795PMC
May 2014

Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: enzyme and cellular studies.

Eur J Med Chem 2014 Jun 15;80:569-78. Epub 2014 Apr 15.

Department of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy; Pasteur Institute, Cenci Bolognetti Foundation, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2014.04.042DOI Listing
June 2014

Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-HDAC inhibitor MC2392.

Cancer Res 2014 Apr 24;74(8):2328-39. Epub 2014 Feb 24.

Authors' Affiliations: Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università degli Studi di Napoli; Istituto di Genetica e Biofisica, IGB, Adriano Buzzati Traverso, Naples; Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, Rome, Italy; NCMLS, Radboud University, Nijmegen, the Netherlands; Inserm, CRCM, U1068, TrGET & ISCB, University of Marseille; and Laboratoire U944 and UMR 7212, University Paris-Diderot, Paris, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-2568DOI Listing
April 2014

Carprofen analogues as sirtuin inhibitors: enzyme and cellular studies.

ChemMedChem 2012 Nov;7(11):1905-8

Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, P.le A. Moro 5, 00185 Roma (Italy).

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http://doi.wiley.com/10.1002/cmdc.201200318
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http://dx.doi.org/10.1002/cmdc.201200318DOI Listing
November 2012

Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells.

J Med Chem 2012 Sep 7;55(18):8193-7. Epub 2012 Sep 7.

Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Roma, Italy.

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http://dx.doi.org/10.1021/jm301115rDOI Listing
September 2012

2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies.

J Med Chem 2012 Apr 26;55(7):3558-62. Epub 2012 Mar 26.

Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma La Sapienza, P.le A. Moro 5, 00185 Rome, Italy.

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http://dx.doi.org/10.1021/jm201308vDOI Listing
April 2012

An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases.

J Mol Biol 2012 Feb 29;416(3):319-27. Epub 2011 Dec 29.

Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.jmb.2011.12.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280428PMC
February 2012

Targeting Histone Demethylases: A New Avenue for the Fight against Cancer.

Genes Cancer 2011 Jun;2(6):663-79

Pasteur Institute-Cenci-Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy.

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http://gan.sagepub.com/lookup/doi/10.1177/1947601911417976
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http://dx.doi.org/10.1177/1947601911417976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174264PMC
June 2011

Modulation of cell differentiation, proliferation, and tumor growth by dihydrobenzyloxopyrimidine non-nucleoside reverse transcriptase inhibitors.

J Med Chem 2011 Aug 22;54(16):5927-36. Epub 2011 Jul 22.

Dipartimento di Scienze Farmaceutiche e Biomediche, Epigenetic Med Chem Lab, Università degli Studi di Salerno, Via Ponte Don Melillo, I-84084 Fisciano (SA), Italy.

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http://dx.doi.org/10.1021/jm200734jDOI Listing
August 2011

A photoreactive small-molecule probe for 2-oxoglutarate oxygenases.

Chem Biol 2011 May;18(5):642-654

Department of Chemistry and the Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1016/j.chembiol.2011.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681097PMC
May 2011

Diarylpyrimidine-dihydrobenzyloxopyrimidine hybrids: new, wide-spectrum anti-HIV-1 agents active at (sub)-nanomolar level.

J Med Chem 2011 Apr 25;54(8):3091-6. Epub 2011 Mar 25.

Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma La Sapienza, Roma, Italy.

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http://dx.doi.org/10.1021/jm101626cDOI Listing
April 2011

Biological effects of MC2050, a quinazoline-based PARP-1 inhibitor, in human neuroblastoma and EBV-positive Burkitt's lymphoma cells.

ChemMedChem 2011 Apr 1;6(4):606-11. Epub 2011 Mar 1.

Department of Biochemical Sciences, "Sapienza" University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.

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http://dx.doi.org/10.1002/cmdc.201000536DOI Listing
April 2011

Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells.

Int J Oncol 2011 May 11;38(5):1427-36. Epub 2011 Feb 11.

Dipartimento di Scienze per Promozione della Salute G. D'Alessandro- Sezione di Farmacologia, Policlinico P. Giaccone, via del Vespro 129, 90127 Palermo, Italy.

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http://dx.doi.org/10.3892/ijo.2011.943DOI Listing
May 2011

Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile.

Bioorg Med Chem 2011 Jun 19;19(12):3659-68. Epub 2011 Jan 19.

Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Università degli Studi di Roma La Sapienza, P.le A. Moro 5, 00185 Roma, Italy.

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http://dx.doi.org/10.1016/j.bmc.2011.01.025DOI Listing
June 2011

Photoactivable peptides for identifying enzyme-substrate and protein-protein interactions.

Chem Commun (Camb) 2011 Feb 13;47(5):1488-90. Epub 2010 Dec 13.

University of Oxford, Department of Chemistry and the Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, United Kingdom.

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http://dx.doi.org/10.1039/c0cc04457aDOI Listing
February 2011

HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation.

J Mol Endocrinol 2010 Oct 16;45(4):219-28. Epub 2010 Jul 16.

Dipartimento di Patologia Generale, Seconda Università di Napoli, Naples, Italy.

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http://dx.doi.org/10.1677/JME-10-0043DOI Listing
October 2010

Identification of tri- and tetracyclic pyrimidinediones as sirtuin inhibitors.

ChemMedChem 2010 May;5(5):674-7

Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Italy.

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http://dx.doi.org/10.1002/cmdc.201000030DOI Listing
May 2010

Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues.

J Med Chem 2010 Feb;53(3):1407-11

INSERM, Laboratory of Neuronal Cell Biology and Pathology, Center for Psychiatry and Neurosciences U894, Paris, France.

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http://dx.doi.org/10.1021/jm9013345DOI Listing
February 2010

Histone deacetylase inhibitors and neurodegenerative disorders: holding the promise.

Curr Pharm Des 2009 ;15(34):3940-57

Pasteur Institute, Cenci-Bolognetti Foundation, Department of Drug Chemistry and Technologies, University of Rome "La Sapienza", P. le A. Moro 5, 00185 Rome, Italy.

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http://dx.doi.org/10.2174/138161209789649349DOI Listing
March 2010

Non-cancer uses of histone deacetylase inhibitors: effects on infectious diseases and beta-hemoglobinopathies.

Curr Top Med Chem 2009 ;9(3):272-91

Pasteur Institute, Cenci-Bolognetti Foundation, Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro, 5, 00185, Rome, Italy.

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http://dx.doi.org/10.2174/156802609788085296DOI Listing
June 2009

Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases.

Bioorg Med Chem Lett 2009 Feb 30;19(4):1132-5. Epub 2008 Dec 30.

Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, P.le A. Moro 5, 00185 Roma, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2008.12.097DOI Listing
February 2009

Chiral HPLC separation and absolute configuration of novel S-DABO derivatives.

Chirality 2009 Jun;21(6):604-12

Dipartimento del Farmaco, Istituto Superiore di Sanità, Rome, Italy.

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http://dx.doi.org/10.1002/chir.20654DOI Listing
June 2009

Histone deacetylase inhibitors and hemoglobin F induction in beta-thalassemia.

Int J Biochem Cell Biol 2008 29;40(11):2341-7. Epub 2008 May 29.

Division of Hematology/Oncology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.biocel.2008.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581454PMC
October 2008

Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases.

Bioorg Med Chem Lett 2008 May 11;18(9):2788-92. Epub 2008 Apr 11.

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy.

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http://dx.doi.org/10.1016/j.bmcl.2008.04.017DOI Listing
May 2008

Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities.

Bioorg Med Chem Lett 2008 Apr 22;18(8):2530-5. Epub 2008 Mar 22.

Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Sapienza Università di Roma, P.le A. Moro 5, 00185 Roma, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2008.03.055DOI Listing
April 2008

Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains.

J Med Chem 2007 Nov 2;50(22):5412-24. Epub 2007 Oct 2.

Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Università degli Studi di Roma La Sapienza, P. le A. Moro 5, 00185 Roma, Italy.

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http://dx.doi.org/10.1021/jm070811eDOI Listing
November 2007