Publications by authors named "Daniela Sia"

42Publications

Copy-Number Alteration Burden Differentially Impacts Immune Profiles and Molecular Features of Hepatocellular Carcinoma.

Clin Cancer Res 2020 Dec 1;26(23):6350-6361. Epub 2020 Sep 1.

Liver Cancer Translational Research Group, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-20-1497DOI Listing
December 2020

Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma.

J Hepatol 2020 Aug 12;73(2):315-327. Epub 2020 Mar 12.

Translational Research in Hepatic Oncology, Liver Unit, IDIBAPS, Hospital Clínic, University of Barcelona, Barcelona, Catalonia, Spain; Liver Cancer Program, Divisions of Liver Diseases, Pathology Department and RM Transplant Institute, Tisch Cancer Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2020.03.008DOI Listing
August 2020

Translating cancer genomics for precision oncology in biliary tract cancers.

Discov Med 2019 Nov-Dec;28(155):255-265

Liver Cancer Program, Divisions of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

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May 2020

An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents.

Gastroenterology 2019 11 22;157(5):1383-1397.e11. Epub 2019 Jul 22.

Liver Cancer Translational Research Liver Cancer Translational Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)-Hospital Clínic, Liver Unit, Universitat de Barcelona, Barcelona, Catalonia, Spain; Mount Sinai Liver Cancer Program, Department of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, USA; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815707PMC
November 2019

Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC.

Clin Cancer Res 2019 04 7;25(7):2021-2023. Epub 2019 Jan 7.

Translational Research in Hepatic Oncology, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445700PMC
April 2019

Molecular therapies and precision medicine for hepatocellular carcinoma.

Nat Rev Clin Oncol 2018 10;15(10):599-616

Department of Medicine, Division of Hematology/Oncology, Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/s41571-018-0073-4DOI Listing
October 2018

A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma.

Oncogene 2018 07 9;37(27):3740-3752. Epub 2018 Apr 9.

Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, USA.

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http://dx.doi.org/10.1038/s41388-018-0206-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035113PMC
July 2018

Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma.

J Hepatol 2017 12 24;67(6):1222-1231. Epub 2017 Aug 24.

Mount Sinai Liver Cancer Program (Divisions of Liver Diseases, Department of Medicine, Department of Pathology, Recanati Miller Transplantation Institute), Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA; Liver Cancer Translational Research Laboratory, BCLC Group, IDIBAPS, Liver Unit, Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.08.013DOI Listing
December 2017

Liver cancer: Translating '-omics' results into precision medicine for hepatocellular carcinoma.

Nat Rev Gastroenterol Hepatol 2017 10 2;14(10):571-572. Epub 2017 Aug 2.

Mount Sinai Liver Cancer Program, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York 10029, USA; at the Liver Cancer Translational Research Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Univesitat de Barcelona, Rosselló 153, Barcelona 08039, Spain; and at the Institució Catalana de Recerca i Estudis Avançats, Passeig de Lluís Companys 23, Barcelona 08010, Spain.

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http://dx.doi.org/10.1038/nrgastro.2017.103DOI Listing
October 2017

Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features.

Gastroenterology 2017 09 15;153(3):812-826. Epub 2017 Jun 15.

Mount Sinai Liver Cancer Program (Divisions of Liver Diseases, Department of Hematology/Oncology, Department of Medicine, Department of Pathology, Recanati Miller Transplantation Institute), Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Liver Cancer Translational Research Laboratory, BCLC, Liver Unit, CIBEREHD, IDIBAPS, Hospital Clinic, University of Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.06.007DOI Listing
September 2017

Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity.

J Hepatol 2017 05 23;66(5):952-961. Epub 2017 Jan 23.

Liver Cancer Translational Research Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, CIBERehd, Universitat de Barcelona, Barcelona, Catalonia, Spain; Mount Sinai Liver Cancer Program, (Divisions of Liver Diseases, Hematology and Medical Oncology, Department of Medicine, Department of Pathology, Recanati Miller Transplantation Institute), Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278173001
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http://dx.doi.org/10.1016/j.jhep.2017.01.010DOI Listing
May 2017

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis.

Gastroenterology 2017 03 30;152(4):745-761. Epub 2016 Dec 30.

Mount Sinai Liver Cancer Program, Divisions of Liver Diseases, Hematology, and Medical Oncology, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Liver Cancer Translational Research Laboratory, BCLC, Liver Unit, CIBEREHD, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.11.048DOI Listing
March 2017

Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis.

Lancet Oncol 2016 Oct 27;17(10):1386-1395. Epub 2016 Aug 27.

Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Catalonia, Spain; School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain; Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(16)30297-2DOI Listing
October 2016

Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma.

Gut 2017 03 11;66(3):530-540. Epub 2015 Dec 11.

Liver Cancer Translational Research Laboratory, Barcelona Clinic Liver Cancer (BCLC) Group, Liver Unit and Pathology Department, IDIBAPS, Hospital Clínic, CIBERehd, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1136/gutjnl-2015-309501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600200PMC
March 2017

Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma.

Clin Cancer Res 2016 Jan 24;22(2):291-300. Epub 2015 Sep 24.

Liver Cancer Translational Research Laboratory, Liver Unit, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, CIBERehd, Universitat de Barcelona, Barcelona, Catalonia, Spain. Liver Cancer Program, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York. Institució Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-3296DOI Listing
January 2016

The future of patient-derived tumor xenografts in cancer treatment.

Pharmacogenomics 2015 24;16(14):1671-83. Epub 2015 Sep 24.

Liver Cancer Program, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue NY 10029, USA.

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https://www.futuremedicine.com/doi/10.2217/pgs.15.102
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http://dx.doi.org/10.2217/pgs.15.102DOI Listing
July 2016

Progenitor cell markers predict outcome of patients with hepatocellular carcinoma beyond Milan criteria undergoing liver transplantation.

J Hepatol 2015 Dec 26;63(6):1368-77. Epub 2015 Jul 26.

Mount Sinai Liver Cancer Program (Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Department of Pathology, Recanati Miller Transplantation Institute, Department of Surgical Oncology), Icahn School of Medicine at Mount Sinai, New York, USA; Liver Cancer Translational Research Laboratory, Barcelona - Clínic Liver Cancer Group (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Liver Unit, Hospital Clínic, Universitat de Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.07.025DOI Listing
December 2015

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression.

Cell Rep 2015 Mar 12;10(10):1692-1707. Epub 2015 Mar 12.

Cancer Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565791PMC
March 2015

Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma.

Nat Commun 2015 Jan 22;6:6087. Epub 2015 Jan 22.

1] Barcelona-Clínic Liver Cancer Group (HCC Translational Research Laboratory, Liver Unit, Hepato-biliary Surgery), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, CIBERehd, Universitat de Barcelona, Barcelona 08036, Spain [2] Mount Sinai Liver Cancer Program (Divisions of Liver Diseases, Department of Medicine, Department of Pathology, Recanati Miller Transplantation Institute), Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York 10029, USA [3] Institució Catalana de Recerca i Estudis Avançats, Barcelona 08010, Spain.

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http://dx.doi.org/10.1038/ncomms7087DOI Listing
January 2015

VEGF signaling in cancer treatment.

Curr Pharm Des 2014 ;20(17):2834-42

HCC Translational Research Laboratory, BCLC Group, Liver Unit, CIBERehd, Hospital Clinic, IDIBAPS, Rossello 153, 08036 Barcelona, Spain.

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http://dx.doi.org/10.2174/13816128113199990590DOI Listing
September 2015

Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes.

Gastroenterology 2013 Apr 4;144(4):829-40. Epub 2013 Jan 4.

Barcelona-Clínic Liver Cancer Group (HCC Translational Research Laboratory, Liver Unit, Pathology Department), Institut d'Investigacions Biomèdiques August Pi I Sunyer, Liver Unit, Hospital Clínic, Universitat de Barcelona, Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1053/j.gastro.2013.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624083PMC
April 2013

microRNAs: new ways to block tumor angiogenesis?

J Hepatol 2012 Sep 9;57(3):490-1. Epub 2012 Jun 9.

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http://dx.doi.org/10.1016/j.jhep.2012.06.005DOI Listing
September 2012

Signaling pathways in hepatocellular carcinoma.

Oncology 2011 22;81 Suppl 1:18-23. Epub 2011 Dec 22.

HCC Translational Research Laboratory, Barcelona Clinic Liver Cancer Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Liver Unit, Hospital Clinic, Barcelona, Spain.

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http://dx.doi.org/10.1159/000333254DOI Listing
February 2012

Gene-expression signature of vascular invasion in hepatocellular carcinoma.

J Hepatol 2011 Dec 13;55(6):1325-31. Epub 2011 Apr 13.

Mount Sinai Liver Cancer Program, (Division of Liver Diseases, Department of Medicine, Surgical Oncology, Department of Surgery, Department of Pathology, Department of Preventive Medicine), Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.jhep.2011.02.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624094PMC
December 2011

microRNAs and the MYC network: a major piece in the puzzle of liver cancer.

Gastroenterology 2011 Jun 22;140(7):2138-40. Epub 2011 Apr 22.

Mount Sinai Liver Cancer Program, Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York.

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http://dx.doi.org/10.1053/j.gastro.2011.04.023DOI Listing
June 2011

Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma.

Gastroenterology 2011 May 12;140(5):1501-12.e2. Epub 2011 Feb 12.

HCC Translational Research Laboratory, Barcelona-Clinic Liver Cancer Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Liver Unit, Hospital Clinic, Barcelona, Spain.

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http://dx.doi.org/10.1053/j.gastro.2011.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081971PMC
May 2011

Cancer gene discovery in hepatocellular carcinoma.

J Hepatol 2010 Jun 20;52(6):921-9. Epub 2010 Mar 20.

Helmholtz Centre for Infection Research, Braunschweig 38124, Germany.

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http://dx.doi.org/10.1016/j.jhep.2009.12.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905725PMC
June 2010

A computational approach to compare microvessel distributions in tumors following antiangiogenic treatments.

Lab Invest 2009 Sep 3;89(9):1063-70. Epub 2009 Aug 3.

Consiglio Nazionale delle Ricerche, Institute of Neuroscience, Cellular and Molecular Pharmacology Section, Milan, Italy.

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http://dx.doi.org/10.1038/labinvest.2009.76DOI Listing
September 2009