Publications by authors named "Daniela Furlan"

52Publications

KRAS inhibition in non-small cell lung cancer: Past failures, new findings and upcoming challenges.

Eur J Cancer 2020 09 31;137:57-68. Epub 2020 Jul 31.

Department of Oncology, University of Turin, S. Luigi Gonzaga Hospital, Orbassano (TO), Italy. Electronic address:

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September 2020

PD-L1 in small bowel adenocarcinoma is associated with etiology and tumor-infiltrating lymphocytes, in addition to microsatellite instability.

Mod Pathol 2020 07 17;33(7):1398-1409. Epub 2020 Feb 17.

Department of Internal Medicine, University of Pavia and Fondazione IRCCS San Matteo Hospital, Pavia, Italy.

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July 2020

Validation and further potentialities of the novel AWM score for progression risk stratification in patients with asymptomatic Waldenström macroglobulinemia.

Leuk Lymphoma 2020 04 14;61(4):987-989. Epub 2019 Nov 14.

Department of Hematology, University Hospital "Ospedale di Circolo e Fondazione Macchi - ASST Sette Laghi", University of Insubria, Varese, Italy.

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April 2020

Mutation in Colorectal Rhabdoid and Poorly Differentiated Medullary Carcinomas.

Cancers (Basel) 2019 Aug 26;11(9). Epub 2019 Aug 26.

Unit of Pathology, Dept. of Medicine and Surgery and Research Center for the Study of Hereditary and Familial tumors, University of Insubria, 21100 Varese, Italy.

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August 2019

Neuroendocrine Differentiation, Microsatellite Instability, and Tumor-infiltrating Lymphocytes in Advanced Colorectal Cancer With BRAF Mutation.

Clin Colorectal Cancer 2019 06 20;18(2):e251-e260. Epub 2018 Dec 20.

Unit of Pathology, Department of Medicine and Surgery, University of Insubria, Varese, Italy; Research Center for the Study of Hereditary and Familial Tumors, Department of Medicine and Surgery, University of Insubria, Varese, Italy.

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June 2019

Epigenomic profiling of archived FFPE tissues by enhanced PAT-ChIP (EPAT-ChIP) technology.

Clin Epigenetics 2018 11 16;10(1):143. Epub 2018 Nov 16.

Department of Biomolecular Sciences, Molecular Pathology Laboratory "PaoLa", University of Urbino "Carlo Bo", Via Arco d'Augusto 2, 61032, Fano, PU, Italy.

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November 2018

Targeted gene sequencing of Lynch syndrome-related and sporadic endometrial carcinomas.

Hum Pathol 2018 11 3;81:235-244. Epub 2018 Jul 3.

Unit of Pathology, Department of Medicine and Surgery, University of Insubria, 21100, Varese, Italy; Research Center for the study of Hereditary and Familial Tumors, Department of Medicine and Surgery, University of Insubria, 21100, Varese, Italy.

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November 2018

Cleaning the genitalia with plain water improves accuracy of urine dipstick in childhood.

Eur J Pediatr 2018 Oct 27;177(10):1573-1579. Epub 2018 Jul 27.

Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 80138, Napoli, Italy.

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October 2018

Nephrogenic Diabetes Insipidus in Childhood: Assessment of Volume Status and Appropriate Fluid Replenishment.

Pediatr Emerg Care 2020 Jul;36(7):e402-e404

From the Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania "Luigi Vanvitelli," Napoli, Italy.

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July 2020

LINE-1 hypomethylation is associated to specific clinico-pathological features in Stage I non-small cell lung cancer.

Lung Cancer 2017 06 6;108:83-89. Epub 2017 Mar 6.

Unit of Pathology, Department of Medicine and Surgery, University of Insubria, ASST Sette Laghi, via Rossi 9, 21100, Varese, Italy; Research Center for the Study of Hereditary and Familial tumors, University of Insubria, Varese, Italy.

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June 2017

Somatic Testing on Gynecological Cancers Improve the Identification of Lynch Syndrome.

Int J Gynecol Cancer 2017 09;27(7):1543-1549

*Department of Pathology, Ospedale di Circolo, ASST Settelaghi, Varese; †Department of Medicine and Surgery, University of Insubria, Varese; ‡Unit of Functional Onco-Genomics and Genetics, CRO Aviano, National Cancer Institute, Aviano (PN); and §Department of Obstetrics and Gynecology, Ospedale di Circolo ASST Settelaghi, Varese, Italy.

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September 2017

Oxidative DNA damage induces hypomethylation in a compromised base excision repair colorectal tumourigenesis.

Br J Cancer 2017 Mar 31;116(6):793-801. Epub 2017 Jan 31.

Molecular Pathology Laboratory, Unit of Pathology, Candiolo Cancer Institute, FPO-IRCCS, Strada Provinciale 142, Candiolo (Torino) 10060, Italy.

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March 2017

In vitro hydroquinone-induced instauration of histone bivalent mark on human retroelements (LINE-1) in HL60 cells.

Toxicol In Vitro 2017 Apr 13;40:1-10. Epub 2016 Dec 13.

Dept. of Biotechnologies and Life Sciences (DBSV), University of Insubria, via L. Manara 7, 21052 Busto Arsizio, Varese, Italy. Electronic address:

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April 2017

Disruption of the APC gene by t(5;7) translocation in a Turcot family.

Cancer Genet 2016 Mar 17;209(3):107-11. Epub 2015 Dec 17.

Ospedale di Circolo di Varese, Unit of Pathology, via O. Rossi 9, IT-21100 Varese, Italy.

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March 2016

Aberrant DNA methylation profiles of inherited and sporadic colorectal cancer.

Clin Epigenetics 2015 21;7:131. Epub 2015 Dec 21.

Department of Surgical and Morphological Sciences, Section of Anatomic Pathology, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy.

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December 2015

Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study.

Gastroenterol Res Pract 2015 19;2015:132190. Epub 2015 Oct 19.

Dipartimento di Medicina Diagnostica, Clinica e Sanità Pubblica, Università di Modena e Reggio Emilia, 41124 Modena, Italy.

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November 2015

Durable recurrence-free survival after pneumonectomy for late lung metastasis from rectal cancer: case report with genetic and epigenetic analyses.

BMC Cancer 2015 Aug 1;15:567. Epub 2015 Aug 1.

Section of Anatomic Pathology, Department of Surgical and Morphological Sciences, University of Insubria, Ospedale di Circolo, Via O. Rossi, 9, Varese, 21100, Italy.

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August 2015

EGFR amplified and overexpressing glioblastomas and association with better response to adjuvant metronomic temozolomide.

J Natl Cancer Inst 2015 May 3;107(5). Epub 2015 Mar 3.

Pathology (MC, BL, MFB, DM, VP, FF, PLP) and Pharmacology Units (CB, MP), Department of Molecular and Translational Medicine, University of Brescia and National Institute of Neuroscience, Italy; Medical Oncology (SG), Neurosurgery (LB), Radiation Oncology (MB), and Neuroradiology Departments (RL), Spedali Civili of Brescia, University of Brescia, Italy; Neural Stem Cell Biology Unit, Division of Regenerative Medicine, Stem Cells & Gene Therapy, San Raffaele Scientific Institute, Milan (SM, RG); Pathology Unit, Department of Surgical and Morphological Sciences, University of Insubria, Italy (DF); Neurological Institute Besta, Milan, Italy (SP, GF); Herbert Irving Comprehensive Cancer Center, Department of Pathology & Cell Biology and Department of Medicine, Division of Digestive and Liver Diseases, Columbia University, New York, NY (PD); IRCCS San Camillo Hospital, Venice, Italy (MP).

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May 2015

Microsatellite unstable gastrointestinal neuroendocrine carcinomas: a new clinicopathologic entity.

Endocr Relat Cancer 2015 Feb 2;22(1):35-45. Epub 2014 Dec 2.

Section of Anatomic PathologyDepartment of Surgical and Morphological Sciences, University of Insubria, Via O. Rossi, 9, 21100 Varese, ItalyCRIBI Biotechnology CenterUniversity of Padova, Padova, ItalyDepartment of Molecular MedicineInstitute of Pathology, University of Pavia, IRCCS Policlinico San Matteo, Pavia, ItalyDepartment of PathologyOspedale di Circolo, Varese, Italy.

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February 2015

Prognostic relevance of aberrant DNA methylation in g1 and g2 pancreatic neuroendocrine tumors.

Neuroendocrinology 2014 5;100(1):26-34. Epub 2014 Jul 5.

Section of Anatomic Pathology, Department of Surgical and Morphological Sciences, University of Insubria and Ospedale di Circolo, Varese, Italy.

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July 2015

The bright and fascinating world of the neuroendocrine cells.

Endocr Pathol 2014 Jun;25(2):121-3

Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy,

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June 2014

Pyrosequencing for EGFR mutation detection: diagnostic accuracy and clinical implications.

Diagn Mol Pathol 2013 Dec;22(4):196-203

*Department of Surgical and Morphological Sciences, Anatomic Pathology Unit, University of Insubria, Varese, Italy †Oncology Unit, Ospedale di Circolo, Varese, Italy.

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December 2013

Diagnostic utility of MS-MLPA in DNA methylation profiling of adenocarcinomas and neuroendocrine carcinomas of the colon-rectum.

Virchows Arch 2013 Jan 9;462(1):47-56. Epub 2012 Dec 9.

Department of Surgical and Morphological Sciences, Anatomic Pathology Unit, University of Insubria and Ospedale di Circolo, Via O. Rossi, 9, 21100, Varese, Italy.

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January 2013

Hierarchical clustering analysis of pathologic and molecular data identifies prognostically and biologically distinct groups of colorectal carcinomas.

Mod Pathol 2011 Jan 17;24(1):126-37. Epub 2010 Sep 17.

Department of Human Morphology, Section of Anatomic Pathology, Centro Insubre di Biotecnologie per la Salute Umana, University of Insubria and Ospedale di Circolo, Varese, Italy.

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January 2011

Identification of the first case of germline duplication of BRCA1 exon 13 in an Italian family.

Fam Cancer 2010 Sep;9(3):275-82

Department of Human Morphology, Anatomic Pathology Unit, Centro Insubre di Biotecnologie per la Salute Umana, Ospedale di Circolo, University of Insubria, Via O. Rossi, 9, 21100, Varese, Italy.

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September 2010

Up-regulation and stabilization of HIF-1alpha in colorectal carcinomas.

Surg Oncol 2007 Dec 26;16 Suppl 1:S25-7. Epub 2007 Nov 26.

Department of Human Morphology, Anatomic Pathology Unit, University of Insubria, Via O. Rossi, 9, 21100 Varese, Italy.

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December 2007

Prognostic factors for ampullary adenocarcinomas: tumor stage, tumor histology, tumor location, immunohistochemistry and microsatellite instability.

Virchows Arch 2007 Sep 26;451(3):649-57. Epub 2007 Jul 26.

Division of Anatomic Pathology, Department of Human Morphology, University of Insubria, Varese, Italy.

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September 2007

The high frequency of de novo promoter methylation in synchronous primary endometrial and ovarian carcinomas.

Clin Cancer Res 2006 Jun;12(11 Pt 1):3329-36

Anatomic Pathology Unit, Department of Human Morphology, University of Insubria, Varese, Italy.

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June 2006

Histidine decarboxylase, DOPA decarboxylase, and vesicular monoamine transporter 2 expression in neuroendocrine tumors: immunohistochemical study and gene expression analysis.

J Histochem Cytochem 2006 Aug 3;54(8):863-75. Epub 2006 Mar 3.

Section of Anatomic Pathology, Dept. of Human Morphology, University of Insubria and Ospedale di Circolo, Via Ottorino Rossi, 9 I-21100 Varese, Italy.

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August 2006

Intratumour T cells, their activation status and survival in gastric carcinomas characterised for microsatellite instability and Epstein-Barr virus infection.

Virchows Arch 2006 Mar 27;448(3):344-53. Epub 2005 Oct 27.

Department of Human Morphology, Section of Anatomic Pathology, University of Insubria and Ospedale di Circolo, Varese, Italy.

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March 2006

Two PMS2 mutations in a Turcot syndrome family with small bowel cancers.

Am J Gastroenterol 2005 Aug;100(8):1886-91

Department of Preclinical Research and Epidemiology, Experimental Oncology 1, Centro Riferimento Oncologico, IRCCS, Aviano, Italy.

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August 2005

Allelotypes and fluorescence in situ hybridization profiles of poorly differentiated endocrine carcinomas of different sites.

Clin Cancer Res 2005 Mar;11(5):1765-75

Department of Human Morphology, Anatomic Pathology Unit, University of Insubria, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy.

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March 2005

Microsatellite instability and p53 expression in gallbladder carcinomas.

Diagn Mol Pathol 2003 Jun;12(2):96-102

Department of Clinical and Biological Sciences, University of Insubria, Varese, Italy.

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June 2003