Publications by authors named "Daniele Fancelli"

13Publications

High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons.

Authors:
Francesca Cavallo Flavia Troglio Giovanni Fagà Daniele Fancelli Reinald Shyti Sebastiano Trattaro Matteo Zanella Giuseppe D'Agostino James M Hughes Maria Rosaria Cera Maurizio Pasi Michele Gabriele Maddalena Lazzarin Marija Mihailovich Frank Kooy Alessandro Rosa Ciro Mercurio Mario Varasi Giuseppe Testa

Mol Autism 2020 Nov 19;11(1):88. Epub 2020 Nov 19.

High Definition Disease Modelling Lab: Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology IRCCS, Via Adamello 16, 20139, Milan, Italy.

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November 2020

GNX-4728, a novel small molecule drug inhibitor of mitochondrial permeability transition, is therapeutic in a mouse model of amyotrophic lateral sclerosis.

Authors:
Lee J Martin Daniele Fancelli Margaret Wong Mark Niedzwiecki Marco Ballarini Simon Plyte Qing Chang

Front Cell Neurosci 2014 19;8:433. Epub 2014 Dec 19.

Department of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine Baltimore, MD, USA.

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January 2015

An update on therapeutic opportunities offered by cancer glycolytic metabolism.

Authors:
Carlotta Granchi Daniele Fancelli Filippo Minutolo

Bioorg Med Chem Lett 2014 Nov 20;24(21):4915-25. Epub 2014 Sep 20.

Dipartimento di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy. Electronic address:

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November 2014

Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo.

Authors:
Daniele Fancelli Agnese Abate Raffaella Amici Paolo Bernardi Marco Ballarini Anna Cappa Giacomo Carenzi Andrea Colombo Cristina Contursi Fabio Di Lisa Giulio Dondio Stefania Gagliardi Eva Milanesi Saverio Minucci Gilles Pain Pier Giuseppe Pelicci Alessandra Saccani Mariangela Storto Florian Thaler Mario Varasi Manuela Villa Simon Plyte

J Med Chem 2014 Jun 11;57(12):5333-47. Epub 2014 Jun 11.

Genextra Group, Congenia s.r.l. , Via Adamello 16, 20139 Milan, Italy.

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June 2014

Quantitative chemical proteomics identifies novel targets of the anti-cancer multi-kinase inhibitor E-3810.

Authors:
Mara Colzani Roberta Noberini Mauro Romanenghi Gennaro Colella Maurizio Pasi Daniele Fancelli Mario Varasi Saverio Minucci Tiziana Bonaldi

Mol Cell Proteomics 2014 Jun 2;13(6):1495-509. Epub 2014 Apr 2.

From the ‡Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milano, Italy;

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June 2014

Thieno[3,2-c]pyrazoles: a novel class of Aurora inhibitors with favorable antitumor activity.

Authors:
Simona Bindi Daniele Fancelli Cristina Alli Daniela Berta Jay A Bertrand Alexander D Cameron Paolo Cappella Patrizia Carpinelli Giovanni Cervi Valter Croci Matteo D'Anello Barbara Forte M Laura Giorgini Aurelio Marsiglio Juergen Moll Enrico Pesenti Valeria Pittalà Maurizio Pulici Federico Riccardi-Sirtori Fulvia Roletto Chiara Soncini Paola Storici Mario Varasi Daniele Volpi Paola Zugnoni Paola Vianello

Bioorg Med Chem 2010 Oct 25;18(19):7113-20. Epub 2010 Jul 25.

Nerviano Medical Sciences-Oncology, via Pasteur 10, 20014 Nerviano, Milan, Italy.

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October 2010

PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer.

Authors:
Patrizia Carpinelli Roberta Ceruti Maria Laura Giorgini Paolo Cappella Laura Gianellini Valter Croci Anna Degrassi Gemma Texido Maurizio Rocchetti Paola Vianello Luisa Rusconi Paola Storici Paola Zugnoni Claudio Arrigoni Chiara Soncini Cristina Alli Veronica Patton Aurelio Marsiglio Dario Ballinari Enrico Pesenti Daniele Fancelli Jürgen Moll

Mol Cancer Ther 2007 Dec;6(12 Pt 1):3158-68

Nerviano Medical Sciences S.r.l.-Oncology, Viale Pasteur 10, 20014 Nerviano, Milan, Italy.

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December 2007

Crystal structure of the T315I Abl mutant in complex with the aurora kinases inhibitor PHA-739358.

Authors:
Michele Modugno Elena Casale Chiara Soncini Pamela Rosettani Riccardo Colombo Rosita Lupi Luisa Rusconi Daniele Fancelli Patrizia Carpinelli Alexander D Cameron Antonella Isacchi Jürgen Moll

Cancer Res 2007 Sep;67(17):7987-90

Nerviano Medical Sciences Srl-Oncology, Milan, Italy.

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September 2007

6-Substituted pyrrolo[3,4-c]pyrazoles: an improved class of CDK2 inhibitors.

Authors:
Maria Gabriella Brasca Clara Albanese Raffaella Amici Dario Ballinari Luca Corti Valter Croci Daniele Fancelli Francesco Fiorentini Marcella Nesi Paolo Orsini Fabrizio Orzi Wilma Pastori Ettore Perrone Enrico Pesenti Paolo Pevarello Federico Riccardi-Sirtori Fulvia Roletto Patrick Roussel Mario Varasi Anna Vulpetti Ciro Mercurio

ChemMedChem 2007 Jun;2(6):841-52

Oncology Business Unit, Department of Chemistry, Nerviano Medical Sciences, Viale Pasteur 10, 20014 Nerviano MI, Italy.

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June 2007

1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.

Authors:
Daniele Fancelli Jürgen Moll Mario Varasi Rodrigo Bravo Roberta Artico Daniela Berta Simona Bindi Alexander Cameron Ilaria Candiani Paolo Cappella Patrizia Carpinelli Walter Croci Barbara Forte Maria Laura Giorgini Jan Klapwijk Aurelio Marsiglio Enrico Pesenti Maurizio Rocchetti Fulvia Roletto Dino Severino Chiara Soncini Paola Storici Roberto Tonani Paola Zugnoni Paola Vianello

J Med Chem 2006 Nov;49(24):7247-51

Nerviano Medical Sciences S.r.l. viale Pasteur 10, 20014 Nerviano, Milan, Italy.

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November 2006

PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity.

Authors:
Chiara Soncini Patrizia Carpinelli Laura Gianellini Daniele Fancelli Paola Vianello Luisa Rusconi Paola Storici Paola Zugnoni Enrico Pesenti Valter Croci Roberta Ceruti Maria Laura Giorgini Paolo Cappella Dario Ballinari Francesco Sola Mario Varasi Rodrigo Bravo Jürgen Moll

Clin Cancer Res 2006 Jul;12(13):4080-9

Nerviano Medical Sciences S.r.l.-Oncology, Milan, Italy.

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July 2006

3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: a new class of CDK2 inhibitors.

Authors:
Paolo Pevarello Daniele Fancelli Anna Vulpetti Raffaella Amici Manuela Villa Valeria Pittalà Paola Vianello Alexander Cameron Marina Ciomei Ciro Mercurio James R Bischoff Fulvia Roletto Mario Varasi Maria Gabriella Brasca

Bioorg Med Chem Lett 2006 Feb 14;16(4):1084-90. Epub 2005 Nov 14.

Department of Chemistry, Nerviano Medical Science, BU-Oncology, Via Pasteur 10, 20014 Nerviano MI, Italy.

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February 2006

Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition.

Authors:
Daniele Fancelli Daniela Berta Simona Bindi Alexander Cameron Paolo Cappella Patrizia Carpinelli Cornel Catana Barbara Forte Patrizia Giordano Maria Laura Giorgini Sergio Mantegani Aurelio Marsiglio Maurizio Meroni Juergen Moll Valeria Pittalà Fulvia Roletto Dino Severino Chiara Soncini Paola Storici Roberto Tonani Mario Varasi Anna Vulpetti Paola Vianello

J Med Chem 2005 Apr;48(8):3080-4

Nerviano Medical Sciences - Oncology, via Pasteur 10, 20014 Nerviano, Milan, Italy.

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April 2005