Daniela Pende

Daniela Pende

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Daniela Pende

Daniela Pende

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Dendritic cell recognition by group 3 innate lymphoid cells through DNAX accessory molecule 1 triggers proinflammatory reciprocal cell activation.

J Allergy Clin Immunol 2019 Oct 24;144(4):1118-1122.e6. Epub 2019 Jun 24.

Laboratory of Immunology and Biotherapy, Department of Human Pathology, University of Messina, Messina, Italy; Cell Factory Center and Division of Clinical Pathology, University Hospital Policlinico G.Martino, Messina, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.06.008DOI Listing
October 2019

Report from the Eleventh Killer Immunoglobulin-like Receptor (KIR) Workshop: Novel insights on KIR polymorphism, ligand recognition, expression and function.

HLA 2019 Aug;94(2):100-110

Laboratorio di Immunologia, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

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http://dx.doi.org/10.1111/tan.13608DOI Listing
August 2019

2B4 dysfunction in XLP1 NK cells: More than inability to control EBV infection.

Clin Immunol 2019 Jul 2;204:31-36. Epub 2018 Nov 2.

IRCCS Istituto Giannina Gaslini, Dipartimento dei Laboratori di Ricerca, Genoa, Italy; Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genoa, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S15216616183042
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http://dx.doi.org/10.1016/j.clim.2018.10.022DOI Listing
July 2019

CD56 Homodimerization and Participation in Anti-Tumor Immune Effector Cell Functioning: A Role for Interleukin-15.

Cancers (Basel) 2019 Jul 22;11(7). Epub 2019 Jul 22.

Laboratory of Experimental Hematology, Tumor Immunology Group (TIGR), Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, 2610 Antwerp, Belgium.

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http://dx.doi.org/10.3390/cancers11071029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678613PMC
July 2019

Natural killer cells: From surface receptors to the cure of high-risk leukemia (Ceppellini Lecture).

HLA 2019 Apr;93(4):185-194

Department of Immunology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.

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http://dx.doi.org/10.1111/tan.13509DOI Listing
April 2019

Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1.

J Immunol 2018 10 17;201(7):2028-2041. Epub 2018 Aug 17.

Manchester Collaborative Centre for Inflammation Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9NT, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1800475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139540PMC
October 2018

Analysis of Polymorphism Provides Relevant Information on Centromeric Gene Content.

J Immunol 2018 09 1;201(5):1460-1467. Epub 2018 Aug 1.

Dipartimento dei Laboratori di Ricerca, Istituto di Ricovero e Cura a Carattere Scientifico, Giannina Gaslini, 16147 Genoa, Italy.

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http://dx.doi.org/10.4049/jimmunol.1800564DOI Listing
September 2018

NK Cells Mediate a Crucial Graft-versus-Leukemia Effect in Haploidentical-HSCT to Cure High-Risk Acute Leukemia.

Trends Immunol 2018 07 21;39(7):577-590. Epub 2018 May 21.

IRCCS Ospedale Pediatrico Bambino Gesù, Area di Ricerca Immunologica, Roma, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.it.2018.04.009DOI Listing
July 2018

Functional evaluation of natural killer cell cytotoxic activity in NFKB2-mutated patients.

Immunol Lett 2018 02 24;194:40-43. Epub 2017 Dec 24.

University of Torino, Department of Public Health and Pediatrics, Piazza Polonia 94, Turin, 10126, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.imlet.2017.12.006DOI Listing
February 2018

The Activating Human NK Cell Receptor KIR2DS2 Recognizes a β-Microglobulin-Independent Ligand on Cancer Cells.

J Immunol 2017 04 15;198(7):2556-2567. Epub 2017 Feb 15.

Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway; and.

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http://dx.doi.org/10.4049/jimmunol.1600930DOI Listing
April 2017

Markers and function of human NK cells in normal and pathological conditions.

Cytometry B Clin Cytom 2017 03 12;92(2):100-114. Epub 2017 Feb 12.

Department of Immunology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

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http://dx.doi.org/10.1002/cyto.b.21508DOI Listing
March 2017

Preparation of Cytokine-activated NK Cells for Use in Adoptive Cell Therapy in Cancer Patients: Protocol Optimization and Therapeutic Potential.

J Immunother 2016 Feb-Mar;39(2):90-100

*Pediatric Immunology Laboratory, Department of Pediatrics Departments of ‡Medical Statistics §Immunohematology and Blood Bank, Leiden University Medical Center, Leiden, The Netherlands †IRCCS AOU San Martino-IST, Genoa, Italy.

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http://dx.doi.org/10.1097/CJI.0000000000000110DOI Listing
November 2016

Human NK cells: From surface receptors to clinical applications.

Immunol Lett 2016 10 13;178:15-9. Epub 2016 May 13.

Department of Experimental Medicine, University of Genova, Genova, Italy; Centro di Eccellenza per la Ricerca Biomedica-CEBR, Genova, Italy.

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http://dx.doi.org/10.1016/j.imlet.2016.05.007DOI Listing
October 2016

γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-αβ+/CD19+ lymphocytes.

Blood 2015 Apr 22;125(15):2349-58. Epub 2015 Jan 22.

Department of Pediatric Hematology and Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy; Department of Pediatric Science, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1182/blood-2014-09-599423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440890PMC
April 2015

Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis.

J Allergy Clin Immunol 2014 Dec 27;134(6):1381-1387.e7. Epub 2014 Jun 27.

Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria San Martino-Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.

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http://dx.doi.org/10.1016/j.jaci.2014.04.043DOI Listing
December 2014

Direct involvement of CD56 in cytokine-induced killer-mediated lysis of CD56+ hematopoietic target cells.

Exp Hematol 2014 Dec 6;42(12):1013-21.e1. Epub 2014 Sep 6.

USS Centre of Cellular Therapy "G.Lanzani", USC Hematology and Bone Marrow Transplantation Unit, A.O. Papa Giovanni XXIII, Bergamo, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0301472X140066
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http://dx.doi.org/10.1016/j.exphem.2014.08.005DOI Listing
December 2014

Modulation of CD112 by the alphaherpesvirus gD protein suppresses DNAM-1-dependent NK cell-mediated lysis of infected cells.

Proc Natl Acad Sci U S A 2014 Nov 28;111(45):16118-23. Epub 2014 Oct 28.

Laboratory of Immunology, Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1409485111
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http://dx.doi.org/10.1073/pnas.1409485111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234607PMC
November 2014

Identification of CD300a as a new hypoxia-inducible gene and a regulator of CCL20 and VEGF production by human monocytes and macrophages.

Innate Immun 2014 Oct 16;20(7):721-34. Epub 2013 Oct 16.

Laboratory of Molecular Biology, Istituto Giannina Gaslini, Genova, Italy

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http://dx.doi.org/10.1177/1753425913507095DOI Listing
October 2014

HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders.

Blood 2014 Jul 28;124(5):822-6. Epub 2014 May 28.

Department of Pediatric Hematology and Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, Italy; Department of Pediatrics, University of Pavia, Pavia, Italy.

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http://dx.doi.org/10.1182/blood-2014-03-563817DOI Listing
July 2014

Human NK cells: from surface receptors to the therapy of leukemias and solid tumors.

Front Immunol 2014 7;5:87. Epub 2014 Mar 7.

Department of Experimental Medicine and Center of Excellence for Biomedical Research, University of Genova , Genova , Italy ; IRCCS AOU San Martino-IST , Genova , Italy.

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http://dx.doi.org/10.3389/fimmu.2014.00087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945935PMC
June 2014

XLP1 inhibitory effect by 2B4 does not affect DNAM-1 and NKG2D activating pathways in NK cells.

Eur J Immunol 2014 May 27;44(5):1526-34. Epub 2014 Feb 27.

Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria San Martino-Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.

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http://dx.doi.org/10.1002/eji.201344312DOI Listing
May 2014

Cellular and molecular basis of haploidentical hematopoietic stem cell transplantation in the successful treatment of high-risk leukemias: role of alloreactive NK cells.

Front Immunol 2013 1;4:15. Epub 2013 Feb 1.

Department of Pediatric Hematology/Oncology, Istituto Di Ricovero e Cura a Carattere Scientifico, Ospedale Pediatrico Bambino Gesù Rome, Italy ; Università di Pavia Pavia, Italy.

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http://dx.doi.org/10.3389/fimmu.2013.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561663PMC
February 2013

Familial hemophagocytic lymphohistiocytosis: a model for understanding the human machinery of cellular cytotoxicity.

Cell Mol Life Sci 2012 Jan 12;69(1):29-40. Epub 2011 Oct 12.

Dipartimento Oncoematologia Pediatrica e Cure Domiciliari, Azienda Ospedaliero-Universitaria Meyer, Viale Pieraccini, 24, 50139 Florence, Italy.

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http://dx.doi.org/10.1007/s00018-011-0835-yDOI Listing
January 2012

Dual-functional capability of CD3+CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity.

Blood 2011 Sep 5;118(12):3301-10. Epub 2011 Aug 5.

Laboratory of Cellular Therapy G. Lanzani, USC Hematology, Ospedali Riuniti di Bergamo, Bergamo, Italy.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2011-02-33
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http://dx.doi.org/10.1182/blood-2011-02-336321DOI Listing
September 2011

Inhibition of NKG2D expression in NK cells by cytokines secreted in response to human cytomegalovirus infection.

Blood 2010 Jun 14;115(25):5170-9. Epub 2010 Apr 14.

Immunology Unit, University Pompeu Fabra (DCEXS), Barcelona, Spain.

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http://dx.doi.org/10.1182/blood-2009-11-256479DOI Listing
June 2010

Ovine CD16+/CD14- blood lymphocytes present all the major characteristics of natural killer cells.

Vet Res 2010 Jan-Feb;41(1). Epub 2009 Sep 16.

Institut National de la Recherche Agronomique, UR1282, Infectiologie Animale et Santé Publique, Laboratoire Contrôle et Immunologie des Maladies Entériques du Nouveau-né, Nouzilly, France.

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http://dx.doi.org/10.1051/vetres/2009052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762129PMC
March 2010

Haploidentical hemopoietic stem cell transplantation for the treatment of high-risk leukemias: how NK cells make the difference.

Clin Immunol 2009 Nov 29;133(2):171-8. Epub 2009 May 29.

Pediatric Hematology/Oncology, University of Pavia, IRCCS Foundation, Policlinico San Matteo, Pavia, Italy.

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http://linkinghub.elsevier.com/retrieve/pii/S152166160900655
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http://dx.doi.org/10.1016/j.clim.2009.04.009DOI Listing
November 2009

Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction.

Blood 2009 Nov 11;114(19):4108-16. Epub 2009 Sep 11.

Dipartimento di Medicina Sperimentale and Centro di Eccellenza per le Ricerche Biomediche, Università degli Studi di Genova, Genova, Italy.

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http://dx.doi.org/10.1182/blood-2009-05-222265DOI Listing
November 2009

Histone deacetylase inhibitors sensitize tumour cells for cytotoxic effects of natural killer cells.

Cancer Lett 2008 Dec 20;272(1):110-21. Epub 2008 Aug 20.

Institut für Immunologie und Transfusionsmedizin, [corrected] Ernst-Moritz-Arndt-Universität Greifswald, Ferdinand-Sauerbruch-Str., D-17487 Greifswald, Germany.

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http://dx.doi.org/10.1016/j.canlet.2008.06.027DOI Listing
December 2008

Natural killer cells in lymph nodes of healthy calves express CD16 and show both cytotoxic and cytokine-producing properties.

Dev Comp Immunol 2008 18;32(7):773-83. Epub 2007 Dec 18.

Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, P.O. Box 8146 Dep., N-0033 Oslo, Norway.

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http://dx.doi.org/10.1016/j.dci.2007.11.006DOI Listing
August 2008

Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals.

PLoS Pathog 2008 Jul 11;4(7):e1000101. Epub 2008 Jul 11.

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1000101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438610PMC
July 2008

CD8(+) T lymphocytes isolated from renal cancer patients recognize tumour cells through an HLA- and TCR/CD3-independent pathway.

Cancer Immunol Immunother 2007 Jul 29;56(7):1065-76. Epub 2006 Dec 29.

Cancer Immunotherapy and Gene Therapy Program, Scientific Institute H. San Raffaele, Milan, Italy.

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http://link.springer.com/10.1007/s00262-006-0268-x
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http://dx.doi.org/10.1007/s00262-006-0268-xDOI Listing
July 2007

Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses.

Blood 2007 May 11;109(9):3776-85. Epub 2007 Jan 11.

Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London, UK.

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http://dx.doi.org/10.1182/blood-2006-10-052977DOI Listing
May 2007

Effector and regulatory events during natural killer-dendritic cell interactions.

Immunol Rev 2006 Dec;214:219-28

Direzione Scientifica, Istituto Giannina Gaslini, Largo G. Gaslini, Genova-Quarto, Italy.

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http://dx.doi.org/10.1111/j.1600-065X.2006.00450.xDOI Listing
December 2006

Expression and function of NKG2D in CD4+ T cells specific for human cytomegalovirus.

Eur J Immunol 2006 Dec;36(12):3198-206

Molecular Immunopathology Unit, Universitat Pompeu Fabra (DCEXS), Barcelona, Spain.

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http://dx.doi.org/10.1002/eji.200636682DOI Listing
December 2006

Surface NK receptors and their ligands on tumor cells.

Semin Immunol 2006 Jun 26;18(3):151-8. Epub 2006 May 26.

Istituto Giannina Gaslini, L.go G. Gaslini, Genova, Italy.

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http://dx.doi.org/10.1016/j.smim.2006.03.002DOI Listing
June 2006

Different checkpoints in human NK-cell activation.

Trends Immunol 2004 Dec;25(12):670-6

Istituto Giannina Gaslini, Largo Gerolamo Gaslini 5, 16147 Genova-Quarto, Italy.

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http://dx.doi.org/10.1016/j.it.2004.09.008DOI Listing
December 2004

Learning how to discriminate between friends and enemies, a lesson from Natural Killer cells.

Mol Immunol 2004 Jul;41(6-7):569-75

Istituto Giannina Gaslini, L.go. G. Gaslini 5, Genova 16148, Italy.

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http://dx.doi.org/10.1016/j.molimm.2004.04.004DOI Listing
July 2004

Cellular and molecular basis of natural killer and natural killer-like activity.

Immunol Lett 2003 Aug;88(2):89-93

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Via L.B. Alberti no. 2, 16132 Genova, Italy.

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http://dx.doi.org/10.1016/s0165-2478(03)00074-9DOI Listing
August 2003

NKG2D engagement of colorectal cancer-specific T cells strengthens TCR-mediated antigen stimulation and elicits TCR independent anti-tumor activity.

Eur J Immunol 2003 Jul;33(7):2033-43

Unit of Immunotherapy of Human Tumors, Istituto Nazionale Tumori, Via Venezian 1, I-20133 Milan, Italy.

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http://dx.doi.org/10.1002/eji.200323909DOI Listing
July 2003

Human NK cells and their receptors.

Microbes Infect 2002 Dec;4(15):1539-44

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy.

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December 2002

Haemophagocytic lymphohistiocytosis: proposal of a diagnostic algorithm based on perforin expression.

Br J Haematol 2002 Oct;119(1):180-8

Onco Ematologia Pediatrica, Ospedale dei Bambini 'G. Di Cristina', Palermo, Italy.

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http://dx.doi.org/10.1046/j.1365-2141.2002.03773.xDOI Listing
October 2002

Human natural killer cells: their origin, receptors and function.

Eur J Immunol 2002 05;32(5):1205-11

Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Genova, Italy.

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http://dx.doi.org/10.1002/1521-4141(200205)32:5<1205::AID-IMMU1205>3.0.CO;2-YDOI Listing
May 2002

Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia.

Blood 2002 May;99(10):3661-7

Unité d'Immunologie des Tumeurs Département d'Hématologie, Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France.

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http://dx.doi.org/10.1182/blood.v99.10.3661DOI Listing
May 2002