Publications by authors named "Danilo A Tagle"

35Publications

Organs-on-chips: into the next decade.

Nat Rev Drug Discov 2020 Sep 10. Epub 2020 Sep 10.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41573-020-0079-3DOI Listing
September 2020

Organs-on-a-Chip.

Adv Exp Med Biol 2020 ;1230:27-42

National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/978-3-030-36588-2_3DOI Listing
April 2020

The NIH microphysiological systems program: developing in vitro tools for safety and efficacy in drug development.

Authors:
Danilo A Tagle

Curr Opin Pharmacol 2019 10 14;48:146-154. Epub 2019 Oct 14.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.coph.2019.09.007DOI Listing
October 2019

Improved Ocular Tissue Models and Eye-On-A-Chip Technologies Will Facilitate Ophthalmic Drug Development.

J Ocul Pharmacol Ther 2020 Jan/Feb;36(1):25-29. Epub 2019 Jun 5.

National Eye Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1089/jop.2018.0139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985761PMC
June 2019

Correction for Han et al., "Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III".

Mol Cell Biol 2018 05 30;38(10). Epub 2018 Apr 30.

Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061.

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http://dx.doi.org/10.1128/MCB.00099-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954200PMC
May 2018

Microphysiological Systems (Tissue Chips) and their Utility for Rare Disease Research.

Adv Exp Med Biol 2017 ;1031:405-415

National Center for Advancing Translational Sciences, National Institutes of Health, Democracy 1 Building, Democracy Boulevard, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/978-3-319-67144-4_23DOI Listing
June 2018

Organs-on-chips: Progress, challenges, and future directions.

Exp Biol Med (Maywood) 2017 10 26;242(16):1573-1578. Epub 2017 Mar 26.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1177/1535370217700523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661765PMC
October 2017

Facilitating the commercialization and use of organ platforms generated by the microphysiological systems (Tissue Chip) program through public-private partnerships.

Comput Struct Biotechnol J 2016 10;14:207-210. Epub 2016 May 10.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, United States.

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http://dx.doi.org/10.1016/j.csbj.2016.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122750PMC
May 2016

Diagnostic potential of extracellular RNA from biofluids.

Expert Rev Mol Diagn 2016 11 8;16(11):1135-1138. Epub 2016 Oct 8.

a Office of the Director, National Center for Advancing Translational Sciences , National Institutes of Health , Bethesda , MD , USA.

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http://dx.doi.org/10.1080/14737159.2016.1241146DOI Listing
November 2016

Tissue Chips to aid drug development and modeling for rare diseases.

Expert Opin Orphan Drugs 2016 19;4(11):1113-1121. Epub 2016 Oct 19.

National Center for Advancing Translational Sciences, National Institutes of Health, 6701 Democracy Boulevard, Bethesda, MD, 20892.

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http://dx.doi.org/10.1080/21678707.2016.1244479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472383PMC
October 2016

Organs-on-chips (microphysiological systems): tools to expedite efficacy and toxicity testing in human tissue.

Exp Biol Med (Maywood) 2014 Sep 24;239(9):1073-7. Epub 2014 Jun 24.

National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892-4874, USA.

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http://dx.doi.org/10.1177/1535370214538916DOI Listing
September 2014

Expanding rare disease drug trials based on shared molecular etiology.

Nat Biotechnol 2014 Jun;32(6):515-8

Office of Rare Diseases Research, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/nbt.2924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548299PMC
June 2014

Phenylketonuria Scientific Review Conference: state of the science and future research needs.

Mol Genet Metab 2014 Jun 6;112(2):87-122. Epub 2014 Mar 6.

The Young Face, Facial Plastic and Reconstructive Surgery, Cumming, GA 30041, USA. Electronic address:

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https://www.team-share.net/Phenylketonuria_Scientific_Review
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http://linkinghub.elsevier.com/retrieve/pii/S109671921400085
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http://dx.doi.org/10.1016/j.ymgme.2014.02.013DOI Listing
June 2014

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage.

Hum Mol Genet 2011 Apr 21;20(7):1438-55. Epub 2011 Jan 21.

Neurogenetics Laboratory, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA.

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http://dx.doi.org/10.1093/hmg/ddr024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049363PMC
April 2011

Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases.

BMC Biochem 2010 May 19;11:19. Epub 2010 May 19.

Department of Biochemistry, Virginia Tech, Blacksburg, 24061, USA.

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http://dx.doi.org/10.1186/1471-2091-11-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890522PMC
May 2010

Structure, expression, and function of kynurenine aminotransferases in human and rodent brains.

Cell Mol Life Sci 2010 Feb 15;67(3):353-68. Epub 2009 Oct 15.

Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1007/s00018-009-0166-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867614PMC
February 2010

Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K.

J Med Chem 2009 May;52(9):2786-93

Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, USA.

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http://dx.doi.org/10.1021/jm9000874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844090PMC
May 2009

Biochemical and structural properties of mouse kynurenine aminotransferase III.

Mol Cell Biol 2009 Feb 24;29(3):784-93. Epub 2008 Nov 24.

Department of Biochemistry, Virginia Tech, Blacksburg, Virginia 24061, USA.

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http://dx.doi.org/10.1128/MCB.01272-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630683PMC
February 2009

Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II.

Biosci Rep 2008 Aug;28(4):205-15

Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, U.S.A.

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http://dx.doi.org/10.1042/BSR20080085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2559858PMC
August 2008

Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family.

Gene 2006 Jan 10;365:111-8. Epub 2006 Jan 10.

Protein-nucleic acid interactions section, Structure Biophysics Laboratory, NCI-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.gene.2005.09.034DOI Listing
January 2006

Endogenous kynurenate controls the vulnerability of striatal neurons to quinolinate: Implications for Huntington's disease.

Exp Neurol 2006 Jan 15;197(1):31-40. Epub 2005 Aug 15.

Maryland Psychiatric Research Center, University of Maryland School of Medicine, P.O. Box 21247, Baltimore, MD 21228, USA.

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http://dx.doi.org/10.1016/j.expneurol.2005.07.004DOI Listing
January 2006

Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements.

J Neurocytol 2004 Sep;33(5):517-33

Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s11068-004-0514-8DOI Listing
September 2004

Glutamic acid decarboxylase autoimmunity in Batten disease and other disorders.

Neurology 2004 Dec;63(11):2001-5

Center for Aging and Developmental Biology, Department of Biochemistry and Biophysics, Box 645, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1212/01.wnl.0000145836.72059.3bDOI Listing
December 2004

Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice.

Mol Cell Biol 2004 Aug;24(16):6919-30

Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1128/MCB.24.16.6919-6930.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC479723PMC
August 2004

PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains.

Hum Mol Genet 2002 Oct;11(21):2547-58

Institute for Biochemistry II, University of Cologne, D-50931 Cologne, Germany.

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http://dx.doi.org/10.1093/hmg/11.21.2547DOI Listing
October 2002

Striatal neurochemical changes in transgenic models of Huntington's disease.

J Neurosci Res 2002 Jun;68(6):716-29

Department of Neuroscience, The Chicago Medical School, North Chicago, Illinois 60064, USA.

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http://dx.doi.org/10.1002/jnr.10272DOI Listing
June 2002

PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain.

Genomics 2002 Jun;79(6):869-74

Structure Biophysics Laboratory, National Cancer Institute-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1006/geno.2002.6770DOI Listing
June 2002